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 PMID:35426438  

Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis.

Paolo Carai | Laura Florit González | Stijn Van Bruggen | Valerie Spalart | Daria De Giorgio | Nadéche Geuens | Kimberly Martinod | Elizabeth Anne Vincent Jones | Stephane Heymans
Cardiovascular research | 2023

Viral myocarditis (VM) is an inflammatory pathology of the myocardium triggered by a viral infection that may cause sudden death or heart failure (HF), especially in the younger population. Current treatments only stabilize and improve cardiac function without resolving the underlying inflammatory cause. The factors that induce VM to progress to HF are still uncertain, but neutrophils have been increasingly associated with the negative evolution of cardiac pathologies. The present study investigates the contribution of neutrophils to VM disease progression in different ways.

Pubmed ID: 35426438

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Charles River Laboratories (tool)

RRID:SCR_003792

Commercial organism provider selling mice, rats and other model animals. American corporation specializing in a variety of pre-clinical and clinical laboratory services for the pharmaceutical, medical device and biotechnology industries. It also supplies assorted biomedical products and research and development outsourcing services for use in the pharmaceutical industry. (Wikipedia)

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Bio X Cell (tool)

RRID:SCR_004997

Commercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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B6.Cg-Padi4tm1.2Kmow/J (tool)

RRID:IMSR_JAX:026708

Mus musculus with name B6.Cg-Padi4tm1.2Kmow/J from IMSR.

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