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PMID:21049052

Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells.

PloS one | 2010

Profilin-1 is an ubiquitous actin binding protein. Under pathological conditions such as diabetes, profilin-1 levels are increased in the vascular endothelium. We recently demonstrated that profilin-1 overexpression triggers indicators of endothelial dysfunction downstream of LDL signaling, and that attenuated expression of profilin-1 confers protection from atherosclerosis in vivo.

Pubmed ID: 21049052

Research resources used in this publication

None found

Additional research tools detected in this publication

WI (RRID:RGD_13508588)

Antibodies used in this publication

None found

Associated grants

Agency: NHLBI NIH HHS, United States
Id: K23 HL068774
Agency: NHLBI NIH HHS, United States
Id: R01 HL098601

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WI (tool)

RRID:RGD_13508588

Rattus norvegicus with name WI from RGD.

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