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 PMID:31129098  

Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF.

Sambad Sharma | Shih-Ying Wu | Hugo Jimenez | Fei Xing | Dongqin Zhu | Yin Liu | Kerui Wu | Abhishek Tyagi | Dan Zhao | Hui-Wen Lo | Linda Metheny-Barlow | Peiqing Sun | John D Bourland | Michael D Chan | Alexandra Thomas | Alexandre Barbault | Ralph B D'Agostino | Christopher T Whitlow | Volker Kirchner | Carl Blackman | Boris Pasche | Kounosuke Watabe
EBioMedicine | 2019

Brain metastases are a major cause of death in patients with metastatic breast cancer. While surgical resection and radiation therapy are effective treatment modalities, the majority of patients will succumb from disease progression. We have developed a novel therapy for brain metastases that delivers athermal radiofrequency electromagnetic fields that are amplitude-modulated at breast cancer specific frequencies (BCF).

Pubmed ID: 31129098

Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA131231
  • Agency: NCI NIH HHS, United States
    Id: R01 CA172115
  • Agency: NCI NIH HHS, United States
    Id: R37 CA230451
  • Agency: NCI NIH HHS, United States
    Id: R01 CA173499
  • Agency: NCI NIH HHS, United States
    Id: P30 CA012197
  • Agency: NCI NIH HHS, United States
    Id: R01 CA205067
  • Agency: NCI NIH HHS, United States
    Id: R01 CA185650

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Addgene (tool)

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Non-profit plasmid repository dedicated to helping scientists around the world share high-quality plasmids. Facilitates archiving and distributing DNA-based research reagents and associated data to scientists worldwide. Repository contains over 65,000 plasmids, including special collections on CRISPR, fluorescent proteins, and ready-to-use viral preparations. There is no cost for scientists to deposit plasmids, which saves time and money associated with shipping plasmids themselves. All plasmids are fully sequenced for validation and sequencing data is openly available. We handle the appropriate Material Transfer Agreements (MTA) with institutions, facilitating open exchange and offering intellectual property and liability protection for depositing scientists. Furthermore, we curate free educational resources for the scientific community including a blog, eBooks, video protocols, and detailed molecular biology resources.

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