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URL: http://www.ara.com/products/mppd.htm
Proper Citation: Multiple-Path Particle Dosimetry Model (RRID:SCR_001486)
Description: Computational model that can be used for estimating human and rat airway particle dosimetry. The model is applicable to risk assessment, research, and education. The MPPD model calculates the deposition and clearance of monodisperse and polydisperse aerosols in the respiratory tracts of rats and human adults and children (deposition only) for particles ranging in size from ultrafine (0.01 micrometers) to coarse (20 micrometers). The models are based on single-path and multiple-path methods for tracking air flow and calculating aerosol deposition in the lung. The single-path method calculates deposition in a typical path per airway generation, while the multiple-path method calculates particle deposition in all airways of the lung and provides lobar-specific and airway-specific information. Within each airway, deposition is calculated using theoretically derived efficiencies for deposition by diffusion, sedimentation, and impaction within the airway or airway bifurcation. Filtration of aerosols by the nose and mouth is determined using empirical efficiency functions. The MPPD model includes calculations of particle clearance in the lung following deposition.
Abbreviations: MPPD
Synonyms: Multiple Path Particle Dosimetry Model
Resource Type: software resource
Defining Citation: PMID:8566482
Keywords: model, computational model, particle dosimetry, risk assessment, adult human, child, aerosol, deposition, clearance, lung
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