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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
| Organism Name | Proper Citation | Species | Synonyms |
Notes |
Phenotype | Affected Gene | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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SD-Nrxn1em1Sage Resource Report Resource Website |
RRID:RGD_11568058 | Rattus norvegicus | The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Nrxn1 into Sprague Dawley embryos. This mutant rat has a 16-bp deletion in exon1 resulting in knockout of Nrxn1. Horizon Discovery | 11568058 | mutant | Rat Genome Database (RGD) | RGD | Live Animals (as of 2018-03-22) | 11568058 | 2026-09-19 01:18:46 | 0 | |||||
|
SD-Il2rgem3Mcwi Resource Report Resource Website |
RRID:RGD_12790659 | Rattus norvegicus | This strain was produced by injecting TALENs targeting the Il2rg gene into Crl:SD rat embryos. The resulting mutation is a 2-bp deletion in exon 2. | 12790659 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2017-02-20) | 12790659 | 2026-09-19 01:18:46 | 0 | |||||
|
SD-Ptenem1Sage Resource Report Resource Website 1+ mentions |
RRID:RGD_11568062 | Rattus norvegicus | The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Pten into Sprague Dawley embryos. This mutant rat has a 7-bp deletion in exon7 resulting in knockout of Pten. Horizon Discovery | 11568062 | mutant | Rat Genome Database (RGD) | RGD | Live Animals (as of 2016-12-13) | 11568062 | 2026-09-19 01:18:46 | 1 | |||||
|
WKY-Mbem6Mcwi Resource Report Resource Website |
RRID:RGD_12790662 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a mutation in the Mb gene of WKY/NCrl rat embryos. The resulting mutation is a 25-bp deletion in the exon 2 of the Mb gene. Contact MCW rat distribution at [email protected] | 12790662 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2021-11-03) | 12790662 | 2026-09-19 01:18:46 | 0 | |||||
|
WKY-Sik2em5Mcwi Resource Report Resource Website |
RRID:RGD_12790944 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a mutation in the Sik2 gene of WKY/NCrl rat embryos. The resulting mutation is a 5-bp deletion in exon 4 of the Sik2 gene. Contact MCW rat distribution at [email protected] | 12790944 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2021-11-03) | 12790944 | 2026-09-19 01:18:46 | 0 | |||||
|
SD-Il2rgem1Ang Resource Report Resource Website |
RRID:RGD_13628730 | Rattus norvegicus | TALEN targeting the 2nd exon of rat Il2rg gene was designed and mRNA coding these TALEN was microinjected into Crl:SD embyo.This strain carrying an 80 bp deletion generated a premature stop codon in the 3rd exon. No Il2rg protein was detected by western blot. | 13628730 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 13628730 | 2026-09-19 01:18:47 | 0 | |||||
|
SD-Appem1Sage Resource Report Resource Website |
RRID:RGD_12880026 | Rattus norvegicus | This rat model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. Horizon Discovery | 12880026 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Embryo (as of 2017-05-01) | 12880026 | 2026-09-19 01:18:47 | 0 | |||||
|
SS-P2rx1em7Mcwi Resource Report Resource Website |
RRID:RGD_13207509 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a mutation in the P2rx1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in Exon 2 of the P2rx1 gene. Contact MCW rat distribution at [email protected] | 13207509 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm; Cryorecovery (as of 2021-11-03) | 13207509 | 2026-09-19 01:18:47 | 0 | |||||
|
LE-Htr3atm1(cre)Sage Resource Report Resource Website |
RRID:RGD_12905036 | Rattus norvegicus | This model expresses cre-recombinase under the control of the endogenous 5 prime-hydroxytryptamine receptor 3A (5Ht3a) promoter enabling specific expression in 5Ht3a positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the 5Ht3a gene. The 5Ht3a-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery | 12905036 | mutant | Rat Genome Database (RGD) | RGD | Live Animals (as of 2017-05-31) | 12905036 | 2026-09-19 01:18:47 | 0 | |||||
|
SD-Rag2em1Sage Resource Report Resource Website |
RRID:RGD_12904903 | Rattus norvegicus | This ZFN model carries a 2 bp deletion within exon 3 of the Rag2 gene on chromosome 3. Homozygous Rag2 knockout rats display loss of RAG2 protein via Western blot. Homozygous Rag2 knockout rats show loss of B and T cells by FACS analysis. Horizon Discovery | 12904903 | mutant | Rat Genome Database (RGD) | RGD | Live Animals (as of 2017-05-24) | 12904903 | 2026-09-19 01:18:47 | 0 | |||||
|
F344-Rag1em1Sage Resource Report Resource Website 1+ mentions |
RRID:RGD_12904902 | Rattus norvegicus | This ZFN model carries a 29 bp deletion within exon 2 of the Rag1 gene on chromosome 3. Rag1 knockout rats lack mature B and T lymphocytes. Horizon Discovery | 12904902 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Embryo (as of 2017-05-24) | 12904902 | 2026-09-19 01:18:47 | 3 | |||||
|
SS-Trpc6em4Mcwi Resource Report Resource Website |
RRID:RGD_11553908 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a mutation in the Trpc6 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 3-bp substitutions to generate P112Q in Exon 2 of the Trpc6 gene. Contact MCW rat distribution at [email protected] | 11553908 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2021-11-03) | 11553908 | 2026-09-19 01:18:47 | 0 | |||||
|
SD-Slc22a1em1Sage Resource Report Resource Website |
RRID:RGD_12904733 | Rattus norvegicus | This ZFN induced knockout model contains 11 bp bi-allelic deletion within exon 1 of the Slc22a1. The homozygous knockout rats display total loss of protein via Western blot. Horizon Discovery | 12904733 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Embryo (as of 2017-05-19) | 12904733 | 2026-09-19 01:18:47 | 0 | |||||
|
SS-Spp1em4Mcwi Resource Report Resource Website |
RRID:RGD_13207529 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a mutation in the Spp1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp deletion in Exon 3 of the Spp1 gene. Contact MCW rat distribution at [email protected] | 13207529 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2021-11-03) | 13207529 | 2026-09-19 01:18:47 | 0 | |||||
|
SD-Bdnfem1Sage+/- Resource Report Resource Website |
RRID:RGD_12902621 | Rattus norvegicus | This ZFN model contains a monoallelic deletion of the Bdnf gene, encoding for the nerve growth factor protein BDNF. Homozygous animals carrying the Bdnf deletion are postnatal lethal. Reductions of BDNF have been observed in patients with Alzheimer's disease (AD), and this model may be useful for understanding the role of BDNF in AD. Horizon Discovery | 12902621 | mutant | Rat Genome Database (RGD) | RGD | Live Animals (as of 2017-06-20) | 12902621 | 2026-09-19 01:18:47 | 0 | |||||
|
SD-Nr1i2em1Sage Resource Report Resource Website |
RRID:RGD_12902625 | Rattus norvegicus | This ZFN model contains a 20-bp deletion within the Nr1i2 gene. No induction of Cyp3a1 in the model. Horizon Discovery | 12902625 | mutant | Rat Genome Database (RGD) | RGD | Live Animals (as of 2017-05-09) | 12902625 | 2026-09-19 01:18:47 | 0 | |||||
|
SD-Apoetm1(APOE*)Sage Resource Report Resource Website |
RRID:RGD_12902616 | Rattus norvegicus | These rats were created using CrISPR/Cas9 system to replace the Rat ApoE gene with the Human 4 allele APOE gene Horizon Discovery | 12902616 | mutant | Rat Genome Database (RGD) | RGD | Live Animals (as of 2017-05-09) | 12902616 | 2026-09-19 01:18:47 | 0 | |||||
|
SS-Tg(Slc12a1-Ncf2-2A-Luc)-Ncf2em1Mcwi Resource Report Resource Website |
RRID:RGD_13207513 | Rattus norvegicus | This is compound transgenic/mutant rat strain derived from the breeding of SS-Tg(Slc12a1-Ncf2-2A-Luc) and SS-Ncf2em1Mcwi. Contact MCW rat distribution at [email protected] | 13207513 | mutant | Rat Genome Database (RGD) | RGD | Cryorecovery (as of 2017-08-03) | 13207513 | 2026-09-19 01:18:47 | 0 | |||||
|
SS-Ptgs2em1Mcwi Resource Report Resource Website |
RRID:RGD_13208842 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a mutation in the Ptgs2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 53-bp deletion of exon 4 in the Ptgs2 gene. Contact MCW rat distribution at [email protected] | 13208842 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2021-11-03) | 13208842 | 2026-09-19 01:18:47 | 0 | |||||
|
SS-Adamts16em1Bj Resource Report Resource Website |
RRID:RGD_13437612 | Rattus norvegicus | This strain was produced by injecting ZFNs target sequence CCGCGGTTGCTTTGCGCTCTGGGTGCTGTTGCTGGCGCA into Dahl S rat eggs as . The resulting mutation is a 17-bp deletion of the sequence gctctgggtgctgttgc in exon 1. | 13437612 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 13437612 | 2026-09-19 01:18:47 | 0 |
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