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Marked alterations in nuclear ultrastructure are a universal hallmark of aging, progeroid syndromes and other age-related pathologies. Here we show that autophagy of nuclear proteins is an important determinant of fertility and aging. Impairment of nucleophagy diminishes stress resistance, germline immortality and longevity. We found that the nematode Caenorhabditis elegans nuclear envelope anchor protein, nuclear anchorage protein 1 (ANC-1) and its mammalian ortholog nesprin-2 are cleared out by autophagy and restrict nucleolar size, a biomarker of aging. We further uncovered a germline immortality assurance mechanism, which involves nucleolar degradation at the most proximal oocyte by ANC-1 and key autophagic components. Perturbation of this clearance pathway causes tumor-like structures in C. elegans, and genetic ablation of nesprin-2 causes ovarian carcinomas in mice. Thus, autophagic recycling of nuclear components is a conserved soma longevity and germline immortality mechanism that promotes youthfulness and delays aging under conditions of stress.
Pubmed ID: 37118512
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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
View all literature mentionsCenter that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
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View all literature mentionsCaenorhabditis elegans with name smIs34. from WB.
View all literature mentionsCaenorhabditis elegans with name adIs2122 from WB.
View all literature mentionsCaenorhabditis elegans with name unc-119(ed3) III; knuSi221. from WB.
View all literature mentionsCaenorhabditis elegans with name rmIs133 [unc-54p::Q40::YFP]X from WB.
View all literature mentionsCaenorhabditis elegans with name unc-119(ed3) III; ltIs37 IV; qaIs3546. from WB.
View all literature mentionsCaenorhabditis elegans with name ccIs4810 X. from WB.
View all literature mentionsCaenorhabditis elegans with name daf-2(e1370);adIs2122 from WB.
View all literature mentionsCaenorhabditis elegans with name daf-2(e1370) aak-1(tm1944)III; tbc-7(rr166) aak-2(ok524)X; adIs2122[lgg-1::GFP rol6(df)] from WB.
View all literature mentionsCaenorhabditis elegans with name anc-1(e1753) I. from WB.
View all literature mentionsCaenorhabditis elegans with name anc-1(e1873) I. from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name daf-2(e1370) from WB.
View all literature mentionsCaenorhabditis elegans with name atg-18(gk378) V. from WB.
View all literature mentionsCaenorhabditis elegans with name ncl-1(e1942) from WB.
View all literature mentionsCaenorhabditis elegans with name anc-1(e1802) I. from WB.
View all literature mentionsCaenorhabditis elegans with name unc-119(ed3) III; ltIs37 IV; ltIs38. from WB.
View all literature mentionsCaenorhabditis elegans with name ncl-1(e1865) III. from WB.
View all literature mentionsCaenorhabditis elegans with name him-5(e1490) V; bpIs151. from WB.
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