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The survival of a host during infection relies on its ability to rapidly sense the invading pathogen and mount an appropriate response. The bacterivorous nematode Caenorhabditis elegans lacks most of the traditional pattern recognition mechanisms. In this study, we hypothesized that the 12 pairs of amphid sensory neurons in the heads of worms provide sensing capability and thus affect survival during infection. We tested animals lacking amphid neurons to three major classes of pathogens, namely-a Gram-negative bacterium Pseudomonas aeruginosa, a Gram-positive bacterium Enterococcus faecalis, and a pathogenic yeast Cryptococcus neoformans By using individual neuronal ablation lines or mutants lacking specific neurons, we demonstrate that some neurons broadly suppress the survival of the host and colonization of all pathogens, whereas other amphid neurons differentially regulate host survival during infection. We also show that the roles of some of these neurons are pathogen-specific, as seen with the AWB odor sensory neurons that promote survival only during infections with P aeruginosa Overall, our study reveals broad and specific roles for amphid neurons during infections.
Pubmed ID: 37258276
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View all literature mentionsCaenorhabditis elegans with name oyIs84. from WB.
View all literature mentionsCaenorhabditis elegans with name pqe-1(rt13) III; rtIs11 V. from WB.
View all literature mentionsCaenorhabditis elegans with name pgIs2. from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name gcy-8(oy44) IV. from WB.
View all literature mentionsEscherichia coli with name E. coli. from WB.
View all literature mentionsCaenorhabditis elegans with name oyIs85. from WB.
View all literature mentionsCaenorhabditis elegans with name qrIs2. from WB.
View all literature mentionsCaenorhabditis elegans with name che-1(p672) I. from WB.
View all literature mentionsCaenorhabditis elegans with name trx-1(ok1449) II. from WB.
View all literature mentionsCaenorhabditis elegans with name odr-7(ky4) X. from WB.
View all literature mentionsCaenorhabditis elegans with name lim-4(yz12) X. from WB.
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