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https://www.clinicaltrials.gov/study/NCT00064753

Multi-center, randomized, double blind controlled clinical trial to determine whether treatment with a standard multivitamin augmented with high doses of folic acid, vitamin B6 and vitamin B12 reduces the rate of cardiovascular disease outcomes in renal transplant recipients relative to participants receiving a similar multivitamin that contains no folic acid. This study hopes to show that by reducing the level of homocysteine in the body, the risk of heart disease is also reduced among kidney transplant patients.

Proper citation: Folic Acid for Vascular Outcome Reduction in Transplantation (RRID:SCR_001505) Copy   

•   Source: SciCrunch Registry

https://clinicaltrials.gov/study/NCT00342927?term=AREA%5BBasicSearch%5D(NIDDK%20endocrine%20and%20diabetes)%20AND%20AREA%5BSponsorSearch%5D(NIDDK)%20AND%20AREA%5BOverallStatus%5D(NOT_YET_RECRUITING%20OR%20RECRUITING%20OR%20ACTIVE_NOT_RECRUITING)&rank=1

Multicenter observational study designed to identify genetic determinants of diabetic nephropathy. It is conducted in eleven U.S. clinical centers and a coordinating center, and with four ethnic groups (European Americans, African Americans, Mexican Americans, and American Indians). Two strategies are used to localize susceptibility genes: a family-based linkage study and a case-control study using mapping by admixture linkage disequilibrium (MALD). In the family-based study, probands with diabetic nephropathy are recruited with their parents and selected siblings. Linkage analyses will be conducted to identify chromosomal regions containing genes that influence the development of diabetic nephropathy or related quantitative traits such as serum creatinine concentration, urinary albumin excretion, and plasma glucose concentrations. Regions showing evidence of linkage will be examined further with both genetic linkage and association studies to identify genes that influence diabetic nephropathy or related traits. Two types of MALD studies are being done. One is a case-control study of unrelated individuals of Mexican American heritage in which both cases and controls have diabetes, but only the case has nephropathy. The other is a case-control study of African American patients with nephropathy (cases) and their spouses (controls) unaffected by diabetes and nephropathy; offspring are genotyped when available to provide haplotype data. The specific goals of this program: * Delineate genomic regions associated with the development and progression of renal disease(s) * Evaluate whether there is a genetic link between diabetic nephropathy and diabetic retinopathy * Improve outcomes * Provide protection for people at risk and slow the progression of renal disease * Help establish a resource for genetic studies of kidney disease and diabetic complications by creating a repository of genetic samples and a database * Encourage studies of the genetics of progressive renal disease

Proper citation: Family Investigation of Nephropathy of Diabetes (RRID:SCR_001525) Copy   

•   Source: SciCrunch Registry

https://clinicaltrials.gov/study/NCT01885559

Consortium established to design and implement clinical trials of treatments that might slow the progressive loss of renal function in Polycystic Kidney Disease (PKD). Two multicenter randomized, double-blind, placebo controlled clinical trials are running concurrently to study the efficacy of renin-angiotensin-aldosterone system blockade on the progression of cystic disease (kidney volume) and on the decline in renal function in autosomal dominant polycystic kidney disease (ADPKD). Study A is to study whether intensive ACE-I/ARB blockade decrease the progression of cystic disease compared to ACE-I monotherapy patients with early disease, relatively preserved renal function, and high-normal BP or hypertension. Study B is to study whether intensive ACE-I/ARB blockade as compared to ACE-I monotherapy slow the decline in kidney function, end-stage of renal disease, or death in the setting of standard blood pressure control in hypertensive patients with moderately advanced disease.

Proper citation: HALT PKD (RRID:SCR_001529) Copy   

•   Source: SciCrunch Registry

http://www.isletstudy.org/

Network of centers to conduct studies of islet transplantation in patients with type 1 diabetes to improve the safety and long-term success of methods for transplanting islets. It is the aim of this trial to improve methods of isolating islets, to improve techniques for the administering those transplanted islets; and to develop approaches to minimize the toxic effects of immunosuppressive drugs required for transplantation.

Proper citation: Clinical Islet Transplantation Study (RRID:SCR_001515) Copy   

•   Source: SciCrunch Registry

https://sites.cscc.unc.edu/cscc/projects/RIVUR%20

Multicenter, randomized, double-blind, placebo-controlled trial is designed to determine whether daily antimicrobial prophylaxis is superior to placebo in preventing recurrence of urinary tract infection (UTI) in children with vesicoureteral reflux (VUR). The basic eligibility criteria are: (1) age at randomization of at least 2 months, but less than 6 years, (2) a diagnosed first febrile or symptomatic UTI within 42 days prior to randomization that was appropriately treated, and (3) presence of Grade I-IV VUR based on voiding cystourethrogram (VCUG). Patients will be randomly assigned to treatment for 2 years with daily antimicrobial prophylaxis (trimethoprim-sulfamethoxazole) or placebo. The study is designed to recruit 600 children (approximately 300 in each treatment group) over an 18-24 month period. The primary endpoint is recurrence of UTI. In addition, patients will be evaluated for secondary endpoints related to renal scarring and antimicrobial resistance. Scarring will be determined based on renal scintigraphy by 99mTc dimercaptosuccinic (DMSA) scan. Quality of life, compliance, safety parameters, utilization of health resources, and change in VUR will be assessed periodically throughout the study.

Proper citation: RiVuR (RRID:SCR_001539) Copy   

•   Source: SciCrunch Registry

https://hddc.hms.harvard.edu/gnotobiotics-microbiology-and-metagenomics

Core facility that assists investigators evaluating host microbiota and its role in normal physiology and disease. It includes a number of resources for groups studying the role of the microbiota in human health and disease.

Proper citation: Harvard Digestive Diseases Center Biomedical CORE D: Gnotobiotic Mice, Microbiology and Metagenomics (RRID:SCR_012319) Copy   

•   Source: SciCrunch Registry

http://sph.unc.edu/norc/norc-diet-and-physical-activity-core/

Core that provides diet, physical activity, or statistical analysis consultation, as well as consultation for the design and development of diet and physical activity data collection protocols.

Proper citation: University of North Carolina at Chapel Hill Nutrition and Obesity Research Center Diet and Physical Activity Core (RRID:SCR_012588) Copy   

•   Source: SciCrunch Registry

https://einsteinmed.edu/centers/diabetes-research/research-areas/biomedical-cores/translational-research-core/index.html

Core services include consultation, technical support and training and mentoring in clinical and translational research methods that are specifically applicable to diabetes, its complications and related metabolic disorders. Personel provides expertise in first-in-human and mechanistic studies in integrative physiology, in clinical trials of diabetes and obesity, and in application of new technologies.

Proper citation: Einstein-Mount Sinai Diabetes Research Center Translational Research Core Facility (RRID:SCR_015068) Copy   

•   Source: SciCrunch Registry

http://drc.ucsf.edu/mouse-metabolism-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 10,2024. Core which provides technical support for UCSF investigators to conduct metabolic studies using a 12-chambered Comprehensive Lab Animal Monitoring System (CLAMS), an EchoMRI, and Dual energy X-ray absorptiometry, which together allow measurement of food intake, water intake, motor activities, core temperature, and body composition in live mice. It also helps to identify emerging technologies that will enhance multiple research programs and coordinates the acquisition and maintenance of those facilities.

Proper citation: University of California San Francisco Diabetes Research Center Mouse Metabolism Core (RRID:SCR_015101) Copy   

•   Source: SciCrunch Registry

https://www.baderc.org/cores/cbmcore/

Services provided include tissue preparation, embedding and sectioning for electron microscopy, use of electron microscope and photography of thin sections, immunogold staining for electron microscopy, preparation and incubation of samples (cells and tissues) for immunofluorescence microscopy, confocal microscopy and digital imaging.

Proper citation: Boston Area Diabetes Endocrinology Research Center Cell Biology and Morphology Core Facility (RRID:SCR_015069) Copy   

•   Source: SciCrunch Registry

https://diabetes.ucsf.edu/drc-islet

Core that enables clinical and basic research that analyzes the function of isolated pancreatic islets. It coordinates and delivers purified human islets to investigators when research need matches the availability of a human pancreas.

Proper citation: University of California San Francisco Diabetes Research Center Islet Production Core Facility (RRID:SCR_015106) Copy   

•   Source: SciCrunch Registry

https://diabetes.ucsf.edu/drc-microscopy

Core that consolidates, enhances and disseminates Diabetes Center resources and expertise in tissue and cell imaging technologies. Confocal fluorescence, widefield fluorescence, high throughput fluorescence and brightfield microscopes are available directly within the DRC Microscopy Core. Image quantification and analysis is performed at dedicated workstations.

Proper citation: University of California San Francisco Diabetes Research Center Microscopy Core Facility (RRID:SCR_015103) Copy   

•   Source: SciCrunch Registry

http://drc.ucsf.edu/lentiviral-rnai-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 5,2024. Core that provides reagents, equipment, training, supervision, and monitoring of investigators wishing to ensure the proper compliance with biosafety containment required for lentiviral-based research, lentiviral preparation services for investigators, and education on RNAi experimentation, through the lentiviral core website, and through protocols available at the facility.

Proper citation: University of California San Francisco Diabetes Research Center Lentiviral RNAi Core Facility (RRID:SCR_015104) Copy   

•   Source: SciCrunch Registry

http://www.baderc.org/cores/molbioCore.html

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 24,2024. Core that provides services for DNA sequencing and oligonucleotide synthesis, as well as support for projects that require research laboratory automation, such as siRNA screens and transcript abundance profiling. It also offers experimental design and advice for automation and high throughput screening of siRNA collections based on the Ambion siRNA collection.

Proper citation: Boston Area Diabetes Endocrinology Research Center Molecular Biology (RRID:SCR_015079) Copy   

•   Source: SciCrunch Registry

http://www.uab.edu/shp/drc/animal-physiology-core-links

Core that provides diabetes researches with diabetes related phenotyping in small animal models. Their services offered include the assessment of body composition, energy balance, glucose homeostasis, cardiovascular assessment, imaging, and transgenic animals models.

Proper citation: University of Alabama at Birmingham Diabetes Research Center Animal Physiology Core Facility (RRID:SCR_015110) Copy   

•   Source: SciCrunch Registry

https://www.derc.cuimc.columbia.edu/services/flow-cytometry-and-cell-sorting-core

Core which assists investigators to quantify and phenotypically characterize cell populations that contribute to the metabolic, immunologic and developmental programs of diabetes and its complications; and to purify populations of cells of relevance to diabetes and its complications.

Proper citation: Columbia Diabetes Research Center Flow Cytometry and Cell Sorting Core Facility (RRID:SCR_015078) Copy   

•   Source: SciCrunch Registry

https://diabetes.med.umich.edu/affiliated-centers/michigan-diabetes-research-center-mdrc/cores/administration

Administration Core of the Michigan Diabetes Research Center (MDRC) provides leadership, infrastructure, and resources to support and enhance diabetes research, including the translation of scientific discoveries from bench to bedside. Establishes, promotes, and enhances multidisciplinary and collaborative basic biomedical and clinical research among member investigators studying diabetes, its complications, and related endocrine and metabolic disorders.

Proper citation: Michigan Diabetes Research Center Administrative Core Facility (RRID:SCR_015115) Copy   

•   Source: SciCrunch Registry

http://www.baderc.org/cores/IsletCore.html

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 23,2024.Core which provides islets to the local diabetes research community in the Boston area. They collaborate with researchers nationally to provide nonhuman primate (NHP) islets for research.

Proper citation: Boston Area Diabetes Endocrinology Research Center Pancreatic Islet (RRID:SCR_015073) Copy   

•   Source: SciCrunch Registry

https://diabetes.med.umich.edu/affiliated-centers/michigan-diabetes-research-center-mdrc/cores/molecular-genetics

Core that provides services related to the application of genetic methodologies to research related to diabetes. Services include generation of targeted genetic mouse models, using CRISPR/Cas9 system in mouse or rat embryos, generation of specialty viral vectors, specialty viral reagents, and specialty mouse models.

Proper citation: Michigan Diabetes Research Center Molecular Genetics Core Facility (RRID:SCR_015119) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/diabetes/administrative-core/

Core facility that supports the Diabetes Research Center in its primary mission to enhance research, education and training in diabetes, obesity and related disorders at the University of Washington and in the Greater Seattle area. The Core coordinates and manages programs, evaluates Center activities, and performs other duties.

Proper citation: University of Washington Diabetes Research Center Administrative Core (RRID:SCR_015124) Copy   

•   Source: SciCrunch Registry