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http://mli.nih.gov/mli/

High throughput screening services to identify small molecules that can be optimized as chemical probes to study the functions of genes, cells, and biochemical pathways, along with medicinal chemistry and informatics. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease. The NIH Molecular Libraries Initiative NIH is designed to discover small molecules that interact with biologically important proteins and pathways and to provide open access to the bioassay and chemical data generated by its research centers. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease. As these HTS Technologies were not previously available to the public sector, many investigators may not be familiar with the components and requirements of high throughput screening. A key challenge is to identify small molecules effective at modulating a given biological process or disease state. The Molecular Libraries Roadmap, through one of its components, the Molecular Libraries Probe Production Centers Network (MLPCN), offers biomedical researchers access to the large-scale screening capacity, along with medicinal chemistry and informatics necessary to identify chemical probes to study the functions of genes, cells, and biochemical pathways. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease. There are two kinds of data that are available to the scientific community through a dedicated database: Chemical Compounds and Bioassay Results (NCBI). Various types of data, including informative records on substances, compound structures, and biologically active properties of small molecules are housed respectively within PubChem''''s three primary databases: PCSubstance, PCCompound, and PCBioAssay. To date, PubChem contains over 11 million substance records, details about approximately 5.5 million unique compound structures with links to bioassay descriptions, relevant literature, references, and assay data points and over 250 bioassays, a good percentage of which were contributed by the pilot phase of the MLP. The deposition will continue during the current MLPCN phase. NIH anticipates that these projects will also facilitate the development of new drugs, by providing early stage chemical compounds that will enable researchers in the public and private sectors to validate new drug targets, which could then move into the drug-development pipeline. This is particularly true for rare diseases, which may not be attractive for development by the private sector. Funding opportunities are available through the site.

Proper citation: Molecular Libraries Program (RRID:SCR_008847) Copy   

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http://trans.nih.gov/bmap/index.htm

The Brain Molecular Anatomy Project is a trans-NIH project aimed at understanding gene expression and function in the nervous system. BMAP has two major scientific goals: # Gene discovery: to catalog of all the genes expressed in the nervous system, under both normal and abnormal conditions. # Gene expression analysis: to monitor gene expression patterns in the nervous system as a function of cell type, anatomical location, developmental stage, and physiological state, and thus gain insight into gene function. In pursuit of these goals, BMAP has launched several initiatives to provide resources and funding opportunities for the scientific community. These include several Requests for Applications and Requests for Proposals, descriptions of which can be found in this Web site. BMAP is also in the process of establishing physical and electronic resources for the community, including repositories of cDNA clones for nervous system genes, and databases of gene expression information for the nervous system. Most of the BMAP initiatives so far have focused on the mouse as a model species because of the ease of experimental and genetic manipulation of this organism, and because many models of human disease are available in the mouse. However, research in humans, other mammalian species, non-mammalian vertebrates, and invertebrates is also being funded through BMAP. For the convenience of interested investigators, we have established this Web site as a central information resource, focusing on major NIH-sponsored funding opportunities, initiatives, genomic resources available to the research community, courses and scientific meetings related to BMAP initiatives, and selected reports and publications. When appropriate, we will also post initiatives not directly sponsored by BMAP, but which are deemed relevant to its goals. Posting decisions are made by the Trans-NIH BMAP Committee

Proper citation: BMAP - Brain Molecular Anatomy Project (RRID:SCR_008852) Copy   

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http://humanconnectome.org/consortia/

Project to map the neural pathways that underlie human brain function for several modalities of neuroimaging data including fMRI. The purpose of the Project is to acquire and share data about the structural and functional connectivity of the human brain. It will greatly advance the capabilities for imaging and analyzing brain connections, resulting in improved sensitivity, resolution, and utility, thereby accelerating progress in the emerging field of human connectomics. Altogether, the Human Connectome Project will lead to major advances in the understanding of what makes us uniquely human and will set the stage for future studies of abnormal brain circuits in many neurological and psychiatric disorders. The sixteen institutes and centers of the NIH Blueprint for Neuroscience have funded two major grants that will take complementary approaches to deciphering the brain's amazingly complex wiring diagram. An 11-institution consortium led by Washington University in St. Louis and the University of Minnesota received a 5-year grant to enable development and utilization of advanced Magnetic Resonance Imaging (MRI) methods to chart brain circuitry. A consortium led by Massachusetts General Hospital and the University of California at Los Angeles received a grant to enable building and refining a next-generation 3T MR scanner that improves the quality and spatial resolution with which brain connectivity data can be acquired at this field strength.

Proper citation: NIH Human Connectome Project (RRID:SCR_006942) Copy   

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http://trans.nih.gov/CEHP/

Trans-NIH project to assess the state of longitudinal and epidemiological research on demographic, social and biologic determinants of cognitive and emotional health in aging adults and the pathways by which cognitive and emotional health may reciprocally influence each other. A database of large scale longitudinal study relevant to healthy aging in 4 domains was created based on responses of investigators conducting these studies and is available for query. The four domains are: * Cognitive Health * Emotional Health * Demographic and Social Factors * Biomedical and Physiologic Factors

Proper citation: Cognitive and Emotional Health Project: The Healthy Brain (RRID:SCR_007390) Copy   

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http://www.nih.gov/science/models/

Information about national and international activities and major resources that are being developed to facilitate biomedical research using animal models Mammalian Models: * Mouse * Rat Non-Mammalian Models * S. cerevisiae (budding yeast) * S.pombe (Fission Yeast) * Neurospora (filamentous fungus) * D. discoideum (social amoebae) * C. elegans (round worm) * Daphnia * D. melanogaster (fruit fly) * D. rerio (zebrafish) * Xenopus (frog) * Gallus (chicken) Other Model Organisms: * Arabidopsis

Proper citation: Model Organisms for Biomedical Research (RRID:SCR_007282) Copy   

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http://www.fic.nih.gov/

The Fogarty International Center is dedicated to advancing the mission of the National Institutes of Health by supporting and facilitating global health research conducted by U.S. and international investigators, building partnerships between health research institutions in the U.S. and abroad, and training the next generation of scientists to address global health needs. Fogarty International Center''s programs provide funding to perform research and to train researcher in a variety of global health topics. Through these extensive programs, Fogarty and its partners throughout the National Institutes of Health (NIH) are working to build sustainable research capacity in low- and middle-income countries. Current Programs Research and Research Training Programs * Biodiversity (ICBG) * Bioethics * Brain Disorders * Chronic Diseases: Chronic, Non-communicable Diseases and Disorders Across the Lifespan (NCD-Lifespan); Millennium Promise Awards: Non-communicable Chronic Diseases Research Training (NCoD); Clinical, Operational and Health Services (ICOHRTA) * Ecology and Evolution of Infectious Diseases (EEID) * Environmental and Occupational Health (ITREOH) * Framework * Framework Innovations * Framework Signature Innovations * Global Environmental and Occupational Health (GEOHealth) * Global Infectious Diseases (GID) * HIV: Fogarty HIV Research Training; AIDS International Training and Research (AITRP); Clinical, Operational and Health Services AIDS/TB (IICOHRTA-AIDS/TB) * Informatics (ITGH) * Medical Education Partnership Initiative (MEPI) * New Foreign Investigators (GRIP) * Research Collaboration (FIRCA) * Tobacco * Trauma and Injury * Womens and Girls Health Administrative Grant Supplements Career Development Opportunities for Individuals * Fellows and Scholars Programs: Global Health Fellows and Scholars; Scholars and Fellows (FICRS-F) * Fulbright-Fogarty Fellowships in Public Health * Independent Scientist in Global Health (ISGHA) * Japanese Researcher Fellowships (JSPS) * Junior Research Scientists (IRSDA) Other Programs * American Reinvestment and Recovery Act (ARRA) * Genetics * Population * Stigma

Proper citation: Fogarty International Center (RRID:SCR_011229) Copy   

•   Source: SciCrunch Registry

http://www.nei.nih.gov/

Institute conducts and supports research, training, health information dissemination, and other programs with respect to blinding eye diseases, visual disorders, mechanisms of visual function, preservation of sight, and special health problems of individuals who are visually impaired or blind. Supports vision research through grants and training awards. Conducts laboratory and patient oriented research at its own facilities located on NIH campus in Bethesda, Maryland. NEI has established National Eye Health Education Program.

Proper citation: National Eye Institute (NEI) Commons (RRID:SCR_011411) Copy   

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http://www.genome.gov/

One of 27 institutes and centers that make up the NIH, National Human Genome Research Institute (NHGRI) is devoted to advancing health through genome research. The Institute led NIH''s contribution to the Human Genome Project, which was successfully completed in 2003 ahead of schedule and under budget. Building on the foundation laid by the sequencing of the human genome, NHGRI''s work now encompasses a broad range of research aimed at expanding understanding of human biology and improving human health. The NHGRI''s mission has expanded to encompass a broad range of studies aimed at understanding the structure and function of the human genome and its role in health and disease. To that end NHGRI supports the development of resources and technology that will accelerate genome research and its application to human health. A critical part of the NHGRI mission continues to be the study of the ethical, legal and social implications (ELSI) of genome research. NHGRI also supports the training of investigators and the dissemination of genome information to the public and to health professionals.

Proper citation: National Human Genome Research Institute (RRID:SCR_011416) Copy   

•   Source: SciCrunch Registry

http://www.nibib.nih.gov/

National institute to improve health by leading the development and accelerating the application of biomedical technologies. The Institute is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care. This is achieved through: research and development of new biomedical imaging and bioengineering techniques and devices to fundamentally improve the detection, treatment, and prevention of disease; enhancing existing imaging and bioengineering modalities; supporting related research in the physical and mathematical sciences; encouraging research and development in multidisciplinary areas; supporting studies to assess the effectiveness and outcomes of new biologics, materials, processes, devices, and procedures; developing technologies for early disease detection and assessment of health status; and developing advanced imaging and engineering techniques for conducting biomedical research at multiple scales.

Proper citation: National Institute of Biomedical Imaging and Bioengineering (RRID:SCR_011422) Copy   

•   Source: SciCrunch Registry

http://www.niehs.nih.gov/

National institute that reduces the burden of human illness and dysfunction from environmental causes by, defining how environmental exposures, genetic susceptibility, and age interact to affect an individual''s health. Its mission is to discover how the environment affects people in order to promote healthier lives. Achieving this mission depends on a set of core values that apply to all activities of the Institute: * Research excellence (innovation; discovery of new scientific knowledge and technology); * Management excellence; and * Community outreach, education, and involvement. At NIEHS and the National Toxicology Program, they engage in a special form of public service - producing scientific knowledge that promotes individual and public health. The Institute is uniquely positioned to help prevent disease and transform new scientific knowledge into improvements in human health. There are many opportunities before us to build and expand the contributions of the NIEHS: * Foster research on environmental triggers of disease; * Communicate advances in environmental health sciences to the public; * Foster training and development of emerging young environmental health scientists and practitioners; * Enhance translation of knowledge from research to disease prevention; and * Foster safety assessment research on chemicals and other environmental factors. The fulfillment of this mission requires the partnership and effort of everyone in the environmental health sciences communities.

Proper citation: National Institute of Environmental Health Sciences (RRID:SCR_011430) Copy   

•   Source: SciCrunch Registry

http://clinicalcenter.nih.gov/

The NIH Clinical Center is the nation's largest hospital devoted entirely to clinical research. Clinician-investigators translate scientific observations and laboratory discoveries into new approaches to diagnosing, treating, and preventing disease. The Clinical Center was recognized with the 2011 Lasker~Bloomberg Public Service Award for serving as a model research hospital—providing innovative therapy and high-quality patient care, treating rare and severe diseases, and producing outstanding clinician-scientists whose collective work has set a standard of excellence in biomedical research. About 1,500 clinical research studies are in progress at the Clinical Center. Half are studies of the natural pathogenesis of disease, especially rare diseases, which often are not studied anywhere else. What researchers learn by studying rare diseases adds to the basic understanding of common diseases. Most other studies are clinical trials, the first tests of new drugs and therapies in people. The clinical trials at the Clinical Center are predominantly Phase I and Phase II—first-in-human to test safety and efficacy. Clinical and laboratory research is conducted shoulder-to-shoulder, and this tandem approach drives all aspects of the Clinical Center's operations. More than 400,000 research volunteers have participated in clinical research studies at the Clinical Center since the hospital opened in 1953. Each year, the center sees 10,000 new research participants, of which there are two types: patient volunteers and healthy volunteers. Patient volunteers are people with specific diseases or conditions who help medical investigators learn more about their condition or test new medications, procedures, or treatments. A healthy volunteer is a person with no known significant health problems who plays a vital role in research to test a new drug, device, or intervention. At the Clinical Center, clinical research participants are active partners in medical discovery, a partnership that has resulted in a long list of medical milestones, including the first cure of a solid tumor with chemotherapy, gene therapy, use of AZT to treat AIDS, and successful replacement of a mitral valve.

Proper citation: NIH Clinical Center (RRID:SCR_011464) Copy   

•   Source: SciCrunch Registry

http://stemcells.nih.gov/research/registry/

A listing of human embryonic cell lines that are eligible for use in NIH funded research. Those lines that carry disease-specific mutations are noted as such under the line name. Total Eligible Lines = 200. The purpose of the Registry is to provide investigators with: # a unique NIH Code for each cell line that must be used when applying for NIH funding and # contact information to facilitate investigators' acquisition of stem cells. Before submitting a new grant application and supporting materials for consideration of a human embryonic stem cell line, scientists may wish to see what lines are already under consideration: * Human embryonic stem cell lines submitted to NIH that are being reviewed to determine if they may be used in NIH-supported research, http://grants.nih.gov/stem_cells/registry/pending.htm President George W. Bush required that the name of the registry be changed in his Executive Order #13435, issued on June 20, 2007. As a result of this Executive Order, the former National Institutes of Health Human Embryonic Stem Cell Registry will now be called the National Institutes of Health Human Pluripotent Stem Cell Registry. The registry will now include both human embryonic stem cells that were derived consistent with the President's policy of August 9, 2001 and human pluripotent stem cells derived from non-embryonic sources.

Proper citation: NIH Human Pluripotent Stem Cell Registry (RRID:SCR_003149) Copy   

•   Source: SciCrunch Registry

http://www.nitrc.org/projects/pediatric_mri

A database which contains longitudinal structural MRIs, spectroscopy, DTI and correlated clinical/behavioral data from approximately 500 healthy, normally developing children, ages newborn to young adult.

Proper citation: NIH Pediatric MRI Data Repository (RRID:SCR_014149) Copy   

•   Source: SciCrunch Registry

http://sigs.nih.gov/biospecimens/Pages/default.aspx

The mission of the Biospecimens Interest Group is to serve as an educational and tutorial vehicle for disseminating information, best practices, regulations, and ethical/legal information formulated and issued by various NIH offices, federal agencies and other leading biospecimens organizations. Please join our listserv so we can inform you about the date, time and the place for future meetings, speakers, website and other activities --- https://list.nih.gov/cgi-bin/wa?SUBED1=biospecimens&A=1. Meetings and seminars are videocast. Vision: #. To create a place where all stakeholders may exchange scientific data, ideas, and information concerning the creation and use of high quality biospecimens for research, assay validation, technology development and other appropriate uses. #. To promote and facilitate interaction between NIH intramural and extramural stakeholders who are interested in and involved with a variety of clinically-oriented, translational research projects using high quality biospecimens. #. To encourage leading stakeholders to address critical elements in study design and statistical analysis of data to facilitate the production of accurate, optimal, and clinically meaningful results (best outcome). #. To educate stakeholders about the potential barriers and obstacles that may obstruct the sharing and collaboration between stakeholders across different organizations and countries. #. To increase the awareness for the necessity of high quality biospecimens and the harmonization, and when appropriate, standardized procedures (best practices, SOPs) for annotating, collecting, transporting, processing, storing, and sharing biospecimens to ensure optimal reproducibility of outcomes and the privacy of the patients (donors) through adherence to the ethical and legal requirements associated with the use of biospecimens. #. To provide the connectivity to various biorepositories and biospecimens around the world, especially those containing rare and difficult to get biospecimens.

Proper citation: NIH Biospecimens Interest Group (RRID:SCR_004903) Copy   

•   Source: SciCrunch Registry

http://www.ninds.nih.gov/research/index.htm

The National Institute of Neurological Disorders and Stroke (NINDS) conducts and supports research on brain and nervous system disorders. Created by the U.S. Congress in 1950, NINDS is one of the more than two dozen research institutes and centers that comprise the National Institutes of Health (NIH). NINDS has occupied a central position in the world of neuroscience for more than 50 years. It provides access to different research programs both extramural and intramural. Research Topics: Epilepsy, Parkinson''s Disease, Traumatic Brain Injury, Anticonvulsant Screening, CounterACT, Bioengineering, Neural Interfaces, Stem Cell Research. Offices and Programs: *Channels, Synapses and Neural Circuits *Neural Environment *Neurodegeneration *Neurogenetics *Office of Clinical Research *Office of International Activities *Office of Minority Health and Research *Office of Translational Research *Office of Training and Career Development *Repair and Plasticity *Systems and Cognitive Neuroscience

Proper citation: National Institutes of Neurological Disorders and Stroke Research Programs (RRID:SCR_007209) Copy   

•   Source: SciCrunch Registry

http://www.nih.gov/icd/od/

The NIH is comprised of the Office of the Director and 27 Institutes and Centers. The Office of the Director is the central office at NIH. The OD is responsible for setting policy for NIH and for planning, managing, and coordinating the programs and activities of all the NIH components. The NIH Director provides overall leadership to NIH activities in both scientific and administrative matters. Although each institute within the NIH has a separate mission, the NIH Director plays an active role in shaping the agency''s research agenda and outlook. With a unique and critical perspective on the mission of the entire NIH, the Director is responsible for providing leadership to the institutes for identifying needs and opportunities, especially for efforts that involve several institutes. The NIH Director is assisted by the Principal Deputy Director, who shares in the overall direction of the agency''s activities. In carrying out these responsibilities, the NIH Director stays informed about program priorities and accomplishments through regular staff meetings, discussions, and briefing sessions with OD and institute staff. The Director also receives input from: * the extramural scientific community, including both individual researchers and scientific organizations * patient advocacy and voluntary health groups that deal directly with NIH or indirectly through Congress and the media * the Congress and the Administration the Council of Public Representatives, which brings public views to NIH. Ongoing discussions with these groups and others provides the basis for an established framework within which priorities for the agency are identified, reviewed, and justified. Dr. Francis Collins, the NIH Director, has outlined five key themes for NIH: * Applying high throughput technologies to understand fundamental biology, and to uncover the causes of specific diseases * Translating basic science discoveries into new and better treatments * Putting science to work for the benefit of health care reform * Encouraging a greater focus on global health * Reinvigorating and empowering the biomedical research community Program offices in the Office of the Director are responsible for stimulating specific areas of research throughout NIH and for planning and supporting research and related activities. Current program areas are: minority health, women''s health, AIDS research, disease prevention, and behavioral and social sciences research. Program offices within the Office of the Director fund research through the institutes.

Proper citation: NIH Office of the Director (RRID:SCR_012748) Copy   

•   Source: SciCrunch Registry

http://www.niaid.nih.gov/Pages/default.aspx

NIAID research strives to understand, treat, and ultimately prevent the myriad infectious, immunologic, and allergic diseases that threaten millions of human lives. Major areas of investigation: * Acquired Immunodeficiency Syndrome (AIDS) * Asthma and Allergic Diseases * Biodefense * Emerging and Re-emerging Infectious Diseases * Enteric Diseases * Fundamental Immunology * Genetics and Transplantation * Immune-Mediated Diseases * Influenza * Pathogen Genomics * Sexually Transmitted Infections (STIs) * Vaccine Development * Drug Research and Development * Antimicrobial Resistance * Minority and Women''s Health

Proper citation: National Institute of Allergy and Infectious Diseases (RRID:SCR_012740) Copy   

•   Source: SciCrunch Registry

http://www.niams.nih.gov/

Established in 1986, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) was established in 1986. The mission of the NIAMS is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress in these diseases. The Institute also conducts and supports basic research on the normal structure and function of bones, joints, muscles, and skin. Basic research involves a wide variety of scientific disciplines, including immunology, genetics, molecular biology, structural biology, biochemistry, physiology, virology, and pharmacology. Clinical research includes rheumatology, orthopaedics, dermatology, metabolic bone diseases, heritable disorders of bone and cartilage, inherited and inflammatory muscle diseases, and sports and rehabilitation medicine.

Proper citation: National Institute of Arthritis and Musculoskeletal and Skin Diseases (RRID:SCR_012715) Copy   

•   Source: SciCrunch Registry

http://ncats.nih.gov/

The National Institutes of Health (NIH) has established a new center, called the National Center for Advancing Translational Sciences (NCATS). Currently, many costly, time-consuming bottlenecks exist in the translational pipeline. Working in partnership with the public and private sectors, the Center will develop innovative ways to reduce, remove or bypass these bottlenecks. This will speed the delivery of new drugs, diagnostics and medical devices to patients. The mission of the National Center for Advancing Translational Sciences is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of human diseases and conditions. NCATS is formed primarily by uniting and realigning existing NIH programs that play key roles in translational science. The Center will not be a drug development company, but will focus on using science to create powerful new tools and technologies that can be adopted widely by translational researchers in all sectors.

Proper citation: National Center for Advancing Translational Sciences (RRID:SCR_012857) Copy   

•   Source: SciCrunch Registry

http://aidsinfo.nih.gov/DrugsNew/Default.aspx?MenuItem=Drugs

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on March 12,2025. The AIDSinfo Drug Database provides fact sheets on HIV/AIDS related drugs. The fact sheets describe the drug''s use, pharmacology, side effects, and other information. The database includes: -Approved and investigational HIV/AIDS related drugs -Three versions of each fact sheet: patient, health professional, and Spanish. AIDSinfo is a 100% federally funded U.S. Department of Health and Human Services (DHHS) project that offers the latest federally approved information on HIV/AIDS clinical research, treatment and prevention, and medical practice guidelines for people living with HIV/AIDS, their families and friends, health care providers, scientists, and researchers. Sponsors: -National Institutes of Health (NIH) Office of AIDS Research National Institute of Allergy and Infectious Diseases (NIAID) National Library of Medicine (NLM) -Health Resources and Services Administration (HRSA) -Centers for Disease Control and Prevention (CDC) -Centers for Medicare and Medicaid Services (CMS)

Proper citation: AIDSinfo Drug Database (RRID:SCR_012899) Copy   

•   Source: SciCrunch Registry