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The modular structure and versatility of antibodies enables one to modify natural immunoglobulins in different ways for various clinical applications. Rational design and molecular engineering make it possible to directionally modify the molecular size, affinity, specificity, and immunogenicity and effector functions of an antibody, as well as to combine them with other functional agents. This review focuses on up-to-date methods of antibody engineering for diagnosing and treating various diseases, particularly on new technologies meant to refine the effector functions of therapeutic antibodies.
Pubmed ID: 22649585
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The Archives of General Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians, scholars, and research scientists in psychiatry, mental health, behavioral science, and allied fields. The Archives seeks to inform and to educate its readers as well as to stimulate debate and further exploration into the nature, causes, treatment, and public health importance of mental illness. Archives of General Psychiatry is an international peer-reviewed journal published 12 times a year. The online version is published on the first Monday of the month. There is a Middle Eastern edition of Archives of Neurology/Psychiatry published quarterly. The editor is interested in publishing high-impact articles that cover the field broadly, from genetic mechanisms to psychotherapeutic intervention trials. The acceptance rate is 17%. The average time from submission to first decision is 32 days; from acceptance to publication, 5.4 months. Its 2008 impact factor is 14.27 (the impact factor is a measure of citation rate per article, and is calculated by dividing 1 year''s worth of citations to a journal''s articles published in the previous 2 years by the number of major articles (eg, research papers, reviews) published by that journal in those 2 years).
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