ACCORD
Resource Report
Resource Website
100+ mentions
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ACCORD (RRID:SCR_009015)
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ACCORD
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clinical trial, resource
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Study testing whether strict glucose control lowers the risk of heart disease and stroke in adults with type 2 diabetes. In addition the study is exploring: 1) Whether in the context of good glycemic control the use of different lowering lipid drugs will further improve these outcomes and 2) If strict control of blood pressure will also have additional beneficial effects on reducing cardiovascular disease. The design was a randomized, multicenter, double 2 X 2 factorial trial in 10,251 patients with type 2 diabetes mellitus. It was designed to test the effects on major CVD events of intensive glycemia control, of fibrate treatment to increase HDL-cholesterol and lower triglycerides (in the context of good LDL-C and glycemia control), and of intensive blood pressure control (in the context of good glycemia control), each compared to an appropriate control. All 10,251 participants were in an overarching glycemia trial. In addition, one 2 X 2 trial addressed the lipid question in 5,518 of the participants and the other 2 X 2 trial addressed the blood pressure question in 4,733 of the participants. The glycemia trial was terminated early due to higher mortality in the intensive compared with the standard glycemia treatment strategies. The results were published in June 2008 (N Eng J Med 2008;358:2545-59). Study-delivered treatment for all ACCORD participants was stopped on June 30, 2009, and the participants were assisted as needed in transferring their care to a personal physician. The lipid and blood pressure results (as well as the microvascular outcomes and eye substudy results) were published in 2010. All participants are continuing to be followed in a non-treatment observational study.
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middle adult human, late adult human, glycemic control, lowering lipid drug, blood pressure, lipid, clinical
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is related to: NIDDK Information Network (dkNET) has parent organization: National Heart Lung and Blood Institute
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Cardiovascular disease, Stroke, Type 2 diabetes, Diabetes, Aging |
NHLBI ; NIDDK ; NEI ; CDC ; NIA |
PMID:23490598 PMID:23253271 PMID:23238658 PMID:22723583 PMID:22646230 |
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nlx_152746 |
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SCR_009015 |
Action to Control Cardiovascular Disease Risk in Diabetes |
2026-09-05 06:33:30 |
180 |
National Heart Lung and Blood Institute
Resource Report
Resource Website
100+ mentions
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National Heart Lung and Blood Institute (RRID:SCR_011413)
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NHLBI
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institution
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NHLBI provides leadership for a national program in diseases of the heart, blood vessels, lung, and blood; blood resources; and sleep disorders. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman''s Health Initiative. The Institute plans, conducts, fosters, and supports an integrated and coordinated program of basic research, clinical investigations and trials, observational studies, and demonstration and education projects. The National Heart, Lung, and Blood Institute (NHLBI) provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives. The NHLBI stimulates basic discoveries about the causes of disease, enables the translation of basic discoveries into clinical practice, fosters training and mentoring of emerging scientists and physicians, and communicates research advances to the public. It creates and supports a robust, collaborative research infrastructure in partnership with private and public organizations, including academic institutions, industry, and other government agencies. The Institute collaborates with patients, families, health care professionals, scientists, professional societies, patient advocacy groups, community organizations, and the media to promote the application of research results and leverage resources to address public health needs. The NHLBI also collaborates with international organizations to help reduce the burden of heart, lung, and blood diseases worldwide.
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has parent organization: National Institutes of Health is parent organization of: Body Mass Index Calculator is parent organization of: ACCORD is parent organization of: National Heart Lung and Blood Institute Office of the Director is parent organization of: NHLBI Division of Blood Diseases and Resources is parent organization of: NHLBI Division of Cardiovascular Sciences is parent organization of: NHLBI Division of Intramural Research is parent organization of: Womens health initiative is parent organization of: NHLBI Division of Lung Diseases is parent organization of: Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC)
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Crossref funder ID: 100000050, nlx_inv_1005097, Wikidata: Q6973027, grid.279885.9, ISNI: 0000 0001 2293 4638 |
https://ror.org/012pb6c26 |
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SCR_011413 |
National Heart Lung and Blood Institute |
2026-09-05 06:27:04 |
124 |