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 PMID:29675795  

Oral adsorbent AST-120 ameliorates gut environment and protects against the progression of renal impairment in CKD rats.

Ayumi Yoshifuji | Shu Wakino | Junichiro Irie | Ayumi Matsui | Kazuhiro Hasegawa | Hirobumi Tokuyama | Koichi Hayashi | Hiroshi Itoh
Clinical and experimental nephrology | 2018

Oral charcoal adsorbent AST-120 (AST) is reported to ameliorate renal dysfunction by the absorption of toxic substance in the gut. Recent study revealed that, in CKD, gut environment is disturbed including the decrease in tight junctions and Lactobacillus (Lact). In this study, we examined whether AST improves the renal dysfunction through gut environment.

Pubmed ID: 29675795

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