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hox genes encode a conserved family of homeodomain transcription factors that are essential to determine the identity of body segments during embryogenesis and maintain adult somatic stem cells competent to regenerate organs. In contrast to higher organisms, somatic cells in C. elegans irreversibly exit the cell cycle after completing their cell lineage and the adult soma cannot regenerate. Here, we show that hox gene expression levels in C. elegans determine the temporal competence of somatic cells to proliferate. Down-regulation of the central hox gene lin-39 in dividing vulval cells results in their premature cell cycle exit, whereas constitutive lin-39 expression causes precocious Pn.p cell and sex myoblast divisions and prolongs the proliferative phase of the vulval cells past their normal point of arrest. Furthermore, ectopic expression of hox genes in the quiescent anchor cell re-activates the cell cycle and induces proliferation until young adulthood. Thus, constitutive expression of a single hox transcription factor is sufficient to prolong somatic cell proliferation beyond the restriction imposed by the cell lineage. The down-regulation of hox gene expression in most somatic cells at the end of larval development may be one cause for the absence of cell proliferation in adult C. elegans.
Pubmed ID: 37891160
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Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
View all literature mentionsSoftware package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.
View all literature mentionsCenter that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name zhIs167[egl-17p>lin-39::gfp]; heSi45[mcm-4::mCherry] from WB.
View all literature mentionsCaenorhabditis elegans with name lin-39(zh120); swIs79[ajm-1::gfp]; zh616.2[hs-16p::zif-1] from WB.
View all literature mentionsCaenorhabditis elegans with name zhEx670.2[egl-17p>nls::gfp]; heSi45[mcm-4::mCherry] from WB.
View all literature mentionsEscherichia coli with name E. coli. from WB.
View all literature mentionsCaenorhabditis elegans with name zhEx670.1[egl-17p>nls::gfp]; heSi45[mcm-4::mCherry] from WB.
View all literature mentionsCaenorhabditis elegans with name lin-39(zh120); swIs79[ajm-1::gfp]; zh616.1[hs-16p::zif-1] from WB.
View all literature mentionsCaenorhabditis elegans with name zhEx630.1[egl-17p>lin-39::gfp] from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name zhEx630.2[egl-17p>lin-39::gfp] from WB.
View all literature mentionsCaenorhabditis elegans with name zhEx630.3[egl-17p>lin-39::gfp] from WB.
View all literature mentionsCaenorhabditis elegans with name zhIs167[egl-17p>lin-39::gfp]; he317[eft-3p>Lox2272-egl-13::nls::bfp2-Lox2272-egl-13::nls::mCherry]; heSi220[lin-31p>cre] from WB.
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