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http://harvard.eagle-i.net/i/00000139-4a28-1319-4d8e-943b80000000

The Partners Research Computing Core was created by Enterprise Research Infrastructure & Services (ERIS) to offer dedicated services, consultation, and support within the teaching hospitals. Please check the service catalog as new services are added, or contact us if you need a consultation. Initial discussion is at no charge.

Proper citation: Harvard Partners Research Computing Core (RRID:SCR_009861) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013e-8557-6524-8a53-38db80000000

There is a growing need for animal models to carry out in vivo developmental and regenerative medicine studies of human cells, tissues and organs. The Humanized Neonatal Mouse Center (HNMC) was created to accelerate research in the stem cell field by providing humanized mouse models to study human stem cell engraftment and differentiation in regenerative medicine. We have over 4 years of experience in constructing different types of humanized mouse models, including neonatal heart, lung and kidney injury models. We have extensive experience in hematopoietic stem cell reconstruction. It is our goal at HNMC to facilitate collaborative research in human stem cell biology, where physiologically relevant microenvironments (niches) may be created in vivo to study human stem cell fate and function under experimental settings where disease, damage or degenerative conditions can be controlled. We can provide customized humanized mouse models to the HSCI research community, to collaborate on research studies of common interest, and to advance the general use of these models for a broad range of translational and preclinical studies.

Proper citation: HSCI Humanized Neonatal Mouse Center (RRID:SCR_009815) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c0-1e2d-db6e-7a3f80000000

Core facility that provides the following services: Complex protein mixture analysis service, Project consultation service, Data analysis service, Protein identification service, Posttranslational modification site determination service, N-terminal Edman Sequence Analysis Service, C-terminal sequence analysis service, De novo sequence analysis service, Quantitative proteomics service, Labeled quantitative proteomics - SILAC, Labeled quantitative proteomics - ICAT service, Labeled quantitative proteomics - iTRAQ service, Labeled quantitative proteomics - AQUA service, Intact molecular weight determination service, Low resolution GC/MS service, Low resolution GC/MS/MS service, Exact mass MS & MS/MS electrospray for structural elucidation service. The FAS Center for Systems Biology Mass Spectrometry and Proteomics Resource Laboratory provides mass spectrometry and strategic consulting in Proteomics and Small Molecule analysis for Life Science and Chemistry researchers as well as others worldwide. This resource brings together the state-of-the-art expertise and instrumentation of the Microchemistry and Proteomics, CCB Mass Spectrometry, and Bauer Center Core laboratories, leveraging our breadth of experience to provide the best possible support for your research.

Proper citation: Harvard FAS Bauer Core: Mass Spectrometry and Proteomics Core Laboratory (RRID:SCR_009837) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-756e-db1e-1971-4f2080000000

Core facility that provides the following services: Nanofabrication cleanroom and instrumentation access, instrument training, staff assistance. The Center for Nanoscale Systems'' Nanofabrication Facility (CNS-NF), offers resource and staff support for fabricating and characterizing nanoscale devices and structures. The facility currently operates the 10,000 sq.ft. LISE Cleanroom with leading-edge equipment capable of electron-beam and optical lithography, physical and chemical vapor deposition, dry and wet processing, metrology, and device characterization.

Proper citation: Harvard CNS Nanofabrication Facility (RRID:SCR_009832) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-7574-3d13-1971-4f2080000000

The National Nanotechnology Infrastructure Network?s computational activity (NNIN/C) is the computational counterpart of the NNIN experimental initiative. Like the NNIN experimental program, NNIN/C is a multi-university initiative, funded by the National Science Foundation (NSF). Harvard University serves as the coordinating hub of NNIN/C, the object of which is to establish a national computing resource that provides hardware resources and simulation tools dedicated to nanoscience research for the academic and industrial research communities. Strong technical and scientific support is provided by staff experts so that the tools and resources can benefit interdisciplinary research. The software tools include commercial software packages for design, characterization and analysis of nanometer scale devices as well as some of the latest academic advances in nanoscale modeling and simulation software. The goals and strategies of NNIN/C are: * Assemble and create a wide suite of robust software that addresses critical issues related to the physical, chemical, and biological properties of artificial and natural nanoscale structures. * Maintain and, where necessary, modify these simulations to address a broad range of research problems. * Provide strong technical support and thorough instruction on the software tools so that even novice users can rapidly develop solutions to their own unique research problems. * Provide web-based graphical user interfaces (GUIs) for user-friendly access to simulation tools as well as web-based resources for instruction and feedback to the community of researchers employing the same tools

Proper citation: Harvard CNS NNIN/C Computational Facility (RRID:SCR_009830) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-7562-84f7-1971-4f2080000000

Center for Nanoscale Systems facility dealing with SEM, TEM, ESEM, sample prep etc.

Proper citation: Harvard CNS Imaging and Analysis Facility (RRID:SCR_009829) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-5e87-861a-55da-381e80000000

Core for data driven projects related to basic, clinical and translational research, with a particular emphasis on diabetes. Aims to ensure that researchers take advantage of the most modern and robust methods available in the field of Bioinformatics and Biostatistics.

Proper citation: Harvard Bioinformatics Core at Joslin Diabetes Center (RRID:SCR_009827) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9143-a911-55da-381e80000000

Core facility that provides the following services: Offline assisted or self-performed analysis.

The HSCI-CRM Flow Cytometry Core Facility seeks to provide high quality, accessible cytometry sorting and analysis services to laboratories in the Center for Regenerative Medicine, Harvard Stem Cell Institute, and MGH research communities at an affordable rate. The Core''s equipment and highly trained operators provide an advanced level of sorting and analysis services to its investigators. Additionally, the Core is dedicated to training users on all aspects of flow cytometry, including practical issues, information about specific applications, and critical interpretation of sorting results. The Core''s three full-time staff members strive to ensure that each investigator''s visit benefits their individual experiments to the greatest extent possible. To ensure the best availability to all users, the Core offers an online scheduling system, and provides extended sorting hours until late evening. HSCI faculty have reduced pricing for use of the Core''s services.

Proper citation: MGH HSCI-CRM Flow Cytometry Core Facility (RRID:SCR_009923) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000139-53f7-02d1-9072-1e4280000000

Core facility that provides the following services: Flow Cytometric Cell Sorting. The mission of Ragon Institute Imaging Core, Flow Cytometry Division is to provide training and access to flow cytometers with up to 18 parameters, as well as cell sorting of biohazardous samples. As an MGH Core Facility, the Ragon Institute Imaging Core serves the greater MGH community. Since the Ragon Institute is also a collaboration between MGH, Harvard, and MIT, so too does the facility welcome members of the MIT and Harvard communities. The facility is equipped with three LSR2?s, an LSR Fortessa, a FACSCalibur, and a FACSAria IIu cell sorter in a biosafety cabinet. The core also serves as a resource for addressing a variety of flow cytometry needs including consultation on topics related to experimental design and sample preparation.

Proper citation: Ragon Institute Imaging Core Flow Cytometry (RRID:SCR_010056) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000139-4f2c-8328-4d8e-943b80000000

Core facility that provides the following services: Microscopy Instrumentation Access, Training in Microscopy/Imaging, Assisted Microscopy. The mission of Ragon Institute Imaging Core, Microscopy Division is to bring the latest imaging modalities and technology to bear on fundamental molecular and cell biological questions pertaining to infectious diseases. As an MGH Core Facility, the Ragon Institute Imaging Core also serves the MGH greater MGH community. Since the Ragon Institute is also a collaboration between MGH, Harvard, and MIT, so too does the facility welcome members of the MIT and Harvard communities as we are now located in Cambridge at MIT. The facility encompasses five imaging systems, including a Zeiss LSM510 laser scanning confocal microscope and a fully automated Zeiss Axio Observer microscope, both housed in BL2+ compliant facilities. These imaging systems are therefore fully equipped for both fixed and live cell imaging. In addition, the facility has two slide scanning systems (MIRAX MIDI and TissueFAXS) for high speed automated imaging and cellular screening of tissue sections and cultured cells on glass slides. In the Flow Cytometry section of the Imaging Core, we also have an ImageStream X Mark II by Amnis. The core also serves as a resource for addressing a variety of imaging needs including consultation on a topics related to imaging applications, experimental design, and sample preparation.

Proper citation: Ragon Institute Imaging Core Microscopy (RRID:SCR_010058) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6e60-8691-55da-381e80000000

Core facility that provides the following services: Website development and hosting for research labs and studies requiring an online presence, interactive functionality, or site traffic tracking.

The Health Communication Core offers a full range of creative communication services to support evidence-based recruitment and retention of study participants and intervention research. HCC serves researchers from diverse disciplines who need websites, logos, brochures, social media campaigns, publications, and interactive media targeted to the needs and preferences of specific audiences.

Proper citation: DF/HCC Health Communication Core (RRID:SCR_000871) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/bauer-core-laboratory-fas-harvard

Core facility that provides the following services: Liquid handling, Long read sequencing, Cell sorting service, Cell analysis service, Imaging systems service, Microarrays service, Sequencing service, Genotyping service, Fragment analysis, Solexa DNA sequencing service, Solexa gene expression service, Solexa small RNA service, Solexa ChIP-Seq service, Real-time quantitative PCR service, Protein-molecule interaction service, Library replication service, Nucleic acid isolation service, Nucleic acid shearing service, DNA, RNA and protein sample analysis service. Their goal is to advance research efforts in the life sciences that cannot readily be accomplished in the traditional academic laboratory because of a need for expensive instrumentation or automation, scientific or organizational infrastructure, or multidisciplinary expertise. To promote cutting-edge research and to foster scientific collaborations, we make our extensive laboratory and computational resources available to scientists at Harvard. Our technical staff provide expertise and hands-on training in protocols and the use of instrumentation for a nominal fee. Researchers can sign up to use the instrumentation through an on-line scheduling system and conduct their experiments independently.

Proper citation: Harvard FAS Bauer Core Laboratory (RRID:SCR_001031) Copy   

•   Source: SciCrunch Registry

https://childrenshospital.corefacilities.org/service_center/show_external/3145

Core with advanced instrumentation in Light and Electron Microscopy.Core provides confocal, multiphoton microscopy,electron microscopy,image analysis.

Proper citation: Harvard Medical School PCMM Microscopy Core Facility (RRID:SCR_018822) Copy   

•   Source: SciCrunch Registry

http://www.hms.harvard.edu/research/brain/atlas.html

2D mouse brain atlas of high quality coronal Nissl- and myelin-stained sections with labels, 3D images of hippocampal formation and limited other brain structures. The data for this digital atlas are based on the Atlas of the Mouse Brain and Spinal Cord, authored by Richard L. Sidman, Jay. B. Angevine and Elizabeth Taber Pierce, published as a hard cover book by Harvard University Press in 1971 and currently out of print. C57BL/6J strain adult specimens were used in creating the atlas.

Proper citation: High Resolution Mouse Brain Atlas (RRID:SCR_006063) Copy   

•   Source: SciCrunch Registry

http://antibodyregistry.org

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 4th,2023. It was integrated with Antibody Registry. The JCN antibody database is a listing of all antibodies used in JCN papers from 2006 onward. The catalog numbers and vendor information is included for all antibodies listed, and with a new collaboration with NIF''''s AntibodyRegistry, a unique identifier is also listed for each antibody. The Journal of Comparative Neurology requires rigorous characterization for all antibodies that are used in JCN papers. The antibodies in the The Journal of Comparative Neurology antibody database have in nearly all cases been described and characterized adequately according to the provided guidelines. This information can be used to identify a particular target immunohistochemically or to design an experiment using the antibody information. If you are looking for an antibody to identify a particular target immunohistochemically, this list is a good place to begin your search. We suggest you then look up the paper in which the antibody was used, to make sure that it will meet your needs and to verify its characterization. (The characterization of antibodies in JCN papers often goes well beyond the material published by the manufacturer, so that examining this information before you order an antibody can be very useful.) While we do not guarantee that these antibodies will identify only the intended target (that is a function of the actual experiment and controls), this is the most carefully verified list of antibodies that we are aware of, and we wanted to share this resource with our readers and authors.

Proper citation: Journal of Comparative Neurology Antibody database (RRID:SCR_006470) Copy   

•   Source: SciCrunch Registry

http://www.strokedatabase.org/

Database and associated software tools providing access to clinical and research data on stroke, including deidentified patient data. Data types include imaging (e.g. CT, MRI, PET), clinical demographic data, genetic data, simulation perfusion data for verifying deconvolution algorithms used in bolus-tracking perfusion-weighted imaging (PWI). Also available are programs for performing deconvolution of bolus-tracking PWI, DTI tractography and an automated program for etiologic classification of ischemic stroke -- Causative Classification System for Ischemic Stroke (CCS)

Proper citation: International Stroke Database (RRID:SCR_007347) Copy   

•   Source: SciCrunch Registry

https://data.broadinstitute.org/chembank/assay

ChemBank is a public, web-based informatics environment that includes freely available data derived from small molecules and small-molecule screens, and resources for studying the data so that biological and medical insights can be gained. ChemBank is intended to guide chemists synthesizing novel compounds or libraries, to assist biologists searching for small molecules that perturb specific biological pathways, and to catalyze the process by which drug hunters discover new and effective medicines. ChemBank stores an increasingly varied set of cell measurements derived from, among other biological objects, cell lines treated with small molecules. Analysis tools are available and are being developed that allow the relationships between cell states, cell measurements and small molecules to be determined. Currently, ChemBank stores information on hundreds of thousands of small molecules and hundreds of biomedically relevant assays that have been performed at the ICG in collaborations involving biomedical researchers worldwide. These scientists have agreed to perform their experiments in an open data-sharing environment. The goals of ChemBank are to provide life scientists unfettered access to biomedically relevant data and tools heretofore available almost exclusively in the private sector. We intend for ChemBank to be a planning and discovery tool for chemists, biologists, and drug hunters anywhere, with the only necessities being a computer, access to the Internet, and a desire to extract knowledge from public experiments whose greatest value is likely to reside in their collective sum.

Proper citation: ChemBank (RRID:SCR_007592) Copy   

•   Source: SciCrunch Registry

http://arep.med.harvard.edu/dpinteract/

DPInteract is a database of DNA-binding site matrices. This dataset is being collected with several purposes in mind: 1. Cataloging demonstrated sites and non-sites for E.coli DNA-binding proteins; 2. Aiding the annotation of such sites in other E.coli databases and sequence entries; 3. Interpreting the results of whole-genome in vivo methylation protection experiments; 4. Developing better computational tools for recognizing DNA binding proteins in sequence data.

Proper citation: DPInteract (RRID:SCR_007627) Copy   

•   Source: SciCrunch Registry

http://bio.dfci.harvard.edu/DFRMLI/

This repository contains full data from MHCPEP database, and selected data including independent data sets of proteins and protein fragments, non-binding peptides, lists of T-cell epitopes, and recommendations for scaling and comparison of performance of prediction systems. It can be used in conjunction with IEDB data sets for the development of advanced machine learning and pattern recognition solutions.

Proper citation: MHCPEP (RRID:SCR_007786) Copy   

•   Source: SciCrunch Registry

https://www.minerva.im/

Software tools for interactive viewing and fast sharing of large image data. Comprises Minerva Author, a tool to create and annotate images, and Minerva Story, a narrative image viewer for web hosting. Used for interpreting and interacting with complex images, organized around guided analysis approach. Enables fast sharing of large image data that is stored on Amazon S3 and viewed using zoomable image viewer implemented using OpenSeadragon, making it ideal for integration into multi-omic browsers for data dissemination of tissue atlases.

Proper citation: Minerva (RRID:SCR_024750) Copy   

•   Source: SciCrunch Registry