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A French research center working with developing countries to tackle international agricultural and development issues. They are a public industrial and commercial enterprise (EPIC) under the joint authority of the Ministry of Higher Education and Research and the Ministry of Foreign Affairs. CIRAD works with the whole range of developing countries to generate and pass on new knowledge, support agricultural development and fuel the debate on the main global issues concerning agriculture. They are a targeted research organization, and base their operations on development needs, from field to laboratory and from a local to a global scale. CIRAD''''s activities involve the life sciences, social sciences and engineering sciences, applied to agriculture, food and rural territories. They work hand-in-hand with local people and the local environment, on complex, ever-changing issues: food security, ecological intensification, emerging diseases, the future of agriculture in developing countries, etc.
Proper citation: CIRAD (RRID:SCR_011153) Copy
Consortium to develop efficient and safe strategies for the production of clinical-grade protein pharmaceuticals in plants, and to define the procedures needed for the production of these proteins in compliance with the strict regulatory standards that govern the manufacture of all pharmaceuticals. Ultimately the consortium aimed to take a candidate product all the way through the development pipeline culminating in a phase I human clinical trial. The consortium has a wide range of expertise spanning the areas of molecular biology, plant biology, immunology, recombinant protein expression technology, vaccinology, and plant biotechnology. The objectives listed at the beginning of the Pharma-Planta project are as follows: # To produce a recombinant pharmaceutical molecule in transgenic plants, which will be developed through all regulatory requirements, GMP (good manufacturing practice) standards and pre-clinical toxicity testing. This will then be evaluated in Phase I human clinical trials. # To develop robust risk assessment practices for recombinant pharmaceutical molecules produced in plants, based on health and environmental impact, working with regulatory authorities within the EU as well as public groups to ensure that the production systems are as safe and as acceptable as possible, and that they comply with all biosafety regulations. # To define and carry out a coordinated program for securing and managing intellectual property that will facilitate the availability of high priority plant-derived recombinant pharmaceuticals to the poor in developing countries while simultaneously allowing the products to be developed commercially in Europe and North America. # To develop and refine new strategies for the expression of recombinant pharmaceuticals in plants, which can be used on a generic basis for molecules that are normally expressed poorly. # To develop and generate transgenic plants expressing a second generation of recombinant molecules that will be used in future clinical trials. In 2011 they reached their benchmark for success launching a phase I clinical study of an antibody that neutralizes HIV, produced in and isolated from tobacco plants. This antibody could one day become an inexpensive component of a microbicide used to prevent the spread of HIV/AIDS. The project has also spun off many additional technologies that are being adopted by researchers all over the world, and has resulted in more than 100 publications in peer-reviewed scientific journals.
Proper citation: Pharma-Planta Consortium (RRID:SCR_003880) Copy
http://www.diplomatie.gouv.fr/en/
The Ministry of Foreign Affairs and is the ministry in the government of France that handles France's foreign relations.
Proper citation: French Ministry of Foreign Affairs and International Development (RRID:SCR_005518) Copy
http://www.agropolis-fondation.fr/uk/home.html
A funding resource which promotes and supports high-level research and higher education in agricultural sciences and sustainable development research. The scientific work supported by the Foundation covers all aspects of the plant, from its genes to its environments, and concerns temperate, Mediterranean, and tropical climates. It supports research initiatives in: genetics and genomics, plant breeding, eco-physiology; integrated crop protection, plant pests and diseases, symbiotes, population ecology; agro-ecosystems, agri-environmental innovations, and resource management; agri-food systems, processing, and quality of food and non-food material; and innovation processes and social management of innovation.
Proper citation: Agropolis Foundation (RRID:SCR_014057) Copy
http://www.enseignementsup-recherche.gouv.fr/
Ministry of Higher Education, Research and Innovation, France is one of the 900 Higher Education-related Organizations and Associations.
Proper citation: French Ministry of Higher Education and Research (RRID:SCR_005532) Copy
A database designed for plant comparative and functional genomics based on complete genomes. It comprises complete proteome sequences from the major phylum of plant evolution. The clustering of these proteomes was performed to define a consistent and extensive set of homeomorphic plant families. Based on this, lists of gene families such as plant or species specific families and several tools are provided to facilitate comparative genomics within plant genomes. The analyses follow two main steps: gene family clustering and phylogenomic analysis of the generated families. Once a group of sequences (cluster) is validated, phylogenetic analyses are performed to predict homolog relationships such as orthologs and ultraparalogs.
Proper citation: GreenPhylDB (RRID:SCR_002834) Copy
http://urgi.versailles.inra.fr/OryzaTagLine/
Oryza Tag Line consists in a searchable database developed under the Oracle management system integrating phenotypic data resulting from the evaluation of the Génoplante rice insertion line library. To display the sequence information (Flanking Sequence Tags) resulting from the molecular characterization of the mutagen insertion sites in the collection, Oryza Tag Line is linked to OryGenesDB a GGB-derived interface or FLAGDB++ a Java based interface. Aside from generic data ( production record and seed stock ) Oryza Tag Line includes textual and pictorial information resulting from the following observations: (i.) GUS/GFP expression assays conducted on the primary transformants (T0) and/or T1 progenies (ii.) morpho-physiological alterations detected during the growth of the T1 progenies either in phytotron -up to the 5-6 leaf stage- or under agronomical conditions in the field (collaboration with CIAT, Cali, Colombia).
Proper citation: Oryza Tag Line (RRID:SCR_013254) Copy
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