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 PMID:29676021  

Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease.

C Ruffmann | N Bengoa-Vergniory | I Poggiolini | D Ritchie | M T Hu | J Alegre-Abarrategui | L Parkkinen
Neuropathology and applied neurobiology | 2018

Gastrointestinal (GI) α-synuclein (aSyn) detection as a potential biomarker of Parkinson's disease (PD) is challenged by conflicting results of recent studies. To increase sensitivity and specificity, we applied three techniques to detect different conformations of aSyn in GI biopsies obtained from a longitudinal, clinically well-characterized cohort of PD patients and healthy controls (HC).

Pubmed ID: 29676021

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Associated grants

  • Agency: Parkinson's UK, United Kingdom
    Id: J-0901
  • Agency: Medical Research Council, United Kingdom
    Id: MR/P007058/1
  • Agency: Michael J Fox Foundation, International

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ProbeMaker (tool)

RRID:SCR_010964

A Java software aimed at providing a framework for design and analysis of sets of oligonucleotide probes for use in multiplex assays for nucleic acid analyses and other purposes.

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Wako (tool)

RRID:SCR_013651

An Antibody supplier

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