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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
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EDGE: Environment, Drugs and Gene Expression Resource Report Resource Website 10+ mentions |
EDGE: Environment, Drugs and Gene Expression (RRID:SCR_008187) | EDGE | data or information resource, material analysis service, production service resource, narrative resource, experimental protocol, analysis service resource, service resource, biomaterial analysis service | THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 15, 2013. EDGE is a scientific resource for toxicology-related gene expression information. The site contains databases and analyses of gene expression studies following exposure to a variety of chemicals or physiological changes. The ultimate goal of the EDGE is to map transcriptional changes from chemical exposure that will someday be used as a diagnostic fingerprint to predict toxicity as well as provide valuable insights into the basic molecular changes responsible. EDGE gives you the ability to easily answer the following fundamental questions about your data 1. Can I compare transcriptional profiles across treatments? 2. What genes respond to my treatment? 3. What influences my favorite gene(s)? One of the major objectives of toxicology is to understand the adverse health effects that result from exposure to foreign chemicals. The traditional method for assessing the toxicity of a test chemical is very resource intensive; requiring the commitment of large amounts of money, time, and animals. According to the National Toxicology Program (NTP), each chemical study requires between 2 and 4 million dollars and several years to complete. Due to the cost and labor intensive nature of these studies, the number of chemicals currently tested by the NTP stands at less than 500. Given these statistics and the fact that there are approximately 70,000 chemicals in commerce today, it is increasingly apparent that alternative methods for assessing toxic potential must be explored if a significant portion of the remaining chemicals is to be tested. One potential solution is to develop a comprehensive database that describes alterations in gene expression resulting from chemical exposure. The pattern of transcriptional activity will not only be highly sensitive indicator of chemical exposure, but that this pattern will be diagnostic for mechanistically linked toxicants. In our laboratory, we have chosen to address this problem through a combination of high throughput sequencing of expressed sequence tags (ESTs) and construction of custom toxicology-related cDNA microarrays derived from the unique ESTs identified in the sequencing effort. By using this approach, we can simultaneously develop a quantitative gene expression profile using ESTs and the reagents for further analyzing these changes in a rapid, highly parallel manner. In addition, the expression profiles are not biased for preselected favorite genes. The resulting gene expression pattern can then be used as diagnostic fingerprint to predict toxicity and/or carcinogenicity as well as provide valuable insight into the basic biochemical and molecular changes responsible for toxicity. Submission of total RNA for Bradfield Lab Microarray Microarray comparisons are made between untreated, control animals and animals treated with ONE treatment. Please make sure the RNA submitted adheres to this experimental design. Necessary information is available on the site. | expressed sequence tags (ests), gene expression, gene expression profile, genes, alterations, cdna microarray, chemical exposure, predictive statistical models, sequencing, toxicogenomics, toxicology, transcriptional changes | has parent organization: University of Wisconsin-Madison; Wisconsin; USA | THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-21140 | SCR_008187 | Drugs and Gene Expression, Environment | 2026-08-07 09:26:40 | 13 | |||||||
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University of Wisconsin-Madison; Wisconsin; USA Resource Report Resource Website 1+ mentions |
University of Wisconsin-Madison; Wisconsin; USA (RRID:SCR_008282) | UW-Madison | university | University of Wisconsin–Madison is a public research university in Madison, Wisconsin.UW–Madison is official state university of Wisconsin, and the flagship campus of the University of Wisconsin System. The UW is one of America's Public Ivy universities, which refers to top public universities in the United States capable of providing a collegiate experience comparable with the Ivy League. |
uses: LabArchives is affiliated with: Big Ten Cancer Research Consortium is affiliated with: PAMGO is related to: ONE Study is related to: Clinical and Translational Science Awards Consortium is related to: LabArchives has parent organization: University of Wisconsin System; Wisconsin; USA is parent organization of: PSGInfer is parent organization of: RSEM is parent organization of: Database Enabled Code for Ideal Probe Hybridization Employing R is parent organization of: National Magnetic Resonance Facility at Madison is parent organization of: UW-Madison Neuroscience Resources is parent organization of: ASAP is parent organization of: Biological Magnetic Resonance Data Bank (BMRB) is parent organization of: Chemistry Molecular Models is parent organization of: DTI-TEMPLATE-RHESUS-MACAQUES is parent organization of: Amplify is parent organization of: Mindtouch DekiWiki is parent organization of: EBSeq is parent organization of: WHAM is parent organization of: Comparative Mammalian Brain Collections is parent organization of: Madison Metabolomics Consortium Database is parent organization of: Callicam is parent organization of: E. coli Genome project is parent organization of: CESG is parent organization of: LOCI is parent organization of: Rhesus Macaque Atlases for Functional and Structural Imaging Studies is parent organization of: Puerto Rican Elderly: Health Conditions is parent organization of: DTI Blog is parent organization of: HI-SPEED Software Packets is parent organization of: Wisconsin White Matter Hyperintensities Segmentation Toolbox is parent organization of: dPeak is parent organization of: MOSAiCS is parent organization of: NucDe is parent organization of: ABNER is parent organization of: UW-Madison Cardiovascular Physiology Core Facility is parent organization of: UW-Madison Mass Spectrometry/Proteomics Facility is parent organization of: University of Wisconsin - Madison Labs and Facilities is parent organization of: Waisman Biomanufacturing is parent organization of: Mauve is parent organization of: Wisconsin National Primate Research Center is parent organization of: RSEM is parent organization of: University of Wisconsin School of Pharmacy is parent organization of: National Survey of Families and Households is parent organization of: Essential genes in E. coli is parent organization of: ScienceExchange is parent organization of: LAMHDI: The Initiative to Link Animal Models to Human DIsease is parent organization of: National Survey of Midlife Development in the United States is parent organization of: EDGE: Environment, Drugs and Gene Expression is parent organization of: Comparative Biomedical Sciences Graduate Program is parent organization of: Multivariate General Linear Models (MGLM) on Riemannian Manifolds is parent organization of: Efficient Permutation Testing is parent organization of: O'Brien Center for Benign Urologic Research at University of Wisconsin-Madision and University of Massachusetts-Boston Rodent Urinary Function Testing Core is parent organization of: Attie Lab Diabetes Database is parent organization of: DETONATE is parent organization of: Real-Time Experimental Control with Graphical User Interface is parent organization of: Wisconsin-Madison University Biotechnology Center Gene Expression Center Core Facility is parent organization of: University of Wisconsin-Madison Advanced Genome Editing Laboratory is parent organization of: Diabetes Data and Hypothesis Hub is parent organization of: University of Wisconsin-Madison Biochemistry Optical Core Facility is parent organization of: XDD is parent organization of: University of Wisconsin Madison Biotechnology Center Animal Models Core Facility is parent organization of: County Health Rankings and Roadmaps is parent organization of: University of Wisconsin-Madison Intellectual and Developmental Disabilities Models Core Facility is parent organization of: Wisconsin National Primate Research Center Pathology Services Core Facility is parent organization of: University of Wisconsin Madison Radiopharmaceutical Analytics and Specimen Research Lab Core Facility is parent organization of: University of Wisconsin Madison Newcomb Imaging Center NIC Core Facility |
ISNI:0000 0001 2167 3675, Crossref funder ID:100007015, nlx_65725, grid.14003.36, Wikidata:Q838330 | https://ror.org/01y2jtd41 | SCR_008282 | Madison, University of Wisconsin-Madison, Wisco, UW Madison, The University of Wisconsin�Madison | 2026-08-01 12:03:29 | 7 |
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