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 PMID:29785122  

Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo.

Zhixin Ling | Han Guan | Zonghao You | Can Wang | Ling Hu | Lei Zhang | Yiduo Wang | Shuqiu Chen | Bin Xu | Ming Chen
OncoTargets and therapy | 2018

Prostate cancer (PCa) is one of the most common malignant diseases among male patients. Although androgen deprivation therapy remains the main treatment for PCa, most patients would inevitably progress to castration-resistant PCa, which is the main cause of cancer-related deaths. Thus, novel antitumor agents are urgently needed. Recent studies demonstrated that aloperine (ALO) as a natural alkaloid showed antitumor effects in other cancer types. However, the biological function and underlying mechanisms of ALO in PCa have not been investigated.

Pubmed ID: 29785122

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