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 PMID:33673858  

Development of a chitosan-modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice.

Jin Zhang | Hongwu Sun | Chen Gao | Ying Wang | Xin Cheng | Yun Yang | Qiang Gou | Langhuang Lei | Yanping Chen | Xingyong Wang | Quanming Zou | Jiang Gu
Journal of nanobiotechnology | 2021

Escherichia coli K1 (E. coli K1) caused neonatal meningitis remains a problem, which rises the urgent need for an effective vaccine. Previously, we rationally designed and produced the recombinant protein OmpAVac (Vo), which elicited protective immunity against E. coli K1 infection. However, Vo has limited stability, which hinders its future industrial application.

Pubmed ID: 33673858

Research resources used in this publication

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ATCC (tool)

RRID:SCR_001672

Global nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.

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HL-60 (tool)

RRID:CVCL_0002

Cell line HL-60 is a Cancer cell line with a species of origin Homo sapiens (Human)

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NCTC clone 929 (tool)

RRID:CVCL_0462

Cell line NCTC clone 929 is a Spontaneously immortalized cell line with a species of origin Mus musculus

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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