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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Conserved Domain Database Resource Report Resource Website 100+ mentions |
Conserved Domain Database (RRID:SCR_002077) | CDD | database, data or information resource | Database of annotations of functional units in proteins including multiple sequence alignment models for ancient domains and full-length proteins. This collection of models includes 3D structures that display the sequence/structure/function relationships in proteins. It also includes alignments of the domains to known three-dimensional protein structures in the MMDB database. The source databases are Pfam, Smart, and COG. Users can identify amino acids in protein sequences with the resources available as well as view single sequences embedded within multiple sequence alignments. | protein, amino acid sequence, nucleic acid, 3d structure, annotation, function, sequence, structure, amino acid, gold standard |
is used by: Mutation Annotation and Genomic Interpretation is listed by: re3data.org is related to: Pfam is related to: SMART is related to: COG is related to: NCBI Structure has parent organization: NCBI works with: Conserved Domains Search |
PMID:25414356 PMID:18984618 |
nif-0000-02647, r3d100010653 | http://www.ncbi.nlm.nih.gov/sites/entrez?db=cdd | SCR_002077 | Conserved Domains Database, Conserved Domains | 2026-08-06 09:25:34 | 306 | ||||||
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SMART Resource Report Resource Website 5000+ mentions |
SMART (RRID:SCR_005026) | SMART | software resource, service resource, data access protocol, production service resource, data analysis service, data or information resource, web service, analysis service resource, database | Software tool for identification and annotation of genetically mobile domains and analysis of domain architectures. | extracellular, gene, genetic, genetically, genome, architecture, chromatin, domain, mobile, phyletic, protein, proteome, signaling, structure, taxonomic, tertiary, bio.tools, FASEB list |
is used by: Mutation Annotation and Genomic Interpretation is listed by: bio.tools is listed by: Debian is related to: Eukaryotic Linear Motif is related to: Conserved Domain Database is related to: GOTaxExplorer has parent organization: EMBL - Bork Group |
European Union | PMID:18978020 PMID:16381859 PMID:14681379 PMID:10592234 PMID:9847187 PMID:9600884 |
Free, Freely available | nif-0000-03471, biotools:smart | http://smart.embl-heidelberg.de/, https://bio.tools/smart | SCR_005026 | Simple Modular Architecture Research Tool | 2026-08-06 09:26:19 | 6760 | ||||
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NCBI Structure Resource Report Resource Website 10+ mentions |
NCBI Structure (RRID:SCR_004218) | NCBI Structure | database, data or information resource | Database of three-dimensional structures of macromolecules that allows the user to retrieve structures for specific molecule types as well as structures for genes and proteins of interest. Three main databases comprise Structure-The Molecular Modeling Database; Conserved Domains and Protein Classification; and the BioSystems Database. Structure also links to the PubChem databases to connect biological activity data to the macromolecular structures. Users can locate structural templates for proteins and interactively view structures and sequence data to closely examine sequence-structure relationships. * Macromolecular structures: The three-dimensional structures of biomolecules provide a wealth of information on their biological function and evolutionary relationships. The Molecular Modeling Database (MMDB), as part of the Entrez system, facilitates access to structure data by connecting them with associated literature, protein and nucleic acid sequences, chemicals, biomolecular interactions, and more. It is possible, for example, to find 3D structures for homologs of a protein of interest by following the Related Structure link in an Entrez Protein sequence record. * Conserved domains and protein classification: Conserved domains are functional units within a protein that act as building blocks in molecular evolution and recombine in various arrangements to make proteins with different functions. The Conserved Domain Database (CDD) brings together several collections of multiple sequence alignments representing conserved domains, in addition to NCBI-curated domains that use 3D-structure information explicitly to define domain boundaries and provide insights into sequence/structure/function relationships. * Small molecules and their biological activity: The PubChem project provides information on the biological activities of small molecules and is a component of NIH''''s Molecular Libraries Roadmap Initiative. PubChem includes three databases: PCSubstance, PCBioAssay, and PCCompound. The PubChem data are linked to other data types (illustrated example) in the Entrez system, making it possible, for example, to retrieve information about a compound and then Link to its biological activity data, retrieve 3D protein structures bound to the compound and interactively view their active sites, and find biosystems that include the compound as a component. * Biological Systems: A biosystem, or biological system, is a group of molecules that interact directly or indirectly, where the grouping is relevant to the characterization of living matter. The NCBI BioSystems Database provides centralized access to biological pathways from several source databases and connects the biosystem records with associated literature, molecular, and chemical data throughout the Entrez system. BioSystem records list and categorize components (illustrated example), such as the genes, proteins, and small molecules involved in a biological system. The companion FLink icon FLink tool, in turn, allows you to input a list of proteins, genes, or small molecules and retrieve a ranked list of biosystems. | macromolecule, conserved domain, protein classification, protein, small molecule, biological activity, molecule, biosystem, biological system, structure, gene, alignment, biomolecule, interaction, function, evolution, 3d spatial image, visualization, gold standard |
is listed by: re3data.org is related to: PubChem is related to: NCBI BioSystems Database is related to: Conserved Domain Database is related to: Molecular Modeling DataBase is related to: CBLAST is related to: NCBI Structure: Cn3D is related to: IBIS: Inferred Biomolecular Interactions Server is related to: Vector Alignment Search Tool is related to: PubMed has parent organization: NCBI |
Free, Public, Acknowledgement requested | nlx_23947, r3d100010927 | http://www.ncbi.nlm.nih.gov/sites/entrez?db=structure, https://doi.org/10.17616/R3PP7J | SCR_004218 | 2026-08-06 09:26:04 | 25 | |||||||
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NCBI Resource Report Resource Website 10000+ mentions |
NCBI (RRID:SCR_006472) | NCBI | nonprofit organization | A portal to biomedical and genomic information. NCBI creates public databases, conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information for the better understanding of molecular processes affecting human health and disease. | biomedical, genomic, molecular biology, health, disease, database, computational biology, bio.tools |
is used by: NIF Data Federation is listed by: NIDDK Information Network (dkNET) is listed by: bio.tools is listed by: Debian is related to: AmiGO is related to: NCBI Viral Genomes is related to: Clone DB is related to: PubReader is related to: OMIA - Online Mendelian Inheritance in Animals is related to: European Nucleotide Archive (ENA) is related to: Plant Co-expression Annotation Resource is related to: METAGENOTE is related to: Phyutility is related to: CaspBase is related to: Prokaryotic Genomes Automatic Annotation Pipeline has parent organization: National Library of Medicine is parent organization of: MedGen is parent organization of: dbSTS is parent organization of: PubMed Health is parent organization of: BLASTP is parent organization of: GQuery is parent organization of: BLASTN is parent organization of: GTEx eQTL Browser is parent organization of: BLASTX is parent organization of: Homology Maps Page is parent organization of: PEDHUNTER is parent organization of: Conserved Domain Database is parent organization of: NCBI Genome Survey Sequences Database is parent organization of: High Throughput Genomic Sequences Division is parent organization of: AceView is parent organization of: dbMHC is parent organization of: dbSNP is parent organization of: Entrez Gene is parent organization of: NCBI Genome is parent organization of: NCBI database of Genotypes and Phenotypes (dbGap) is parent organization of: GenBank is parent organization of: International HapMap Project is parent organization of: IgBLAST is parent organization of: Lowes Syndrome Mutation Database is parent organization of: HomoloGene is parent organization of: Influenza Virus Resource is parent organization of: Distant Regulatory Elements is parent organization of: e-PCR is parent organization of: MapViewer is parent organization of: Primer-BLAST is parent organization of: dbVar is parent organization of: NCBI Taxonomy is parent organization of: NCBI Protein Database is parent organization of: Gene Reference into Function is parent organization of: Protein Clusters is parent organization of: RefSeq is parent organization of: TPA is parent organization of: GENSAT at NCBI - Gene Expression Nervous System Atlas is parent organization of: COBALT: Constraint-based Multiple Alignment Tool is parent organization of: PubMed Central is parent organization of: UniLib is parent organization of: NCBI Structure is parent organization of: PubChem is parent organization of: Anopheles gambiae (African malaria mosquito) genome view is parent organization of: UniGene is parent organization of: NLM Catalog is parent organization of: Entrez GEO Profiles is parent organization of: Nucleotide database is parent organization of: NCBI BioSystems Database is parent organization of: CBLAST is parent organization of: NCBI BioProject is parent organization of: NCBI Probe is parent organization of: PubMed is parent organization of: NCBI BioSample is parent organization of: NCBI Nucleotide is parent organization of: NCBI Structure: Cn3D is parent organization of: NCBI BLAST is parent organization of: IBIS: Inferred Biomolecular Interactions Server is parent organization of: NCBI Sequence Read Archive (SRA) is parent organization of: Gene Expression Omnibus (GEO) is parent organization of: NCBI Popset is parent organization of: PIE the search is parent organization of: Genetic Testing Registry is parent organization of: NCBI Resource List is parent organization of: NCBI dbRBC is parent organization of: NCBI YouTube Channel is parent organization of: NCBI Epigenomics is parent organization of: ClinVar is parent organization of: Genome Reference Consortium is parent organization of: GeneReviews is parent organization of: Molecular Imaging and Contrast Agent Database is parent organization of: Consensus CDS is parent organization of: UniSTS is parent organization of: HIV-1 Human Protein Interaction Database is parent organization of: Assay Guidance Manual is parent organization of: Bookshelf is parent organization of: COG is parent organization of: Gene Expression Omnibus is parent organization of: Molecular Modelling DataBase is parent organization of: Organelle Genome Resources is parent organization of: SKY/M-FISH/CGH is parent organization of: dbEST is parent organization of: JournalReview.org is parent organization of: NCBI GenBank via FTP is parent organization of: PubChem Compound is parent organization of: Molecular Modeling DataBase is parent organization of: Vector Alignment Search Tool is parent organization of: PubChem BioAssay is parent organization of: NCBI Genome Workbench is parent organization of: TBLASTN is parent organization of: TBLASTX is parent organization of: Mega BLAST is parent organization of: Genetic Codes is parent organization of: HIV-1, Human Protein Interaction Database is parent organization of: PubReader is parent organization of: PubChem Substance is parent organization of: OMIA - Online Mendelian Inheritance in Animals is parent organization of: OMIM is parent organization of: 1000 Genomes: A Deep Catalog of Human Genetic Variation is parent organization of: GeneTests is parent organization of: NCBI Genome Survey Sequences Database is parent organization of: MagicBlast is parent organization of: RefSeq is parent organization of: Sequin is parent organization of: Batch Entrez is parent organization of: Entrez is parent organization of: tbl2asn is parent organization of: Whole Genome Shotgun (WGS) Project is parent organization of: Digital Differential Display (DDD) is parent organization of: BLASTClust is parent organization of: PASC is parent organization of: Open Reading Frame Finder is parent organization of: Genotyping works with: Human Mouse Disease Connection works with: A plasmid Editor works with: Database of genes related to Repeat Expansion Diseases |
Public, The community can contribute to this resource | nif-0000-00139, biotools:ncbi_resources | https://bio.tools/ncbi_resources | http://www.ncbi.nih.gov/ | SCR_006472 | National Center for Biotechnology Information, NCBI - National Center for Biotechnology Information | 2026-08-01 12:03:10 | 25993 | |||||
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Pfam Resource Report Resource Website 10000+ mentions |
Pfam (RRID:SCR_004726) | database, data or information resource | A database of protein families, each represented by multiple sequence alignments and hidden Markov models (HMMs). Users can analyze protein sequences for Pfam matches, view Pfam family annotation and alignments, see groups of related families, look at the domain organization of a protein sequence, find the domains on a PDB structure, and query Pfam by keywords. There are two components to Pfam: Pfam-A and Pfam-B. Pfam-A entries are high quality, manually curated families that may automatically generate a supplement using the ADDA database. These automatically generated entries are called Pfam-B. Although of lower quality, Pfam-B families can be useful for identifying functionally conserved regions when no Pfam-A entries are found. Pfam also generates higher-level groupings of related families, known as clans (collections of Pfam-A entries which are related by similarity of sequence, structure or profile-HMM). | database, clan, structure, sequence, protein family, domain, bio.tools, FASEB list |
is used by: Mutation Annotation and Genomic Interpretation is used by: MobiDB is listed by: OMICtools is listed by: bio.tools is listed by: Debian is related to: Conserved Domain Database is related to: SUPFAM is related to: DBD: Transcription factor prediction database is related to: DOMINE: Database of Protein Interactions is related to: GeneSpeed- A Database of Unigene Domain Organization is related to: Eukaryotic Linear Motif is related to: TopoSNP is related to: GOTaxExplorer is related to: TrED is related to: ProOpDB is related to: Algal Functional Annotation Tool has parent organization: Wellcome Trust Sanger Institute; Hinxton; United Kingdom |
EMBL core funds ; Howard Hughes Medical Institute ; BBSRC BB/L024136/1; Wellcome Trust 108433/Z/15/Z |
PMID:24288371 PMID:19920124 |
Acknowledgement requested, Available via FTP | biotools:pfam, OMICS_01696, r3d100012850, nlx_72111 | https://bio.tools/pfam, https://doi.org/10.17616/R3QV4F | http://pfam.sanger.ac.uk/ | SCR_004726 | Pfam Database, Protein Families Database, PFAM, Pfam protein families database | 2026-08-06 09:26:13 | 15523 | ||||
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re3data.org Resource Report Resource Website 50+ mentions |
re3data.org (RRID:SCR_006782) | re3data.org | registry, database, data or information resource | Global registry of research data repositories from all academic disciplines that allows the easy identification of appropriate research data repositories, both for data producers and users. Information icons display principal attributes of a repository that can be used for multi-faceted searches. Repository operators can suggest their infrastructures to be listed via a simple application form. A repository is indexed when the minimum requirements are met, i.e. mode of access to the data and repository, as well as the terms of use. | vocabulary, registry, metadata standard, data sharing, FASEB list |
lists: Academic Seismic Portal at UTIG lists: National Addiction and HIV Data Archive Program (NAHDAP) lists: Alaska Climate Research Center lists: MINT lists: Internet Archive lists: MatrixDB lists: Animal QTLdb lists: MPIDB lists: BeetleBase lists: Conserved Domain Database lists: NeuroMorpho.Org lists: Marine Geoscience Data System lists: Cell Centered Database lists: dbMHC lists: Human Mortality Database lists: UniProt lists: Ligand-Gated Ion Channel Database lists: EcoGene lists: NCBI Genome lists: ESTHER lists: Genomes Online Database lists: Gramene lists: American FactFinder lists: Human Proteinpedia lists: IMGT/HLA lists: Influenza Virus Resource lists: DOE Joint Genome Institute lists: MetaCrop lists: ISPS Data Archive lists: MorphBank lists: miRBase lists: Inter-university Consortium for Political and Social Research (ICPSR) lists: Mouse Phenome Database (MPD) lists: MorphoBank lists: dbVar lists: Open Science Framework lists: TalkBank lists: Nucleic Acid Database lists: NCBI Taxonomy lists: NCBI Protein Database lists: PHI-base lists: Alberta Geological Survey lists: Protein Clusters lists: Reactome lists: Cell Image Library (CIL) lists: eyeMoviePedia lists: ALLBUS - German General Social Survey lists: TPA lists: Agency for Healthcare Research and Quality lists: Alaska Satellite Facility lists: Current German Weather Stations lists: NCBI Structure lists: BOLD lists: PDBe - Protein Data Bank in Europe lists: FishBase lists: Nucleotide database lists: NCBI BioSystems Database lists: SGD lists: Data.gov lists: RHEA lists: European Bioinformatics Institute lists: NCBI Probe lists: NCBI Nucleotide lists: Database of Genomic Variants Archive (DGVa) lists: NCBI Popset lists: Whole Brain Atlas lists: EMAGE Gene Expression Database lists: Limited Access Datasets From NIMH Clinical Trials lists: Tree of Life Web Project lists: TreeBASE lists: UCSC Genome Browser lists: UniPROBE lists: Crystallography Open Database (COD) lists: National Archive of Computerized Data on Aging (NACDA) lists: EOL - Encyclopedia of Life lists: VectorBase lists: caArray lists: NCBI Epigenomics lists: GWAS Central lists: QTL Archive lists: Proteome Commons lists: XNAT Central lists: 4TU.Datacentrum lists: Amazon Web Services Public Data Sets lists: ChemSpider lists: DataStaR lists: Rat Genome Database (RGD) lists: Atlas of Living Australia lists: Electron Microscopy Data Bank at PDBe (MSD-EBI) lists: Phytozome lists: FlyBase lists: MaizeGDB lists: Tuberculosis Database lists: InterPro lists: UNAVCO lists: The Human Protein Atlas lists: InnateDB lists: UniSTS lists: Launchpad lists: Surveillance Epidemiology and End Results lists: FAOSTAT lists: Adult Blood Lead Epidemiology and Surveillance Interactive Database lists: HIstome: The Histone Infobase lists: HPRD - Human Protein Reference Database lists: Biological General Repository for Interaction Datasets (BioGRID) lists: INFEVERS lists: Reciprocal Net lists: Africa Centre for Health and Population Studies lists: BeeBase lists: Biodiversity Heritage Library lists: Databrary lists: ACADIS Gateway lists: ACEpepDB lists: AIMS Data Centre lists: ALADDIN lists: ASTER lists: Access to Archival Databases lists: AidData lists: Alaska Ocean Observing System lists: J. Craig Venter Institute lists: Wellcome Trust Sanger Institute; Hinxton; United Kingdom lists: Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) lists: myExperiment lists: BioModels lists: Addgene lists: Antarctic and Southern Ocean Data Portal lists: OpenTopography lists: National Snow and Ice Data Center lists: Biological Magnetic Resonance Data Bank (BMRB) lists: dbSNP lists: Ensembl lists: DNA DataBank of Japan (DDBJ) lists: Entrez Gene lists: Zebrafish Information Network (ZFIN) lists: GitHub lists: DrugBank lists: NCBI database of Genotypes and Phenotypes (dbGap) lists: Gene Expression Nervous System Atlas lists: SumsDB lists: GenBank lists: GermOnline lists: HGNC lists: Greengenes lists: Neuroscience Information Framework lists: HomoloGene lists: ArrayExpress lists: JASPAR lists: WormBase lists: Database of Interacting Proteins (DIP) lists: EMDataResource.org lists: ResearchCompendia lists: Proteomics Identifications (PRIDE) lists: RefSeq lists: FAIRsharing lists: PubChem lists: FigShare lists: UniGene lists: NIMH Data Archive lists: TAIR lists: NCBI BioProject lists: SMD lists: OpenNeuro lists: SoyBase lists: Beta Cell Biology Consortium lists: Biomedical Informatics Research Network lists: Dryad Digital Repository lists: Atlantic Canada Conservation Data Centre lists: Agri-environmental Research Data Repository lists: Australian Antarctic Data Centre lists: Antibody Registry lists: Mouse Genome Informatics (MGI) lists: European Nucleotide Archive (ENA) lists: NIDDK Central Repository lists: GigaScience lists: PeptideAtlas lists: 1000 Genomes: A Deep Catalog of Human Genetic Variation lists: IntAct lists: fMRI Data Center lists: Gene Expression Omnibus lists: Data and Specimen Hub (NICHD DASH) lists: NIDA Data Share lists: The NINDS Human Cell and Data Repository (NHCDR) lists: Microphysiology Systems Database lists: Dataverse Network Project lists: Mendeley lists: Vivli lists: Metabolomics Workbench lists: Qualitative Data Repository lists: Protocols.io lists: ZENODO lists: STRENDA lists: Code Ocean lists: Brain Image Library lists: German Collection of Microorganisms and Cell Cultures lists: INPTDAT lists: DataONE lists: GBIF - Global Biodiversity Information Facility lists: Lamont-Doherty Core Repository lists: CaltechDATA lists: Synapse lists: Incorporated Research Institutions for Seismology lists: Cancer Imaging Archive (TCIA) lists: Mendeley Data lists: UK Data Archive lists: GigaDB lists: PhysioNet lists: Project Data Sphere lists: Influenza Research Database (IRD) lists: Simtk.org lists: ResearchGate lists: Virus Pathogen Resource (ViPR) lists: Cambridge Structural Data Base lists: 4TU.ResearchData lists: Aperta Turkey Open Archive lists: Polar Data Catalogue lists: Arch lists: Australian Data Archive lists: Australian Ocean Data Network lists: Barbara A. Mikulski Archive for Space Telescopes lists: Aston Data Explorer lists: Birkbeck Research Data lists: B2SHARE Eudat lists: BioHeritage National Science Challenge Data Repository lists: Bolin Centre Database lists: Brown Digital Repository is listed by: FORCE11 is related to: U.S. Census Bureau is related to: Rat Genome Database (RGD) is related to: ResearchCompendia has parent organization: Humboldt University of Berlin; Berlin; Germany has parent organization: Karlsruhe Institute of Technology; Karlsruhe; Germany |
DFG | The community can contribute to this resource | nlx_152589 | SCR_006782 | Registry of Research Data Repositories, re3data.org: Registry of Research Data Repositories, re3data | 2026-08-06 09:26:40 | 76 | ||||||
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COG Resource Report Resource Website 1000+ mentions |
COG (RRID:SCR_007139) | COG, COG Cluster, COG Function, COG Pathway | database, data or information resource | A database for phylogenetic classification for proteins encoded in complete genomes. Clusters of Orthologous Groups of proteins (COGs) were delineated by comparing protein sequences encoded in complete genomes, representing major phylogenetic lineages. Each COG consists of individual proteins or groups of paralogs from at least 3 lineages and thus corresponds to an ancient conserved domain. Please be aware that COGs hasn't been updated in many years and will not be. | ortholog, protein, cog, conserved protein sequence, unicellular cluster, genome, order, class, phyla, eukaryotic cluster, gold standard |
is listed by: OMICtools is related to: MLTreeMap is related to: ProOpDB is related to: Conserved Domain Database has parent organization: NCBI is parent organization of: Clusters of Orthologous Groups Analysis Ontology |
PMID:12969510 PMID:9381173 |
OMICS_01688, nif-0000-02672 | SCR_007139 | COG Database, Clusters of Orthologous Groups of proteins, COGs, COGs - Clusters of Orthologous Groups of proteins, COGs - Phylogenetic classification of proteins encoded in complete genomes, COG Cluster, COG Pathway, COG Function | 2026-08-06 09:26:46 | 1117 | |||||||
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Mutation Annotation and Genomic Interpretation Resource Report Resource Website |
Mutation Annotation and Genomic Interpretation (RRID:SCR_002800) | MAGI | data analysis service, production service resource, analysis service resource, service resource | A tool for annotating, exploring, and analyzing gene sets that may be associated with cancer. | mutation, interaction, transcript, copy number aberration, network |
uses: The Cancer Genome Atlas uses: HINT uses: HPRD - Human Protein Reference Database uses: Pfam uses: SMART uses: Conserved Domain Database is listed by: OMICtools has parent organization: Brown University; Rhode Island; USA |
Cancer | NSF ; NIH ; Brown University; Rhode Island; USA |
Free, Freely available, Available for download | OMICS_06145 | SCR_002800 | MAGI - A tool for Mutation Annotation and Genomic Interpretation | 2026-08-06 09:25:43 | 0 | |||||
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Conserved Domains Search Resource Report Resource Website 1000+ mentions |
Conserved Domains Search (RRID:SCR_018729) | software resource, service resource, data access protocol, web service, data or information resource | Web tool for conserved domains searching within protein or coding nucleotide sequence. | Conserved domain, protein, coding nucleotide sequence, domain search, domain, nucleotide sequence | works with: Conserved Domain Database | Free, Freely available | SCR_018729 | CD-search | 2026-08-06 09:29:29 | 1241 |
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