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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
T-Coffee
 
Resource Report
Resource Website
1000+ mentions
T-Coffee (RRID:SCR_011818) T-Coffee analysis service resource, data analysis service, production service resource, service resource A multiple sequence alignment server which can align Protein, DNA and RNA sequences. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
has parent organization: Center for Genomic Regulation; Barcelona; Spain
PMID:10964570
DOI:10.1006/jmbi.2000.4042
biotools:tcoffee, OMICS_00989 https://bio.tools/tcoffee, https://sources.debian.org/src/t-coffee/ SCR_011818 T-Coffee: Aligns DNA RNA or Proteins using the default T-Coffee 2026-09-19 12:57:25 1157
ProbCons
 
Resource Report
Resource Website
100+ mentions
ProbCons (RRID:SCR_011813) ProbCons analysis service resource, data analysis service, production service resource, service resource Efficient protein multiple sequence alignment program, which has demonstrated a statistically significant improvement in accuracy compared to several leading alignment tools. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
has parent organization: Stanford University; Stanford; California
PMID:15687296
DOI:10.1101/gr.2821705
OMICS_00986, biotools:probcons https://bio.tools/probcons, https://sources.debian.org/src/probcons/ SCR_011813 ProbCons: Probabilistic Consistency-based Multiple Alignment of Amino Acid Sequences 2026-09-19 12:57:25 109
Genome Database for Rosaceae
 
Resource Report
Resource Website
500+ mentions
Genome Database for Rosaceae (RRID:SCR_012756) data or information resource, database GDR is a curated and integrated web-based relational database. GDR contains comprehensive data of the genetically anchored peach physical map, annotated EST databases of apple, peach, almond, cherry, rose, raspberry and strawberry, Rosaceae maps and markers and all publicly available Rosaceae sequences. Annotations of ESTs include contig assembly, putative function, simple sequence repeats, ORFs, Gene Ontology and anchored position to the peach physical map where applicable. Our integrated map viewer provides graphical interface to the genetic, transcriptome and physical mapping information. We continue to add Rosaceae map data to CMap, a web-based tool that allows users to view comparisons of genetic and physical maps. ESTs, BACs and markers can be queried by various categories and the search result sites are linked to the integrated map viewer or to the WebFPC physical map sites. In addition to browsing and querying the database, users can compare their sequences with the annotated GDR sequences via a dedicated sequence similarity server running either the BLAST or FASTA algorithm, search their sequences for microsatellites using the SSR server or assemble their ESTs using the CAP3 Server. est, genome sequence, rosaceae, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
has parent organization: Washington State University; Washington; USA
nif-0000-02896, biotools:gdr https://bio.tools/gdr http://www.bioinfo.wsu.edu/gdr/ SCR_012756 GDR 2026-09-19 12:57:27 662
CleanEx
 
Resource Report
Resource Website
10+ mentions
CleanEx (RRID:SCR_012911) data or information resource, database CleanEx is a database which provides access to public gene expression data via unique approved gene symbols and which represents heterogeneous expression data produced by different technologies in a way that facilitates joint analysis and cross-dataset comparisons. To achieve this goal, each single gene expression experiment is regularly mapped on a permanent target identifier consisting of a physical description of the targeted RNA. There is one entry per gene. To have a complete view of the transcript and its product, we also link each entry to the corresponding protein. We further provide the genomic position of the transcription start site from EPD, when available. Otherwise we give the annotated start site position in Ensembl. gene expression, data comparison, heterogeneous expression, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: SIB Swiss Institute of Bioinformatics
nif-0000-02667, biotools:cleanex https://bio.tools/cleanex SCR_012911 CleanEx 2026-09-19 12:57:27 29
FGENESH
 
Resource Report
Resource Website
100+ mentions
FGENESH (RRID:SCR_011928) FGENESH analysis service resource, data analysis service, production service resource, service resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 10,2020. Data analysis service for Hidden Markov Model (HMM)-based gene structure prediction (multiple genes, both chains). bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
THIS RESOURCE IS NO LONGER IN SERVICE biotools:fgenesh, OMICS_01483 https://bio.tools/fgenesh SCR_011928 2026-09-19 12:57:25 330
HSLPred
 
Resource Report
Resource Website
HSLPred (RRID:SCR_011972) HSLPred analysis service resource, data analysis service, production service resource, service resource A support vector machine (SVM)-based method for the prediction of 4 major subcellular localization (cytoplasm, mitochondrial, nuclear and plasma membrane) of human proteins using various features such as i) amino acid composition, ii) dipeptide composition and iii) evolutionary information of proteins. subcellular localization, protein, support vector machine, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Institute of Microbial Technology; Chandigarh; India
PMID:15647269 Acknowledgement requested biotools:hslpred, OMICS_01622 https://bio.tools/hslpred SCR_011972 HSLPred - A SVM-based Method for Subcellular Localization of Human Proteins 2026-09-19 12:57:26 0
MBGD - Microbial Genome Database
 
Resource Report
Resource Website
50+ mentions
MBGD - Microbial Genome Database (RRID:SCR_012824) data or information resource, database MBGD is a database for comparative analysis of completely sequenced microbial genomes, the number of which is now growing rapidly. The aim of MBGD is to facilitate comparative genomics from various points of view such as ortholog identification, paralog clustering, motif analysis and gene order comparison. The heart of MBGD function is to create orthologous or homologous gene cluster table. For this purpose, similarities between all genes are precomputed and stored into the database, in addition to the annotations of genes such as function categories that were assigned by the original authors and motifs that were found in the translated sequence. Using these homology data, MBGD dynamically creates orthologous gene cluster table. Users can change a set of organisms or cutoff parameters to create their own orthologous grouping. Based on this cluster table, users can further analyze multiple genomes from various points of view with the functions such as global map comparison, local map comparison, multiple sequence alignment and phylogenetic tree construction. bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
has parent organization: National Institute for Basic Biology; Okazaki; Japan
nif-0000-03105, biotools:mbgd https://bio.tools/mbgd SCR_012824 MBGD 2026-09-19 12:57:27 62
Mouse Genome Database
 
Resource Report
Resource Website
500+ mentions
Mouse Genome Database (RRID:SCR_012953) MGD data or information resource, database Community model organism database for laboratory mouse and authoritative source for phenotype and functional annotations of mouse genes. MGD includes complete catalog of mouse genes and genome features with integrated access to genetic, genomic and phenotypic information, all serving to further the use of the mouse as a model system for studying human biology and disease. MGD is a major component of the Mouse Genome Informatics.Contains standardized descriptions of mouse phenotypes, associations between mouse models and human genetic diseases, extensive integration of DNA and protein sequence data, normalized representation of genome and genome variant information. Data are obtained and integrated via manual curation of the biomedical literature, direct contributions from individual investigators and downloads from major informatics resource centers. MGD collaborates with the bioinformatics community on the development and use of biomedical ontologies such as the Gene Ontology (GO) and the Mammalian Phenotype (MP) Ontology. gene, genome, genetic, chromosome, clone, cytogenetic, dna, genomic, inbred, mammalian, mouse, mutant, ortholog, phenotype, primer, protein, reagent, sequence, strain, bio.tools is used by: DisGeNET
is listed by: Debian
is listed by: bio.tools
is related to: Mouse Genome Informatics (MGI)
has parent organization: Jackson Laboratory
NHGRI HG000330 PMID:21051359 biotools:mgi, biotools:mgd, nif-0000-10301 http://www.informatics.jax.org/mgihome/projects/overview.shtml, https://bio.tools/mgd, https://bio.tools/mgi SCR_012953 Mouse Genome Informatics: Mouse Genome Database, MGID, Mouse Genome Informatics Database 2026-09-19 12:57:27 545
PREDDIMER
 
Resource Report
Resource Website
10+ mentions
PREDDIMER (RRID:SCR_011963) PREDDIMER analysis service resource, data analysis service, production service resource, service resource Prediction tool to reconstruct putative dimer conformations for given sequences of transmembrane protein fragments, which are considered as ideal alpha-helices. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:24202542 Free OMICS_01614, biotools:preddimer https://bio.tools/preddimer SCR_011963 PREDDIMER - Prediction tool for an ensemble of transmembrane ?-helical dimer conformations 2026-09-19 12:57:26 15
psRNATarget
 
Resource Report
Resource Website
1000+ mentions
psRNATarget (RRID:SCR_013321) psRNATarget analysis service resource, data analysis service, production service resource, service resource A plant small RNA target analysis server which features two important analysis functions: 1) reverse complementary matching between miRNA and target transcript using a proven scoring schema, and 2) target site accessibility evaluation by calculating unpaired energy (UPE) required to ?open? secondary structure around miRNA?s target site on mRNA. PsRNATarget incorporates recent discoveries in plant miRNA target recognition, e.g. it distinguishes translational and post-transcriptional inhibition, and it reports the number of miRNA/target site pairs that may affect miRNA binding activity to target transcript. PsRNATarget is designed for high-throughput analysis of next-generation data with an efficient distributed computing back-end pipeline that runs on a Linux cluster. The server front-end integrates three simplified user-friendly interfaces to accept user-submitted or preloaded miRNAs and transcript sequences; and outputs a comprehensive list of miRNA / target pairs along with the online tools for batch downloading, key word searching and results sorting., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Samuel Roberts Noble Foundation
PMID:21622958 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_00414, biotools:psrnatarget https://bio.tools/psrnatarget SCR_013321 psRNATarget: A Plant Small RNA Target Analysis Server 2026-09-19 12:57:29 1117
MINAS - Metal Ions in Nucleic AcidS
 
Resource Report
Resource Website
1+ mentions
MINAS - Metal Ions in Nucleic AcidS (RRID:SCR_013145) MINAS data or information resource, database Database compiling the detailed information on innersphere, outersphere and larger coordination environment of >70,000 metal ions of 36 elements found in >2000 structures of nucleic acids contained today in the PDB and NDB. MINAS is updated monthly with new structures and offers a multitude of search functions, e.g. the kind of metal ion, metal-ligand distance, innersphere and outersphere ligands defined by element or functional group, residue, experimental method, as well as PDB entry-related information. The results of each search can be saved individually for later use with so-called miniPDB files containing the respective metal ion together with the coordination environment within a 15 A radius. MINAS thus offers a unique way to explore the coordination geometries and ligands of metal ions together with the respective binding pockets in nucleic acids. metal ion, binding pocket, nucleic acid, metal-ligand distance, innersphere ligand, outersphere ligand, ligand, element, functional group, residue, protein databank, bio.tools is listed by: 3DVC
is listed by: Debian
is listed by: bio.tools
is related to: Nucleic Acid Database
is related to: Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB)
has parent organization: University of Zurich; Zurich; Switzerland
Swiss National Science Foundation PP002-68733/1 PMID:22096233 nlx_151459, biotools:minas https://bio.tools/minas SCR_013145 Metal Ions in Nucleic AcidS, MINAS - A Database of Metal Ions in Nucleic AcidS 2026-09-19 12:57:28 5
GENSCAN
 
Resource Report
Resource Website
500+ mentions
GENSCAN (RRID:SCR_013362) genscan analysis service resource, data analysis service, production service resource, service resource Web server for identification of complete gene structures in genomic DNA.Tool for predicting locations and exon-intron structures of genes in genomic sequences from variety of organisms. Used for prediction of complete gene structures in human genomic DNA. complete gene structures identyfication, genomic DNA, predicting locations, exon-intron structures, genomic sequences, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: Stanford University; Stanford; California
has parent organization: Massachusetts Institute of Technology; Massachusetts; USA;
PMID:9149143 Restricted biotools:genscan, OMICS_01494 https://bio.tools/genscan SCR_013362 GENSCAN Web Server at MIT 2026-09-19 12:57:30 772
eProbalign
 
Resource Report
Resource Website
eProbalign (RRID:SCR_013247) analysis service resource, data analysis service, production service resource, service resource Data analysis service that computes maximal expected accuracy multiple sequence alignments from partition function posterior probabilities. multiple sequence alignments, partition function posterior probabilities, bio.tools uses: Probalign
is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: New Jersey Institute of Technology; New Jersey; USA
NIGMS R01 GM073082 PMID:17485479 OMICS_00975, biotools:eprobalign https://bio.tools/eprobalign SCR_013247 eProbalign web server, EProbalign 2026-09-19 12:57:29 0
SYFPEITHI: A Database for MHC Ligands and Peptide Motifs
 
Resource Report
Resource Website
100+ mentions
SYFPEITHI: A Database for MHC Ligands and Peptide Motifs (RRID:SCR_013182) SYFPEITHI data or information resource, database SYFPEITHI is a database comprising more than 7000 peptide sequences known to bind class I and class II MHC molecules. The entries are compiled from published reports only. It contains a collection of MHC class I and class II ligands and peptide motifs of humans and other species, such as apes, cattle, chicken, and mouse, for example, and is continuously updated. Searches for MHC alleles, MHC motifs, natural ligands, T-cell epitopes, source proteins/organisms and references are possible. Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are available for a number of MHC allelic products. The database is based on previous publications on T-cell epitopes and MHC ligands. It contains information on: -Peptide sequences -anchor positions -MHC specificity -source proteins, source organisms -publication references Since the number of motifs continuously increases, it was necessary to set up a database which facilitates the search for peptides and allows the prediction of T-cell epitopes. The prediction is based on published motifs (pool sequencing, natural ligands) and takes into consideration the amino acids in the anchor and auxiliary anchor positions, as well as other frequent amino acids. The score is calculated according to the following rules: The amino acids of a certain peptide are given a specific value depending on whether they are anchor, auxiliary anchor or preferred residue. Ideal anchors will be given 10 points, unusual anchors 6-8 points, auxiliary anchors 4-6 and preferred residues 1-4 points. Amino acids that are regarded as having a negative effect on the binding ability are given values between -1 and -3. Sponsors: SYFPEITHI is supported by DFG-Sonderforschungsbereich 685 and theEuropean Union: EU BIOMED CT95-1627, BIOTECH CT95-0263, and EU QLQ-CT-1999-00713. epitope, allele, allelic, amino acid, ape, bind, cattle, chicken, class i, class ii, human, immunological database, ligand, mhc, molecule, motif, mouse, natural, organism, peptide, product, protein, sequence, specie, t-cell, bio.tools, FASEB list is listed by: bio.tools
is listed by: Debian
has parent organization: University of Tubingen; Tubingen; Germany
nif-0000-21383, biotools:syfpeithi https://bio.tools/syfpeithi SCR_013182 SYFPEITHI 2026-09-19 12:57:28 269
Cube-DB
 
Resource Report
Resource Website
1+ mentions
Cube-DB (RRID:SCR_013233) Cube-DB data or information resource, database Cube-DB is a database of pre-evaluated conservation and specialization scores for residues in paralogous proteins belonging to multi-member families of human proteins. Protein family classification follows (largely) the classification suggested by HUGO Gene Nomenclature Committee. Sets of orhtologous protein sequences were generated by mutual-best-hit strategy using full vertebrate genomes available in Ensembl. The scores, described on documentation page, are assigned to each individual residue in a protein, and presented in the form of a table (html or downloadable xls formats) and mapped, when appropriate, onto the related structure (Jmol, Pymol, Chimera). protein, functional divergence, vertebrate, genome, ortholog, protein sequence, data set, bio.tools is listed by: 3DVC
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioinformatics Institute; Singapore; Singapore
PMID:22139934 nlx_149432, biotools:cube-db https://bio.tools/cube-db SCR_013233 Cube-DB: Detection of Functional Divergence in Human Protein Families 2026-09-19 12:57:29 3
e-Driver
 
Resource Report
Resource Website
1+ mentions
e-Driver (RRID:SCR_002674) software application, software resource, standalone software Software tool to identify cancer driver genes based on linear annotations of biological regions such as protein domains.Uses information on three-dimensional structures of mutated proteins to identify specific structural features. Then algorithm analyzes whether these features are enriched in cancer somatic mutations and are candidate driver genes. Identify cancer driver genes, candidate driver genes, perl, protein, mutated proteins, cancer somatic mutations, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
Cancer PMID:25064568 Free, Available for download, Freely available biotools:e-Driver, OMICS_05288 https://bio.tools/e-Driver SCR_002674 2026-09-19 12:57:46 5
MRFSEQ
 
Resource Report
Resource Website
MRFSEQ (RRID:SCR_002972) algorithm resource, software resource Algorithm based on a Markov random field (MRF) model that uses additional gene coexpression data to enhance differential gene expression prediction power. It is able to call differentially expressed (DE) genes but also assign confidence scores to each inferred DE gene. markov, algorithm, gene expression, prediction algorithm, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of California at Riverside; California; USA
PMID:23793751 Free, Available for download, Freely available biotools:mrfseq, OMICS_01309 https://bio.tools/mrfseq SCR_002972 2026-09-19 12:57:46 0
IgBLAST
 
Resource Report
Resource Website
500+ mentions
IgBLAST (RRID:SCR_002873) software application, software resource THIS RESOURCE IS NO LONGER IN SERVICE.Documented on January 4,2023. IgBLAST was developed at NCBI to facilitate analysis of immunoglobulin V region sequences in GenBank. In addition to performing a regular BLAST search, IgBLAST has several additional functions: - Reports the germline V, D and J gene matches to the query sequence. - Annotates the immunoglobulin domains (FWR1 through FWR3). - Matches the returned hits (for databases other than germline genes) to the closest germline V genes, making it easier to identify related sequences. - Reveals the V(D)J junction details such as nucleotide homology between the ends of V(D)J segments and N nucleotide insertions. D and J gene reporting is only for nucleotide sequence search and requires a stretch of five or more nucleotide identity between the query and D or J genes. Sponsors: This resource is supported by the National Center for Biotechnology Information, a division of the U.S. National Library of Medicine. gene, analysis, domain, homology, immunoglobulin v, nucleotide, sequence, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
has parent organization: NCBI
PMID:23671333 Free, Freely available nif-0000-25554, biotools:igblast, OMICS_06083 https://bio.tools/igblast, https://sources.debian.org/src/ncbi-igblast/ SCR_002873 IgBLAST 2026-09-19 12:57:46 625
GoSurfer
 
Resource Report
Resource Website
1+ mentions
GoSurfer (RRID:SCR_005789) GoSurfer software application, software resource GoSurfer uses Gene Ontology (GO) information to analyze gene sets obtained from genome-wide computations or microarray analyses. GoSurfer is a graphical interactive data mining tool. It associates user input genes with GO terms and visualizes such GO terms as a hierarchical tree. Users can manipulate the tree output by various means, like setting heuristic thresholds or using statistical tests. Significantly important GO terms resulted from a statistical test can be highlighted. All related information are exportable either as texts or as graphics. Platform: Windows compatible gene, gene ontology, genome-wide, microarray, graph, data mining, statistical analysis, bioinformatics, genomics, gene cluster, multiple hypothesis testing, false discovery rate, bio.tools is listed by: Gene Ontology Tools
is listed by: Debian
is listed by: bio.tools
is related to: Gene Ontology
has parent organization: University of Illinois at Urbana-Champaign; Illinois; USA
has parent organization: Harvard T.H. Chan School of Public Health
PMID:15702958 Free for academic use biotools:gosurfer, nlx_149268 http://www.gosurfer.org, https://bio.tools/gosurfer http://bioinformatics.bioen.illinois.edu/gosurfer/index.htm SCR_005789 2026-09-19 12:57:51 2
BOMP: beta-barrel Outer Membrane protein Predictor
 
Resource Report
Resource Website
1+ mentions
BOMP: beta-barrel Outer Membrane protein Predictor (RRID:SCR_007268) software application, software resource BOMP is a tool for prediction of beta-barrel integral outer membrane proteins. The user may submit a list of proteins, and receive a list of predicted BOMPs. The program, called the beta-barrel Outer Membrane protein Predictor (BOMP), is based on two separate components to recognize integral beta-barrel proteins. The first component is a C-terminal pattern typical of many integral beta-barrel proteins. The second component calculates an integral beta-barrel score of the sequence based on the extent to which the sequence contains stretches of amino acids typical of transmembrane -strands. To use the BOMP tool simply paste your fasta-formatted sequences into the text area, or choose a file which contains sequences. Then hit the submit button. It is possible to perform a BLAST search parallel with the predictions, which may be suitable in some cases. Using the BLAST search will however increase the running time substantially. Sponsors: This work was supported in part by grants from the Norwegian Research Council [SUP 140785/420 (GABI); FUGE/CBU151899/ISO], and the Meltzer Foundation, University of Bergen. Keywords: Beta-barrel, Membrane, Protein, Program, Software, Beta strand, Bacteria, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: University of Bergen; Bergen; Norway
biotools:bomp, nif-0000-30236 https://bio.tools/bomp SCR_007268 BOMP Program 2026-09-19 12:57:54 5

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