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 PMID:29859097  

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

Solange Moll | Yukari Yasui | Ahmed Abed | Takeshi Murata | Hideaki Shimada | Akira Maeda | Naoshi Fukushima | Masakazu Kanamori | Sabine Uhles | Laura Badi | Thomas Cagarelli | Ivan Formentini | Faye Drawnel | Guy Georges | Tobias Bergauer | Rodolfo Gasser | R Daniel Bonfil | Rafael Fridman | Hans Richter | Juergen Funk | Marcus J Moeller | Christos Chatziantoniou | Marco Prunotto
Journal of translational medicine | 2018

Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed using either a gene deletion or a gene silencing approaches, have shown this receptor being a major driver target of fibrosis and glomerulosclerosis.

Pubmed ID: 29859097

Research resources used in this publication

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