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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
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ProTECT Resource Report Resource Website 500+ mentions |
ProTECT (RRID:SCR_004531) | ProTECT | topical portal, data or information resource, disease-related portal, research forum portal, portal | Recently, our team completed an NINDS-funded, Phase IIa double-blinded, placebo-controlled pilot clinical trial that examined the pharmacokinetics, safety, and activity of progesterone, a steroid found to have powerful neuroprotective effects in multiple animal models of brain injury. Our pilot study demonstrated a 50% reduction in death among severe TBI patients and less disability among moderate TBI patients treated with progesterone. Based on these promising results and supportive preclinical data, we are conducting a large, phase III clinical trial (ProTECT III) to definitively assess the safety and efficacy of this treatment for adults with moderate to severe acute TBI. The study is slated to begin August 2008. WHY Progesterone: Although progresterone is widely considered a sex steroid, it is also a potent neurosteroid. Progesterone is naturally synthesized in the CNS. A large and growing body of animal studies indicate that early administration of progesterone after TBI reduces cerebral edema, neuronal loss, and behavioral deficits in laboratory animals. Certain properties of progesterone make it an ideal therapeutic candidate. First, in contrast to most drugs tested to date, progesterone rapidly enters the brain and reaches equilibrium with the plasma within an hour of administration. Second, unlike other experimental agents, progesterone has a long history of safe use in humans. Finally, the findings of our pilot clinical trial (presented in the Preliminary Data Section, below) indicate that progesterone has consistent and predictable pharmacokinetic properties, is unlikely to produce harm, and may be efficacious for treating acute TBI in humans. | traumatic brain injury, progesterone, clinical trial, neuroprotection, one mind tbi | has parent organization: Emory University; Georgia; USA | NIH | PMID:22033509 PMID:17011666 |
nlx_143806 | SCR_004531 | ProTECT III - Progesterone for Traumatic Brain Injury: Experimental Clinical Treatment: Phase III Clinical Trial | 2026-08-13 09:27:11 | 603 | ||||||
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Emory University; Georgia; USA Resource Report Resource Website 1+ mentions |
Emory University; Georgia; USA (RRID:SCR_011205) | Emory | university | Emory University, a top 20 research university located in Atlanta, Georgia, is an inquiry-driven, ethically engaged and diverse community whose members work collaboratively for positive transformation in the world through courageous leadership in teaching, research, scholarship, health care and social action. The university offers academic degrees and programs ( undergraduate, graduate and professional) through nine schools, with particular strengths in the arts and sciences, business, law, theology and the health professions. The university is recognized internationally for its outstanding liberal arts college, superb professional schools and one of the Southeast''s leading health care systems. Emory maintains an uncommon balance for an institution of its standing: it generates more research funding than any other Georgia university, while maintaining its traditional emphasis on teaching. The university is enriched by the legacy and energy of Atlanta, and by collaboration among its schools, units and centers, as well as with affiliated institutions. |
uses: Scizzle uses: LabArchives is related to: Alzheimers Disease Genetics Consortium is related to: Clinical and Translational Science Awards Consortium is related to: LabArchives is parent organization of: Phosphor Antibody Array Data Analysis is parent organization of: Living Links: Center for the Advanced Study of Ape and Human Evolution is parent organization of: Yerkes National Primate Research Center is parent organization of: Emory University, Molecular and Systems Pharmacology is parent organization of: eBIRT is parent organization of: ProTECT is parent organization of: SeqAnt is parent organization of: Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit is parent organization of: polyaPeak is parent organization of: MitoDat - Mendelian Inheritance and the Mitochondrion is parent organization of: Crustacean stomatogastric model neuron database is parent organization of: BSMac is parent organization of: MethLAB is parent organization of: Emory University Labs and Facilities is parent organization of: Emory University School of Medicine; Atlanta; Georgia; USA is parent organization of: PANDORA Matlab Toolbox is parent organization of: GoMiner is parent organization of: Yerkes Collection Non-Human Primate Resource is parent organization of: omniBiomarker is parent organization of: Transgenic Huntington's Disease Monkey Resources is parent organization of: Georgia Center for Diabetes Translation Research is parent organization of: Translational Research in Neuroimaging and Data Science datasets is parent organization of: OpenEpi is parent organization of: Emory University and Pediatric Winship Flow Cytometry Core Facility is parent organization of: Emory University Emory Stem Cell Core Facility is parent organization of: Emory University School of Medicine Flow Cytometry Core Facility is parent organization of: Emory University Mouse Transgenic and Gene Targeting Core Facility is parent organization of: Emory University Emory Integrated Cellular Imaging Core Facility is parent organization of: Emory University Emory Cellular and Immunotherapy Core Facility is parent organization of: Emory University Emory Investigational Drug Service Core Facility is parent organization of: Emory University Emory HPLC Bioanalytical Core Facility is parent organization of: Emory University Emory Integrated Proteomics Core Facility is parent organization of: Emory University Emory Integrated Genomics Core Facility is parent organization of: Emory University Emory Multiplexed Immunoassay Core Facility is parent organization of: Emory University Emory Integrated Metabolomics and Lipidomics Core Facility is parent organization of: Emory University Emory Gnobiotic Animal Core Facility is parent organization of: Emory University Emory Integrated Computational Core Facility is parent organization of: Emory University Emory Glycomics and Molecular Interactions Core Facility is parent organization of: Emory University Division of Animal Resources Core Facility is parent organization of: Emory University Center for Systems Imaging Core Facility is parent organization of: Emory University Biostatistics Collaboration Core Facility is parent organization of: Emory University Robert P. Apkarian Integrated Electron Microscopy Core Facility is parent organization of: Emory University Pediatric Biomarkers Core Facility is parent organization of: Emory University Animal Physiology Core Facility is parent organization of: Emory University Pediatric Biostatistics Core Facility is parent organization of: Emory University EPC Genomics Core Facility is parent organization of: Emory University NIH Tetramer Core Facility is parent organization of: Emory University AI Image Extraction Core Facility is parent organization of: Emory University EHCF High Containment Core Facility is parent organization of: Emory University Translational Neuroscience Core Facility is parent organization of: Emory University Winship Cancer Institute Cancer Tissue and Pathology Core Facility |
, nif-0000-01943, Crossref Funder ID 100006939, GRID grid.189967.8, ISNI 0000 0004 1936 7398, Wikidata Q621043 | https://ror.org/03czfpz43 | SCR_011205 | Emory University | 2026-08-08 11:59:47 | 8 |
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