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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.

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Organism Name Proper Citation Species Synonyms Notes Phenotype Affected Gene Genomic Alteration Catalog Number Background Database Database Abbreviation Availability Source References Alternate IDs Record Last Update Mentions Count
F344-Albem4(cre)Larc
 
Resource Report
Resource Website
1+ mentions
RRID:RGD_616336067 Rattus norvegicus Fertilized eggs from F344/Jcl rats were microinjected and then transplanted into the oviducts of pseudopregnant females. From the resulting offspring, rats with the 2A-Cre sequence inserted into the Albumin gene were selected and established. National BioResource Project for the Rat in Japan 616336067 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-05-14) 616336067 2026-09-19 01:18:57 1
F344-ROSA26em10(Alb-cre)Larc
 
Resource Report
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RRID:RGD_616336065 Rattus norvegicus F344/Jcl rat fertilized eggs were microinjected and then transplanted into the oviducts of pseudopregnant females. From the resulting offspring, rats with the Alb promoter-Cre sequence inserted into the Rosa26 gene were selected and established. Although the Alb promoter is inserted, cre leakage is confirmed throughout the body. National BioResource Project for the Rat in Japan 616336065 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-05-14) 616336065 2026-09-19 01:18:57 0
LE-Them2-1(cre)Koba
 
Resource Report
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1+ mentions
RRID:RGD_598092591 Rattus norvegicus The T2A, nlsCre, and BGHpolyA are knocked in at the stop codon in the 13th exon of the tyrosine hydroxylase (TH) gene (NCBI Gene ID: 25085). National BioResource Project for the Rat in Japan 598092591 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-03-27) 598092591 2026-09-19 01:18:56 1
SD-ROSA26 em1(CAG-DdCBE-Mt-co3, NeuN-Cre/Ilas
 
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1+ mentions
RRID:RGD_616336063 Rattus norvegicus This rat strain with neuronal specific knock out of Mt-co3 was generated by crossing a rat neuron-specific Cre strain (NeuN-Cre) with SD-ROSA26 em1(CAG-loxP-stop-loxP-DdCBE-Mt-co3/Ilas. Compared with the controls, the neuron-specific Mt-co3 knock out rats were largely normal in the first postnatal month, but progressively developed ALS-like symptoms afterward. Rat Resource Center of China (www.ratresource.com) 616336063 mutant Rat Genome Database (RGD) RGD Unknown 616336063 2026-09-19 01:18:57 1
LE-Them1(cre)Koba
 
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RRID:RGD_598092592 Rattus norvegicus The T2A, nlsCre, and BGHpolyA are knocked in at the stop codon in the 13th exon of the tyrosine hydroxylase (TH) gene (NCBI Gene ID: 25085). National BioResource Project for the Rat in Japan 598092592 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-03-27) 598092592 2026-09-19 01:18:56 0
W-Gpr143em19Gosh
 
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RRID:RGD_598092593 Rattus norvegicus Deletion of exon1 of Gpr143 gene in Wistar rats (Charles River, Japan) by CRISPR/Cas9. Line No. is 19. National BioResource Project for the Rat in Japan 598092593 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-03-28) 598092593 2026-09-19 01:18:56 0
SD-ROSA26 em1(CAG-DdCBE-Mt-co3/Ilas
 
Resource Report
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RRID:RGD_616335894 Rattus norvegicus The knock in of "CAG-loxP-stop-loxP-DdCBE-Mt-co3" to ROSA26 was induced by CRISPR/Cas9 in SD embryos from Vital River. This ROSA 26 knock in construct carrying DddA-derived cytosine base editor (DdCBE)linked to Mt-co3 was used to introduce premature stop codons in the rat Mt-co3 in mitochondrial genome in the presence of Cre recombinase. Rat Resource Center of China (www.ratresource.com) 616335894 mutant Rat Genome Database (RGD) RGD Unknown 616335894 2026-09-19 01:18:57 0
SD-C5ar1em22Taoki
 
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RRID:RGD_598092525 Rattus norvegicus This strain was established by CRISPR/Cas9 system in the Research Institute, National Cerebral and Cardiovascular Center. Genetic background is Slc:SD. guide RNA gRNA No1; ATAAGTAACGACAGCAGTGA gRNA No2; GAGTTTCACTCGGTCCACGA National BioResource Project for the Rat in Japan 598092525 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-03-25) 598092525 2026-09-19 01:18:56 0
Slc:WSRC-KitWs
 
Resource Report
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RRID:RGD_598092524 Rattus norvegicus In 1987, a Ws mutant (RGD:12910762) with a light-colored coat and large abdominal white spots was discovered in a colony of BN/fMai inbred rats that had been allocated to Yagi Memorial Park from the Institute of Laboratory Animals Graduate School of Medicine, Kyoto University. However, homozygous for the Ws mutation could not be obtained in BN inbred rats due to embryonic lethality. Therefore, they crossed with Donryu outbred rats and obtained homozygous by crossing F1 heterozygous. This strain was designated as WsRC and was supplied to Japan SLC, Inc. in 1993. National BioResource Project for the Rat in Japan 598092524 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo (as of 2025-03-25) 598092524 2026-09-19 01:18:56 0
SD-Cyp2dem2(CYP2D6)Kg
 
Resource Report
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RRID:RGD_407446371 Rattus norvegicus A ~58.0 kb deletion of the rat Cyp2d gene cluster (1-5) was created using the CRISPR-Cas9 system. Subsequently, the human CYP2D6 gene (~6.2 kb) was inserted in place of the rat Cyp2d gene cluster. The rat strain is deposited to Rat Research and Resource Contact [email protected] for availability. 407446371 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo; Cryopreserved Sperm (as of 2024-08-29) 407446371 2026-09-19 01:18:56 0
SD-Cyp2dem1Kg
 
Resource Report
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RRID:RGD_407446370 Rattus norvegicus A ~58.0 kb deletion of the rat Cyp2d gene cluster (1-5) was created using the CRISPR-Cas9 system. The rat strain is deposited to Rat Research and Resource Contact [email protected] for availability. 407446370 mutant Rat Genome Database (RGD) RGD Unknown (as of 2024-08-29) 407446370 2026-09-19 01:18:56 0
SHR-Tti2em1Ipcv+/-
 
Resource Report
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RRID:RGD_405849381 Rattus norvegicus This Tti2 knockout rats were generated by microinjecting fertilized ova of SHR/OlaIpcv rats with the ZFN (Zinc Finger Nuclease) construct from Sigma-Aldrich. The construct was designed to target the first exon using the following sequence of ZFN binding (capital letters) and cutting site (small letters): TCTGACCCGGATCCAAGCaccaagGGTGGGTGGCAGGGC. DNA samples isolated from 452 rats born after microinjection with ZFN construct were amplified using primers flanking the target sequence: ZFN F: 5'-TACACTGTGATTGGCTGGGA-3' and ZFN R: 5'-GGCGCAGTGGAGTGATC-3'. SHR-Tti2+/- with an 8 bp deletion (NM_001013883.1(Tti2):c.243_250delCGAGATCC; on the protein level: NP_001013905.1:p.Glu82Glyfs) has been selected for further analyses. The heterozygous founder was crossed with SHR and F1 rats were intercrossed. SHR-Tti2+/- heterozygotes were selected for breeding and phenotyping while their wild type littermates were used as controls. 405849381 mutant Rat Genome Database (RGD) RGD Unknown 405849381 2026-09-19 01:18:56 0
SD-Vdrem2Hfd
 
Resource Report
Resource Website
RRID:RGD_408364956 Rattus norvegicus The CRISPR/Cas9 system was used to introduce deletion and insertion in exon 3 of the VDR gene of Hsd:SD rat embryos WT: GGAGGCAACAGCGGCCAGCACCTCCCTGCccgaccCTGGTGACTTTGACCggaacgtgccccGGATCTGTGGAGTGTGTGGAGACCGAGCCAC KO: GGAGGCAACAGCGGCCAGCACCTCCCTGCtggt– CTGGTGACTTTGACC------GGATCTGTGGAGTGTGTGGAGACCGAGCCAC Rat Resource and Research Center (RRRC); strain ID 1034 408364956 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo (as of 2024-11-05) 408364956 2026-09-19 01:18:56 0
F344-ApcPirc/UwmVdrem3Hfd
 
Resource Report
Resource Website
RRID:RGD_408364957 Rattus norvegicus The F344-ApcPirc rat was generated previously by ENU mutagenesis (RGD ID 1641862). These fertilized rat embryos were used with the CRISPR/Cas9 system to introduce a 5-bp deletion (CCCCG) in exon 3 of the Vdr gene. This mutant was heterozygous for the Apc mutation and homozygous for the VDR deletion. WT: GGAGGCAACAGCGGCCAGCACCTCCCTGCCCGACCCTGGTGACTTTGACCGGAACGTGCCCCGGATCTGTGGAGTGTGTGGAGACCGAGCCAC KO: GGAGGCAACAGCGGCCAGCACCTCCCTGCCCGACCCTGGTGACTTTGACCGGAACGTGG ATCTGTGGAGTGTGTGGAGACCGAGCCAC Rat Resource and Research Center (RRRC); strain ID 1033 408364957 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2024-11-05) 408364957 2026-09-19 01:18:56 0
SD-Eml1tish/Scrb
 
Resource Report
Resource Website
RRID:RGD_597538479 Rattus norvegicus The first tish animals were identified on the basis of postmortem histological analyses during the course of unrelated experiments using a strain of Sprague Dawley rats maintained at the University of Virginia. It is called tish (telencephalic internal structural heterotopia) rat. The brain of this mutant animal exhibits a large region of heterotopic gray matter that is located bilaterally beneath the neocortex. Mild to moderate ventriculomegaly is also observed in most tish animals. A breeding colony was established by identifying living relatives of deceased tish individuals, and then these relatives were screened using magnetic resonance imaging (MRI). The tish is identified recessive to wild type by breeding. The mutation was identified as a 1215 bp deletion in the unannotated exon 1 of Eml1 genome (Rnor_6.0; ENSRNOG00000043143). University of Virginia, Charlottesville, VA, United States 597538479 mutant Rat Genome Database (RGD) RGD Unknown 597538479 2026-09-19 01:18:56 0
SD-Il6em1Yona-/-
 
Resource Report
Resource Website
RRID:RGD_407450413 Rattus norvegicus The Il6 knockout (KO) rats were generated using the CRISPR/Cas9 technique to induce a shift in the reading frame of the second exon of Il6 by KAC Co. Ltd (Kyoto, Japan). This strain carried a 118 bp deleted in the second exon of IL-6 National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 564-8565, Japan 407450413 mutant Rat Genome Database (RGD) RGD Unknown 407450413 2026-09-19 01:18:56 0
WIC;W-Oprk1em1(cre)Nurep
 
Resource Report
Resource Website
RRID:RGD_598154602 Rattus norvegicus Oprk1-cre rats were generated by Dr. Hiroko Tsukamura, Dr. Yoshihisa Uenoyama, Dr. Naoko Inoue, Dr. Mayuko Nagae (Nagoya University) and Dr. Masumi Hirabayashi (National Institute for Physiological Sciences). The CRISPR/Cas9 and adeno-associated virus vector (Oprk1 [exon 4], T2A, Cre) were introduced into the pronuclear stage embryos of Wistar rats (Crlj:WI). It was maintained by mating with the Wistar-Imamichi rats (Iar:WIC) (RGD:125097496) or by sibling mating. National BioResource Project for the Rat in Japan 598154602 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-04-30) 598154602 2026-09-19 01:18:57 0
ZFDM-Lcn2em1Nyo
 
Resource Report
Resource Website
RRID:RGD_598154604 Rattus norvegicus "This knock-in rat was generated by injecting guide RNA, Cas9 protein, and ssODN targeting the Lcn2 gene into fertilized eggs of ZFDM rats. The Lcn2 gene of ZFDM rats has a nonsense mutation (c.409C>T, p.Gln137X), but in this line, this mutation is replaced with the wild type sequence by homologous recombination with the introduced ssODN. The target sequence of the guide RNA is TGACTACGACTAGTTTGCCA. The ssODN sequence for inducing homologous recombination is AAGTGGCCGACACTGACTACGACCAGTTTGCCATGGTATTTTTCCAGAAGACCTCTGAAA. " National BioResource Project for the Rat in Japan 598154604 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-04-30) 598154604 2026-09-19 01:18:57 0
SD-Crhtm1(Cre)Kji
 
Resource Report
Resource Website
1+ mentions
RRID:RGD_401976372 Rattus norvegicus CRISPR/Cas9 technology was used to insert an IRES for Cre expression after the corticotropin-releasing hormone (Crh) gene and is expressed in cells that produce CRH. 401976372 mutant Rat Genome Database (RGD) RGD Unknown 401976372 2026-09-19 01:18:56 1
SD-Prnpem1Evm
 
Resource Report
Resource Website
RRID:RGD_630350554 Rattus norvegicus A deletion mutation was induced using CRISPR/Cas9 system in embryos of Spague-Dawley rats from Charles River. This strain has been deposited with the RRRC 630350554 mutant Rat Genome Database (RGD) RGD Live Animals (as of 2026-01-15) 630350554 2026-09-19 01:18:57 0

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