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The nervous system plays a critical role in maintaining whole-organism homeostasis; neurons experiencing mitochondrial stress can coordinate the induction of protective cellular pathways, such as the mitochondrial unfolded protein response (UPRMT), between tissues. However, these studies largely ignored nonneuronal cells of the nervous system. Here, we found that UPRMT activation in four astrocyte-like glial cells in the nematode, Caenorhabditis elegans, can promote protein homeostasis by alleviating protein aggregation in neurons. Unexpectedly, we find that glial cells use small clear vesicles (SCVs) to signal to neurons, which then relay the signal to the periphery using dense-core vesicles (DCVs). This work underlines the importance of glia in establishing and regulating protein homeostasis within the nervous system, which can then affect neuron-mediated effects in organismal homeostasis and longevity.
Pubmed ID: 37831769
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Center that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name unc-31(e928) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name vab-3(e648) X. from WB.
View all literature mentionsCaenorhabditis elegans with name ldrIs1. from WB.
View all literature mentionsCaenorhabditis elegans with name dgEx80. from WB.
View all literature mentionsCaenorhabditis elegans with name zcIs13 V. from WB.
View all literature mentionsCaenorhabditis elegans with name zcIs39 II. from WB.
View all literature mentionsCaenorhabditis elegans with name lin-65(n3441) I. from WB.
View all literature mentionsCaenorhabditis elegans with name bqSi294 II; bqSi506 IV. from WB.
View all literature mentionsCaenorhabditis elegans with name unc-13(s69) I. from WB.
View all literature mentionsCaenorhabditis elegans with name egl-3(ok979) V. from WB.
View all literature mentionsCaenorhabditis elegans with name egl-20(n585) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name rmIs110. from WB.
View all literature mentionsCaenorhabditis elegans with name ubl-5(ok3389) I. from WB.
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