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 PMID:31253149  

Primary allogeneic mitochondrial mix (PAMM) transfer/transplant by MitoCeption to address damage in PBMCs caused by ultraviolet radiation.

Francisco Cabrera | Mayra Ortega | Francesca Velarde | Eliseo Parra | Stephany Gallardo | Diego Barba | Lina Soto | Gabriela Peña | Luis Alberto Pedroza | Christian Jorgensen | Maroun Khoury | Andrés Caicedo
BMC biotechnology | 2019

Artificial Mitochondrial Transfer or Transplant (AMT/T) can be used to reduce the stress and loss of viability of damaged cells. In MitoCeption, a type of AMT/T, the isolated mitochondria and recipient cells are centrifuged together at 4 °C and then co-incubated at 37 °C in normal culture conditions, inducing the transfer. Ultraviolet radiation (UVR) can affect mitochondria and other cell structures, resulting in tissue stress, aging, and immunosuppression. AMT/T could be used to repair UVR cellular and mitochondrial damage. We studied if a mitochondrial mix from different donors (Primary Allogeneic Mitochondrial Mix, PAMM) can repair UVR damage and promote cell survival.

Pubmed ID: 31253149

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