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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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European Mouse Phenotyping Resource of Standardised Screens Resource Report Resource Website 50+ mentions |
European Mouse Phenotyping Resource of Standardised Screens (RRID:SCR_003087) | EMPReSS | data or information resource, data set, standard specification, narrative resource | Database of validated Standard Operating Procedures (SOPs) for screens to determine the phenotype of a mouse, developed by the EUMORPHIA consortium. The SOP's cover all of the main body systems including: clinical chemistry, hormonal and metabolic systems, cardiovascular, allergy and infection, renal function, sensory function, neurological and behavioral function, cancer, bone and cartilage, and respiratory function. In addition, there are generic SOPs in histology, necropsy, pathology and gene expression. EMPReSS is a platform of individual tests. These can be performed as individual tests or grouped together in sequences, recommended in the EMPReSS database, to give more information on particular phenotype. Quick List of Current Pipelines: * EUMODIC Pipeline 1 * EUMODIC Pipeline 2 * GMC Pipeline * MGP Pipeline * Additional Tests * EUMODIC Pipeline 3 | phenotype, phenotyping, dysmorphology, body weight, blood pressure, calorimetry, ipgtt, dexa, x-ray, chemistry, clinical, heart weight, tibia length, standard operating procedure, FASEB list |
is related to: Understanding Human Disease Through Mouse Genetics is related to: Europhenome Mouse Phenotyping Resource is related to: Impress is related to: Europhenome Mouse Phenotyping Resource has parent organization: MRC Mammalian Genetics Unit |
PMID:17905814 | Free, Freely available | nif-0000-30492 | https://academic.oup.com/bioinformatics/article/21/12/2930/268092 | SCR_003087 | European Mouse Phenotyping Resource of Standardized Screens | 2026-08-05 10:43:45 | 78 | |||||
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Understanding Human Disease Through Mouse Genetics Resource Report Resource Website 10+ mentions |
Understanding Human Disease Through Mouse Genetics (RRID:SCR_000785) | EUMORPHIA | data or information resource, training resource, portal, group | A portal documenting a project for the development of novel approaches in phenotyping, mutagenesis and informatics to improve the characterization of mouse models for understanding human molecular physiology and pathology. EUMORPHIA has developed a new robust primary screening platform for determining the phenotype of mice: EMPReSS - European Mouse Phenotyping Resource for Standardised Screens. The project is also focused on training new young scientists by funding them to work in a variety of laboratories to gain a broader swathe of techniques. The project has also identified the need for more trained mouse pathologists. To address this, they are setting up training courses in pathology and working at a European level to establish more training. | european, european union, mouse, gene, phenotype, model, physiology, molecular, informatics, mutagenesis |
is related to: European Mouse Phenotyping Resource of Standardised Screens is related to: Europhenome Mouse Phenotyping Resource has parent organization: University of Strasbourg; Strasbourg; France |
European Union under FP5 from October 2002 until March 2006 | THIS RESOURCE IS NO LONGER IN SERVICE | nif-0000-30502 | http://www.eumorphia.org | SCR_000785 | European Union Mouse Research for Public Health and Industrial Applications | 2026-08-05 10:43:14 | 12 | |||||
|
MRC Mammalian Genetics Unit Resource Report Resource Website 100+ mentions |
MRC Mammalian Genetics Unit (RRID:SCR_005378) | MGU | data or information resource, topical portal, portal | It is now widely known that animals share many genes with humans and can suffer from the same diseases, for example diabetes or deafness. Investigating these diseases in animals can provide vital leads to understanding both their causes and ways to treat them in humans. This approach to medical research lies at the heart of work at the MRC Mammalian Genetics Unit (MGU) at Harwell in Oxfordshire. In 1995 the MRC Radiobiology Unit was reconstituted to form two new units, the Radiation and Genome Stability Unit and the MGU. These opened in January 1996, together with the UK Mouse Genome Centre which is now part of MGU, making MRC Harwell a unique campus for multi-disciplinary genetics research. Since MGU's Director Steve Brown took the reins in 1996, the unit has dramatically expanded its scientific scope and increased its personnel from 40 to over 100. It now has 13 research programs encompassing molecular genetics, genomics, genetic manipulation and data analysis at all levels, from single genes to the whole genome. With a combination of cutting-edge facilities and expertise unrivaled in Europe, MGU Harwell has become firmly established as one of the world's leading academic centres for mouse genetics. | mouse, genetics, gene |
is parent organization of: European Mouse Phenotyping Resource of Standardised Screens is parent organization of: Europhenome Mouse Phenotyping Resource is parent organization of: International Mouse Strain Resource |
nlx_144449 | http://www.mrc.ac.uk/Ourresearch/Unitscentresinstitutes/Profiles/MGU/index.htm | SCR_005378 | Medical Research Council Mammalian Genetics Unit, MGU Harwell, MRC MGU | 2026-08-05 10:44:15 | 236 | |||||||
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Impress Resource Report Resource Website 50+ mentions |
Impress (RRID:SCR_006160) | IMPReSS | data or information resource, narrative resource, experimental protocol, international standard specification, data access protocol, software resource, standard specification, web service | Contains standardized phenotyping protocols essential for the characterization of mouse phenotypes. IMPReSS holds definitions of the phenotyping Pipelines and mandatory and optional Procedures and Parameters carried out and data collected by international mouse clinics following the protocols defined. This allows data to be comparable and shareable and ontological annotations permit interspecies comparison which may help in the identification of phenotypic mouse-models of human diseases. The IMPC (International Mouse Phenotyping Consortium) core pipeline describes the phenotype pipeline that has been agreed by the research institutions. IMPReSS has a SOAP web service machine interface. The WSDL can be accessed here: http://www.mousephenotype.org/impress/soap/server?wsdl | phenotype, phenotyping, adult, embryonic, ontology, enu-induced gene knockout, gene, knockout mouse, ethylnitrosourea |
is related to: European Mouse Phenotyping Resource of Standardised Screens has parent organization: International Mouse Phenotyping Consortium (IMPC) |
nlx_151661 | SCR_006160 | International Mouse Phenotyping Resource of Standardised Screens, IMPReSS - International Mouse Phenotyping Resource of Standardised Screens | 2026-08-05 10:44:27 | 60 | ||||||||
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Europhenome Mouse Phenotyping Resource Resource Report Resource Website 10+ mentions |
Europhenome Mouse Phenotyping Resource (RRID:SCR_006935) | EuroPhenome | data or information resource, database, data analysis service, production service resource, service resource, analysis service resource | Open source software system for capturing, storing and analyzing raw phenotyping data from SOPs contained in EMPReSS, it provides access to raw and annotated mouse phenotyping data generated from primary pipelines such as EMPReSSlim and secondary procedures from specialist centers. Mutants of interest can be identified by searching the gene or the predicted phenotype. You can also access phenotype data from the EMPReSSlim Pipeline for inbred mouse strains. Initially EuroPhenome was developed within the EUMORPHIA programme to capture and store pilot phenotyping data obtained on four background strains (C57BL/6J, C3H/HeBFeJ, BALB/cByJ and 129/SvPas). EUMORPHIA (European Union Mouse Research for Public Health and Industrial Applications) was a large project comprising of 18 research centers in 8 European countries, with the main focus of the project being the development of novel approaches in phenotyping, mutagenesis and informatics to improve the characterization of mouse models for understanding human molecular physiology and pathology. The current version of EuroPhenome is capturing data from the EUMODIC project as well as the WTSI MGP, HMGU GMC pipeline and the CMHD. EUMODIC is undertaking a primary phenotype assessment of up to 500 mouse mutant lines derived from ES cells developed in the EUCOMM project as well as other lines. Lines showing an interesting phenotype will be subject to a more in depth assessment. EUMODIC is building upon the comprehensive database of standardized phenotyping protocols, called EMPReSS, developed by the EUMORPHIA project. EUMODIC has developed a selection of these screens, called EMPReSSslim, to enable comprehensive, high throughput, primary phenotyping of large numbers of mice. Phenovariants are annotated using a automated pipeline, which assigns a MP term if the mutant data is statistically different to the baseline data. This data is shown in the Phenomap and the mine for a mutant tool. Please note that a statistically significant result and the subsequent MP annotation does not necessarily mean a true phenovariant. There are other factors that could cause this result that have not been accounted for in the analysis. It is the responsibility of the user to download the data and use their expert knowledge or further analysis to decide whether they agree or not. EuroPhenome is primarily based in the bioinformatics group at MRC Harwell. The development of EuroPhenome is in collaboration with the Helmholtz Zentrum Munchen, Germany, the Wellcome Trust Sanger Institute, UK and the Institut Clinique de la Souris, France. | phenotype, gene, mutant mouse strain, inbred mouse strain, annotation, ortholog, high-throughput, phenovariant, disorder, c57bl/6j, c3h/hebfej, balb/cbyj, 129/svpas |
is related to: European Mouse Phenotyping Resource of Standardised Screens is related to: OMIM is related to: Understanding Human Disease Through Mouse Genetics is related to: European Conditional Mouse Mutagenesis Program is related to: European Mouse Phenotyping Resource of Standardised Screens has parent organization: MRC Mammalian Genetics Unit |
European Union FP6 contract LSHG-CT-2006-037188; MRC ; National Genome Research Network |
PMID:19933761 PMID:17905814 |
Open unspecified license, Acknowledgement requested | nif-0000-30535 | SCR_006935 | 2026-08-05 10:44:34 | 19 |
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