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Animals rely on chemosensory cues to survive in pathogen-rich environments. In Caenorhabditis elegans, pathogenic bacteria trigger aversive behaviors through neuronal perception and activate molecular defenses throughout the animal. This suggests that neurons can coordinate the activation of organism-wide defensive responses upon pathogen perception. In this study, we found that exposure to volatile pathogen-associated compounds induces activation of the endoplasmic reticulum unfolded protein response (UPRER) in peripheral tissues after xbp-1 splicing in neurons. This odorant-induced UPRER activation is dependent upon DAF-7/transforming growth factor beta (TGF-β) signaling and leads to extended lifespan and enhanced clearance of toxic proteins. Notably, rescue of the DAF-1 TGF-β receptor in RIM/RIC interneurons is sufficient to significantly recover UPRER activation upon 1-undecene exposure. Our data suggest that the cell non-autonomous UPRER rewires organismal proteostasis in response to pathogen detection, pre-empting proteotoxic stress. Thus, chemosensation of particular odors may be a route to manipulation of stress responses and longevity.
Pubmed ID: 37500972
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View all literature mentionsCenter that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name daf-1(m40) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name zcIs4 V. from WB.
View all literature mentionsCaenorhabditis elegans with name ire-1(zc14) II; zcIs4 V. from WB.
View all literature mentionsEscherichia coli with name E. coli. from WB.
View all literature mentionsCaenorhabditis elegans with name daf-11(m47) V. from WB.
View all literature mentionsCaenorhabditis elegans with name rmIs132 [unc-54p::Q35::YFP] from WB.
View all literature mentionsCaenorhabditis elegans with name zIs356[daf-16::gfp] from WB.
View all literature mentionsCaenorhabditis elegans with name daf-7(e1372) III. from WB.
View all literature mentionsCaenorhabditis elegans with name dvIs70. from WB.
View all literature mentionsEscherichia coli with name E. coli. from WB.
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