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 PMID:32233077  

Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients.

Sandra Crnko | Markella I Printezi | Tijn P J Jansen | Laurynas Leiteris | Manon G van der Meer | Hilde Schutte | Martijn van Faassen | Bastiaan C du Pré | Nicolaas de Jonge | Folkert W Asselbergs | Carlo A J M Gaillard | Hans Kemperman | Pieter A Doevendans | Joost P G Sluijter | Linda W van Laake
ESC heart failure | 2020

Soluble suppression of tumorigenicity-2 (sST2) is a strong prognostic biomarker in heart failure. The emerging understanding of circadian biology in cardiovascular disease may lead to novel applications in prognosis and diagnosis and may provide insight into mechanistic aspects of the disease-biomarker interaction. So far, it is unknown whether sST2 exhibits a diurnal rhythm. Repeated measurements of sST2 may aid in clinical decision making. The goal of this study was to investigate whether sST2 exhibits diurnal variation in patients with heart failure with reduced ejection fraction (HFrEF) and in control subjects, thereby enhancing its diagnostic and prognostic values.

Pubmed ID: 32233077

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Associated grants

  • Agency: Netherlands Heart Foundation Dekker, International
    Id: 2013T056 to LL
  • Agency: Koninklijke Nederlandse Akademie van Wetenschappen, International
  • Agency: ZonMw, International
  • Agency: Dutch Federation of University Medical Centres, International
  • Agency: Innovation and the Netherlands CardioVascular Research Initiative (CVON): The Dutch Heart Foundation, International
  • Agency: Horizon2020 ERC-2016-COG EVICARE, International
    Id: 725229
  • Agency: Jacob Jongbloed Talent Society Grant, International

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