Searching the RRID Resource Information Network
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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
| Organism Name | Proper Citation | Species | Synonyms |
Notes |
Phenotype | Affected Gene | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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B6.129-H2-Ab1tm1Gru N12 Resource Report Resource Website 1+ mentions Issue |
RRID:IMSR_TAC:ABBN12 | Mus musculus |
ABBN12. B6.129S2-H2-Ab1 |
gene symbol note: histocompatibility 2; class II antigen A; beta 1|; mutant strain|congenic strain: H2-Ab1| | histocompatibility 2; class II antigen A; beta 1| | targeted mutation 1; Michael J Grusby| | TAC:ABBN12 | Taconic Biosciences | TAC | live | 2026-07-31 10:02:12 | 1 | ||||
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NOD.Cg-Prkdcscid Il2rg Resource Report Resource Website 1+ mentions Issue Issue |
RRID:IMSR_TAC:NOG | Mus musculus | CIEA NOG | gene symbol note: interleukin 2 receptor; gamma chain|protein kinase; DNA activated; catalytic polypeptide|; mutant strain|congenic strain: Il2rg|Prkdc| | interleukin 2 receptor; gamma chain|protein kinase; DNA activated; catalytic polypeptide| | targeted mutation 1; Kazuo Sugamura|severe combined immunodeficiency| | TAC:NOG | Taconic Biosciences | TAC | live | 2026-07-31 10:02:14 | 1 | ||||
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B6:129S5-Csmd1tm1Lex Resource Report Resource Website Issue |
RRID:IMSR_TAC:TF0137 | Mus musculus | gene symbol note: CUB and Sushi multiple domains 1; mutant strain: Csmd1 | CUB and Sushi multiple domains 1 | targeted mutation 1; Lexicon Genetics | TAC:TF0137 | Taconic Biosciences | TAC | archived | 2026-07-31 10:02:17 | 0 | |||||
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NOD.129S7(B6)-Itgb2tm2Bay/CgkJ Resource Report Resource Website Issue |
RRID:IMSR_JAX:016897 | Mus musculus | gene symbol note: integrin beta 2; mutant strain|congenic strain: Itgb2 | integrin beta 2 | targeted mutation 2; Baylor College of Medicine | JAX:016897 | JAX Mice and Services | JAX | sperm | 2026-07-31 10:04:47 | 0 | |||||
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B6.129-Apoetm1Unc Apptm1Dbo/Mmjax Resource Report Resource Website Issue |
RRID:MMRRC_042049-JAX | Mus musculus | Research areas: Cardiovascular, Diabetes, Immunology and Inflammation, Models for Human Disease, Obesity; Mutation Type: Targeted Mutation ; Collection: | abnormal cochlea morphology [MP:0000031]| organ of Corti degeneration [MP:0000043]| abnormal stria vascularis morphology [MP:0000048]| increased bone mineral density [MP:0000062]| decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| abnormal vertebrae morphology [MP:0000137]| abnormal circulating cholesterol level [MP:0000180]| increased circulating LDL cholesterol level [MP:0000182]| decreased circulating HDL cholesterol level [MP:0000186]| decreased hematocrit [MP:0000208]| increased monocyte cell number [MP:0000220]| decreased monocyte cell number [MP:0000223]| hypertension [MP:0000231]| abnormal blood flow velocity [MP:0000233]| macrocytosis [MP:0000248]| abnormal blood vessel physiology [MP:0000249]| echinocytosis [MP:0000256]| abnormal heart morphology [MP:0000266]| abnormal aorta morphology [MP:0000272]| enlarged heart [MP:0000274]| altered response to myocardial infarction [MP:0000343]| decreased hair follicle number [MP:0000379]| alopecia [MP:0000414]| sparse hair [MP:0000416]| abnormal femur morphology [MP:0000559]| abnormal liver morphology [MP:0000598]| amyloidosis [MP:0000604]| abnormal liver physiology [MP:0000609]| abnormal adrenal gland morphology [MP:0000639]| abnormal immune system morphology [MP:0000685]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| enlarged thymus [MP:0000709]| abnormal skin condition [MP:0001191]| thick skin [MP:0001200]| skin lesions [MP:0001212]| hyperkeratosis [MP:0001242]| abnormal dermal layer morphology [MP:0001243]| thick dermal layer [MP:0001245]| mixed cellular infiltration to dermis [MP:0001246]| decreased body length [MP:0001258]| increased body weight [MP:0001260]| obese [MP:0001261]| decreased body weight [MP:0001262]| abnormal retina morphology [MP:0001325]| dry eyes [MP:0001337]| Meibomian gland atrophy [MP:0001345]| increased anxiety-related response [MP:0001363]| abnormal stationary movement [MP:0001388]| abnormal locomotor behavior [MP:0001392]| abnormal response to new environment [MP:0001413]| decreased exploration in new environment [MP:0001417]| abnormal spatial learning [MP:0001463]| increased startle reflex [MP:0001488]| decreased startle reflex [MP:0001489]| abnormal kindling response [MP:0001499]| abnormal coat appearance [MP:0001510]| abnormal skeleton physiology [MP:0001533]| abnormal hematopoietic system physiology [MP:0001545]| abnormal lipid level [MP:0001547]| hyperlipidemia [MP:0001548]| increased circulating triglyceride level [MP:0001552]| increased circulating free fatty acid level [MP:0001554]| increased circulating HDL cholesterol level [MP:0001556]| hyperglycemia [MP:0001559]| anemia [MP:0001577]| cardiac hypertrophy [MP:0001625]| hypersecretion of corticosterone [MP:0001744]| increased circulating corticosterone level [MP:0001745]| abnormal immune system physiology [MP:0001790]| impaired macrophage phagocytosis [MP:0001798]| abnormal inflammatory response [MP:0001845]| heart inflammation [MP:0001853]| kidney inflammation [MP:0001859]| lung inflammation [MP:0001861]| vascular inflammation [MP:0001863]| abnormal lung volume [MP:0001942]| deafness [MP:0001967]| abnormal skin morphology [MP:0002060]| abnormal fear/anxiety-related behavior [MP:0002065]| increased circulating insulin level [MP:0002079]| premature death [MP:0002083]| abnormal lipid homeostasis [MP:0002118]| abnormal cardiovascular system morphology [MP:0002127]| abnormal kidney morphology [MP:0002135]| abnormal brain morphology [MP:0002152]| abnormal gland physiology [MP:0002164]| gliosis [MP:0002183]| abnormal artery morphology [MP:0002191]| neurodegeneration [MP:0002229]| abnormal pulmonary alveolus morphology [MP:0002270]| abnormal lymph node morphology [MP:0002339]| abnormal dendritic cell physiology [MP:0002376]| abnormal cell-mediated immunity [MP:0002421]| abnormal macrophage morphology [MP:0002446]| abnormal erythrocyte morphology [MP:0002447]| abnormal macrophage physiology [MP:0002451]| increased immunoglobulin level [MP:0002461]| abnormal neutrophil physiology [MP:0002463]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| abnormal blood coagulation [MP:0002551]| hepatic steatosis [MP:0002628]| reticulocytosis [MP:0002640]| poikilocytosis [MP:0002643]| decreased circulating triglyceride level [MP:0002644]| abnormal sciatic nerve morphology [MP:0002651]| abnormal immune serum protein physiology [MP:0002723]| decreased circulating insulin level [MP:0002727]| abnormal thermal nociception [MP:0002733]| glomerulonephritis [MP:0002743]| dilated heart left ventricle [MP:0002753]| decreased vertical activity [MP:0002757]| abnormal retinal vasculature morphology [MP:0002792]| increased thigmotaxis [MP:0002797]| increased heart weight [MP:0002833]| increased systemic arterial blood pressure [MP:0002842]| decreased systemic arterial blood pressure [MP:0002843]| cochlear ganglion degeneration [MP:0002857]| increased growth rate [MP:0002865]| albuminuria [MP:0002871]| decreased hemoglobin content [MP:0002874]| increased insulin sensitivity [MP:0002891]| thick ventricular wall [MP:0002953]| increased urine protein level [MP:0002962]| increased liver weight [MP:0002981]| abnormal cytokine secretion [MP:0003009]| increased vasoconstriction [MP:0003025]| decreased myocardial infarction size [MP:0003038]| abnormal impulse conducting system conduction [MP:0003137]| cardiac fibrosis [MP:0003141]| abnormal tectorial membrane morphology [MP:0003149]| impaired muscle relaxation [MP:0003157]| increased cholesterol efflux [MP:0003192]| amyloid beta deposits [MP:0003329]| hypopituitarism [MP:0003348]| increased cardiac output [MP:0003394]| abnormal nervous system physiology [MP:0003633]| abnormal response/metabolism to endogenous compounds [MP:0003638]| abnormal axon extension [MP:0003651]| oxidative stress [MP:0003674]| xanthoma [MP:0003692]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal retinal inner nuclear layer morphology [MP:0003733]| abnormal bone structure [MP:0003795]| impaired macrophage chemotaxis [MP:0003799]| vascular smooth muscle hypoplasia [MP:0003814]| enhanced coordination [MP:0003858]| abnormal myelin sheath morphology [MP:0003871]| decreased macrophage cell number [MP:0003884]| abnormal ST segment [MP:0003897]| decreased kidney weight [MP:0003918]| abnormal lymphocyte physiology [MP:0003945]| abnormal cholesterol level [MP:0003947]| abnormal circulating lipid level [MP:0003949]| increased circulating VLDL triglyceride level [MP:0003975]| increased circulating phospholipid level [MP:0003980]| increased cholesterol level [MP:0003982]| decreased cholesterol level [MP:0003983]| arteriosclerosis [MP:0003991]| aortic dissection [MP:0004044]| abnormal coronary artery morphology [MP:0004111]| abnormal aortic arch morphology [MP:0004113]| increased compact bone thickness [MP:0004148]| increased renal tubule apoptosis [MP:0004153]| abnormal basilar membrane morphology [MP:0004308]| cochlear inner hair cell degeneration [MP:0004398]| cochlear outer hair cell degeneration [MP:0004404]| abnormal spiral modiolar artery morphology [MP:0004629]| spiral modiolar artery stenosis [MP:0004630]| increased anti-double stranded DNA antibody level [MP:0004762]| abnormal synaptic vesicle morphology [MP:0004769]| increased macrophage derived foam cell number [MP:0004778]| increased anti-nuclear antigen antibody level [MP:0004794]| increased susceptibility to systemic lupus erythematosus [MP:0004801]| increased mean systemic arterial blood pressure [MP:0004875]| decreased systemic vascular resistance [MP:0004879]| abnormal vascular wound healing [MP:0004883]| decreased adiponectin level [MP:0004893]| increased uterus weight [MP:0004904]| skin inflammation [MP:0004947]| increased spleen weight [MP:0004952]| abnormal osteoblast physiology [MP:0005006]| increased B cell number [MP:0005014]| increased T cell number [MP:0005015]| decreased T cell number [MP:0005018]| increased susceptibility to parasitic infection [MP:0005027]| abnormal thrombosis [MP:0005048]| decreased acute inflammation [MP:0005087]| decreased cardiac muscle contractility [MP:0005140]| increased circulating VLDL cholesterol level [MP:0005145]| decreased circulating VLDL cholesterol level [MP:0005146]| abnormal blood-brain barrier function [MP:0005167]| increased circulating cholesterol level [MP:0005178]| decreased circulating cholesterol level [MP:0005179]| glomerulosclerosis [MP:0005264]| abnormal cholesterol homeostasis [MP:0005278]| improved glucose tolerance [MP:0005292]| impaired glucose tolerance [MP:0005293]| abnormal circulating amino acid level [MP:0005311]| increased triglyceride level [MP:0005317]| abnormal enzyme/coenzyme level [MP:0005319]| abnormal renal glomerulus morphology [MP:0005325]| insulin resistance [MP:0005331]| abnormal gonadal fat pad morphology [MP:0005335]| atherosclerotic lesions [MP:0005338]| increased susceptibility to atherosclerosis [MP:0005339]| altered susceptibility to atherosclerosis [MP:0005340]| decreased susceptibility to atherosclerosis [MP:0005341]| abnormal bile salt homeostasis [MP:0005365]| vascular stenosis [MP:0005412]| abnormal circulating protein level [MP:0005416]| increased macrophage cell number [MP:0005425]| increased susceptibility to weight gain [MP:0005455]| vascular smooth muscle hyperplasia [MP:0005489]| abnormal eye electrophysiology [MP:0005551]| increased circulating creatinine level [MP:0005553]| increased circulating glucose level [MP:0005559]| decreased circulating glucose level [MP:0005560]| abnormal enzyme/coenzyme activity [MP:0005584]| increased vasodilation [MP:0005590]| decreased vasodilation [MP:0005591]| abnormal vascular smooth muscle morphology [MP:0005592]| abnormal vascular smooth muscle physiology [MP:0005595]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| decreased susceptibility to diet-induced obesity [MP:0005659]| decreased circulating leptin level [MP:0005668]| increased circulating leptin level [MP:0005669]| increased apoptosis [MP:0006042]| abnormal vascular endothelial cell morphology [MP:0006055]| decreased cerebral infarction size [MP:0006058]| increased cerebral infarction size [MP:0006060]| abnormal circulating homocysteine level [MP:0006076]| increased fat cell size [MP:0006094]| calcified artery [MP:0006133]| artery occlusion [MP:0006134]| increased systemic arterial systolic blood pressure [MP:0006144]| decreased systemic arterial systolic blood pressure [MP:0006264]| aortic aneurysm [MP:0006278]| abnormal T cell number [MP:0006387]| delayed cellular replicative senescence [MP:0008009]| impaired lipolysis [MP:0008033]| abnormal CD4-positive [MP:0008073]| alpha beta T cell number [MP:0008074]| increased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| decreased CD4-positive [MP:0008090]| alpha beta T cell number [MP:0008143]| decreased CD8-positive [MP:0008174]| alpha-beta T cell number [MP:0008181]| increased T-helper 2 cell number [MP:0008182]| abnormal dendrite morphology [MP:0008217]| decreased follicular B cell number [MP:0008243]| increased marginal zone B cell number [MP:0008248]| decreased marginal zone B cell number [MP:0008288]| abnormal B cell activation [MP:0008289]| abnormal macrophage derived foam cell morphology [MP:0008389]| abnormal mononuclear phagocyte morphology [MP:0008406]| abnormal adrenal cortex morphology [MP:0008428]| abnormal adrenal medulla morphology [MP:0008511]| hypochromic macrocytic anemia [MP:0008515]| increased cellular sensitivity to hydrogen peroxide [MP:0008544]| abnormal spatial working memory [MP:0008553]| thin retinal inner nuclear layer [MP:0008561]| thin retinal outer nuclear layer [MP:0008566]| impaired olfaction [MP:0008567]| increased circulating tumor necrosis factor level [MP:0008577]| decreased tumor necrosis factor secretion [MP:0008596]| increased interferon-gamma secretion [MP:0008597]| decreased interferon-gamma secretion [MP:0008617]| increased circulating interferon-gamma level [MP:0008660]| increased circulating interleukin-6 level [MP:0008817]| decreased circulating interleukin-6 level [MP:0008916]| increased circulating interleukin-12 level [MP:0009278]| increased interleukin-10 secretion [MP:0009289]| hematoma [MP:0009346]| abnormal astrocyte physiology [MP:0009538]| abnormal bone marrow cell physiology [MP:0009763]| decreased epididymal fat pad weight [MP:0009764]| decreased trabecular bone thickness [MP:0009814]| abnormal synapse morphology [MP:0009862]| increased sensitivity to induced morbidity/mortality [MP:0009864]| decreased sensitivity to induced morbidity/mortality [MP:0009866]| increased prostaglandin level [MP:0009868]| abnormal aorta elastic tissue morphology [MP:0009873]| abnormal aorta endothelium morphology [MP:0009932]| abnormal aorta wall morphology [MP:0010210]| abnormal descending thoracic aorta morphology [MP:0010451]| abnormal aorta tunica media morphology [MP:0010483]| skin fibrosis [MP:0010574]| abnormal circulating cytokine level [MP:0010658]| kidney microaneurysm [MP:0010659]| aortic sinus aneurysm [MP:0010663]| aorta dilation [MP:0010724]| thoracic aorta aneurysm [MP:0010760]| abdominal aorta aneurysm [MP:0010868]| abnormal brachiocephalic trunk morphology [MP:0010869]| thick interventricular septum [MP:0010879]| abnormal macrophage chemotaxis [MP:0010895]| increased bone trabecula number [MP:0010922]| decreased bone trabecula number [MP:0010933]| decreased trabecular bone volume [MP:0010935]| increased lung compliance [MP:0010950]| alveolitis [MP:0011086]| decreased trabecular bone connectivity density [MP:0011231]| increased airway resistance [MP:0011294]| abnormal lung hysteresivity [MP:0011309]| postnatal lethality [MP:0011339]| incomplete penetrance [MP:0011353]| abnormal vitamin E level [MP:0011368]| renal glomerulus hypertrophy [MP:0011430]| abnormal kidney arterial blood vessel morphology [MP:0011477]| abnormal glomerular mesangium morphology [MP:0011508]| expanded mesangial matrix [MP:0011509]| increased kidney apoptosis [MP:0011561]| mesangiolysis [MP:0011567]| abnormal urine nucleoside level [MP:0011572]| glomerular capillary thrombosis [MP:0011578]| dilated glomerular capillary [MP:0011581]| renal glomerulus lipidosis [MP:0011599]| increased renal glomerulus lobularity [MP:0011939]| abnormal aorta bulb morphology [MP:0011941]| increased lipoprotein lipase activity [MP:0011951]| increased triglyceride lipase activity [MP:0011967]| increased phosphatidylcholine-sterol O-acyltransferase activity [MP:0012307]| increased food intake [MP:0012335]| increased fluid intake [MP:0013022]| increased cardiac stroke volume [MP:0014169]| increased or absent threshold for auditory brainstem response [MP:0020253]| impaired spatial learning [MP:0020408]| increased circulating homocysteine level [MP:0020519]| weakness [MP:0000746]| decreased brain size [MP:0000774]| small cerebellum [MP:0000852]| Purkinje cell degeneration [MP:0000876]| demyelination [MP:0000921]| abnormal neuromuscular synapse morphology [MP:0001053]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| decreased body size [MP:0001265]| ataxia [MP:0001393]| hypoactivity [MP:0001402]| impaired coordination [MP:0001405]| spinning [MP:0001411]| abnormal spatial learning [MP:0001463]| impaired righting response [MP:0001523]| intracerebral hemorrhage [MP:0001916]| reduced fertility [MP:0001921]| premature death [MP:0002083]| gliosis [MP:0002183]| abnormal long term potentiation [MP:0002207]| abnormal active avoidance behavior [MP:0002798]| abnormal neuron morphology [MP:0002882]| abnormal locomotor activation [MP:0003313]| astrocytosis [MP:0003354]| pallor [MP:0003717]| head tilt [MP:0005191]| hematoma [MP:0008817]| absent gastric milk in neonates [MP:0009546]| abnormal neuron differentiation [MP:0009937]| decreased grip strength [MP:0010053]| increased brain cholesterol level [MP:0010162]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011086]| postnatal lethality [MP:0011110]| incomplete penetrance [MP:0020408] | |Apoe|App| | 042049-JAX | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_42049-JAX, MMRRC_042049, MMRRC_4249 | 2026-08-01 05:45:21 | 0 | ||||
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B6.SB-Lynm2Anu/AnuApbMmucd Resource Report Resource Website Issue |
RRID:MMRRC_041278-UCD | Mus musculus | Research areas: Immunology and Inflammation; Mutation Type: chemically induced mutation ; Collection: NHMRC Australian PhenomeBank | decreased mature B cell number [MP:0008211]| increased immature B cell number [MP:0008214]| increased monocyte cell number [MP:0000220]| abnormal mast cell morphology [MP:0000359]| abnormal hair follicle morphology [MP:0000377]| abnormal hair follicle orientation [MP:0000383]| sparse hair [MP:0000416]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| thick epidermis [MP:0001219]| decreased body size [MP:0001265]| absent vibrissae [MP:0001284]| extended life span [MP:0001661]| decreased IgG level [MP:0001805]| abnormal immune cell physiology [MP:0001819]| autoimmune response [MP:0001844]| increased T cell derived lymphoma incidence [MP:0002024]| premature death [MP:0002083]| abnormal kidney morphology [MP:0002135]| abnormal B cell differentiation [MP:0002144]| abnormal lymph node morphology [MP:0002339]| abnormal effector T cell morphology [MP:0002435]| increased IgG level [MP:0002493]| abnormal monocyte morphology [MP:0002620]| abnormal immune serum protein physiology [MP:0002723]| glomerulonephritis [MP:0002743]| decreased erythrocyte cell number [MP:0002875]| increased urine protein level [MP:0002962]| increased autoantibody level [MP:0003725]| abnormal T cell subpopulation ratio [MP:0003944]| increased anti-double stranded DNA antibody level [MP:0004762]| increased anti-single stranded DNA antibody level [MP:0004771]| increased anti-nuclear antigen antibody level [MP:0004794]| decreased anti-nuclear antigen antibody level [MP:0004795]| increased anti-erythrocyte antigen antibody level [MP:0004797]| increased susceptibility to systemic lupus erythematosus [MP:0004801]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| increased anti-chromatin antibody level [MP:0004829]| increased spleen weight [MP:0004952]| decreased B cell number [MP:0005017]| increased susceptibility to autoimmune disorder [MP:0005350]| decreased susceptibility to autoimmune disorder [MP:0005351]| increased susceptibility to type III hypersensitivity reaction [MP:0005615]| porphyria [MP:0005654]| decreased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008097]| increased plasma cell number [MP:0008182]| decreased marginal zone B cell number [MP:0008470]| abnormal spleen B cell follicle morphology [MP:0008499]| increased IgG1 level [MP:0008500]| increased IgG2a level [MP:0008501]| increased IgG2b level [MP:0008502]| increased IgG3 level [MP:0009060]| increased circulating interleukin-21 level [MP:0009333]| abnormal splenocyte physiology [MP:0009336]| increased splenocyte proliferation [MP:0009338]| increased splenocyte number [MP:0012431]| increased lymphoma incidence [MP:0020519] | |Lyn| | 041278-UCD | chemically induced mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_41278-UCD, MMRRC_041278, MMRRC_41278 | 2026-08-01 05:44:57 | 0 | ||||
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NOD.Cg-Cd28tm1Mak Cd40tm1Kik Ifngtm1Ts H2h4/HbmMmmh Resource Report Resource Website 1+ mentions Issue |
RRID:MMRRC_037143-MU | Mus musculus | Research areas: Immunology and Inflammation; Mutation Type: Targeted Mutation ; Collection: Mullen | increased leukocyte cell number [MP:0000218]| increased monocyte cell number [MP:0000220]| extramedullary hematopoiesis [MP:0000240]| increased granulocyte number [MP:0000322]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| abnormal lymph node size [MP:0000701]| enlarged lymph nodes [MP:0000702]| increased body weight [MP:0001260]| decreased body weight [MP:0001262]| increased metastatic potential [MP:0001272]| abnormal response to new environment [MP:0001413]| altered susceptibility to infection [MP:0001793]| abnormal humoral immune response [MP:0001800]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| brain inflammation [MP:0001847]| kidney inflammation [MP:0001859]| liver inflammation [MP:0001860]| lung inflammation [MP:0001861]| stomach inflammation [MP:0001873]| decreased inflammatory response [MP:0001876]| abnormal lactation [MP:0001882]| mammary gland alveolar hyperplasia [MP:0001884]| decreased litter size [MP:0001935]| abnormal lung volume [MP:0001942]| increased airway responsiveness [MP:0001952]| emphysema [MP:0001958]| increased B cell derived lymphoma incidence [MP:0002023]| increased T cell derived lymphoma incidence [MP:0002024]| increased lung adenocarcinoma incidence [MP:0002027]| increased sarcoma incidence [MP:0002032]| increased carcinoma incidence [MP:0002038]| increased pituitary adenoma incidence [MP:0002041]| decreased tumor incidence [MP:0002052]| premature death [MP:0002083]| abnormal spleen size [MP:0002224]| abnormal pulmonary alveolus morphology [MP:0002270]| decreased airway responsiveness [MP:0002335]| abnormal lymph node cortex morphology [MP:0002343]| abnormal lymph node primary follicle morphology [MP:0002345]| abnormal lymph node secondary follicle morphology [MP:0002346]| abnormal spleen red pulp morphology [MP:0002356]| abnormal spleen white pulp morphology [MP:0002357]| abnormal dendritic cell physiology [MP:0002376]| increased susceptibility to bacterial infection [MP:0002412]| increased susceptibility to viral infection [MP:0002418]| abnormal adaptive immunity [MP:0002420]| altered susceptibility to autoimmune disorder [MP:0002425]| abnormal macrophage physiology [MP:0002451]| abnormal dendritic cell antigen presentation [MP:0002455]| abnormal B cell physiology [MP:0002459]| decreased immunoglobulin level [MP:0002460]| increased immunoglobulin level [MP:0002461]| abnormal immunoglobulin level [MP:0002490]| decreased IgE level [MP:0002492]| increased IgE level [MP:0002497]| abnormal type IV hypersensitivity reaction [MP:0002534]| glomerulonephritis [MP:0002743]| decreased vertical activity [MP:0002757]| albuminuria [MP:0002871]| increased circulating alanine transaminase level [MP:0002941]| abnormal cytokine secretion [MP:0003009]| abnormal redox activity [MP:0003186]| small intestinal inflammation [MP:0003306]| abnormal tumor morphology [MP:0003448]| increased fear-related response [MP:0003459]| abnormal pancreatic beta cell physiology [MP:0003562]| increased ovarian carcinoma incidence [MP:0003579]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal nitric oxide homeostasis [MP:0003957]| abnormal lung vasculature morphology [MP:0004007]| abnormal maternal decidual layer morphology [MP:0004256]| decreased length of allograft survival [MP:0004752]| decreased anti-nuclear antigen antibody level [MP:0004795]| decreased anti-double stranded DNA antibody level [MP:0004798]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| decreased susceptibility to autoimmune diabetes [MP:0004804]| abnormal immune tolerance [MP:0005000]| increased eosinophil cell number [MP:0005011]| increased lymphocyte cell number [MP:0005013]| increased T cell number [MP:0005015]| abnormal response to infection [MP:0005025]| decreased susceptibility to parasitic infection [MP:0005026]| increased susceptibility to parasitic infection [MP:0005027]| abnormal MHC II cell surface expression on macrophages [MP:0005040]| impaired natural killer cell mediated cytotoxicity [MP:0005070]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased double-negative T cell number [MP:0005089]| cachexia [MP:0005150]| abnormal response to injury [MP:0005164]| decreased susceptibility to injury [MP:0005166]| abnormal renal glomerulus morphology [MP:0005325]| atherosclerotic lesions [MP:0005338]| decreased susceptibility to autoimmune disorder [MP:0005351]| abnormal Langerhans cell physiology [MP:0005362]| increased susceptibility to fungal infection [MP:0005399]| abnormal skin physiology [MP:0005501]| corneal vascularization [MP:0005542]| decreased circulating creatinine level [MP:0005554]| increased blood urea nitrogen level [MP:0005565]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| increased susceptibility to type IV hypersensitivity reaction [MP:0005617]| abnormal response to transplant [MP:0005671]| abnormal mammary gland growth during pregnancy [MP:0006269]| increased NK T cell number [MP:0008039]| abnormal uterine NK cell morphology [MP:0008054]| increased CD4-positive [MP:0008074]| alpha beta T cell number [MP:0008078]| increased CD8-positive [MP:0008135]| alpha-beta T cell number [MP:0008466]| small Peyer's patches [MP:0008474]| enlarged mesenteric lymph nodes [MP:0008496]| absent spleen germinal center [MP:0008497]| decreased IgG2a level [MP:0008498]| decreased IgG2b level [MP:0008499]| decreased IgG3 level [MP:0008523]| increased IgG1 level [MP:0008567]| absent lymph node germinal center [MP:0008596]| decreased interferon-gamma secretion [MP:0008660]| increased circulating interleukin-6 level [MP:0008661]| increased interleukin-10 secretion [MP:0008663]| decreased interleukin-10 secretion [MP:0008681]| increased interleukin-12 secretion [MP:0008687]| increased interleukin-17 secretion [MP:0008699]| increased interleukin-2 secretion [MP:0008702]| increased interleukin-4 secretion [MP:0008713]| increased interleukin-5 secretion [MP:0008770]| abnormal cytokine level [MP:0008828]| decreased survivor rate [MP:0008874]| abnormal lymph node cell ratio [MP:0009099]| decreased physiological sensitivity to xenobiotic [MP:0009246]| abnormal uterine NK cell physiology [MP:0009336]| pale spleen [MP:0009394]| increased splenocyte proliferation [MP:0009419]| increased uterine NK cell number [MP:0009643]| skeletal muscle fibrosis [MP:0009763]| abnormal urine homeostasis [MP:0009766]| increased sensitivity to induced morbidity/mortality [MP:0009788]| increased sensitivity to xenobiotic induced morbidity/mortality [MP:0009791]| increased susceptibility to bacterial infection induced morbidity/mortality [MP:0009828]| increased susceptibility to viral infection induced morbidity/mortality [MP:0010210]| increased tumor latency [MP:0010308]| abnormal circulating cytokine level [MP:0010574]| decreased tumor latency [MP:0010639]| aorta dilation [MP:0010659]| altered tumor pathology [MP:0010740]| abdominal aorta aneurysm [MP:0010750]| abnormal dendritic cell chemotaxis [MP:0010751]| increased susceptibility to parasitic infection induced morbidity/mortality [MP:0010760]| decreased susceptibility to parasitic infection induced morbidity/mortality [MP:0010766]| abnormal macrophage chemotaxis [MP:0011086]| abnormal NK cell physiology [MP:0011320]| postnatal lethality [MP:0011427]| incomplete penetrance [MP:0012431]| abnormal glomerular capillary morphology [MP:0013239]| mesangial cell hyperplasia [MP:0013590]| increased lymphoma incidence [MP:0030466]| decreased bone mineral density [MP:0000063]| decreased neutrophil cell number [MP:0000222]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| abnormal humoral immune response [MP:0001800]| decreased IgA level [MP:0001807]| no abnormal phenotype detected [MP:0002169]| abnormal thymus medulla morphology [MP:0002375]| abnormal dendritic cell physiology [MP:0002376]| increased susceptibility to bacterial infection [MP:0002412]| abnormal B cell physiology [MP:0002459]| decreased immunoglobulin level [MP:0002460]| decreased IgE level [MP:0002492]| glomerulonephritis [MP:0002743]| increased urine protein level [MP:0002962]| increased anti-double stranded DNA antibody level [MP:0004762]| abnormal class switch recombination [MP:0004816]| decreased B cell number [MP:0005017]| decreased susceptibility to type II hypersensitivity reaction [MP:0005612]| decreased cerebral infarction size [MP:0006058]| increased follicular B cell number [MP:0008173]| absent germinal center B cells [MP:0008179]| increased marginal zone B cell number [MP:0008181]| increased transitional stage B cell number [MP:0008189]| abnormal B cell activation [MP:0008217]| absent spleen germinal center [MP:0008474]| decreased IgG1 level [MP:0008495]| decreased IgG2a level [MP:0008496]| decreased IgG2b level [MP:0008497]| decreased IgG3 level [MP:0008498]| abnormal thymus epithelium morphology [MP:0009544]| decreased platelet aggregation [MP:0009549]| decreased trabecular bone mass [MP:0010873]| decreased compact bone mass [MP:0010962]| renal glomerular immunoglobulin deposits [MP:0020519]| abnormal cytokine secretion [MP:0003009]| thyroid inflammation [MP:0003504]| insulitis [MP:0004031]| decreased susceptibility to autoimmune diabetes [MP:0004804]| periinsulitis [MP:0005580]| decreased physiological sensitivity to xenobiotic [MP:0008874]| abnormal esophageal epithelium morphology [MP:0000468]| enlarged thymus [MP:0000709]| increased activated T cell number [MP:0001829]| brain inflammation [MP:0001847]| increased T cell derived lymphoma incidence [MP:0002024]| abnormal T cell differentiation [MP:0002145]| abnormal lymphopoiesis [MP:0002401]| decreased immunoglobulin level [MP:0002460]| abnormal cytokine secretion [MP:0003009]| esophageal inflammation [MP:0003278]| insulitis [MP:0004031]| increased length of allograft survival [MP:0004751]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| abnormal class switch recombination [MP:0004816]| abnormal regulatory T cell physiology [MP:0004946]| decreased regulatory T cell number [MP:0004974]| abnormal T cell clonal deletion [MP:0005002]| increased eosinophil cell number [MP:0005011]| increased susceptibility to parasitic infection [MP:0005027]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased cytotoxic T cell cytolysis [MP:0005079]| decreased T cell proliferation [MP:0005095]| increased T cell proliferation [MP:0005348]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005465]| abnormal T-helper 1 physiology [MP:0005466]| abnormal T-helper 2 physiology [MP:0005596]| increased susceptibility to type I hypersensitivity reaction [MP:0005671]| abnormal response to transplant [MP:0006413]| increased T cell apoptosis [MP:0008049]| increased memory T cell number [MP:0008074]| increased CD4-positive [MP:0008078]| alpha beta T cell number [MP:0008192]| increased CD8-positive [MP:0008482]| alpha-beta T cell number [MP:0008495]| abnormal germinal center B cell physiology [MP:0008496]| decreased spleen germinal center number [MP:0008497]| decreased IgG1 level [MP:0008500]| decreased IgG2a level [MP:0008566]| decreased IgG2b level [MP:0008567]| increased IgG2a level [MP:0008578]| increased interferon-gamma secretion [MP:0008603]| decreased interferon-gamma secretion [MP:0008687]| decreased circulating interferon-gamma level [MP:0008688]| decreased circulating interleukin-4 level [MP:0008699]| increased interleukin-2 secretion [MP:0008700]| decreased interleukin-2 secretion [MP:0008747]| increased interleukin-4 secretion [MP:0009335]| decreased interleukin-4 secretion [MP:0010268]| abnormal T cell anergy [MP:0010766] | Cd28||Ifng||Cd40||| | 037143-MU | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_37143-MU, MMRRC_037143, MMRRC_37143 | 2026-08-01 05:43:50 | 1 | ||||
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NOD.Cg-Ifngtm1Ts H2h4 Tg(tetO-Tcra)1Doi/HbmMmmh Resource Report Resource Website Issue |
RRID:MMRRC_037147-MU | Mus musculus | Research areas: Immunology and Inflammation; Mutation Type: Transgenic ; Collection: Mullen | increased leukocyte cell number [MP:0000218]| increased monocyte cell number [MP:0000220]| extramedullary hematopoiesis [MP:0000240]| increased granulocyte number [MP:0000322]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| abnormal lymph node size [MP:0000701]| enlarged lymph nodes [MP:0000702]| increased body weight [MP:0001260]| decreased body weight [MP:0001262]| increased metastatic potential [MP:0001272]| abnormal response to new environment [MP:0001413]| altered susceptibility to infection [MP:0001793]| abnormal humoral immune response [MP:0001800]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| brain inflammation [MP:0001847]| kidney inflammation [MP:0001859]| liver inflammation [MP:0001860]| lung inflammation [MP:0001861]| stomach inflammation [MP:0001873]| decreased inflammatory response [MP:0001876]| abnormal lactation [MP:0001882]| mammary gland alveolar hyperplasia [MP:0001884]| decreased litter size [MP:0001935]| abnormal lung volume [MP:0001942]| increased airway responsiveness [MP:0001952]| emphysema [MP:0001958]| increased B cell derived lymphoma incidence [MP:0002023]| increased T cell derived lymphoma incidence [MP:0002024]| increased lung adenocarcinoma incidence [MP:0002027]| increased sarcoma incidence [MP:0002032]| increased carcinoma incidence [MP:0002038]| increased pituitary adenoma incidence [MP:0002041]| decreased tumor incidence [MP:0002052]| premature death [MP:0002083]| abnormal spleen size [MP:0002224]| abnormal pulmonary alveolus morphology [MP:0002270]| decreased airway responsiveness [MP:0002335]| abnormal lymph node cortex morphology [MP:0002343]| abnormal lymph node primary follicle morphology [MP:0002345]| abnormal lymph node secondary follicle morphology [MP:0002346]| abnormal spleen red pulp morphology [MP:0002356]| abnormal spleen white pulp morphology [MP:0002357]| abnormal dendritic cell physiology [MP:0002376]| increased susceptibility to bacterial infection [MP:0002412]| increased susceptibility to viral infection [MP:0002418]| abnormal adaptive immunity [MP:0002420]| altered susceptibility to autoimmune disorder [MP:0002425]| abnormal macrophage physiology [MP:0002451]| abnormal dendritic cell antigen presentation [MP:0002455]| abnormal B cell physiology [MP:0002459]| decreased immunoglobulin level [MP:0002460]| increased immunoglobulin level [MP:0002461]| abnormal immunoglobulin level [MP:0002490]| decreased IgE level [MP:0002492]| increased IgE level [MP:0002497]| abnormal type IV hypersensitivity reaction [MP:0002534]| glomerulonephritis [MP:0002743]| decreased vertical activity [MP:0002757]| albuminuria [MP:0002871]| increased circulating alanine transaminase level [MP:0002941]| abnormal cytokine secretion [MP:0003009]| abnormal redox activity [MP:0003186]| small intestinal inflammation [MP:0003306]| abnormal tumor morphology [MP:0003448]| increased fear-related response [MP:0003459]| abnormal pancreatic beta cell physiology [MP:0003562]| increased ovarian carcinoma incidence [MP:0003579]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal nitric oxide homeostasis [MP:0003957]| abnormal lung vasculature morphology [MP:0004007]| abnormal maternal decidual layer morphology [MP:0004256]| decreased length of allograft survival [MP:0004752]| decreased anti-nuclear antigen antibody level [MP:0004795]| decreased anti-double stranded DNA antibody level [MP:0004798]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| decreased susceptibility to autoimmune diabetes [MP:0004804]| abnormal immune tolerance [MP:0005000]| increased eosinophil cell number [MP:0005011]| increased lymphocyte cell number [MP:0005013]| increased T cell number [MP:0005015]| abnormal response to infection [MP:0005025]| decreased susceptibility to parasitic infection [MP:0005026]| increased susceptibility to parasitic infection [MP:0005027]| abnormal MHC II cell surface expression on macrophages [MP:0005040]| impaired natural killer cell mediated cytotoxicity [MP:0005070]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased double-negative T cell number [MP:0005089]| cachexia [MP:0005150]| abnormal response to injury [MP:0005164]| decreased susceptibility to injury [MP:0005166]| abnormal renal glomerulus morphology [MP:0005325]| atherosclerotic lesions [MP:0005338]| decreased susceptibility to autoimmune disorder [MP:0005351]| abnormal Langerhans cell physiology [MP:0005362]| increased susceptibility to fungal infection [MP:0005399]| abnormal skin physiology [MP:0005501]| corneal vascularization [MP:0005542]| decreased circulating creatinine level [MP:0005554]| increased blood urea nitrogen level [MP:0005565]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| increased susceptibility to type IV hypersensitivity reaction [MP:0005617]| abnormal response to transplant [MP:0005671]| abnormal mammary gland growth during pregnancy [MP:0006269]| increased NK T cell number [MP:0008039]| abnormal uterine NK cell morphology [MP:0008054]| increased CD4-positive [MP:0008074]| alpha beta T cell number [MP:0008078]| increased CD8-positive [MP:0008135]| alpha-beta T cell number [MP:0008466]| small Peyer's patches [MP:0008474]| enlarged mesenteric lymph nodes [MP:0008496]| absent spleen germinal center [MP:0008497]| decreased IgG2a level [MP:0008498]| decreased IgG2b level [MP:0008499]| decreased IgG3 level [MP:0008523]| increased IgG1 level [MP:0008567]| absent lymph node germinal center [MP:0008596]| decreased interferon-gamma secretion [MP:0008660]| increased circulating interleukin-6 level [MP:0008661]| increased interleukin-10 secretion [MP:0008663]| decreased interleukin-10 secretion [MP:0008681]| increased interleukin-12 secretion [MP:0008687]| increased interleukin-17 secretion [MP:0008699]| increased interleukin-2 secretion [MP:0008702]| increased interleukin-4 secretion [MP:0008713]| increased interleukin-5 secretion [MP:0008770]| abnormal cytokine level [MP:0008828]| decreased survivor rate [MP:0008874]| abnormal lymph node cell ratio [MP:0009099]| decreased physiological sensitivity to xenobiotic [MP:0009246]| abnormal uterine NK cell physiology [MP:0009336]| pale spleen [MP:0009394]| increased splenocyte proliferation [MP:0009419]| increased uterine NK cell number [MP:0009643]| skeletal muscle fibrosis [MP:0009763]| abnormal urine homeostasis [MP:0009766]| increased sensitivity to induced morbidity/mortality [MP:0009788]| increased sensitivity to xenobiotic induced morbidity/mortality [MP:0009791]| increased susceptibility to bacterial infection induced morbidity/mortality [MP:0009828]| increased susceptibility to viral infection induced morbidity/mortality [MP:0010210]| increased tumor latency [MP:0010308]| abnormal circulating cytokine level [MP:0010574]| decreased tumor latency [MP:0010639]| aorta dilation [MP:0010659]| altered tumor pathology [MP:0010740]| abdominal aorta aneurysm [MP:0010750]| abnormal dendritic cell chemotaxis [MP:0010751]| increased susceptibility to parasitic infection induced morbidity/mortality [MP:0010760]| decreased susceptibility to parasitic infection induced morbidity/mortality [MP:0010766]| abnormal macrophage chemotaxis [MP:0011086]| abnormal NK cell physiology [MP:0011320]| postnatal lethality [MP:0011427]| incomplete penetrance [MP:0012431]| abnormal glomerular capillary morphology [MP:0013239]| mesangial cell hyperplasia [MP:0013590]| increased lymphoma incidence [MP:0030466]| abnormal cytokine secretion [MP:0003009]| thyroid inflammation [MP:0003504]| insulitis [MP:0004031]| decreased susceptibility to autoimmune diabetes [MP:0004804]| periinsulitis [MP:0005580]| decreased physiological sensitivity to xenobiotic [MP:0008874] | |Tcra|||Ifng| | 037147-MU | Transgenic | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | PMID:22298883 | MMRRC_37147-MU, MMRRC_037147, MMRRC_37147 | 2026-08-01 05:43:46 | 0 | |||
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NOD.Cg-Cd28tm1Mak Ifngtm1Ts H2h4/HbmMmmh Resource Report Resource Website 1+ mentions Issue |
RRID:MMRRC_037141-MU | Mus musculus | Research areas: Immunology and Inflammation; Mutation Type: Targeted Mutation ; Collection: Mullen | increased leukocyte cell number [MP:0000218]| increased monocyte cell number [MP:0000220]| extramedullary hematopoiesis [MP:0000240]| increased granulocyte number [MP:0000322]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| abnormal lymph node size [MP:0000701]| enlarged lymph nodes [MP:0000702]| increased body weight [MP:0001260]| decreased body weight [MP:0001262]| increased metastatic potential [MP:0001272]| abnormal response to new environment [MP:0001413]| altered susceptibility to infection [MP:0001793]| abnormal humoral immune response [MP:0001800]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| brain inflammation [MP:0001847]| kidney inflammation [MP:0001859]| liver inflammation [MP:0001860]| lung inflammation [MP:0001861]| stomach inflammation [MP:0001873]| decreased inflammatory response [MP:0001876]| abnormal lactation [MP:0001882]| mammary gland alveolar hyperplasia [MP:0001884]| decreased litter size [MP:0001935]| abnormal lung volume [MP:0001942]| increased airway responsiveness [MP:0001952]| emphysema [MP:0001958]| increased B cell derived lymphoma incidence [MP:0002023]| increased T cell derived lymphoma incidence [MP:0002024]| increased lung adenocarcinoma incidence [MP:0002027]| increased sarcoma incidence [MP:0002032]| increased carcinoma incidence [MP:0002038]| increased pituitary adenoma incidence [MP:0002041]| decreased tumor incidence [MP:0002052]| premature death [MP:0002083]| abnormal spleen size [MP:0002224]| abnormal pulmonary alveolus morphology [MP:0002270]| decreased airway responsiveness [MP:0002335]| abnormal lymph node cortex morphology [MP:0002343]| abnormal lymph node primary follicle morphology [MP:0002345]| abnormal lymph node secondary follicle morphology [MP:0002346]| abnormal spleen red pulp morphology [MP:0002356]| abnormal spleen white pulp morphology [MP:0002357]| abnormal dendritic cell physiology [MP:0002376]| increased susceptibility to bacterial infection [MP:0002412]| increased susceptibility to viral infection [MP:0002418]| abnormal adaptive immunity [MP:0002420]| altered susceptibility to autoimmune disorder [MP:0002425]| abnormal macrophage physiology [MP:0002451]| abnormal dendritic cell antigen presentation [MP:0002455]| abnormal B cell physiology [MP:0002459]| decreased immunoglobulin level [MP:0002460]| increased immunoglobulin level [MP:0002461]| abnormal immunoglobulin level [MP:0002490]| decreased IgE level [MP:0002492]| increased IgE level [MP:0002497]| abnormal type IV hypersensitivity reaction [MP:0002534]| glomerulonephritis [MP:0002743]| decreased vertical activity [MP:0002757]| albuminuria [MP:0002871]| increased circulating alanine transaminase level [MP:0002941]| abnormal cytokine secretion [MP:0003009]| abnormal redox activity [MP:0003186]| small intestinal inflammation [MP:0003306]| abnormal tumor morphology [MP:0003448]| increased fear-related response [MP:0003459]| abnormal pancreatic beta cell physiology [MP:0003562]| increased ovarian carcinoma incidence [MP:0003579]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal nitric oxide homeostasis [MP:0003957]| abnormal lung vasculature morphology [MP:0004007]| abnormal maternal decidual layer morphology [MP:0004256]| decreased length of allograft survival [MP:0004752]| decreased anti-nuclear antigen antibody level [MP:0004795]| decreased anti-double stranded DNA antibody level [MP:0004798]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| decreased susceptibility to autoimmune diabetes [MP:0004804]| abnormal immune tolerance [MP:0005000]| increased eosinophil cell number [MP:0005011]| increased lymphocyte cell number [MP:0005013]| increased T cell number [MP:0005015]| abnormal response to infection [MP:0005025]| decreased susceptibility to parasitic infection [MP:0005026]| increased susceptibility to parasitic infection [MP:0005027]| abnormal MHC II cell surface expression on macrophages [MP:0005040]| impaired natural killer cell mediated cytotoxicity [MP:0005070]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased double-negative T cell number [MP:0005089]| cachexia [MP:0005150]| abnormal response to injury [MP:0005164]| decreased susceptibility to injury [MP:0005166]| abnormal renal glomerulus morphology [MP:0005325]| atherosclerotic lesions [MP:0005338]| decreased susceptibility to autoimmune disorder [MP:0005351]| abnormal Langerhans cell physiology [MP:0005362]| increased susceptibility to fungal infection [MP:0005399]| abnormal skin physiology [MP:0005501]| corneal vascularization [MP:0005542]| decreased circulating creatinine level [MP:0005554]| increased blood urea nitrogen level [MP:0005565]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| increased susceptibility to type IV hypersensitivity reaction [MP:0005617]| abnormal response to transplant [MP:0005671]| abnormal mammary gland growth during pregnancy [MP:0006269]| increased NK T cell number [MP:0008039]| abnormal uterine NK cell morphology [MP:0008054]| increased CD4-positive [MP:0008074]| alpha beta T cell number [MP:0008078]| increased CD8-positive [MP:0008135]| alpha-beta T cell number [MP:0008466]| small Peyer's patches [MP:0008474]| enlarged mesenteric lymph nodes [MP:0008496]| absent spleen germinal center [MP:0008497]| decreased IgG2a level [MP:0008498]| decreased IgG2b level [MP:0008499]| decreased IgG3 level [MP:0008523]| increased IgG1 level [MP:0008567]| absent lymph node germinal center [MP:0008596]| decreased interferon-gamma secretion [MP:0008660]| increased circulating interleukin-6 level [MP:0008661]| increased interleukin-10 secretion [MP:0008663]| decreased interleukin-10 secretion [MP:0008681]| increased interleukin-12 secretion [MP:0008687]| increased interleukin-17 secretion [MP:0008699]| increased interleukin-2 secretion [MP:0008702]| increased interleukin-4 secretion [MP:0008713]| increased interleukin-5 secretion [MP:0008770]| abnormal cytokine level [MP:0008828]| decreased survivor rate [MP:0008874]| abnormal lymph node cell ratio [MP:0009099]| decreased physiological sensitivity to xenobiotic [MP:0009246]| abnormal uterine NK cell physiology [MP:0009336]| pale spleen [MP:0009394]| increased splenocyte proliferation [MP:0009419]| increased uterine NK cell number [MP:0009643]| skeletal muscle fibrosis [MP:0009763]| abnormal urine homeostasis [MP:0009766]| increased sensitivity to induced morbidity/mortality [MP:0009788]| increased sensitivity to xenobiotic induced morbidity/mortality [MP:0009791]| increased susceptibility to bacterial infection induced morbidity/mortality [MP:0009828]| increased susceptibility to viral infection induced morbidity/mortality [MP:0010210]| increased tumor latency [MP:0010308]| abnormal circulating cytokine level [MP:0010574]| decreased tumor latency [MP:0010639]| aorta dilation [MP:0010659]| altered tumor pathology [MP:0010740]| abdominal aorta aneurysm [MP:0010750]| abnormal dendritic cell chemotaxis [MP:0010751]| increased susceptibility to parasitic infection induced morbidity/mortality [MP:0010760]| decreased susceptibility to parasitic infection induced morbidity/mortality [MP:0010766]| abnormal macrophage chemotaxis [MP:0011086]| abnormal NK cell physiology [MP:0011320]| postnatal lethality [MP:0011427]| incomplete penetrance [MP:0012431]| abnormal glomerular capillary morphology [MP:0013239]| mesangial cell hyperplasia [MP:0013590]| increased lymphoma incidence [MP:0030466]| abnormal cytokine secretion [MP:0003009]| thyroid inflammation [MP:0003504]| insulitis [MP:0004031]| decreased susceptibility to autoimmune diabetes [MP:0004804]| periinsulitis [MP:0005580]| decreased physiological sensitivity to xenobiotic [MP:0008874]| abnormal esophageal epithelium morphology [MP:0000468]| enlarged thymus [MP:0000709]| increased activated T cell number [MP:0001829]| brain inflammation [MP:0001847]| increased T cell derived lymphoma incidence [MP:0002024]| abnormal T cell differentiation [MP:0002145]| abnormal lymphopoiesis [MP:0002401]| decreased immunoglobulin level [MP:0002460]| abnormal cytokine secretion [MP:0003009]| esophageal inflammation [MP:0003278]| insulitis [MP:0004031]| increased length of allograft survival [MP:0004751]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| abnormal class switch recombination [MP:0004816]| abnormal regulatory T cell physiology [MP:0004946]| decreased regulatory T cell number [MP:0004974]| abnormal T cell clonal deletion [MP:0005002]| increased eosinophil cell number [MP:0005011]| increased susceptibility to parasitic infection [MP:0005027]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased cytotoxic T cell cytolysis [MP:0005079]| decreased T cell proliferation [MP:0005095]| increased T cell proliferation [MP:0005348]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005465]| abnormal T-helper 1 physiology [MP:0005466]| abnormal T-helper 2 physiology [MP:0005596]| increased susceptibility to type I hypersensitivity reaction [MP:0005671]| abnormal response to transplant [MP:0006413]| increased T cell apoptosis [MP:0008049]| increased memory T cell number [MP:0008074]| increased CD4-positive [MP:0008078]| alpha beta T cell number [MP:0008192]| increased CD8-positive [MP:0008482]| alpha-beta T cell number [MP:0008495]| abnormal germinal center B cell physiology [MP:0008496]| decreased spleen germinal center number [MP:0008497]| decreased IgG1 level [MP:0008500]| decreased IgG2a level [MP:0008566]| decreased IgG2b level [MP:0008567]| increased IgG2a level [MP:0008578]| increased interferon-gamma secretion [MP:0008603]| decreased interferon-gamma secretion [MP:0008687]| decreased circulating interferon-gamma level [MP:0008688]| decreased circulating interleukin-4 level [MP:0008699]| increased interleukin-2 secretion [MP:0008700]| decreased interleukin-2 secretion [MP:0008747]| increased interleukin-4 secretion [MP:0009335]| decreased interleukin-4 secretion [MP:0010268]| abnormal T cell anergy [MP:0010766] | Cd28||Ifng||| | 037141-MU | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_37141-MU, MMRRC_037141, MMRRC_37141 | 2026-08-01 05:43:46 | 1 | ||||
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NOD.Cg-Cd28tm1Mak Ighmtm1Cgn H2h4/HbmMmmh Resource Report Resource Website Issue Issue |
RRID:MMRRC_037353-MU | Mus musculus | Research areas: ; Mutation Type: Targeted Mutation ; Collection: Mullen | decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| decreased compact bone thickness [MP:0000135]| enlarged heart [MP:0000274]| increased cell proliferation [MP:0000351]| abnormal intestinal epithelium morphology [MP:0000488]| abnormal spleen morphology [MP:0000689]| enlarged lymph nodes [MP:0000702]| abnormal skin condition [MP:0001191]| abnormal cardiovascular system physiology [MP:0001544]| abnormal humoral immune response [MP:0001800]| arrested B cell differentiation [MP:0001802]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| thymus hypoplasia [MP:0001823]| abnormal antigen presentation [MP:0001835]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| heart inflammation [MP:0001853]| myocarditis [MP:0001856]| kidney inflammation [MP:0001859]| abnormal lymphatic vessel morphology [MP:0001879]| premature death [MP:0002083]| abnormal respiratory system physiology [MP:0002133]| abnormal B cell differentiation [MP:0002144]| abnormal spleen marginal sinus morphology [MP:0002363]| abnormal B lymphocyte antigen presentation [MP:0002453]| decreased immunoglobulin level [MP:0002460]| abnormal immunoglobulin level [MP:0002490]| decreased IgE level [MP:0002492]| tubular nephritis [MP:0002704]| increased urine protein level [MP:0002962]| abnormal cytokine secretion [MP:0003009]| cardiac fibrosis [MP:0003141]| thrombocytopenia [MP:0003179]| small intestinal inflammation [MP:0003306]| increased susceptibility to induced arthritis [MP:0003724]| increased autoantibody level [MP:0003725]| abnormal compact bone morphology [MP:0003797]| abnormal PR interval [MP:0003901]| insulitis [MP:0004031]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| decreased spleen weight [MP:0004953]| increased osteoclast cell number [MP:0004984]| increased T cell number [MP:0005015]| decreased B cell number [MP:0005017]| abnormal response to infection [MP:0005025]| increased susceptibility to parasitic infection [MP:0005027]| abnormal T cell proliferation [MP:0005094]| decreased T cell proliferation [MP:0005095]| cachexia [MP:0005150]| decreased susceptibility to injury [MP:0005166]| abnormal pancreatic islet morphology [MP:0005215]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005559]| increased circulating glucose level [MP:0005616]| decreased susceptibility to type IV hypersensitivity reaction [MP:0006387]| abnormal T cell number [MP:0008071]| absent B cells [MP:0008075]| decreased CD4-positive [MP:0008079]| alpha beta T cell number [MP:0008127]| decreased CD8-positive [MP:0008171]| alpha-beta T cell number [MP:0008201]| decreased dendritic cell number [MP:0008211]| abnormal mature B cell morphology [MP:0008212]| absent follicular dendritic cells [MP:0008213]| decreased mature B cell number [MP:0008240]| absent mature B cells [MP:0008241]| absent immature B cells [MP:0008401]| abnormal spleen marginal zone macrophage morphology [MP:0008470]| abnormal metallophilic macrophage morphology [MP:0008495]| abnormal CD8 positive [MP:0009346]| alpha-beta intraepithelial T cell morphology [MP:0010965]| abnormal spleen B cell follicle morphology [MP:0012431]| abnormal cytokine secretion [MP:0003009]| thyroid inflammation [MP:0003504]| insulitis [MP:0004031]| decreased susceptibility to autoimmune diabetes [MP:0004804]| periinsulitis [MP:0005580]| decreased physiological sensitivity to xenobiotic [MP:0008874]| abnormal esophageal epithelium morphology [MP:0000468]| enlarged thymus [MP:0000709]| increased activated T cell number [MP:0001829]| brain inflammation [MP:0001847]| increased T cell derived lymphoma incidence [MP:0002024]| abnormal T cell differentiation [MP:0002145]| abnormal lymphopoiesis [MP:0002401]| decreased immunoglobulin level [MP:0002460]| abnormal cytokine secretion [MP:0003009]| esophageal inflammation [MP:0003278]| insulitis [MP:0004031]| increased length of allograft survival [MP:0004751]| decreased susceptibility to experimental autoimmune encephalomyelitis [MP:0004800]| increased susceptibility to autoimmune diabetes [MP:0004803]| abnormal class switch recombination [MP:0004816]| abnormal regulatory T cell physiology [MP:0004946]| decreased regulatory T cell number [MP:0004974]| abnormal T cell clonal deletion [MP:0005002]| increased eosinophil cell number [MP:0005011]| increased susceptibility to parasitic infection [MP:0005027]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased cytotoxic T cell cytolysis [MP:0005079]| decreased T cell proliferation [MP:0005095]| increased T cell proliferation [MP:0005348]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005465]| abnormal T-helper 1 physiology [MP:0005466]| abnormal T-helper 2 physiology [MP:0005596]| increased susceptibility to type I hypersensitivity reaction [MP:0005671]| abnormal response to transplant [MP:0006413]| increased T cell apoptosis [MP:0008049]| increased memory T cell number [MP:0008074]| increased CD4-positive [MP:0008078]| alpha beta T cell number [MP:0008192]| increased CD8-positive [MP:0008482]| alpha-beta T cell number [MP:0008495]| abnormal germinal center B cell physiology [MP:0008496]| decreased spleen germinal center number [MP:0008497]| decreased IgG1 level [MP:0008500]| decreased IgG2a level [MP:0008566]| decreased IgG2b level [MP:0008567]| increased IgG2a level [MP:0008578]| increased interferon-gamma secretion [MP:0008603]| decreased interferon-gamma secretion [MP:0008687]| decreased circulating interferon-gamma level [MP:0008688]| decreased circulating interleukin-4 level [MP:0008699]| increased interleukin-2 secretion [MP:0008700]| decreased interleukin-2 secretion [MP:0008747]| increased interleukin-4 secretion [MP:0009335]| decreased interleukin-4 secretion [MP:0010268]| abnormal T cell anergy [MP:0010766] | Cd28||Ighm||| | 037353-MU | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_37353-MU, MMRRC_037353, MMRRC_37353 | 2026-08-01 05:43:47 | 0 | ||||
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B6.Cg-Apoetm1Unc Tg(MSR1-TXN*)23Arem/Mmjax Resource Report Resource Website Issue |
RRID:MMRRC_037627-JAX | Mus musculus | Research areas: Cardiovascular, Models for Human Disease, Neurobiology; Mutation Type: Transgenic ; Collection: | abnormal cochlea morphology [MP:0000031]| organ of Corti degeneration [MP:0000043]| abnormal stria vascularis morphology [MP:0000048]| increased bone mineral density [MP:0000062]| decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| abnormal vertebrae morphology [MP:0000137]| abnormal circulating cholesterol level [MP:0000180]| increased circulating LDL cholesterol level [MP:0000182]| decreased circulating HDL cholesterol level [MP:0000186]| decreased hematocrit [MP:0000208]| increased monocyte cell number [MP:0000220]| decreased monocyte cell number [MP:0000223]| hypertension [MP:0000231]| abnormal blood flow velocity [MP:0000233]| macrocytosis [MP:0000248]| abnormal blood vessel physiology [MP:0000249]| echinocytosis [MP:0000256]| abnormal heart morphology [MP:0000266]| abnormal aorta morphology [MP:0000272]| enlarged heart [MP:0000274]| altered response to myocardial infarction [MP:0000343]| decreased hair follicle number [MP:0000379]| alopecia [MP:0000414]| sparse hair [MP:0000416]| abnormal femur morphology [MP:0000559]| abnormal liver morphology [MP:0000598]| amyloidosis [MP:0000604]| abnormal liver physiology [MP:0000609]| abnormal adrenal gland morphology [MP:0000639]| abnormal immune system morphology [MP:0000685]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| enlarged thymus [MP:0000709]| abnormal skin condition [MP:0001191]| thick skin [MP:0001200]| skin lesions [MP:0001212]| hyperkeratosis [MP:0001242]| abnormal dermal layer morphology [MP:0001243]| thick dermal layer [MP:0001245]| mixed cellular infiltration to dermis [MP:0001246]| decreased body length [MP:0001258]| increased body weight [MP:0001260]| obese [MP:0001261]| decreased body weight [MP:0001262]| abnormal retina morphology [MP:0001325]| dry eyes [MP:0001337]| Meibomian gland atrophy [MP:0001345]| increased anxiety-related response [MP:0001363]| abnormal stationary movement [MP:0001388]| abnormal locomotor behavior [MP:0001392]| abnormal response to new environment [MP:0001413]| decreased exploration in new environment [MP:0001417]| abnormal spatial learning [MP:0001463]| increased startle reflex [MP:0001488]| decreased startle reflex [MP:0001489]| abnormal kindling response [MP:0001499]| abnormal coat appearance [MP:0001510]| abnormal skeleton physiology [MP:0001533]| abnormal hematopoietic system physiology [MP:0001545]| abnormal lipid level [MP:0001547]| hyperlipidemia [MP:0001548]| increased circulating triglyceride level [MP:0001552]| increased circulating free fatty acid level [MP:0001554]| increased circulating HDL cholesterol level [MP:0001556]| hyperglycemia [MP:0001559]| anemia [MP:0001577]| cardiac hypertrophy [MP:0001625]| hypersecretion of corticosterone [MP:0001744]| increased circulating corticosterone level [MP:0001745]| abnormal immune system physiology [MP:0001790]| impaired macrophage phagocytosis [MP:0001798]| abnormal inflammatory response [MP:0001845]| heart inflammation [MP:0001853]| kidney inflammation [MP:0001859]| lung inflammation [MP:0001861]| vascular inflammation [MP:0001863]| abnormal lung volume [MP:0001942]| deafness [MP:0001967]| abnormal skin morphology [MP:0002060]| abnormal fear/anxiety-related behavior [MP:0002065]| increased circulating insulin level [MP:0002079]| premature death [MP:0002083]| abnormal lipid homeostasis [MP:0002118]| abnormal cardiovascular system morphology [MP:0002127]| abnormal kidney morphology [MP:0002135]| abnormal brain morphology [MP:0002152]| abnormal gland physiology [MP:0002164]| gliosis [MP:0002183]| abnormal artery morphology [MP:0002191]| neurodegeneration [MP:0002229]| abnormal pulmonary alveolus morphology [MP:0002270]| abnormal lymph node morphology [MP:0002339]| abnormal dendritic cell physiology [MP:0002376]| abnormal cell-mediated immunity [MP:0002421]| abnormal macrophage morphology [MP:0002446]| abnormal erythrocyte morphology [MP:0002447]| abnormal macrophage physiology [MP:0002451]| increased immunoglobulin level [MP:0002461]| abnormal neutrophil physiology [MP:0002463]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| abnormal blood coagulation [MP:0002551]| hepatic steatosis [MP:0002628]| reticulocytosis [MP:0002640]| poikilocytosis [MP:0002643]| decreased circulating triglyceride level [MP:0002644]| abnormal sciatic nerve morphology [MP:0002651]| abnormal immune serum protein physiology [MP:0002723]| decreased circulating insulin level [MP:0002727]| abnormal thermal nociception [MP:0002733]| glomerulonephritis [MP:0002743]| dilated heart left ventricle [MP:0002753]| decreased vertical activity [MP:0002757]| abnormal retinal vasculature morphology [MP:0002792]| increased thigmotaxis [MP:0002797]| increased heart weight [MP:0002833]| increased systemic arterial blood pressure [MP:0002842]| decreased systemic arterial blood pressure [MP:0002843]| cochlear ganglion degeneration [MP:0002857]| increased growth rate [MP:0002865]| albuminuria [MP:0002871]| decreased hemoglobin content [MP:0002874]| increased insulin sensitivity [MP:0002891]| thick ventricular wall [MP:0002953]| increased urine protein level [MP:0002962]| increased liver weight [MP:0002981]| abnormal cytokine secretion [MP:0003009]| increased vasoconstriction [MP:0003025]| decreased myocardial infarction size [MP:0003038]| abnormal impulse conducting system conduction [MP:0003137]| cardiac fibrosis [MP:0003141]| abnormal tectorial membrane morphology [MP:0003149]| impaired muscle relaxation [MP:0003157]| increased cholesterol efflux [MP:0003192]| amyloid beta deposits [MP:0003329]| hypopituitarism [MP:0003348]| increased cardiac output [MP:0003394]| abnormal nervous system physiology [MP:0003633]| abnormal response/metabolism to endogenous compounds [MP:0003638]| abnormal axon extension [MP:0003651]| oxidative stress [MP:0003674]| xanthoma [MP:0003692]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal retinal inner nuclear layer morphology [MP:0003733]| abnormal bone structure [MP:0003795]| impaired macrophage chemotaxis [MP:0003799]| vascular smooth muscle hypoplasia [MP:0003814]| enhanced coordination [MP:0003858]| abnormal myelin sheath morphology [MP:0003871]| decreased macrophage cell number [MP:0003884]| abnormal ST segment [MP:0003897]| decreased kidney weight [MP:0003918]| abnormal lymphocyte physiology [MP:0003945]| abnormal cholesterol level [MP:0003947]| abnormal circulating lipid level [MP:0003949]| increased circulating VLDL triglyceride level [MP:0003975]| increased circulating phospholipid level [MP:0003980]| increased cholesterol level [MP:0003982]| decreased cholesterol level [MP:0003983]| arteriosclerosis [MP:0003991]| aortic dissection [MP:0004044]| abnormal coronary artery morphology [MP:0004111]| abnormal aortic arch morphology [MP:0004113]| increased compact bone thickness [MP:0004148]| increased renal tubule apoptosis [MP:0004153]| abnormal basilar membrane morphology [MP:0004308]| cochlear inner hair cell degeneration [MP:0004398]| cochlear outer hair cell degeneration [MP:0004404]| abnormal spiral modiolar artery morphology [MP:0004629]| spiral modiolar artery stenosis [MP:0004630]| increased anti-double stranded DNA antibody level [MP:0004762]| abnormal synaptic vesicle morphology [MP:0004769]| increased macrophage derived foam cell number [MP:0004778]| increased anti-nuclear antigen antibody level [MP:0004794]| increased susceptibility to systemic lupus erythematosus [MP:0004801]| increased mean systemic arterial blood pressure [MP:0004875]| decreased systemic vascular resistance [MP:0004879]| abnormal vascular wound healing [MP:0004883]| decreased adiponectin level [MP:0004893]| increased uterus weight [MP:0004904]| skin inflammation [MP:0004947]| increased spleen weight [MP:0004952]| abnormal osteoblast physiology [MP:0005006]| increased B cell number [MP:0005014]| increased T cell number [MP:0005015]| decreased T cell number [MP:0005018]| increased susceptibility to parasitic infection [MP:0005027]| abnormal thrombosis [MP:0005048]| decreased acute inflammation [MP:0005087]| decreased cardiac muscle contractility [MP:0005140]| increased circulating VLDL cholesterol level [MP:0005145]| decreased circulating VLDL cholesterol level [MP:0005146]| abnormal blood-brain barrier function [MP:0005167]| increased circulating cholesterol level [MP:0005178]| decreased circulating cholesterol level [MP:0005179]| glomerulosclerosis [MP:0005264]| abnormal cholesterol homeostasis [MP:0005278]| improved glucose tolerance [MP:0005292]| impaired glucose tolerance [MP:0005293]| abnormal circulating amino acid level [MP:0005311]| increased triglyceride level [MP:0005317]| abnormal enzyme/coenzyme level [MP:0005319]| abnormal renal glomerulus morphology [MP:0005325]| insulin resistance [MP:0005331]| abnormal gonadal fat pad morphology [MP:0005335]| atherosclerotic lesions [MP:0005338]| increased susceptibility to atherosclerosis [MP:0005339]| altered susceptibility to atherosclerosis [MP:0005340]| decreased susceptibility to atherosclerosis [MP:0005341]| abnormal bile salt homeostasis [MP:0005365]| vascular stenosis [MP:0005412]| abnormal circulating protein level [MP:0005416]| increased macrophage cell number [MP:0005425]| increased susceptibility to weight gain [MP:0005455]| vascular smooth muscle hyperplasia [MP:0005489]| abnormal eye electrophysiology [MP:0005551]| increased circulating creatinine level [MP:0005553]| increased circulating glucose level [MP:0005559]| decreased circulating glucose level [MP:0005560]| abnormal enzyme/coenzyme activity [MP:0005584]| increased vasodilation [MP:0005590]| decreased vasodilation [MP:0005591]| abnormal vascular smooth muscle morphology [MP:0005592]| abnormal vascular smooth muscle physiology [MP:0005595]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| decreased susceptibility to diet-induced obesity [MP:0005659]| decreased circulating leptin level [MP:0005668]| increased circulating leptin level [MP:0005669]| increased apoptosis [MP:0006042]| abnormal vascular endothelial cell morphology [MP:0006055]| decreased cerebral infarction size [MP:0006058]| increased cerebral infarction size [MP:0006060]| abnormal circulating homocysteine level [MP:0006076]| increased fat cell size [MP:0006094]| calcified artery [MP:0006133]| artery occlusion [MP:0006134]| increased systemic arterial systolic blood pressure [MP:0006144]| decreased systemic arterial systolic blood pressure [MP:0006264]| aortic aneurysm [MP:0006278]| abnormal T cell number [MP:0006387]| delayed cellular replicative senescence [MP:0008009]| impaired lipolysis [MP:0008033]| abnormal CD4-positive [MP:0008073]| alpha beta T cell number [MP:0008074]| increased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| decreased CD4-positive [MP:0008090]| alpha beta T cell number [MP:0008143]| decreased CD8-positive [MP:0008174]| alpha-beta T cell number [MP:0008181]| increased T-helper 2 cell number [MP:0008182]| abnormal dendrite morphology [MP:0008217]| decreased follicular B cell number [MP:0008243]| increased marginal zone B cell number [MP:0008248]| decreased marginal zone B cell number [MP:0008288]| abnormal B cell activation [MP:0008289]| abnormal macrophage derived foam cell morphology [MP:0008389]| abnormal mononuclear phagocyte morphology [MP:0008406]| abnormal adrenal cortex morphology [MP:0008428]| abnormal adrenal medulla morphology [MP:0008511]| hypochromic macrocytic anemia [MP:0008515]| increased cellular sensitivity to hydrogen peroxide [MP:0008544]| abnormal spatial working memory [MP:0008553]| thin retinal inner nuclear layer [MP:0008561]| thin retinal outer nuclear layer [MP:0008566]| impaired olfaction [MP:0008567]| increased circulating tumor necrosis factor level [MP:0008577]| decreased tumor necrosis factor secretion [MP:0008596]| increased interferon-gamma secretion [MP:0008597]| decreased interferon-gamma secretion [MP:0008617]| increased circulating interferon-gamma level [MP:0008660]| increased circulating interleukin-6 level [MP:0008817]| decreased circulating interleukin-6 level [MP:0008916]| increased circulating interleukin-12 level [MP:0009278]| increased interleukin-10 secretion [MP:0009289]| hematoma [MP:0009346]| abnormal astrocyte physiology [MP:0009538]| abnormal bone marrow cell physiology [MP:0009763]| decreased epididymal fat pad weight [MP:0009764]| decreased trabecular bone thickness [MP:0009814]| abnormal synapse morphology [MP:0009862]| increased sensitivity to induced morbidity/mortality [MP:0009864]| decreased sensitivity to induced morbidity/mortality [MP:0009866]| increased prostaglandin level [MP:0009868]| abnormal aorta elastic tissue morphology [MP:0009873]| abnormal aorta endothelium morphology [MP:0009932]| abnormal aorta wall morphology [MP:0010210]| abnormal descending thoracic aorta morphology [MP:0010451]| abnormal aorta tunica media morphology [MP:0010483]| skin fibrosis [MP:0010574]| abnormal circulating cytokine level [MP:0010658]| kidney microaneurysm [MP:0010659]| aortic sinus aneurysm [MP:0010663]| aorta dilation [MP:0010724]| thoracic aorta aneurysm [MP:0010760]| abdominal aorta aneurysm [MP:0010868]| abnormal brachiocephalic trunk morphology [MP:0010869]| thick interventricular septum [MP:0010879]| abnormal macrophage chemotaxis [MP:0010895]| increased bone trabecula number [MP:0010922]| decreased bone trabecula number [MP:0010933]| decreased trabecular bone volume [MP:0010935]| increased lung compliance [MP:0010950]| alveolitis [MP:0011086]| decreased trabecular bone connectivity density [MP:0011231]| increased airway resistance [MP:0011294]| abnormal lung hysteresivity [MP:0011309]| postnatal lethality [MP:0011339]| incomplete penetrance [MP:0011353]| abnormal vitamin E level [MP:0011368]| renal glomerulus hypertrophy [MP:0011430]| abnormal kidney arterial blood vessel morphology [MP:0011477]| abnormal glomerular mesangium morphology [MP:0011508]| expanded mesangial matrix [MP:0011509]| increased kidney apoptosis [MP:0011561]| mesangiolysis [MP:0011567]| abnormal urine nucleoside level [MP:0011572]| glomerular capillary thrombosis [MP:0011578]| dilated glomerular capillary [MP:0011581]| renal glomerulus lipidosis [MP:0011599]| increased renal glomerulus lobularity [MP:0011939]| abnormal aorta bulb morphology [MP:0011941]| increased lipoprotein lipase activity [MP:0011951]| increased triglyceride lipase activity [MP:0011967]| increased phosphatidylcholine-sterol O-acyltransferase activity [MP:0012307]| increased food intake [MP:0012335]| increased fluid intake [MP:0013022]| increased cardiac stroke volume [MP:0014169]| increased or absent threshold for auditory brainstem response [MP:0020253]| impaired spatial learning [MP:0020408]| increased circulating homocysteine level [MP:0020519] | MSR1|TXN||Apoe| | 037627-JAX | Transgenic | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | PMID:22933306 | MMRRC_37627-JAX, MMRRC_037627, MMRRC_37627 | 2026-08-01 05:43:54 | 0 | |||
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C.129S2(B6)-Ighmtm1Cgn/Mmmh Resource Report Resource Website Issue Issue |
RRID:MMRRC_000205-MU | Mus musculus | Research areas: Cardiovascular, Immunology and Inflammation, Research Tools, Virology; Mutation Type: Targeted Mutation ; Collection: | decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| decreased compact bone thickness [MP:0000135]| enlarged heart [MP:0000274]| increased cell proliferation [MP:0000351]| abnormal intestinal epithelium morphology [MP:0000488]| abnormal spleen morphology [MP:0000689]| enlarged lymph nodes [MP:0000702]| abnormal skin condition [MP:0001191]| abnormal cardiovascular system physiology [MP:0001544]| abnormal humoral immune response [MP:0001800]| arrested B cell differentiation [MP:0001802]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| thymus hypoplasia [MP:0001823]| abnormal antigen presentation [MP:0001835]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| heart inflammation [MP:0001853]| myocarditis [MP:0001856]| kidney inflammation [MP:0001859]| abnormal lymphatic vessel morphology [MP:0001879]| premature death [MP:0002083]| abnormal respiratory system physiology [MP:0002133]| abnormal B cell differentiation [MP:0002144]| abnormal spleen marginal sinus morphology [MP:0002363]| abnormal B lymphocyte antigen presentation [MP:0002453]| decreased immunoglobulin level [MP:0002460]| abnormal immunoglobulin level [MP:0002490]| decreased IgE level [MP:0002492]| tubular nephritis [MP:0002704]| increased urine protein level [MP:0002962]| abnormal cytokine secretion [MP:0003009]| cardiac fibrosis [MP:0003141]| thrombocytopenia [MP:0003179]| small intestinal inflammation [MP:0003306]| increased susceptibility to induced arthritis [MP:0003724]| increased autoantibody level [MP:0003725]| abnormal compact bone morphology [MP:0003797]| abnormal PR interval [MP:0003901]| insulitis [MP:0004031]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| increased susceptibility to autoimmune diabetes [MP:0004803]| decreased susceptibility to autoimmune diabetes [MP:0004804]| decreased spleen weight [MP:0004953]| increased osteoclast cell number [MP:0004984]| increased T cell number [MP:0005015]| decreased B cell number [MP:0005017]| abnormal response to infection [MP:0005025]| increased susceptibility to parasitic infection [MP:0005027]| abnormal T cell proliferation [MP:0005094]| decreased T cell proliferation [MP:0005095]| cachexia [MP:0005150]| decreased susceptibility to injury [MP:0005166]| abnormal pancreatic islet morphology [MP:0005215]| abnormal CD4-positive [MP:0005463]| alpha-beta T cell physiology [MP:0005559]| increased circulating glucose level [MP:0005616]| decreased susceptibility to type IV hypersensitivity reaction [MP:0006387]| abnormal T cell number [MP:0008071]| absent B cells [MP:0008075]| decreased CD4-positive [MP:0008079]| alpha beta T cell number [MP:0008127]| decreased CD8-positive [MP:0008171]| alpha-beta T cell number [MP:0008201]| decreased dendritic cell number [MP:0008211]| abnormal mature B cell morphology [MP:0008212]| absent follicular dendritic cells [MP:0008213]| decreased mature B cell number [MP:0008240]| absent mature B cells [MP:0008241]| absent immature B cells [MP:0008401]| abnormal spleen marginal zone macrophage morphology [MP:0008470]| abnormal metallophilic macrophage morphology [MP:0008495]| abnormal CD8 positive [MP:0009346]| alpha-beta intraepithelial T cell morphology [MP:0010965]| abnormal spleen B cell follicle morphology [MP:0012431] | Ighm | 000205-MU | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | PMID:10553048 | MMRRC_205-MU, MMRRC_000205, MMRRC_25 | 2026-08-01 05:32:03 | 0 | |||
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B6.129-Tcrbtm1Mom Ifngtm1Ts/Mmnc Resource Report Resource Website Issue |
RRID:MMRRC_000337-UNC | Mus musculus | Research areas: Cancer, Immunology and Inflammation; Mutation Type: Targeted Mutation ; Collection: | enlarged liver [MP:0000599]| enlarged spleen [MP:0000691]| spleen hypoplasia [MP:0000694]| absent CD8-positive [MP:0000727]| alpha-beta T cells [MP:0000938]| motor neuron degeneration [MP:0001219]| thick epidermis [MP:0001243]| abnormal dermal layer morphology [MP:0001263]| weight loss [MP:0001805]| decreased IgG level [MP:0001807]| decreased IgA level [MP:0001823]| thymus hypoplasia [MP:0001825]| arrested T cell differentiation [MP:0002023]| increased B cell derived lymphoma incidence [MP:0002083]| premature death [MP:0002132]| abnormal respiratory system morphology [MP:0002133]| abnormal respiratory system physiology [MP:0002144]| abnormal B cell differentiation [MP:0002492]| decreased IgE level [MP:0002494]| increased IgM level [MP:0002495]| increased IgA level [MP:0002816]| colitis [MP:0003691]| abnormal microglial cell physiology [MP:0003725]| increased autoantibody level [MP:0003726]| decreased autoantibody level [MP:0003790]| absent CD4-positive [MP:0004762]| alpha beta T cells [MP:0004796]| increased anti-double stranded DNA antibody level [MP:0004829]| increased anti-histone antibody level [MP:0004939]| increased anti-chromatin antibody level [MP:0004947]| abnormal B cell morphology [MP:0005014]| skin inflammation [MP:0005015]| increased B cell number [MP:0005016]| increased T cell number [MP:0005017]| decreased lymphocyte cell number [MP:0005018]| decreased B cell number [MP:0005025]| decreased T cell number [MP:0005092]| abnormal response to infection [MP:0008075]| decreased double-positive T cell number [MP:0008079]| decreased CD4-positive [MP:0008098]| alpha beta T cell number [MP:0008173]| decreased CD8-positive [MP:0008181]| alpha-beta T cell number [MP:0008188]| decreased plasma cell number [MP:0008210]| increased follicular B cell number [MP:0008214]| increased marginal zone B cell number [MP:0008495]| abnormal transitional stage B cell morphology [MP:0009925]| increased mature B cell number [MP:0010229]| increased immature B cell number [MP:0010286]| decreased IgG1 level [MP:0011320]| increased transitional stage T2 B cell number [MP:0011427]| increased transitional stage T3 B cell number [MP:0020519]| increased leukocyte cell number [MP:0000218]| increased monocyte cell number [MP:0000220]| extramedullary hematopoiesis [MP:0000240]| increased granulocyte number [MP:0000322]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| abnormal lymph node size [MP:0000701]| enlarged lymph nodes [MP:0000702]| increased body weight [MP:0001260]| decreased body weight [MP:0001262]| increased metastatic potential [MP:0001272]| abnormal response to new environment [MP:0001413]| altered susceptibility to infection [MP:0001793]| abnormal humoral immune response [MP:0001800]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| abnormal inflammatory response [MP:0001845]| increased inflammatory response [MP:0001846]| brain inflammation [MP:0001847]| kidney inflammation [MP:0001859]| liver inflammation [MP:0001860]| lung inflammation [MP:0001861]| stomach inflammation [MP:0001873]| decreased inflammatory response [MP:0001876]| abnormal lactation [MP:0001882]| mammary gland alveolar hyperplasia [MP:0001884]| decreased litter size [MP:0001935]| abnormal lung volume [MP:0001942]| increased airway responsiveness [MP:0001952]| emphysema [MP:0001958]| increased B cell derived lymphoma incidence [MP:0002023]| increased T cell derived lymphoma incidence [MP:0002024]| increased lung adenocarcinoma incidence [MP:0002027]| increased sarcoma incidence [MP:0002032]| increased carcinoma incidence [MP:0002038]| increased pituitary adenoma incidence [MP:0002041]| decreased tumor incidence [MP:0002052]| premature death [MP:0002083]| abnormal spleen size [MP:0002224]| abnormal pulmonary alveolus morphology [MP:0002270]| decreased airway responsiveness [MP:0002335]| abnormal lymph node cortex morphology [MP:0002343]| abnormal lymph node primary follicle morphology [MP:0002345]| abnormal lymph node secondary follicle morphology [MP:0002346]| abnormal spleen red pulp morphology [MP:0002356]| abnormal spleen white pulp morphology [MP:0002357]| abnormal dendritic cell physiology [MP:0002376]| increased susceptibility to bacterial infection [MP:0002412]| increased susceptibility to viral infection [MP:0002418]| abnormal adaptive immunity [MP:0002420]| altered susceptibility to autoimmune disorder [MP:0002425]| abnormal macrophage physiology [MP:0002451]| abnormal dendritic cell antigen presentation [MP:0002455]| abnormal B cell physiology [MP:0002459]| decreased immunoglobulin level [MP:0002460]| increased immunoglobulin level [MP:0002461]| abnormal immunoglobulin level [MP:0002490]| decreased IgE level [MP:0002492]| increased IgE level [MP:0002497]| abnormal type IV hypersensitivity reaction [MP:0002534]| glomerulonephritis [MP:0002743]| decreased vertical activity [MP:0002757]| albuminuria [MP:0002871]| increased circulating alanine transaminase level [MP:0002941]| abnormal cytokine secretion [MP:0003009]| abnormal redox activity [MP:0003186]| small intestinal inflammation [MP:0003306]| abnormal tumor morphology [MP:0003448]| increased fear-related response [MP:0003459]| abnormal pancreatic beta cell physiology [MP:0003562]| increased ovarian carcinoma incidence [MP:0003579]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal nitric oxide homeostasis [MP:0003957]| abnormal lung vasculature morphology [MP:0004007]| abnormal maternal decidual layer morphology [MP:0004256]| decreased length of allograft survival [MP:0004752]| decreased anti-nuclear antigen antibody level [MP:0004795]| decreased anti-double stranded DNA antibody level [MP:0004798]| increased susceptibility to experimental autoimmune encephalomyelitis [MP:0004799]| decreased susceptibility to systemic lupus erythematosus [MP:0004802]| decreased susceptibility to autoimmune diabetes [MP:0004804]| abnormal immune tolerance [MP:0005000]| increased eosinophil cell number [MP:0005011]| increased lymphocyte cell number [MP:0005013]| increased T cell number [MP:0005015]| abnormal response to infection [MP:0005025]| decreased susceptibility to parasitic infection [MP:0005026]| increased susceptibility to parasitic infection [MP:0005027]| abnormal MHC II cell surface expression on macrophages [MP:0005040]| impaired natural killer cell mediated cytotoxicity [MP:0005070]| abnormal cytotoxic T cell physiology [MP:0005078]| decreased double-negative T cell number [MP:0005089]| cachexia [MP:0005150]| abnormal response to injury [MP:0005164]| decreased susceptibility to injury [MP:0005166]| abnormal renal glomerulus morphology [MP:0005325]| atherosclerotic lesions [MP:0005338]| decreased susceptibility to autoimmune disorder [MP:0005351]| abnormal Langerhans cell physiology [MP:0005362]| increased susceptibility to fungal infection [MP:0005399]| abnormal skin physiology [MP:0005501]| corneal vascularization [MP:0005542]| decreased circulating creatinine level [MP:0005554]| increased blood urea nitrogen level [MP:0005565]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| increased susceptibility to type IV hypersensitivity reaction [MP:0005617]| abnormal response to transplant [MP:0005671]| abnormal mammary gland growth during pregnancy [MP:0006269]| increased NK T cell number [MP:0008039]| abnormal uterine NK cell morphology [MP:0008054]| increased CD4-positive [MP:0008074]| alpha beta T cell number [MP:0008078]| increased CD8-positive [MP:0008135]| alpha-beta T cell number [MP:0008466]| small Peyer's patches [MP:0008474]| enlarged mesenteric lymph nodes [MP:0008496]| absent spleen germinal center [MP:0008497]| decreased IgG2a level [MP:0008498]| decreased IgG2b level [MP:0008499]| decreased IgG3 level [MP:0008523]| increased IgG1 level [MP:0008567]| absent lymph node germinal center [MP:0008596]| decreased interferon-gamma secretion [MP:0008660]| increased circulating interleukin-6 level [MP:0008661]| increased interleukin-10 secretion [MP:0008663]| decreased interleukin-10 secretion [MP:0008681]| increased interleukin-12 secretion [MP:0008687]| increased interleukin-17 secretion [MP:0008699]| increased interleukin-2 secretion [MP:0008702]| increased interleukin-4 secretion [MP:0008713]| increased interleukin-5 secretion [MP:0008770]| abnormal cytokine level [MP:0008828]| decreased survivor rate [MP:0008874]| abnormal lymph node cell ratio [MP:0009099]| decreased physiological sensitivity to xenobiotic [MP:0009246]| abnormal uterine NK cell physiology [MP:0009336]| pale spleen [MP:0009394]| increased splenocyte proliferation [MP:0009419]| increased uterine NK cell number [MP:0009643]| skeletal muscle fibrosis [MP:0009763]| abnormal urine homeostasis [MP:0009766]| increased sensitivity to induced morbidity/mortality [MP:0009788]| increased sensitivity to xenobiotic induced morbidity/mortality [MP:0009791]| increased susceptibility to bacterial infection induced morbidity/mortality [MP:0009828]| increased susceptibility to viral infection induced morbidity/mortality [MP:0010210]| increased tumor latency [MP:0010308]| abnormal circulating cytokine level [MP:0010574]| decreased tumor latency [MP:0010639]| aorta dilation [MP:0010659]| altered tumor pathology [MP:0010740]| abdominal aorta aneurysm [MP:0010750]| abnormal dendritic cell chemotaxis [MP:0010751]| increased susceptibility to parasitic infection induced morbidity/mortality [MP:0010760]| decreased susceptibility to parasitic infection induced morbidity/mortality [MP:0010766]| abnormal macrophage chemotaxis [MP:0011086]| abnormal NK cell physiology [MP:0011320]| postnatal lethality [MP:0011427]| incomplete penetrance [MP:0012431]| abnormal glomerular capillary morphology [MP:0013239]| mesangial cell hyperplasia [MP:0013590]| increased lymphoma incidence [MP:0030466] | |Tcrb||Ifngr2 | 000337-UNC | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | PMID:1359428 PMID:11705890 |
MMRRC_337-UNC, MMRRC_000337, MMRRC_337 | 2026-08-01 05:32:13 | 0 | |||
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B6.Cg-Apoetm1Unc Lipctm1Unc Tg(LIPC*S145G)1Ssf/Mmmh Resource Report Resource Website Issue |
RRID:MMRRC_011858-MU | Mus musculus | Research areas: Cardiovascular, Metabolism, Models for Human Disease; Mutation Type: Transgenic ; Collection: | abnormal cochlea morphology [MP:0000031]| organ of Corti degeneration [MP:0000043]| abnormal stria vascularis morphology [MP:0000048]| increased bone mineral density [MP:0000062]| decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| abnormal vertebrae morphology [MP:0000137]| abnormal circulating cholesterol level [MP:0000180]| increased circulating LDL cholesterol level [MP:0000182]| decreased circulating HDL cholesterol level [MP:0000186]| decreased hematocrit [MP:0000208]| increased monocyte cell number [MP:0000220]| decreased monocyte cell number [MP:0000223]| hypertension [MP:0000231]| abnormal blood flow velocity [MP:0000233]| macrocytosis [MP:0000248]| abnormal blood vessel physiology [MP:0000249]| echinocytosis [MP:0000256]| abnormal heart morphology [MP:0000266]| abnormal aorta morphology [MP:0000272]| enlarged heart [MP:0000274]| altered response to myocardial infarction [MP:0000343]| decreased hair follicle number [MP:0000379]| alopecia [MP:0000414]| sparse hair [MP:0000416]| abnormal femur morphology [MP:0000559]| abnormal liver morphology [MP:0000598]| amyloidosis [MP:0000604]| abnormal liver physiology [MP:0000609]| abnormal adrenal gland morphology [MP:0000639]| abnormal immune system morphology [MP:0000685]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| enlarged thymus [MP:0000709]| abnormal skin condition [MP:0001191]| thick skin [MP:0001200]| skin lesions [MP:0001212]| hyperkeratosis [MP:0001242]| abnormal dermal layer morphology [MP:0001243]| thick dermal layer [MP:0001245]| mixed cellular infiltration to dermis [MP:0001246]| decreased body length [MP:0001258]| increased body weight [MP:0001260]| obese [MP:0001261]| decreased body weight [MP:0001262]| abnormal retina morphology [MP:0001325]| dry eyes [MP:0001337]| Meibomian gland atrophy [MP:0001345]| increased anxiety-related response [MP:0001363]| abnormal stationary movement [MP:0001388]| abnormal locomotor behavior [MP:0001392]| abnormal response to new environment [MP:0001413]| decreased exploration in new environment [MP:0001417]| abnormal spatial learning [MP:0001463]| increased startle reflex [MP:0001488]| decreased startle reflex [MP:0001489]| abnormal kindling response [MP:0001499]| abnormal coat appearance [MP:0001510]| abnormal skeleton physiology [MP:0001533]| abnormal hematopoietic system physiology [MP:0001545]| abnormal lipid level [MP:0001547]| hyperlipidemia [MP:0001548]| increased circulating triglyceride level [MP:0001552]| increased circulating free fatty acid level [MP:0001554]| increased circulating HDL cholesterol level [MP:0001556]| hyperglycemia [MP:0001559]| anemia [MP:0001577]| cardiac hypertrophy [MP:0001625]| hypersecretion of corticosterone [MP:0001744]| increased circulating corticosterone level [MP:0001745]| abnormal immune system physiology [MP:0001790]| impaired macrophage phagocytosis [MP:0001798]| abnormal inflammatory response [MP:0001845]| heart inflammation [MP:0001853]| kidney inflammation [MP:0001859]| lung inflammation [MP:0001861]| vascular inflammation [MP:0001863]| abnormal lung volume [MP:0001942]| deafness [MP:0001967]| abnormal skin morphology [MP:0002060]| abnormal fear/anxiety-related behavior [MP:0002065]| increased circulating insulin level [MP:0002079]| premature death [MP:0002083]| abnormal lipid homeostasis [MP:0002118]| abnormal cardiovascular system morphology [MP:0002127]| abnormal kidney morphology [MP:0002135]| abnormal brain morphology [MP:0002152]| abnormal gland physiology [MP:0002164]| gliosis [MP:0002183]| abnormal artery morphology [MP:0002191]| neurodegeneration [MP:0002229]| abnormal pulmonary alveolus morphology [MP:0002270]| abnormal lymph node morphology [MP:0002339]| abnormal dendritic cell physiology [MP:0002376]| abnormal cell-mediated immunity [MP:0002421]| abnormal macrophage morphology [MP:0002446]| abnormal erythrocyte morphology [MP:0002447]| abnormal macrophage physiology [MP:0002451]| increased immunoglobulin level [MP:0002461]| abnormal neutrophil physiology [MP:0002463]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| abnormal blood coagulation [MP:0002551]| hepatic steatosis [MP:0002628]| reticulocytosis [MP:0002640]| poikilocytosis [MP:0002643]| decreased circulating triglyceride level [MP:0002644]| abnormal sciatic nerve morphology [MP:0002651]| abnormal immune serum protein physiology [MP:0002723]| decreased circulating insulin level [MP:0002727]| abnormal thermal nociception [MP:0002733]| glomerulonephritis [MP:0002743]| dilated heart left ventricle [MP:0002753]| decreased vertical activity [MP:0002757]| abnormal retinal vasculature morphology [MP:0002792]| increased thigmotaxis [MP:0002797]| increased heart weight [MP:0002833]| increased systemic arterial blood pressure [MP:0002842]| decreased systemic arterial blood pressure [MP:0002843]| cochlear ganglion degeneration [MP:0002857]| increased growth rate [MP:0002865]| albuminuria [MP:0002871]| decreased hemoglobin content [MP:0002874]| increased insulin sensitivity [MP:0002891]| thick ventricular wall [MP:0002953]| increased urine protein level [MP:0002962]| increased liver weight [MP:0002981]| abnormal cytokine secretion [MP:0003009]| increased vasoconstriction [MP:0003025]| decreased myocardial infarction size [MP:0003038]| abnormal impulse conducting system conduction [MP:0003137]| cardiac fibrosis [MP:0003141]| abnormal tectorial membrane morphology [MP:0003149]| impaired muscle relaxation [MP:0003157]| increased cholesterol efflux [MP:0003192]| amyloid beta deposits [MP:0003329]| hypopituitarism [MP:0003348]| increased cardiac output [MP:0003394]| abnormal nervous system physiology [MP:0003633]| abnormal response/metabolism to endogenous compounds [MP:0003638]| abnormal axon extension [MP:0003651]| oxidative stress [MP:0003674]| xanthoma [MP:0003692]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal retinal inner nuclear layer morphology [MP:0003733]| abnormal bone structure [MP:0003795]| impaired macrophage chemotaxis [MP:0003799]| vascular smooth muscle hypoplasia [MP:0003814]| enhanced coordination [MP:0003858]| abnormal myelin sheath morphology [MP:0003871]| decreased macrophage cell number [MP:0003884]| abnormal ST segment [MP:0003897]| decreased kidney weight [MP:0003918]| abnormal lymphocyte physiology [MP:0003945]| abnormal cholesterol level [MP:0003947]| abnormal circulating lipid level [MP:0003949]| increased circulating VLDL triglyceride level [MP:0003975]| increased circulating phospholipid level [MP:0003980]| increased cholesterol level [MP:0003982]| decreased cholesterol level [MP:0003983]| arteriosclerosis [MP:0003991]| aortic dissection [MP:0004044]| abnormal coronary artery morphology [MP:0004111]| abnormal aortic arch morphology [MP:0004113]| increased compact bone thickness [MP:0004148]| increased renal tubule apoptosis [MP:0004153]| abnormal basilar membrane morphology [MP:0004308]| cochlear inner hair cell degeneration [MP:0004398]| cochlear outer hair cell degeneration [MP:0004404]| abnormal spiral modiolar artery morphology [MP:0004629]| spiral modiolar artery stenosis [MP:0004630]| increased anti-double stranded DNA antibody level [MP:0004762]| abnormal synaptic vesicle morphology [MP:0004769]| increased macrophage derived foam cell number [MP:0004778]| increased anti-nuclear antigen antibody level [MP:0004794]| increased susceptibility to systemic lupus erythematosus [MP:0004801]| increased mean systemic arterial blood pressure [MP:0004875]| decreased systemic vascular resistance [MP:0004879]| abnormal vascular wound healing [MP:0004883]| decreased adiponectin level [MP:0004893]| increased uterus weight [MP:0004904]| skin inflammation [MP:0004947]| increased spleen weight [MP:0004952]| abnormal osteoblast physiology [MP:0005006]| increased B cell number [MP:0005014]| increased T cell number [MP:0005015]| decreased T cell number [MP:0005018]| increased susceptibility to parasitic infection [MP:0005027]| abnormal thrombosis [MP:0005048]| decreased acute inflammation [MP:0005087]| decreased cardiac muscle contractility [MP:0005140]| increased circulating VLDL cholesterol level [MP:0005145]| decreased circulating VLDL cholesterol level [MP:0005146]| abnormal blood-brain barrier function [MP:0005167]| increased circulating cholesterol level [MP:0005178]| decreased circulating cholesterol level [MP:0005179]| glomerulosclerosis [MP:0005264]| abnormal cholesterol homeostasis [MP:0005278]| improved glucose tolerance [MP:0005292]| impaired glucose tolerance [MP:0005293]| abnormal circulating amino acid level [MP:0005311]| increased triglyceride level [MP:0005317]| abnormal enzyme/coenzyme level [MP:0005319]| abnormal renal glomerulus morphology [MP:0005325]| insulin resistance [MP:0005331]| abnormal gonadal fat pad morphology [MP:0005335]| atherosclerotic lesions [MP:0005338]| increased susceptibility to atherosclerosis [MP:0005339]| altered susceptibility to atherosclerosis [MP:0005340]| decreased susceptibility to atherosclerosis [MP:0005341]| abnormal bile salt homeostasis [MP:0005365]| vascular stenosis [MP:0005412]| abnormal circulating protein level [MP:0005416]| increased macrophage cell number [MP:0005425]| increased susceptibility to weight gain [MP:0005455]| vascular smooth muscle hyperplasia [MP:0005489]| abnormal eye electrophysiology [MP:0005551]| increased circulating creatinine level [MP:0005553]| increased circulating glucose level [MP:0005559]| decreased circulating glucose level [MP:0005560]| abnormal enzyme/coenzyme activity [MP:0005584]| increased vasodilation [MP:0005590]| decreased vasodilation [MP:0005591]| abnormal vascular smooth muscle morphology [MP:0005592]| abnormal vascular smooth muscle physiology [MP:0005595]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| decreased susceptibility to diet-induced obesity [MP:0005659]| decreased circulating leptin level [MP:0005668]| increased circulating leptin level [MP:0005669]| increased apoptosis [MP:0006042]| abnormal vascular endothelial cell morphology [MP:0006055]| decreased cerebral infarction size [MP:0006058]| increased cerebral infarction size [MP:0006060]| abnormal circulating homocysteine level [MP:0006076]| increased fat cell size [MP:0006094]| calcified artery [MP:0006133]| artery occlusion [MP:0006134]| increased systemic arterial systolic blood pressure [MP:0006144]| decreased systemic arterial systolic blood pressure [MP:0006264]| aortic aneurysm [MP:0006278]| abnormal T cell number [MP:0006387]| delayed cellular replicative senescence [MP:0008009]| impaired lipolysis [MP:0008033]| abnormal CD4-positive [MP:0008073]| alpha beta T cell number [MP:0008074]| increased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| decreased CD4-positive [MP:0008090]| alpha beta T cell number [MP:0008143]| decreased CD8-positive [MP:0008174]| alpha-beta T cell number [MP:0008181]| increased T-helper 2 cell number [MP:0008182]| abnormal dendrite morphology [MP:0008217]| decreased follicular B cell number [MP:0008243]| increased marginal zone B cell number [MP:0008248]| decreased marginal zone B cell number [MP:0008288]| abnormal B cell activation [MP:0008289]| abnormal macrophage derived foam cell morphology [MP:0008389]| abnormal mononuclear phagocyte morphology [MP:0008406]| abnormal adrenal cortex morphology [MP:0008428]| abnormal adrenal medulla morphology [MP:0008511]| hypochromic macrocytic anemia [MP:0008515]| increased cellular sensitivity to hydrogen peroxide [MP:0008544]| abnormal spatial working memory [MP:0008553]| thin retinal inner nuclear layer [MP:0008561]| thin retinal outer nuclear layer [MP:0008566]| impaired olfaction [MP:0008567]| increased circulating tumor necrosis factor level [MP:0008577]| decreased tumor necrosis factor secretion [MP:0008596]| increased interferon-gamma secretion [MP:0008597]| decreased interferon-gamma secretion [MP:0008617]| increased circulating interferon-gamma level [MP:0008660]| increased circulating interleukin-6 level [MP:0008817]| decreased circulating interleukin-6 level [MP:0008916]| increased circulating interleukin-12 level [MP:0009278]| increased interleukin-10 secretion [MP:0009289]| hematoma [MP:0009346]| abnormal astrocyte physiology [MP:0009538]| abnormal bone marrow cell physiology [MP:0009763]| decreased epididymal fat pad weight [MP:0009764]| decreased trabecular bone thickness [MP:0009814]| abnormal synapse morphology [MP:0009862]| increased sensitivity to induced morbidity/mortality [MP:0009864]| decreased sensitivity to induced morbidity/mortality [MP:0009866]| increased prostaglandin level [MP:0009868]| abnormal aorta elastic tissue morphology [MP:0009873]| abnormal aorta endothelium morphology [MP:0009932]| abnormal aorta wall morphology [MP:0010210]| abnormal descending thoracic aorta morphology [MP:0010451]| abnormal aorta tunica media morphology [MP:0010483]| skin fibrosis [MP:0010574]| abnormal circulating cytokine level [MP:0010658]| kidney microaneurysm [MP:0010659]| aortic sinus aneurysm [MP:0010663]| aorta dilation [MP:0010724]| thoracic aorta aneurysm [MP:0010760]| abdominal aorta aneurysm [MP:0010868]| abnormal brachiocephalic trunk morphology [MP:0010869]| thick interventricular septum [MP:0010879]| abnormal macrophage chemotaxis [MP:0010895]| increased bone trabecula number [MP:0010922]| decreased bone trabecula number [MP:0010933]| decreased trabecular bone volume [MP:0010935]| increased lung compliance [MP:0010950]| alveolitis [MP:0011086]| decreased trabecular bone connectivity density [MP:0011231]| increased airway resistance [MP:0011294]| abnormal lung hysteresivity [MP:0011309]| postnatal lethality [MP:0011339]| incomplete penetrance [MP:0011353]| abnormal vitamin E level [MP:0011368]| renal glomerulus hypertrophy [MP:0011430]| abnormal kidney arterial blood vessel morphology [MP:0011477]| abnormal glomerular mesangium morphology [MP:0011508]| expanded mesangial matrix [MP:0011509]| increased kidney apoptosis [MP:0011561]| mesangiolysis [MP:0011567]| abnormal urine nucleoside level [MP:0011572]| glomerular capillary thrombosis [MP:0011578]| dilated glomerular capillary [MP:0011581]| renal glomerulus lipidosis [MP:0011599]| increased renal glomerulus lobularity [MP:0011939]| abnormal aorta bulb morphology [MP:0011941]| increased lipoprotein lipase activity [MP:0011951]| increased triglyceride lipase activity [MP:0011967]| increased phosphatidylcholine-sterol O-acyltransferase activity [MP:0012307]| increased food intake [MP:0012335]| increased fluid intake [MP:0013022]| increased cardiac stroke volume [MP:0014169]| increased or absent threshold for auditory brainstem response [MP:0020253]| impaired spatial learning [MP:0020408]| increased circulating homocysteine level [MP:0020519]| abnormal circulating cholesterol level [MP:0000180]| increased circulating LDL cholesterol level [MP:0000182]| small ovary [MP:0001127]| abnormal lipid level [MP:0001547]| increased circulating triglyceride level [MP:0001552]| increased circulating HDL cholesterol level [MP:0001556]| abnormal reproductive system physiology [MP:0001919]| decreased litter size [MP:0001935]| decreased circulating corticosterone level [MP:0002665]| decreased ovulation rate [MP:0003355]| increased circulating cholesterol level [MP:0005178]| abnormal circulating phospholipid level [MP:0006084] | |LIPC||Apoe||Lipc | 011858-MU | Transgenic | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | PMID:15304509 | MMRRC_11858-MU, MMRRC_011858, MMRRC_11858 | 2026-08-01 05:36:00 | 0 | |||
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MRL.Cg-Igh-8tm1Schr Faslpr/Mmmh Resource Report Resource Website Issue |
RRID:MMRRC_015868-MU | Mus musculus | Research areas: Apoptosis, Cancer, Cardiovascular, Dermatology, Hematology, Immunology and Inflammation, Models for Human Disease; Mutation Type: Targeted Mutation ; Collection: | increased susceptibility to bacterial infection [MP:0002412]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| abnormal stria vascularis morphology [MP:0000048]| decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| abnormal vertebrae morphology [MP:0000137]| increased leukocyte cell number [MP:0000218]| increased neutrophil cell number [MP:0000219]| abnormal erythropoiesis [MP:0000245]| abnormal heart morphology [MP:0000266]| abnormal aorta morphology [MP:0000272]| abnormal mast cell morphology [MP:0000359]| abnormal hair follicle morphology [MP:0000377]| abnormal hair follicle orientation [MP:0000383]| alopecia [MP:0000414]| sparse hair [MP:0000416]| ruffled hair [MP:0000420]| cortical renal glomerulopathies [MP:0000523]| abnormal femur morphology [MP:0000559]| abnormal hepatocyte morphology [MP:0000607]| abnormal liver physiology [MP:0000609]| abnormal thyroid gland morphology [MP:0000681]| abnormal immune system morphology [MP:0000685]| enlarged spleen [MP:0000691]| spleen hyperplasia [MP:0000693]| abnormal lymph node size [MP:0000701]| enlarged lymph nodes [MP:0000702]| enlarged thymus [MP:0000709]| abnormal lymphocyte cell number [MP:0000717]| abnormal cerebellum morphology [MP:0000849]| small cerebellum [MP:0000852]| abnormal cerebellar foliation [MP:0000857]| decreased Purkinje cell number [MP:0000880]| thin cerebellar molecular layer [MP:0000890]| demyelination [MP:0000921]| abnormal stellate ganglion morphology [MP:0001017]| arrest of spermatogenesis [MP:0001155]| abnormal skin condition [MP:0001191]| dermatitis [MP:0001194]| skin lesions [MP:0001212]| thick epidermis [MP:0001219]| epidermal necrosis [MP:0001220]| increased body weight [MP:0001260]| decreased body size [MP:0001265]| absent vibrissae [MP:0001284]| abnormal lacrimal gland morphology [MP:0001346]| ataxia [MP:0001393]| impaired coordination [MP:0001405]| abnormal spatial learning [MP:0001463]| abnormal cardiovascular system physiology [MP:0001544]| focal hepatic necrosis [MP:0001656]| extended life span [MP:0001661]| abnormal immune system physiology [MP:0001790]| abnormal humoral immune response [MP:0001800]| arrested B cell differentiation [MP:0001802]| decreased IgG level [MP:0001805]| decreased IgM level [MP:0001806]| decreased IgA level [MP:0001807]| increased activated T cell number [MP:0001829]| decreased activated T cell number [MP:0001830]| autoimmune response [MP:0001844]| brain inflammation [MP:0001847]| conjunctivitis [MP:0001852]| kidney inflammation [MP:0001859]| liver inflammation [MP:0001860]| lung inflammation [MP:0001861]| vascular inflammation [MP:0001863]| vasculitis [MP:0001864]| salivary gland inflammation [MP:0001870]| male infertility [MP:0001925]| female infertility [MP:0001926]| increased tumor incidence [MP:0002020]| premature death [MP:0002083]| abnormal kidney morphology [MP:0002135]| abnormal kidney physiology [MP:0002136]| abnormal gland morphology [MP:0002163]| decreased brain weight [MP:0002175]| abnormal outer ear morphology [MP:0002177]| small lymph nodes [MP:0002217]| abnormal spleen size [MP:0002224]| abnormal airway responsiveness [MP:0002334]| abnormal lymph node morphology [MP:0002339]| abnormal thymus medulla morphology [MP:0002375]| increased susceptibility to bacterial infection [MP:0002412]| increased susceptibility to viral infection [MP:0002418]| abnormal CD4-positive [MP:0002432]| alpha beta T cell morphology [MP:0002435]| abnormal effector T cell morphology [MP:0002444]| abnormal T cell physiology [MP:0002458]| abnormal B cell number [MP:0002460]| decreased immunoglobulin level [MP:0002461]| increased immunoglobulin level [MP:0002490]| abnormal immunoglobulin level [MP:0002492]| decreased IgE level [MP:0002493]| increased IgG level [MP:0002494]| increased IgM level [MP:0002495]| increased IgA level [MP:0002497]| increased IgE level [MP:0002533]| abnormal type III hypersensitivity reaction [MP:0002687]| oligozoospermia [MP:0002722]| abnormal immune system organ morphology [MP:0002743]| glomerulonephritis [MP:0002828]| abnormal renal glomerular capsule morphology [MP:0002871]| albuminuria [MP:0002936]| joint swelling [MP:0002962]| increased urine protein level [MP:0002965]| increased circulating serum albumin level [MP:0003009]| abnormal cytokine secretion [MP:0003204]| decreased neuron apoptosis [MP:0003504]| thyroid inflammation [MP:0003606]| kidney failure [MP:0003628]| abnormal leukocyte adhesion [MP:0003644]| thymus atrophy [MP:0003670]| dilated renal glomerular capsule [MP:0003725]| increased autoantibody level [MP:0003726]| decreased autoantibody level [MP:0003793]| abnormal submandibular gland morphology [MP:0003944]| abnormal T cell subpopulation ratio [MP:0003946]| renal necrosis [MP:0004031]| insulitis [MP:0004111]| abnormal coronary artery morphology [MP:0004153]| increased renal tubule apoptosis [MP:0004367]| abnormal strial intermediate cell morphology [MP:0004368]| abnormal stria vascularis vasculature morphology [MP:0004481]| abnormal conjunctival epithelium morphology [MP:0004696]| abnormal thyroid follicle morphology [MP:0004762]| increased anti-double stranded DNA antibody level [MP:0004771]| increased anti-single stranded DNA antibody level [MP:0004794]| increased anti-nuclear antigen antibody level [MP:0004795]| decreased anti-nuclear antigen antibody level [MP:0004796]| increased anti-histone antibody level [MP:0004797]| increased anti-erythrocyte antigen antibody level [MP:0004798]| decreased anti-double stranded DNA antibody level [MP:0004801]| increased susceptibility to systemic lupus erythematosus [MP:0004802]| decreased susceptibility to systemic lupus erythematosus [MP:0004803]| increased susceptibility to autoimmune diabetes [MP:0004804]| decreased susceptibility to autoimmune diabetes [MP:0004829]| increased anti-chromatin antibody level [MP:0004939]| abnormal B cell morphology [MP:0004952]| increased spleen weight [MP:0004953]| decreased spleen weight [MP:0004955]| increased thymus weight [MP:0004977]| increased B-1 B cell number [MP:0005012]| decreased eosinophil cell number [MP:0005014]| increased B cell number [MP:0005015]| increased T cell number [MP:0005017]| decreased B cell number [MP:0005078]| abnormal cytotoxic T cell physiology [MP:0005089]| decreased double-negative T cell number [MP:0005090]| increased double-negative T cell number [MP:0005094]| abnormal T cell proliferation [MP:0005178]| increased circulating cholesterol level [MP:0005179]| decreased circulating cholesterol level [MP:0005264]| glomerulosclerosis [MP:0005265]| abnormal blood urea nitrogen level [MP:0005325]| abnormal renal glomerulus morphology [MP:0005329]| abnormal myocardium layer morphology [MP:0005338]| atherosclerotic lesions [MP:0005339]| increased susceptibility to atherosclerosis [MP:0005350]| increased susceptibility to autoimmune disorder [MP:0005351]| decreased susceptibility to autoimmune disorder [MP:0005416]| abnormal circulating protein level [MP:0005425]| increased macrophage cell number [MP:0005466]| abnormal T-helper 2 physiology [MP:0005554]| decreased circulating creatinine level [MP:0005565]| increased blood urea nitrogen level [MP:0005566]| decreased blood urea nitrogen level [MP:0005568]| increased circulating total protein level [MP:0005584]| abnormal enzyme/coenzyme activity [MP:0005614]| decreased susceptibility to type III hypersensitivity reaction [MP:0005615]| increased susceptibility to type III hypersensitivity reaction [MP:0005621]| abnormal cell physiology [MP:0006042]| increased apoptosis [MP:0006043]| decreased apoptosis [MP:0006055]| abnormal vascular endothelial cell morphology [MP:0006082]| CNS inflammation [MP:0006099]| thin cerebellar granule layer [MP:0006315]| abnormal urine protein level [MP:0006387]| abnormal T cell number [MP:0008037]| abnormal T cell morphology [MP:0008049]| increased memory T cell number [MP:0008056]| abnormal retinal ganglion cell morphology [MP:0008074]| increased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008078]| decreased CD4-positive [MP:0008079]| alpha beta T cell number [MP:0008097]| increased CD8-positive [MP:0008098]| alpha-beta T cell number [MP:0008102]| decreased CD8-positive [MP:0008126]| alpha-beta T cell number [MP:0008136]| increased plasma cell number [MP:0008139]| decreased plasma cell number [MP:0008140]| lymph node hyperplasia [MP:0008173]| increased dendritic cell number [MP:0008180]| enlarged Peyer's patches [MP:0008181]| fused podocyte foot processes [MP:0008182]| podocyte foot process effacement [MP:0008189]| increased follicular B cell number [MP:0008190]| abnormal marginal zone B cell morphology [MP:0008206]| increased marginal zone B cell number [MP:0008211]| decreased marginal zone B cell number [MP:0008214]| increased transitional stage B cell number [MP:0008215]| decreased transitional stage B cell number [MP:0008217]| increased B-2 B cell number [MP:0008246]| decreased mature B cell number [MP:0008346]| increased immature B cell number [MP:0008350]| decreased immature B cell number [MP:0008477]| abnormal B cell activation [MP:0008478]| abnormal leukocyte morphology [MP:0008481]| increased gamma-delta T cell number [MP:0008482]| increased gamma-delta intraepithelial T cell number [MP:0008495]| decreased spleen red pulp amount [MP:0008496]| increased spleen white pulp amount [MP:0008497]| increased spleen germinal center number [MP:0008498]| decreased spleen germinal center number [MP:0008499]| decreased IgG1 level [MP:0008500]| decreased IgG2a level [MP:0008501]| decreased IgG2b level [MP:0008502]| decreased IgG3 level [MP:0008542]| increased IgG1 level [MP:0008567]| increased IgG2a level [MP:0008573]| increased IgG2b level [MP:0008578]| increased IgG3 level [MP:0008602]| enlarged cervical lymph nodes [MP:0008626]| decreased interferon-gamma secretion [MP:0008688]| increased circulating interferon-alpha level [MP:0008699]| decreased circulating interferon-gamma level [MP:0008713]| increased circulating interleukin-4 level [MP:0008721]| increased circulating interleukin-5 level [MP:0008722]| decreased interleukin-2 secretion [MP:0008750]| increased interleukin-4 secretion [MP:0008751]| abnormal cytokine level [MP:0008752]| abnormal chemokine level [MP:0008766]| abnormal chemokine secretion [MP:0008769]| abnormal interferon level [MP:0008783]| abnormal interleukin level [MP:0008826]| abnormal tumor necrosis factor level [MP:0008828]| abnormal B cell receptor editing [MP:0008879]| abnormal plasmacytoid dendritic cell physiology [MP:0008880]| decreased B cell apoptosis [MP:0008891]| abnormal splenic cell ratio [MP:0008978]| abnormal lymph node cell ratio [MP:0009338]| submandibular gland inflammation [MP:0009346]| lacrimal gland inflammation [MP:0009642]| decreased hepatocyte apoptosis [MP:0009643]| abnormal vagina weight [MP:0009763]| increased splenocyte number [MP:0010065]| decreased trabecular bone thickness [MP:0010138]| abnormal blood homeostasis [MP:0010760]| abnormal urine homeostasis [MP:0010766]| increased sensitivity to induced morbidity/mortality [MP:0010869]| decreased circulating creatine level [MP:0010879]| arteritis [MP:0010933]| abnormal macrophage chemotaxis [MP:0011081]| abnormal NK cell physiology [MP:0011294]| decreased bone trabecula number [MP:0011320]| decreased trabecular bone volume [MP:0011346]| decreased trabecular bone connectivity density [MP:0011348]| decreased macrophage apoptosis [MP:0011353]| renal glomerulus hypertrophy [MP:0011368]| abnormal glomerular capillary morphology [MP:0011369]| renal tubule atrophy [MP:0011377]| abnormal renal glomerulus basement membrane morphology [MP:0011402]| expanded mesangial matrix [MP:0011409]| increased kidney apoptosis [MP:0011427]| increased renal glomerulus apoptosis [MP:0011440]| renal glomerulus fibrosis [MP:0011445]| renal cast [MP:0011453]| increased renal glomerulus basement membrane thickness [MP:0011483]| mesangial cell hyperplasia [MP:0011506]| increased kidney cell proliferation [MP:0011567]| abnormal renal protein reabsorption [MP:0011742]| abnormal glomerular capillary endothelium morphology [MP:0011967]| renal glomerular synechia [MP:0013452]| glomerular crescent [MP:0013455]| increased renal glomerulus lobularity [MP:0013585]| decreased urine nitrite level [MP:0020332]| increased or absent threshold for auditory brainstem response [MP:0020518]| increased lacrimal gland apoptosis [MP:0020519] | |Igh-8||Fas | 015868-MU | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_15868-MU, MMRRC_015868, MMRRC_15868 | 2026-08-01 05:37:26 | 0 | ||||
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B6J.Cg-Apoetm1Unc Tg(MSR1-Plau)1Ddi/Mmmh Resource Report Resource Website Issue |
RRID:MMRRC_067987-MU | Mus musculus | Research areas: Cardiovascular, Models for Human Disease; Mutation Type: Transgenic ; Collection: | abnormal cochlea morphology [MP:0000031]| organ of Corti degeneration [MP:0000043]| abnormal stria vascularis morphology [MP:0000048]| increased bone mineral density [MP:0000062]| decreased bone mineral density [MP:0000063]| abnormal trabecular bone morphology [MP:0000130]| abnormal vertebrae morphology [MP:0000137]| abnormal circulating cholesterol level [MP:0000180]| increased circulating LDL cholesterol level [MP:0000182]| decreased circulating HDL cholesterol level [MP:0000186]| decreased hematocrit [MP:0000208]| increased monocyte cell number [MP:0000220]| decreased monocyte cell number [MP:0000223]| hypertension [MP:0000231]| abnormal blood flow velocity [MP:0000233]| macrocytosis [MP:0000248]| abnormal blood vessel physiology [MP:0000249]| echinocytosis [MP:0000256]| abnormal heart morphology [MP:0000266]| abnormal aorta morphology [MP:0000272]| enlarged heart [MP:0000274]| altered response to myocardial infarction [MP:0000343]| decreased hair follicle number [MP:0000379]| alopecia [MP:0000414]| sparse hair [MP:0000416]| abnormal femur morphology [MP:0000559]| abnormal liver morphology [MP:0000598]| amyloidosis [MP:0000604]| abnormal liver physiology [MP:0000609]| abnormal adrenal gland morphology [MP:0000639]| abnormal immune system morphology [MP:0000685]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| enlarged thymus [MP:0000709]| abnormal skin condition [MP:0001191]| thick skin [MP:0001200]| skin lesions [MP:0001212]| hyperkeratosis [MP:0001242]| abnormal dermal layer morphology [MP:0001243]| thick dermal layer [MP:0001245]| mixed cellular infiltration to dermis [MP:0001246]| decreased body length [MP:0001258]| increased body weight [MP:0001260]| obese [MP:0001261]| decreased body weight [MP:0001262]| abnormal retina morphology [MP:0001325]| dry eyes [MP:0001337]| Meibomian gland atrophy [MP:0001345]| increased anxiety-related response [MP:0001363]| abnormal stationary movement [MP:0001388]| abnormal locomotor behavior [MP:0001392]| abnormal response to new environment [MP:0001413]| decreased exploration in new environment [MP:0001417]| abnormal spatial learning [MP:0001463]| increased startle reflex [MP:0001488]| decreased startle reflex [MP:0001489]| abnormal kindling response [MP:0001499]| abnormal coat appearance [MP:0001510]| abnormal skeleton physiology [MP:0001533]| abnormal hematopoietic system physiology [MP:0001545]| abnormal lipid level [MP:0001547]| hyperlipidemia [MP:0001548]| increased circulating triglyceride level [MP:0001552]| increased circulating free fatty acid level [MP:0001554]| increased circulating HDL cholesterol level [MP:0001556]| hyperglycemia [MP:0001559]| anemia [MP:0001577]| cardiac hypertrophy [MP:0001625]| hypersecretion of corticosterone [MP:0001744]| increased circulating corticosterone level [MP:0001745]| abnormal immune system physiology [MP:0001790]| impaired macrophage phagocytosis [MP:0001798]| abnormal inflammatory response [MP:0001845]| heart inflammation [MP:0001853]| kidney inflammation [MP:0001859]| lung inflammation [MP:0001861]| vascular inflammation [MP:0001863]| abnormal lung volume [MP:0001942]| deafness [MP:0001967]| abnormal skin morphology [MP:0002060]| abnormal fear/anxiety-related behavior [MP:0002065]| increased circulating insulin level [MP:0002079]| premature death [MP:0002083]| abnormal lipid homeostasis [MP:0002118]| abnormal cardiovascular system morphology [MP:0002127]| abnormal kidney morphology [MP:0002135]| abnormal brain morphology [MP:0002152]| abnormal gland physiology [MP:0002164]| gliosis [MP:0002183]| abnormal artery morphology [MP:0002191]| neurodegeneration [MP:0002229]| abnormal pulmonary alveolus morphology [MP:0002270]| abnormal lymph node morphology [MP:0002339]| abnormal dendritic cell physiology [MP:0002376]| abnormal cell-mediated immunity [MP:0002421]| abnormal macrophage morphology [MP:0002446]| abnormal erythrocyte morphology [MP:0002447]| abnormal macrophage physiology [MP:0002451]| increased immunoglobulin level [MP:0002461]| abnormal neutrophil physiology [MP:0002463]| increased IgG level [MP:0002493]| increased IgM level [MP:0002494]| abnormal blood coagulation [MP:0002551]| hepatic steatosis [MP:0002628]| reticulocytosis [MP:0002640]| poikilocytosis [MP:0002643]| decreased circulating triglyceride level [MP:0002644]| abnormal sciatic nerve morphology [MP:0002651]| abnormal immune serum protein physiology [MP:0002723]| decreased circulating insulin level [MP:0002727]| abnormal thermal nociception [MP:0002733]| glomerulonephritis [MP:0002743]| dilated heart left ventricle [MP:0002753]| decreased vertical activity [MP:0002757]| abnormal retinal vasculature morphology [MP:0002792]| increased thigmotaxis [MP:0002797]| increased heart weight [MP:0002833]| increased systemic arterial blood pressure [MP:0002842]| decreased systemic arterial blood pressure [MP:0002843]| cochlear ganglion degeneration [MP:0002857]| increased growth rate [MP:0002865]| albuminuria [MP:0002871]| decreased hemoglobin content [MP:0002874]| increased insulin sensitivity [MP:0002891]| thick ventricular wall [MP:0002953]| increased urine protein level [MP:0002962]| increased liver weight [MP:0002981]| abnormal cytokine secretion [MP:0003009]| increased vasoconstriction [MP:0003025]| decreased myocardial infarction size [MP:0003038]| abnormal impulse conducting system conduction [MP:0003137]| cardiac fibrosis [MP:0003141]| abnormal tectorial membrane morphology [MP:0003149]| impaired muscle relaxation [MP:0003157]| increased cholesterol efflux [MP:0003192]| amyloid beta deposits [MP:0003329]| hypopituitarism [MP:0003348]| increased cardiac output [MP:0003394]| abnormal nervous system physiology [MP:0003633]| abnormal response/metabolism to endogenous compounds [MP:0003638]| abnormal axon extension [MP:0003651]| oxidative stress [MP:0003674]| xanthoma [MP:0003692]| increased autoantibody level [MP:0003725]| decreased autoantibody level [MP:0003726]| abnormal retinal inner nuclear layer morphology [MP:0003733]| abnormal bone structure [MP:0003795]| impaired macrophage chemotaxis [MP:0003799]| vascular smooth muscle hypoplasia [MP:0003814]| enhanced coordination [MP:0003858]| abnormal myelin sheath morphology [MP:0003871]| decreased macrophage cell number [MP:0003884]| abnormal ST segment [MP:0003897]| decreased kidney weight [MP:0003918]| abnormal lymphocyte physiology [MP:0003945]| abnormal cholesterol level [MP:0003947]| abnormal circulating lipid level [MP:0003949]| increased circulating VLDL triglyceride level [MP:0003975]| increased circulating phospholipid level [MP:0003980]| increased cholesterol level [MP:0003982]| decreased cholesterol level [MP:0003983]| arteriosclerosis [MP:0003991]| aortic dissection [MP:0004044]| abnormal coronary artery morphology [MP:0004111]| abnormal aortic arch morphology [MP:0004113]| increased compact bone thickness [MP:0004148]| increased renal tubule apoptosis [MP:0004153]| abnormal basilar membrane morphology [MP:0004308]| cochlear inner hair cell degeneration [MP:0004398]| cochlear outer hair cell degeneration [MP:0004404]| abnormal spiral modiolar artery morphology [MP:0004629]| spiral modiolar artery stenosis [MP:0004630]| increased anti-double stranded DNA antibody level [MP:0004762]| abnormal synaptic vesicle morphology [MP:0004769]| increased macrophage derived foam cell number [MP:0004778]| increased anti-nuclear antigen antibody level [MP:0004794]| increased susceptibility to systemic lupus erythematosus [MP:0004801]| increased mean systemic arterial blood pressure [MP:0004875]| decreased systemic vascular resistance [MP:0004879]| abnormal vascular wound healing [MP:0004883]| decreased adiponectin level [MP:0004893]| increased uterus weight [MP:0004904]| skin inflammation [MP:0004947]| increased spleen weight [MP:0004952]| abnormal osteoblast physiology [MP:0005006]| increased B cell number [MP:0005014]| increased T cell number [MP:0005015]| decreased T cell number [MP:0005018]| increased susceptibility to parasitic infection [MP:0005027]| abnormal thrombosis [MP:0005048]| decreased acute inflammation [MP:0005087]| decreased cardiac muscle contractility [MP:0005140]| increased circulating VLDL cholesterol level [MP:0005145]| decreased circulating VLDL cholesterol level [MP:0005146]| abnormal blood-brain barrier function [MP:0005167]| increased circulating cholesterol level [MP:0005178]| decreased circulating cholesterol level [MP:0005179]| glomerulosclerosis [MP:0005264]| abnormal cholesterol homeostasis [MP:0005278]| improved glucose tolerance [MP:0005292]| impaired glucose tolerance [MP:0005293]| abnormal circulating amino acid level [MP:0005311]| increased triglyceride level [MP:0005317]| abnormal enzyme/coenzyme level [MP:0005319]| abnormal renal glomerulus morphology [MP:0005325]| insulin resistance [MP:0005331]| abnormal gonadal fat pad morphology [MP:0005335]| atherosclerotic lesions [MP:0005338]| increased susceptibility to atherosclerosis [MP:0005339]| altered susceptibility to atherosclerosis [MP:0005340]| decreased susceptibility to atherosclerosis [MP:0005341]| abnormal bile salt homeostasis [MP:0005365]| vascular stenosis [MP:0005412]| abnormal circulating protein level [MP:0005416]| increased macrophage cell number [MP:0005425]| increased susceptibility to weight gain [MP:0005455]| vascular smooth muscle hyperplasia [MP:0005489]| abnormal eye electrophysiology [MP:0005551]| increased circulating creatinine level [MP:0005553]| increased circulating glucose level [MP:0005559]| decreased circulating glucose level [MP:0005560]| abnormal enzyme/coenzyme activity [MP:0005584]| increased vasodilation [MP:0005590]| decreased vasodilation [MP:0005591]| abnormal vascular smooth muscle morphology [MP:0005592]| abnormal vascular smooth muscle physiology [MP:0005595]| decreased susceptibility to type IV hypersensitivity reaction [MP:0005616]| decreased susceptibility to diet-induced obesity [MP:0005659]| decreased circulating leptin level [MP:0005668]| increased circulating leptin level [MP:0005669]| increased apoptosis [MP:0006042]| abnormal vascular endothelial cell morphology [MP:0006055]| decreased cerebral infarction size [MP:0006058]| increased cerebral infarction size [MP:0006060]| abnormal circulating homocysteine level [MP:0006076]| increased fat cell size [MP:0006094]| calcified artery [MP:0006133]| artery occlusion [MP:0006134]| increased systemic arterial systolic blood pressure [MP:0006144]| decreased systemic arterial systolic blood pressure [MP:0006264]| aortic aneurysm [MP:0006278]| abnormal T cell number [MP:0006387]| delayed cellular replicative senescence [MP:0008009]| impaired lipolysis [MP:0008033]| abnormal CD4-positive [MP:0008073]| alpha beta T cell number [MP:0008074]| increased CD4-positive [MP:0008075]| alpha beta T cell number [MP:0008079]| decreased CD4-positive [MP:0008090]| alpha beta T cell number [MP:0008143]| decreased CD8-positive [MP:0008174]| alpha-beta T cell number [MP:0008181]| increased T-helper 2 cell number [MP:0008182]| abnormal dendrite morphology [MP:0008217]| decreased follicular B cell number [MP:0008243]| increased marginal zone B cell number [MP:0008248]| decreased marginal zone B cell number [MP:0008288]| abnormal B cell activation [MP:0008289]| abnormal macrophage derived foam cell morphology [MP:0008389]| abnormal mononuclear phagocyte morphology [MP:0008406]| abnormal adrenal cortex morphology [MP:0008428]| abnormal adrenal medulla morphology [MP:0008511]| hypochromic macrocytic anemia [MP:0008515]| increased cellular sensitivity to hydrogen peroxide [MP:0008544]| abnormal spatial working memory [MP:0008553]| thin retinal inner nuclear layer [MP:0008561]| thin retinal outer nuclear layer [MP:0008566]| impaired olfaction [MP:0008567]| increased circulating tumor necrosis factor level [MP:0008577]| decreased tumor necrosis factor secretion [MP:0008596]| increased interferon-gamma secretion [MP:0008597]| decreased interferon-gamma secretion [MP:0008617]| increased circulating interferon-gamma level [MP:0008660]| increased circulating interleukin-6 level [MP:0008817]| decreased circulating interleukin-6 level [MP:0008916]| increased circulating interleukin-12 level [MP:0009278]| increased interleukin-10 secretion [MP:0009289]| hematoma [MP:0009346]| abnormal astrocyte physiology [MP:0009538]| abnormal bone marrow cell physiology [MP:0009763]| decreased epididymal fat pad weight [MP:0009764]| decreased trabecular bone thickness [MP:0009814]| abnormal synapse morphology [MP:0009862]| increased sensitivity to induced morbidity/mortality [MP:0009864]| decreased sensitivity to induced morbidity/mortality [MP:0009866]| increased prostaglandin level [MP:0009868]| abnormal aorta elastic tissue morphology [MP:0009873]| abnormal aorta endothelium morphology [MP:0009932]| abnormal aorta wall morphology [MP:0010210]| abnormal descending thoracic aorta morphology [MP:0010451]| abnormal aorta tunica media morphology [MP:0010483]| skin fibrosis [MP:0010574]| abnormal circulating cytokine level [MP:0010658]| kidney microaneurysm [MP:0010659]| aortic sinus aneurysm [MP:0010663]| aorta dilation [MP:0010724]| thoracic aorta aneurysm [MP:0010760]| abdominal aorta aneurysm [MP:0010868]| abnormal brachiocephalic trunk morphology [MP:0010869]| thick interventricular septum [MP:0010879]| abnormal macrophage chemotaxis [MP:0010895]| increased bone trabecula number [MP:0010922]| decreased bone trabecula number [MP:0010933]| decreased trabecular bone volume [MP:0010935]| increased lung compliance [MP:0010950]| alveolitis [MP:0011086]| decreased trabecular bone connectivity density [MP:0011231]| increased airway resistance [MP:0011294]| abnormal lung hysteresivity [MP:0011309]| postnatal lethality [MP:0011339]| incomplete penetrance [MP:0011353]| abnormal vitamin E level [MP:0011368]| renal glomerulus hypertrophy [MP:0011430]| abnormal kidney arterial blood vessel morphology [MP:0011477]| abnormal glomerular mesangium morphology [MP:0011508]| expanded mesangial matrix [MP:0011509]| increased kidney apoptosis [MP:0011561]| mesangiolysis [MP:0011567]| abnormal urine nucleoside level [MP:0011572]| glomerular capillary thrombosis [MP:0011578]| dilated glomerular capillary [MP:0011581]| renal glomerulus lipidosis [MP:0011599]| increased renal glomerulus lobularity [MP:0011939]| abnormal aorta bulb morphology [MP:0011941]| increased lipoprotein lipase activity [MP:0011951]| increased triglyceride lipase activity [MP:0011967]| increased phosphatidylcholine-sterol O-acyltransferase activity [MP:0012307]| increased food intake [MP:0012335]| increased fluid intake [MP:0013022]| increased cardiac stroke volume [MP:0014169]| increased or absent threshold for auditory brainstem response [MP:0020253]| impaired spatial learning [MP:0020408]| increased circulating homocysteine level [MP:0020519] | Plau||MSR1||Apoe | 067987-MU | Transgenic | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | PMID:15096455 PMID:15297377 PMID:16554301 PMID:27262672 PMID:23536772 PMID:20380835 |
MMRRC_67987-MU, MMRRC_067987, MMRRC_67987 | 2026-08-01 05:54:22 | 0 | |||
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STOCK Gpd2tm1Tka Slc25a13tm1Lct/Mmjax Resource Report Resource Website Issue |
RRID:MMRRC_069611-JAX | Mus musculus | Research areas: Metabolism, Models for Human Disease, Research Tools; Mutation Type: Targeted Mutation ; Collection: | hypoglycemia [MP:0000189]| decreased body weight [MP:0001262]| increased circulating free fatty acid level [MP:0001554]| postnatal growth retardation [MP:0001732]| premature death [MP:0002083]| hepatic steatosis [MP:0002628]| decreased circulating insulin level [MP:0002727]| increased circulating alkaline phosphatase level [MP:0002968]| abnormal gluconeogenesis [MP:0003383]| increased circulating glycerol level [MP:0003443]| increased circulating ammonia level [MP:0005309]| abnormal circulating amino acid level [MP:0005311]| abnormal amino acid level [MP:0005332]| increased liver triglyceride level [MP:0009355]| abnormal blood homeostasis [MP:0009642]| abnormal urine homeostasis [MP:0009643]| hypoglycemia [MP:0000189]| decreased body weight [MP:0001262]| decreased body size [MP:0001265]| abnormal eating behavior [MP:0001431]| increased circulating free fatty acid level [MP:0001554]| postnatal growth retardation [MP:0001732]| premature death [MP:0002083]| hepatic steatosis [MP:0002628]| decreased circulating insulin level [MP:0002727]| increased circulating alkaline phosphatase level [MP:0002968]| decreased insulin secretion [MP:0003059]| increased circulating glycerol level [MP:0003443]| increased circulating cholesterol level [MP:0005178]| decreased oxygen consumption [MP:0005290]| increased circulating ammonia level [MP:0005309]| abnormal circulating amino acid level [MP:0005311]| abnormal amino acid level [MP:0005332]| abnormal triiodothyronine level [MP:0005472]| increased circulating thyroxine level [MP:0005477]| increased circulating triiodothyronine level [MP:0005480]| increased body temperature [MP:0005533]| decreased brown fat cell lipid droplet size [MP:0009125]| increased liver triglyceride level [MP:0009355]| abnormal blood homeostasis [MP:0009642]| impaired adaptive thermogenesis [MP:0011049]| decreased brown adipose tissue mass [MP:0014169] | |Gpd2||Slc25a13 | 069611-JAX | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | PMID:17591776 PMID:14701727 |
MMRRC_69611-JAX, MMRRC_069611, MMRRC_69611 | 2026-08-01 05:54:21 | 0 | |||
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C.129-Slc25a13tm1Lct/SinaMmjax Resource Report Resource Website Issue |
RRID:MMRRC_069594-JAX | Mus musculus | Research areas: Metabolism; Mutation Type: Targeted Mutation ; Collection: | hypoglycemia [MP:0000189]| decreased body weight [MP:0001262]| increased circulating free fatty acid level [MP:0001554]| postnatal growth retardation [MP:0001732]| premature death [MP:0002083]| hepatic steatosis [MP:0002628]| decreased circulating insulin level [MP:0002727]| increased circulating alkaline phosphatase level [MP:0002968]| abnormal gluconeogenesis [MP:0003383]| increased circulating glycerol level [MP:0003443]| increased circulating ammonia level [MP:0005309]| abnormal circulating amino acid level [MP:0005311]| abnormal amino acid level [MP:0005332]| increased liver triglyceride level [MP:0009355]| abnormal blood homeostasis [MP:0009642]| abnormal urine homeostasis [MP:0009643] | Slc25a13 | 069594-JAX | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | PMID:14701727 | MMRRC_69594-JAX, MMRRC_069594, MMRRC_69594 | 2026-08-01 05:54:36 | 0 | |||
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FVB.Cg-Cdkn2atm1Rdp Ptentm1Ffur/Mmucd Resource Report Resource Website Issue |
RRID:MMRRC_043553-UCD | Mus musculus | Research areas: Cancer, Developmental Biology, Neurobiology; Mutation Type: Targeted Mutation ; Collection: | kyphosis [MP:0000160]| extramedullary hematopoiesis [MP:0000240]| increased cell proliferation [MP:0000351]| decreased cell proliferation [MP:0000352]| abnormal intestine morphology [MP:0000477]| enlarged liver [MP:0000599]| abnormal branching of the mammary ductal tree [MP:0000662]| abnormal spleen morphology [MP:0000689]| enlarged spleen [MP:0000691]| enlarged lymph nodes [MP:0000702]| abnormal myogenesis [MP:0000729]| increased satellite cell number [MP:0000730]| paralysis [MP:0000753]| abnormal retinal photoreceptor morphology [MP:0001004]| abnormal prostate gland morphology [MP:0001158]| hyperpigmentation [MP:0001188]| skin lesions [MP:0001212]| epidermal hyperplasia [MP:0001222]| hyperkeratosis [MP:0001242]| decreased body weight [MP:0001262]| decreased body size [MP:0001265]| increased metastatic potential [MP:0001272]| microphthalmia [MP:0001297]| cataract [MP:0001304]| abnormal somite development [MP:0001688]| embryonic growth arrest [MP:0001730]| mammary gland duct hyperplasia [MP:0001885]| hydroencephaly [MP:0001891]| increased tumor incidence [MP:0002020]| increased B cell derived lymphoma incidence [MP:0002023]| increased leukemia incidence [MP:0002026]| increased lung adenocarcinoma incidence [MP:0002027]| increased neurofibrosarcoma incidence [MP:0002030]| increased sarcoma incidence [MP:0002032]| increased rhabdomyosarcoma incidence [MP:0002036]| premature death [MP:0002083]| abnormal spleen red pulp morphology [MP:0002356]| abnormal cell cycle [MP:0003077]| abnormal telomere length [MP:0003155]| increased neuron apoptosis [MP:0003203]| testicular atrophy [MP:0003205]| abnormal forebrain development [MP:0003232]| decreased tumor growth/size [MP:0003447]| abnormal keratinocyte physiology [MP:0003453]| increased hemangiosarcoma incidence [MP:0003667]| premature aging [MP:0003786]| skeletal muscle interstitial fibrosis [MP:0003851]| abnormal skin development [MP:0003941]| increased squamous cell carcinoma incidence [MP:0004207]| increased cellular sensitivity to ionizing radiation [MP:0004227]| increased incidence of tumors by chemical induction [MP:0004499]| increased incidence of tumors by UV-induction [MP:0004501]| abnormal posterior eye segment morphology [MP:0005195]| abnormal skin physiology [MP:0005501]| abnormal lens development [MP:0005545]| abnormal cell physiology [MP:0005621]| abnormal retinal neuronal layer morphology [MP:0006069]| abnormal common myeloid progenitor cell morphology [MP:0006410]| delayed cellular replicative senescence [MP:0008009]| increased lung tumor incidence [MP:0008014]| abnormal male germ cell apoptosis [MP:0008280]| increased spleen white pulp amount [MP:0008478]| increased pancreatic ductal adenocarcinoma incidence [MP:0009151]| increased pancreas tumor incidence [MP:0009153]| increased prostate gland adenocarcinoma incidence [MP:0009220]| increased brain tumor incidence [MP:0009277]| abnormal mammary gland duct morphology [MP:0009503]| increased keratinocyte proliferation [MP:0009583]| skin fibrosis [MP:0009932]| increased melanoma incidence [MP:0010275]| increased intraocular melanoma incidence [MP:0010276]| increased glioma incidence [MP:0010278]| increased skin tumor incidence [MP:0010300]| decreased tumor latency [MP:0010308]| increased oligodendroglioma incidence [MP:0010312]| increased cutaneous melanoma incidence [MP:0010322]| increased fibrosarcoma incidence [MP:0010363]| persistent hyperplastic primary vitreous [MP:0010711]| increased glioblastoma incidence [MP:0010727]| prenatal lethality [MP:0011091]| complete penetrance [MP:0011703]| increased fibroblast proliferation [MP:0011748]| intestinal fibrosis [MP:0012431] | PtenCdkn2a | 043553-UCD | Targeted Mutation | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_43553-UCD, MMRRC_043553, MMRRC_43553 | 2026-08-03 09:09:14 | 0 | ||||
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B6.Cg-Tg(Nes-cre)1Kln/MullMmmh Resource Report Resource Website Issue |
RRID:MMRRC_031750-MU | Mus musculus | Research areas: ; Mutation Type: Transgenic ; Collection: Neuroscience Blueprint | Nes|cre| | 031750-MU | Transgenic | Mutant Mouse Resource and Research Center (MMRRC) | MMRRC | MMRRC_31750-MU, MMRRC_031750, MMRRC_3175 | 2026-08-01 05:42:29 | 0 |
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Welcome to the Neuroscience Information Framework Project, designed to serve the biomedical research community. NIF maintains the largest searchable collection of neuroscience data, the largest catalog of biomedical resources, and the largest ontology for neuroscience on the web. We welcome all feedback and suggestions and are actively looking for resource providers to make their resources accessible through NIF. Learn about the tools available to help you share your data and discover a dynamic inventory of Web-based neuroscience resources.
