Searching the Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
Autophagy-lysosomal function is crucial for maintaining healthy lifespan and preventing age-related diseases. The transcription factor TFEB plays a key role in regulating this pathway. Decreased TFEB expression is associated with various age-related disorders, making it a promising therapeutic target. In this study, we screened a natural product library and discovered mitophagy-inducing coumarin (MIC), a benzocoumarin compound that enhances TFEB expression and lysosomal function. MIC robustly increases the lifespan of Caenorhabditis elegans in an HLH-30/TFEB-dependent and mitophagy-dependent manner involving DCT-1/BNIP3 while also preventing mitochondrial dysfunction in mammalian cells. Mechanistically, MIC acts by inhibiting ligand-induced activation of the nuclear hormone receptor DAF-12/FXR, which, in turn, induces mitophagy and extends lifespan. In conclusion, our study uncovers MIC as a promising drug-like molecule that enhances mitochondrial function and extends lifespan by targeting DAF-12/FXR. Furthermore, we discovered DAF-12/FXR as a previously unknown upstream regulator of HLH-30/TFEB and mitophagy.
Pubmed ID: 37957360
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Center that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name gas-1(fc21) X. from WB.
View all literature mentionsCaenorhabditis elegans with name adIs2122 from WB.
View all literature mentionsCaenorhabditis elegans with name hlh-30(tm1978) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name vha-3(ok1501) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name ttTi5605 II; unc-119(ed3) III; uwaEx8. from WB.
View all literature mentionsCaenorhabditis elegans with name pkIs2386 [unc-54p::alpha-synnuclein::YFP + unc-119(+)] from WB.
View all literature mentionsCaenorhabditis elegans with name sqIs19. from WB.
View all literature mentionsCaenorhabditis elegans with name drp-1(tm1108) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name zcIs17. from WB.
View all literature mentionsCaenorhabditis elegans with name lmp-1(nr2045). from WB.
View all literature mentionsCaenorhabditis elegans with name smg-1(cc546ts); dvIs27 [Pmyo-3::human Amyloid beta 1-42; let-851 3'UTR; rol-6(su1006)] from WB.
View all literature mentionsCaenorhabditis elegans with name unc-119(ed3) III; pwIs50. from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name dvIs62 X. from WB.
View all literature mentionsCaenorhabditis elegans with name cuIs2 IV. from WB.
View all literature mentionsCaenorhabditis elegans with name sqIs24. from WB.
View all literature mentionsCaenorhabditis elegans with name mev-1(kn1) III. from WB.
View all literature mentionsCaenorhabditis elegans with name daf-12(rh61rh411) X. from WB.
View all literature mentionsWelcome to the Neuroscience Information Framework Project, designed to serve the biomedical research community. NIF maintains the largest searchable collection of neuroscience data, the largest catalog of biomedical resources, and the largest ontology for neuroscience on the web. We welcome all feedback and suggestions and are actively looking for resource providers to make their resources accessible through NIF. Learn about the tools available to help you share your data and discover a dynamic inventory of Web-based neuroscience resources.
