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Growth factor signaling is initiated at the plasma membrane and propagated through the cytoplasm for eventual relay to intracellular organelles such as lysosomes. The serine/threonine kinase mTOR participates in growth factor signaling as a component of two multi-subunit complexes, mTORC1 and mTORC2. mTORC1 associates with lysosomes, and its activity depends on the positioning of lysosomes within the cytoplasm, although there is no consensus regarding the exact effect of perinuclear versus peripheral distribution. mTORC2 and its substrate kinase AKT have a widespread distribution, but they are thought to act mainly at the plasma membrane. Using cell lines with knockout of components of the lysosome-positioning machinery, we show that perinuclear clustering of lysosomes delays reactivation of not only mTORC1, but also mTORC2 and AKT upon serum replenishment. These experiments demonstrate the existence of pools of mTORC2 and AKT that are sensitive to lysosome positioning.
Pubmed ID: 31130364
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This monoclonal targets Calnexin
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis monoclonal targets
View all literature mentionsThis monoclonal targets 4E-BP1, phospho (Thr37 / Thr46)
View all literature mentionsThis monoclonal targets mTOR
View all literature mentionsThis monoclonal targets ULK1
View all literature mentionsThis monoclonal targets Phospho-AS160 (Ser318) (D3D11) Rabbit mAb
View all literature mentionsThis monoclonal targets p70 S6 Kinase
View all literature mentionsThis monoclonal targets Sin1
View all literature mentionsThis monoclonal targets p70 S6 Kinase, phospho (Thr389)
View all literature mentionsThis monoclonal targets TSC2
View all literature mentionsThis monoclonal targets ULK1
View all literature mentionsThis monoclonal targets GSK-3 beta
View all literature mentionsThis polyclonal targets 4E-BP1
View all literature mentionsThis monoclonal targets Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
View all literature mentionsThis monoclonal targets Akt (pan) (C67E7) Rabbit mAb
View all literature mentionsThis monoclonal targets Tuberin, phospho (Thr1462)
View all literature mentionsThis recombinant monoclonal targets Insulin Receptor beta
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis monoclonal targets FoxO3a
View all literature mentionsThis unknown targets PDK1, phospho (Ser241)
View all literature mentionsThis polyclonal targets Rictor
View all literature mentionsThis monoclonal targets FoxO3a
View all literature mentionsThis polyclonal targets Beta-Tubulin
View all literature mentionsCell line HEK293T/17 is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HeLa is a Cancer cell line with a species of origin Homo sapiens
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