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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://www.cyagen.com/mouseatlas/S-KO-18845
Source Database: Cyagen Biosciences
Affected Genes: adenylosuccinate lyase
Genomic Alteration: endonuclease-mediated mutation 1; Cyagen Biosciences
Availability: sperm
Notes: gene symbol note: adenylosuccinate lyase; coisogenic strain|mutant strain: Adsl
Proper citation: RRID:IMSR_S-KO-18845 Copy
https://www.cyagen.com/mouseatlas/S-KO-20861
Source Database: Cyagen Biosciences
Affected Genes: unc-51 like kinase 1
Genomic Alteration: endonuclease-mediated mutation 3; Cyagen Biosciences
Availability: sperm
Notes: gene symbol note: unc-51 like kinase 1; coisogenic strain|mutant strain: Ulk1
Proper citation: RRID:IMSR_S-KO-20861 Copy
https://www.jax.org/strain/040961
Source Database: JAX Mice and Services
Affected Genes: immunoglobulin heavy constant gamma 1 (G1m marker)
Genomic Alteration: endonuclease-mediated mutation 2; Klaus Rajewsky
Availability: live
Notes: gene symbol note: immunoglobulin heavy constant gamma 1 (G1m marker); mutant strain: Ighg1
Proper citation: RRID:IMSR_JAX:040961 Copy
https://www.jax.org/strain/040962
Source Database: JAX Mice and Services
Affected Genes: forkhead box O1
Genomic Alteration: endonuclease-mediated mutation 1; Klaus Rajewsky
Availability: live
Notes: gene symbol note: forkhead box O1; mutant strain: Foxo1
Proper citation: RRID:IMSR_JAX:040962 Copy
https://en.gempharmatech.com/product/search_1.html?searchKey=T069084
Source Database: GemPharmatech
Affected Genes: thymus cell antigen 1; theta
Availability: sperm
Notes: gene symbol note: thymus cell antigen 1; theta; coisogenic strain: Thy1
Proper citation: RRID:IMSR_GPT:T069084 Copy
https://www.jax.org/strain/041202
Source Database: JAX Mice and Services
Affected Genes: phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha|gene trap ROSA 26; Philippe Soriano
Genomic Alteration: targeted mutation 1; Sean E Egan
Availability: live
Notes: gene symbol note: phosphatidylinositol-4;5-bisphosphate 3-kinase catalytic subunit alpha|gene trap ROSA 26; Philippe Soriano; mutant strain|congenic strain: Pik3ca|Gt(ROSA)26Sor
Proper citation: RRID:IMSR_JAX:041202 Copy
https://en.gempharmatech.com/product/search_1.html?searchKey=T021933
Source Database: GemPharmatech
Affected Genes: dual specificity phosphatase-like 15
Availability: sperm
Notes: gene symbol note: dual specificity phosphatase-like 15; coisogenic strain: Dusp15
Proper citation: RRID:IMSR_GPT:T021933 Copy
https://www.modelorg.bio/portal/article/index.html?id=239071&post_type=3
Source Database: Shanghai Model Organisms Center, Inc.
Availability: live
Notes: gene symbol note: ; mutant strain:
Proper citation: RRID:IMSR_NM-XA-241984 Copy
https://archive.har.mrc.ac.uk/stock?id=12684
Source Database: MRC Harwell
Affected Genes: autophagy related 16 like 1
Genomic Alteration: targeted mutation 1.1; Ulrike Mayer
Availability: embryo
Notes: gene symbol note: autophagy related 16 like 1; mutant strain: Atg16l1
Proper citation: RRID:IMSR_HAR:12684 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695055
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: inbred
Availability: Unknown
Alternate IDs: RGD_14695055, 14695055, RRRC_794, RRRC_0794, RRRC_00794
Notes: Inbred hypertension model linked to a mutation in Add1 gene that has been validated as one of the genes linked to hypertension in numerous human genetic studies. Inbred strain originally developed by Dr. Bianchi in Milan in 1979. Rat Resource and Research Center
Proper citation: RRID:RRRC_00794 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695054
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2019-07-01)
Alternate IDs: RGD_14695054, 14695054, RRRC_795, RRRC_0795, RRRC_00795
Notes: Rat Resource and Research Center
Proper citation: RRID:RRRC_00795 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13462045
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2024-01-17)
Alternate IDs: RGD_13462045, 13462045, RRRC_830, RRRC_0830, RRRC_00830
Notes: Pronuclear injection was used to introduce an expression cassette containing the Thy-1 enhancer and GCaMP6f protein coding sequence. GCaMP6f is a genetically encoded calcium indicator. It is a synthetic fusion of green fluorescent protein, calmodulin, and M13, a peptide sequence from myosin light-chain kinase. Rat Resource & Research Center
Proper citation: RRID:RRRC_00830 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=10401201
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals; Cryopreserved Sperm (as of 2017-05-31)
Alternate IDs: RGD_10401201, 10401201, RRRC_659, RRRC_0659, RRRC_00659
Notes: Cre gene was introduced immediately before the ATG of the mouse tyrosine hydroxylase (Th) gene on BAC RP23-350E13 Rat Resource and Research Center
Proper citation: RRID:RRRC_00659 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150519896
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: RGD_150519896, 150519896, RRRC_931, RRRC_0931, RRRC_00931
Notes: CRISPR/Cas9 mediated single nucleotide deletion resulting in a frameshift that creates a premature stop and generates a null allele. This strain serves as a model for Alexander disease - nulls are of interest for traumatic brain injury and many other studies of CNS disease and astrocyte response. Rat Resource and Research Center
Proper citation: RRID:RRRC_00931 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695052
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2019-07-01)
Alternate IDs: RGD_14695052, 14695052, RRRC_817, RRRC_0817, RRRC_00817
Notes: F344-Tg(ROSA26-ALPP)EpsRrrc (RGD:1566458) received in 1999 from Dr. Eric Sandgren, Univ. Wisconsin-Madison. Since 1999 bred on ACI background. Rat Resource and Research Center
Proper citation: RRID:RRRC_00817 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=11667088
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2017-01-26)
Alternate IDs: RGD_11667088, 11667088, RRRC_701, RRRC_0701, RRRC_00701
Notes: zinc finger nucleases were used to generate a 482 bp deletion in Esr1 gene, resulting in a knock out. Rat Resource and Research Center
Proper citation: RRID:RRRC_00701 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=149735364
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2021-07-19)
Alternate IDs: RGD_149735364, 149735364, RRRC_877, RRRC_0877, RRRC_00877
Notes: The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Tie2 gene linked by 2A peptide. This model is used to lineage tracing of vascular endothelial cells by tissue specific expression of creERT2 deposited at Rat Resource and Research Center
Proper citation: RRID:RRRC_00877 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=10412325
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2019-03-18)
Alternate IDs: RGD_10412325, 10412325, RRRC_767, RRRC_0767, RRRC_00767
Notes: The transgene expresses BAC transgenic using rat dopamine receptor 1 promoter to express Cre recombinase in D1R neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00767 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=10412327
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2019-03-18)
Alternate IDs: RGD_10412327, 10412327, RRRC_768, RRRC_0768, RRRC_00768
Notes: The transgene expresses BAC transgenic using rat dopamine receptor 2 promoter to express Cre recombinase in D2R neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00768 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14398499
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: mutant
Availability: Live Animals (as of 2021-02-12)
Alternate IDs: RGD_14398499, 14398499, RRRC_856, RRRC_0856, RRRC_00856
Notes: The CRISPR system was used to created target insertion of iCre recombinase to the Drd1 (Drd1a) locus of the embryos of BluHsd:LE. Rat Resource and Research Center
Proper citation: RRID:RRRC_00856 Copy
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