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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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Inspiralis Resource Report Resource Website 1+ mentions |
Inspiralis (RRID:SCR_004082) | commercial organization | Commercial organization supplying topoisimerase products and services to the pharmaceutical industry and academia to aid research in the anti-infectives and anti-cancer markets. Their aim is to provide pharmaceutical companies, and others involved in drug development, with the necessary tools to develop and screen novel anti-infective and anti-cancer compounds. Products All their proteins are expressed as the native sequences without additional tags. The only exception is the M. tuberculosis gyrase which is currently produced with a C-terminal His tag. An untagged version of this protein will be available soon. * Topoisomerase Enzymes and Assay Kits * Specific Gyrase Protein Domains * DNA Substrates and Markers * Antibodies Services * Gel Based Assays * Medium / High Throughput Assay * Investigation protein DNA interaction ReDCaT chip | topoisomerase, enzyme, substrate, drug development, anti-infective, anti-cancer, assay, protein-dna interaction, protein, dna | is related to: European Gram Negative AntiBacterial Engine | nlx_158540 | SCR_004082 | Inspiralis Limited, Inspiralis Ltd | 2026-09-03 04:46:58 | 4 | |||||||||
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European Gram Negative AntiBacterial Engine Resource Report Resource Website 1+ mentions |
European Gram Negative AntiBacterial Engine (RRID:SCR_003859) | ENABLE | consortium, data or information resource, organization portal, portal | Consortium working to advance the development of potential antibiotics against Gram-negative bacteria, such as Escherichia coli. The project creates and manages a drug discovery engine for testing and optimizing molecules that are still in the earlier stages of drug discovery but have the potential to become future drug candidates capable of treating resistant Gram-negative infections. The project will focus on the discovery and pre-clinical stages of drug development, as well as (potentially) phase 1 clinical trials. ENABLE will run several drug discovery programs in parallel and the consortium seeks external hit and lead programs to join, through a series of open calls during the project. Researchers who have interesting molecules will have the opportunity to collaborate with a diverse range of experts in microbiology, pharmacology and chemistry to help advance their molecule through the drug development process until it is an attractive candidate for clinical testing. Specifically, the project is working towards: # identifying three antibacterial lead molecules which, following extensive testing, have been identified as having promising antimicrobial activity; # identifying two antibacterial clinical candidate molecules # advancing at least one compound into preclinical and phase 1 clinical studies, i.e. early clinical safety testing in humans. | drug, drug discovery, drug candidate, molecule, antibiotic, antimicrobial resistance, drug development, tool development, basic research, clinical trial, pre-clinical, antimicrobial, antibacterial, gram-negative bacteria |
is listed by: Consortia-pedia is related to: Spanish National Research Council; Madrid; Spain is related to: Aston University; Birmingham; United Kingdom is related to: Cardiff University; Wales; United Kingdom is related to: European Biotechnology Network is related to: MEDINA Foundation is related to: University of Helsinki; Helsinki; Finland is related to: Hvidovre Hospital; Hvidovre; Denmark is related to: John Innes Centre; Norwich; United Kingdom is related to: University of Copenhagen; Copenhagen; Denmark is related to: Latvian Institute of Organic Synthesis; Riga; Latvia is related to: National Medicines Institute; Warsaw; Poland is related to: SP Process Development; Sodermanland; Sweden is related to: University of Oxford; Oxford; United Kingdom is related to: University of Barcelona; Barcelona; Spain is related to: University of Liege; Wallonia; Belgium is related to: Uppsala University; Uppsala; Sweden is related to: Asclepia MedChem Solutions is related to: Beactica is related to: Biomol-Informatics is related to: Inspiralis is related to: KeytoLead is related to: Molecular Discovery is related to: MPS Hamburg is related to: OnTarget Chemistry has parent organization: Uppsala University; Uppsala; Sweden |
Innovative Medicines Initiative ; New Drugs for Bad Bugs ND4BB program ; EFPIA |
nlx_158183 | SCR_003859 | European Gram Negative Antibacterial Engine (ENABLE), European Gram-negative Antibacterial Engine | 2026-09-03 04:46:42 | 4 |
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