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In Caenorhabditis elegans , nose touch avoidance behavior is regulated by the Amphid Sheath (AMsh) glial cells via release of GABA. AMsh glia themselves exhibit calcium responses to mechanical stimulation, although the mechanosensitive channel responsible remains unidentified . Here, we investigated whether pezo-1 , the sole C. elegans homolog of mammalian PIEZO1 and PIEZO2, mediates AMsh glial mechanosensitivity and contributes to nose touch avoidance. We examined behavioral responses in three pezo-1 mutant strains, including a full gene deletion and two truncation alleles lacking the pore-forming transmembrane domains. In addition, we monitored calcium transients in the full gene deletion strain. While pezo-1 ( av149 ) mutants showed a slight reduction in nose touch response, pezo-1 ( av240 ) and pezo-1 ( sy1199 ) mutants behaved like wild-type animals. In vivo calcium imaging revealed that AMsh glial responses to touch were preserved in pezo-1 ( av240 ) mutants, with no significant difference in peak calcium signals compared to wild-type. These findings indicate that pezo-1 is not required for AMsh glial mechanosensory responses or nose touch avoidance behavior. Further research is needed to identify the channels and pathways mediating mechanotransduction in AMsh glia.
Pubmed ID: 40625671
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View all literature mentionsNational institute that leads the federal government in conducting and supporting research on aging and the health and well-being of older people. The Institute seeks to understand the nature of aging and the aging process, and diseases and conditions associated with growing older, in order to extend the healthy, active years of life. In 1974, Congress granted authority to form NIA to provide leadership in aging research, training, health information dissemination, and other programs relevant to aging and older people. Subsequent amendments to this legislation designated NIA as the primary Federal agency on Alzheimer's disease research. Mission The Institute's mission is to: * Support and conduct genetic, biological, clinical, behavioral, social, and economic research on aging. * Foster the development of research and clinician scientists in aging. * Provide research resources. * Disseminate information about aging and advances in research to the public, health care professionals, and the scientific community,among a variety of audiences. Programs NIA sponsors research on aging through extramural and intramural programs. The extramural program funds research and training at universities, hospitals, medical centers, and other public and private organizations nationwide. The intramural program conducts basic and clinical research in Baltimore, MD, and on the NIH campus in Bethesda, MD.
View all literature mentionsNational institute whose mission is to reduce the burden of neurological disease - a burden borne by every age group, by every segment of society, by people all over the world. To accomplish this goal the NINDS supports and conducts basic, translational, and clinical research on the normal and diseased nervous system. The Institute also fosters the training of investigators in the basic and clinical neurosciences, and seeks better understanding, diagnosis, treatment, and prevention of neurological disorders. NINDS: * Conducts, fosters, coordinates, and guides research on the causes, prevention, diagnosis, and treatment of neurological disorders and stroke, and supports basic research in related scientific areas. * Provides grants-in-aid to public and private institutions and individuals in fields related to its areas of interest, including research project, program project, and research center grants. * Operates a program of contracts for the funding of research and research support efforts in selected areas of institute need. * Provides individual and institutional fellowships to increase scientific expertise in neurological fields. * Conducts a diversified program of intramural and collaborative research in its own laboratories, branches, and clinics. * Collects and disseminates research information related to neurological disorders.
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