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 PMID:31248447  

Generation of functional dopaminergic neurons from human spermatogonial stem cells to rescue parkinsonian phenotypes.

Hao Yang | Dingjun Hao | Cheng Liu | Dageng Huang | Bo Chen | Hong Fan | Cuicui Liu | Lingling Zhang | Qian Zhang | Jing An | Jingjing Zhao
Stem cell research & therapy | 2019

Recent progress in the induced generation of dopaminergic (DA) neurons from different types of stem cells or reprogrammed somatic cells holds tremendous potential for the treatment of Parkinson's disease (PD). However, the lack of a reliable source for cell replacement therapy remains a major limitation in the treatment of human neurological disorders. Additionally, the current protocols for in vitro differentiation or cell reprogramming to generate human DA neurons are laborious, time-consuming, and expensive, and efficient conversion of human spermatogonial stem cells (hSSCs) to functional DA neurons has not yet been achieved.

Pubmed ID: 31248447

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Abcam (tool)

RRID:SCR_012931

A commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.

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BALB/cAnNCrl (tool)

RRID:MGI:2683685

laboratory mouse with name BALB/cAnNCrl from MGI.

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