Searching the Resource Information Network
Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
Down syndrome (DS) is a common neurodevelopmental disorder, and cognitive defects in DS patients may arise from imbalances in excitatory and inhibitory neurotransmission. Understanding the mechanisms underlying such imbalances may provide opportunities for therapeutic intervention. Here, we show that human induced pluripotent stem cells (hiPSCs) derived from DS patients overproduce OLIG2+ ventral forebrain neural progenitors. As a result, DS hiPSC-derived cerebral organoids excessively produce specific subclasses of GABAergic interneurons and cause impaired recognition memory in neuronal chimeric mice. Increased OLIG2 expression in DS cells directly upregulates interneuron lineage-determining transcription factors. shRNA-mediated knockdown of OLIG2 largely reverses abnormal gene expression in early-stage DS neural progenitors, reduces interneuron production in DS organoids and chimeric mouse brains, and improves behavioral deficits in DS chimeric mice. Thus, altered OLIG2 expression may underlie neurodevelopmental abnormalities and cognitive defects in DS patients.
Pubmed ID: 31130512
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsThis polyclonal targets FOS
View all literature mentionsThis polyclonal targets Choline Acetyltransferase (ChAT)
View all literature mentionsThis unknown targets Somatostatin-14
View all literature mentionsThis polyclonal targets Glutamate Decarboxylase 65 & 67
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets Neuropeptide Y antibody
View all literature mentionsThis monoclonal targets S-100 (beta-Subunit)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Vesicular GABA Transporter (VGAT)
View all literature mentionsThis monoclonal targets Olig1 antibody [EPR6790]
View all literature mentionsThis polyclonal targets Phospho-Histone H3 (Ser10)
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets GABA
View all literature mentionsThis polyclonal targets FOXG1
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets GFP Antibody Dylight 488 Conjugated Pre-Adsorbed
View all literature mentionsThis monoclonal targets GAPDH (6C5)
View all literature mentionsThis monoclonal targets GFP
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets TTF1
View all literature mentionsThis polyclonal targets Human Calretinin
View all literature mentionsThis polyclonal targets Parvalbumin
View all literature mentionsThis monoclonal targets MAP-2 (Microtubule Associated Protein, MAP-2A and -2B)
View all literature mentionsThis polyclonal targets Synapsin I
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Myelin Basic Protein (MBP), aa 82-87
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets OLIG2
View all literature mentionsThis polyclonal targets NG2 Chondroitin Sulfate Proteoglycan
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets TUBB2A
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets MAP-2 (B-8)
View all literature mentionsThis polyclonal targets PDGFRA
View all literature mentionsThis unknown targets Rabbit anti-human mouse rat GFAP
View all literature mentionsThis polyclonal targets nestin
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis monoclonal targets Ki67
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal targets Rabbit NeuN (polyclonal)
View all literature mentionsThis monoclonal targets Nuclei
View all literature mentionsThis polyclonal targets Calbindin D-28K
View all literature mentionsThis unknown targets PSD-95
View all literature mentionsMus musculus with name C.129S7(B6)-Rag1tm1Mom/J from IMSR.
View all literature mentionsWelcome to the Neuroscience Information Framework Project, designed to serve the biomedical research community. NIF maintains the largest searchable collection of neuroscience data, the largest catalog of biomedical resources, and the largest ontology for neuroscience on the web. We welcome all feedback and suggestions and are actively looking for resource providers to make their resources accessible through NIF. Learn about the tools available to help you share your data and discover a dynamic inventory of Web-based neuroscience resources.
