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 PMID:32690516  

HIV and other STIs self-testing to reduce risk compensation among men who have sex with men who use oral pre-exposure prophylaxis in China: protocol for a randomised waitlist-controlled trial.

Jing Zhang | Xiaojie Huang | Yaokai Chen | Hui Wang | Yonghui Zhang | Hongyi Wang | Zhu Mei | Yueru Jia | ZhenXing Chu | Qing-Hai Hu | Xiaoqing He | Lukun Zhang | Zhili Hu | Rantong Bao | Shangcao Li | Haibo Ding | Yongjun Jiang | Wenqing Geng | Weiming Tang | Junjie Xu | CROPrEP Group
BMJ open | 2020

Pre-exposure prophylaxis (PrEP) reduces the risk of HIV infection among men who have sex with men by up to 99%. However, in real-world settings, PrEP users may exhibit risk compensation after uptake of PrEP, including more condomless anal intercourse (CAI) and increased sexually transmitted infection (STI) acquisition. HIV self-testing (HIVST) decreases CAI among men who have sex with men (MSM) by providing awareness of the HIV status of oneself and one's sexual partners. Here, we describe the rationale and design of a randomised waitlist-controlled trial to examine the impact of HIVST on risk compensation among PrEP users.

Pubmed ID: 32690516

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PASS (tool)

RRID:SCR_005490

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 19, 2020.A program to align short sequences that has been developed with an innovative strategy to perform fast gapped and ungapped alignment onto a reference sequence. It supports several data formats and allows the user to modulate very finely the sensitivity of the alignments. The program is designed to handle huge amounts of short reads generated by ILLUMINA, SOLiD and Roche-454 technology. The optimization of the internal data structure and a filter based on precomputed short-word alignments allow the program to skip false positives in the extension phase, thus reducing the execution time without loss of sensitivity. The final alignment is performed by dynamic programming.

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