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Animals generate a wide range of highly coordinated motor outputs, which allows them to execute purposeful behaviors. Individual neurons in the circuits that generate behaviors have a remarkable capacity for flexibility as they exhibit multiple axonal projections, transmitter systems, and modes of neural activity. How these multi-functional properties of neurons enable the generation of adaptive behaviors remains unknown. Here, we show that the HSN neuron in C. elegans evokes multiple motor programs over different timescales to enable a suite of behavioral changes during egg laying. Using HSN activity perturbations and in vivo calcium imaging, we show that HSN acutely increases egg laying and locomotion while also biasing the animals toward low-speed dwelling behavior over minutes. The acute effects of HSN on egg laying and high-speed locomotion are mediated by separate sets of HSN transmitters and different HSN axonal compartments. The long-lasting effects on dwelling are mediated in part by HSN release of serotonin, which is taken up and re-released by NSM, another serotonergic neuron class that directly evokes dwelling. Our results show how the multi-functional properties of a single neuron allow it to induce a coordinated suite of behaviors and also reveal that neurons can borrow serotonin from one another to control behavior.
Pubmed ID: 37769660
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Center that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name EMPTY from WB.
View all literature mentionsCaenorhabditis elegans with name lin-15B&lin-15A(n765) qaIs2241 X. from WB.
View all literature mentionsCaenorhabditis elegans with name flp-17(n4894) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name egl-6(n4537) X. from WB.
View all literature mentionsCaenorhabditis elegans with name ttx-1(p767) V from WB.
View all literature mentionsCaenorhabditis elegans with name flp-10(ok2624) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name peIs1715. from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name oyIs84. from WB.
View all literature mentionsCaenorhabditis elegans with name kyIs140 I; ceh-36(ky640) X. from WB.
View all literature mentionsCaenorhabditis elegans with name qrIs2. from WB.
View all literature mentionsCaenorhabditis elegans with name tax-2(p691) I. from WB.
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