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https://www.brown.edu/research/facilities/structural-biology/

Core provides equipment used for structural modeling in crystals and in solution, using X-ray diffraction and scattering, as well as magnetic resonance.

Proper citation: Brown University Structural Biology Core Facility (RRID:SCR_017900) Copy   

•   Source: SciCrunch Registry

http://www.lrgc.ca/

Core provides Next Generation Sequencing and Bioinformatics services.Services include:RNA assessment using Agilent 2100 Bioanalyzer,Next Generation Sequencing:Single cell RNA-seq,DNA-seq,RNA-seq,miRNA-seq,ChIP-seq,Microbiome (16S rRNA),ATAC-seq,Data Analysis (Partek Flow, Transcription Analysis Console).

Proper citation: London Regional Genomics Centre Core Facility (RRID:SCR_017865) Copy   

•   Source: SciCrunch Registry

http://cryogenics.facilities.northwestern.edu/

Facility provides liquid helium and liquid nitrogen to researchers and laboratories at Northwestern University.

Proper citation: Northwestern University Cryogenics Core Facility (RRID:SCR_017869) Copy   

•   Source: SciCrunch Registry

http://biolchem.bs.jhmi.edu/tssf/

Core provides services including Peptide Synthesis and Purification,Protein/Peptide Sequence Analysis,DNA Synthesis and Purification,Sanger DNA Sequencing,Next Generation Sequencing.

Proper citation: Johns Hopkins University School of Medicine Synthesis and Sequencing Core Facility (RRID:SCR_017908) Copy   

•   Source: SciCrunch Registry

http://sites.northwestern.edu/stemcell/

Core provides iPSC technology services.Specialize in creating custom patient-derived iPSCs, providing training in stem cell culture, project consultation, CRISPR gene editing services, cell banking, and facility usage.

Proper citation: Northwestern University Stem Cell Core Facility (RRID:SCR_017873) Copy   

•   Source: SciCrunch Registry

http://rppc.mccormick.northwestern.edu/

Core provides quality controlled recombinant proteins. rPPC operates based on the two service models: Training model where Northwestern researchers use specialized bioreactor systems and participate in hands-on-training activities and Production model where staff carry out expression (mg to gm scale) and purification of recombinant or synthetic biologics, including potential therapeutic proteins and peptides, among others. Main focus of rPPC is to be user-facility;facility has parallel bioreactor systems for multiplexed lab-scale cultivation of microbial, insect, and mammalian cells. rPPC also serves as a production facility, providing low-cost recombinant biologics for researchers at Northwestern University.Services include: TRANSFECTION/TRANSFORMATION, ANALYTICAL (SMALL SCALE) EXPRESSION IN E.COLI AND MAMMALIAN CELLS,PROTEIN EXPRESSION IN E. COLI (LARGE SCALE),PROTEIN EXPRESSION IN MAMMALIAN CELL SYSTEM (LARGE SCALE),PROTEIN EXPRESSION IN INSECT CELL SYSTEM,GENERATION OF MOUSE HYBRIDOMA, PRODUCING MONOCLONAL ANTIBODIES, per one fusion,RESCUING AND CULTIVATING EUKARYOTIC CELLS,DOWNSTREAM PROCESSING OF GROWN CULTURE (BEFORE PROTEIN PURIFICATION),RECOMBINANT PROTEIN PURIFICATION,TAG CLEAVAGE WITH TEV. PROTEASE,LARGE SCALE mAb PRODUCTION ,DNA PLASMID PROPAGATION AND PURIFICATION,SDS-PAGE ANALYSIS,WESTERN BLOT ANALYSIS, INSTRUMENT TIME SHARING TECHNICAL/INSTRUMENT ASSISTANCE TIME,PROTEIN RECOVERING FROM INCLUSION BODIES.

Proper citation: Northwestern University Recombinant Protein Production Core Facility (RRID:SCR_017872) Copy   

•   Source: SciCrunch Registry

https://www.brown.edu/research/facilities/proteomics/

Core provides instrumentation and proteomics expertise to Brown University and Rhode Island-EPSCoR scientific communities and training in emerging proteomic techniques. Mass Spectrometry proteomics resources and services are provided by COBRE Center for Cancer Research Development (CCRD) at Rhode Island Hospital: Proteomics Core.

Proper citation: Brown University Division of Biology and Medicine Proteomics Shared Resource Core Facility (RRID:SCR_017910) Copy   

•   Source: SciCrunch Registry

http://mousebiology.org

Core located on campus of UC Davis, providing fully customized support for scientific research using genetically altered mice. Provides access to develop, plan, execute, and analyze research project involving genetically-altered mice. Provides description of project, including alternative approaches, accurate timelines, and cost estimates.Provides regular and informative communication throughout project, including email updates on completion of each milestone. Project progress can be followed at each stage by viewing detailed information anytime by accessing our online and secure project tracking system (PTS) available 24 hours a day.

Proper citation: University of California-Davis Mouse Biology Program CRISPR Based Genome Editing Service Core Facility (RRID:SCR_017851) Copy   

•   Source: SciCrunch Registry

http://www.mskcc.org/research/molecular-cytogenetics

Core supports cytogenetic analysis of cells from human and research animal sources. Range of chromosome analysis techniques are ranging from basic G-banded karyotyping, to 24-color Spectral Karyotyping (SKY), as well as Fluorescence in situ Hybridization (FISH) mapping of cloned DNAs.Services include:Karyotype characterization of new cell lines,Confirmation of cell line identity or stability,Karyotype screening of ES cells prior to transgenesis,Mapping of transgene integration sites,Chromosome or locus copy number enumeration,Publication-quality illustrations.Cytogenetic techniques available:Short-term cell culture,Metaphase chromosome preparation,G-banded karyotyping.FISH techniques available:DNA labeling for custom probe generation (for FISH projects),DNA amplification by DOP-PCR,Chromosome painting,FISH mapping (on chromosomes, interphase nuclei or DNA fibers),Tissue FISH (paraffin or frozen sections),Immuno-FISH (DNA FISH combined with fluorescent immunostaining) , Spectral karyotyping (SKY),Q-FISH (measurement of telomere lengths).

Proper citation: Memorial Sloan Kettering Cancer Center Molecular Cytogenetics Core Facility (RRID:SCR_017850) Copy   

•   Source: SciCrunch Registry

https://nyumc.ilab.agilent.com/service_center/show_external/4440?name=preclinical-imaging-laboratory

Core provides investigators with access to imaging technologies and strategies to image live animals on organ, tissue, cell, or molecular level.Core for studying and monitoring disease in small living subjects.Performs noninvasive and nonlethal three-dimensional imaging. Equipped with instruments for micromagnetic resonance imaging, micropositron emission tomography, X-ray microcomputed tomography, bioluminescence and fluorescence scanning, and high-frequency ultrasound.

Proper citation: New York University School of Medicine Langone Health Preclinical Imaging Laboratory (RRID:SCR_017937) Copy   

•   Source: SciCrunch Registry

https://med.nyu.edu/research/scientific-cores-shared-resources/metabolomics-laboratory

Core offers custom metabolomics services,specializes in mass spectrometry based metabolomics, offering global (untargeted) and targeted methods for metabolite identification and quantification.Commonly assayed targets include glycolytic and tricarboxylic acid (TCA) cycle intermediates, amino acids, nucleotides, and lipids. Using custom-targeted method, we can perform absolute or relative quantification, flux analysis, and biotransformation analysis.

Proper citation: New York University School of Medicine Langone Health Metabolomics Laboratory Core Facility (RRID:SCR_017935) Copy   

•   Source: SciCrunch Registry

https://med.nyu.edu/research/scientific-cores-shared-resources/microscopy-laboratory

Core offers comprehensive light and electron microscopy technologies. Our scientists use light microscopes and electron microscopes at resolutions ranging from centimeters to angstroms, providing clear and detailed images.We assist at every stage of your experiment, offering research-design consultation and instrument training, as well as guidance in study execution, analysis, and presentation for publication.

Proper citation: New York University School of Medicine Langone Health Microscopy Laboratory Core Facility (RRID:SCR_017934) Copy   

•   Source: SciCrunch Registry

http://nau.edu/enggen

Core facility for genomics research offers range of DNA sequencing, assistance and advising in planning, data acquisition, and data analysis. Provides genetic and genomic support to environmental and biomedical research projects. Creates education and training opportunities for students and professionals.

Proper citation: Northern Arizona University Environmental Genetics and Genomics Laboratory (RRID:SCR_017939) Copy   

•   Source: SciCrunch Registry

https://labs.gladstone.org/histology/index.html

Core provides technical assistance, training, consultation and assistance with all aspects of experimental design, sample preparation, image processing, and data analysis to scientists from Gladstone, UCSF, and Bay Area scientific community. Core is equipped with expertise in histological techniques including complex immunolabeling and histological image analysis, high-resolution imaging, confocal microscopy, light-sheet microscopy, spinning disk microscopy, and optical projection tomography and advanced image analysis.Histology Services includeTissue dissection and fixation, Paraffin processing and embedding,Frozen (cryo) processing and embedding,Tissue sectioning,Section staining.Microscopy Services include Epifluorescence, confocal and light sheet microscopy,Whole slide scanning,Microscopy consultation and training,Digital image analysis.

Proper citation: Gladstone Institutes Histology and Light Microscopy Core Facility (RRID:SCR_017940) Copy   

•   Source: SciCrunch Registry

https://med.nyu.edu/research/scientific-cores-shared-resources/rodent-behavior-laboratory

Core offers equipment, facilities, and expertise to quantitatively assess broad range of behaviors in mice and rats, develop and validate novel paradigms to improve translation of preclinical behavioral results to clinically relevant outcome measures and create better tools for biobehavioral research.Core helped develop novel touch-screen tests to assess rodent attention, working memory, and reinforcement learning.

Proper citation: New York University School of Medicine Langone Health Rodent Behavior Laboratory (RRID:SCR_017942) Copy   

•   Source: SciCrunch Registry

http://matci.facilities.northwestern.edu

Core offers characterization and sample preparation equipment. Characterization techniques include optical microscopy, thermal imaging, thermal analysis (DSC, TGA), hardness testing (Vicker, Knoop, Rockwell), electronic characterization (Hall Effect, Impedance Spectroscopy, Kelvin Probe, Charge Transport) and rheological characterization. Sample and surface preparation capabilities include mounting (castable mounts, hot pressure mounting, vacuum impregnation), cutting, sectioning and wafer dicing, polishing/grinding, electropolishing, ion beam milling and cross-sectional polishing. Tube and box furnaces are available with temperature range up to 1700C for thermal processing.

Proper citation: Northwestern University Materials Characterization and Imaging Core Facility (RRID:SCR_017947) Copy   

•   Source: SciCrunch Registry

http://www.ohsu.edu/bbc

Core provides statistical and big data analysis support. Performs data analysis and manuscript preparation services in Biostatistics, such as statistical genetics, longitudinal, survival, and high-throughput/high-dimensional omics data analysis; and Bioinformatics, such as DNA- and RNA-seq alignment, single cell DNA- and RNA-seq analysis, variant calling, differential expression and pathway analysis, data integration, online data submission, and custom script writing. Provides training to lab staff to enable them to perform future analyses.

Proper citation: Oregon Health and Science University Bioinformatics and Biostatistics Core Facility (RRID:SCR_017946) Copy   

•   Source: SciCrunch Registry

https://www.utsouthwestern.edu/education/medical-school/departments/neurology/research/microscopy-facility/

Core suited to advance study of traumatic brain injury, as well as other neurological and psychiatric disorders.Utilizes microscopy strategies to evaluate neuropathology across micro-, meso-, and macro-scales of inquiry. Provides access to microscopes including TissueCyte 1000 multi-photon microscopes,Hamamatsu NanoZoomer 2.0-HT,Zeiss Axioscan.Z1. Offers access to fluorescence stereomicroscope and upright microscope, both with digital cameras, as well as sectioning equipment (cryostat, microtome, and vibrotome). Provide computer available for use running MicroBrightField Stereo Investigator and Neurolucida software packages for offline stereological analysis, neuron tracing, and 3D rendering of large, whole-brain datasets.

Proper citation: Texas University Southwestern Medical Center Whole Brain Microscopy Core Facility (RRID:SCR_017949) Copy   

•   Source: SciCrunch Registry

http://ncore.web.unc.edu/

Core provides physicochemical characterization of nanoscale entities. Offers characterization of several classes of nanomaterials:Polymer conjugates,Polymeric micelles,Liposomes,Nanogels,Polyion complexes of small drugs and biomacromolecules (proteins, DNA, and RNA),Inorganic/metal nanoparticles,Bio-derived nanoparticles such as exosomes with protein and nucleic acid cargo.

Proper citation: North Carolina University at Chapel Hill Nanomedicines Characterization Core Facility (RRID:SCR_017951) Copy   

•   Source: SciCrunch Registry

https://www.bidmc.org/research/research-by-department/radiology/mri-research/mri-facilities/translational-mri-research-core

Core provides MRI capabilities for imaging human subjects and potentially large animals as part of research studies. Facility operates GE Discovery MR750 3T whole-body scanner and can provide access to 1.5T system. Scanner is FDA cleared for clinical use. It has proprietary software including pulse programming environments and reconstruction programs and customizable software and protocols for applications including functional and structural brain imaging, abdominal perfusion and diffusion, muscle functional imaging and spectroscopy are available to users.Support for fMRI acquisition and visual and auditory stimulus presentation, diffusion tensor imaging, spectroscopy, and high quality anatomic imaging is available. The system has specialized receiver coils for sensitive imaging of particular anatomy. Additional customized coils can be manufactured in our RF lab. The system also has full broadband capability for multinuclear MRI and MRS, including (F-19, C-13, P-31, and Na-23).Our facility can also provide Image Post-processing and computerized image transfer, assistance to ensure MRI equipment safety, and can facilitate Clinical Readings.

Proper citation: Beth Israel Deaconess Medical Center Translational MRI Research Core Facility (RRID:SCR_017950) Copy   

•   Source: SciCrunch Registry