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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.bioconductor.org/packages/devel/bioc/html/OmicCircos.html
An R software application and package used to generate high-quality circular plots for visualizing genomic variations, including mutation patterns, copy number variations (CNVs), expression patterns, and methylation patterns.
Proper citation: OmicCircos (RRID:SCR_003292) Copy
https://www.bioconductor.org/packages//2.11/bioc/html/flowQB.html
A fully automated R Bioconductor package to calculate automatically the detector efficiency (Q), optical background (B) and intrinsic CV of the beads.
Proper citation: flowQB (RRID:SCR_002144) Copy
http://www.nitrc.org/projects/voxbo
Software package for brain image manipulation and analysis, focusing on fMRI and lesion analysis. VoxBo can be used independently or in conjunction with other packages. It provides GLM-based statistical tools, an architecture for interoperability with other tools (they encourage users to incorporate SPM and FSL into their processing pipelines), an automation system, a system for parallel distributed computing, numerous stand-alone tools, decent wiki-based documentation, and lots more.
Proper citation: VoxBo (RRID:SCR_002166) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowFit.html
A Bioconductor package designed to perform quantitative analysis of cell proliferation in tracking dye-based experiments. The package uses an R implementation of the Levenberg-Marquardt algorithm (minpack.lm) to fit a set of peaks (corresponding to different generations of cells) over the proliferation-tracking dye distribution in a FACS experiment.
Proper citation: flowFit (RRID:SCR_002286) Copy
Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
Proper citation: Fiji (RRID:SCR_002285) Copy
http://www.bioconductor.org/packages/2.13/bioc/html/spliceR.html
An easy-to-use R package for classification of alternative splicing and prediction of coding potential from RNA-seq data.
Proper citation: spliceR (RRID:SCR_002280) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowPlots.html
Software for analysis plots and data class for gated flow cytometry data.
Proper citation: flowPlots (RRID:SCR_002177) Copy
http://cran.r-project.org/web/packages/metaRNASeq/
Software package for meta-analysis of RNA-seq data. This package implements two p-value combination techniques (inverse normal and Fisher methods). It also provides a vignette explaining how to combine data from multiple RNA-seq experiments.
Proper citation: metaRNASeq (RRID:SCR_002174) Copy
https://cran.r-project.org/src/contrib/Archive/demi/
R package for estimating differential expression from multiple indicators that capitalizes on the high number of concurrent measurements. It extends to various experimental designs and target categories (transcripts, genes, genomic regions) as well as small sample sizes.
Proper citation: DEMI (RRID:SCR_002291) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowCore.html
A Bioconductor software package for high throughput flow cytometry that provides S4 data structures and basic functions.
Proper citation: flowCore (RRID:SCR_002205) Copy
http://www.nitrc.org/projects/nptk/
Non-rigid registration / distortion correction tools for enhanced functional localization through the registration of EPI fMRI to high-resolution anatomical MRI.
Proper citation: NPTK (RRID:SCR_002496) Copy
http://www.ncdc.noaa.gov/paleo/softlib/paleovu.html
A complete browse and visualization tool for all types of paleoclimate and paleoecological data (Version 1.0 for Windows 3.1 and the Macintosh). Point and click to create queries, list site information, display or plot variables and data, or export the data for further processing and analysis. Note: PaleoVu is no longer maintained or supported. Data content is not being updated, and compatibility problems may exist with newer operating systems. PaleoVu is still suitable as a teaching tool, but our internet-based browsing tools are the most up to date source for paleoclimatic data.
Proper citation: PaleoVu (RRID:SCR_002411) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowBeads.html
Software package for the analysis of flow cytometry bead data. It extends flowCore to provide functionality specific to bead data. One of the goals of this package is to automate analysis of bead data for the purpose of normalization.
Proper citation: flowBeads (RRID:SCR_002440) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowCyBar.html
A software package to analyze flow cytometric data using gate information to follow population / community dynamics.
Proper citation: flowCyBar (RRID:SCR_002319) Copy
http://www.med.unc.edu/bric/ideagroup/free-softwares/hammer
Software for both groupwise registration and longitudinal registration, which are the necessary steps for many brain-related applications. Specifically, groupwise registration is important for unbiased analysis of a large set of MR brain images. Therefore, in this software package, they have included two of their recently-developed groupwise registration algorithms: 1) Improved unbiased groupwise registration guided with the sharp group-mean image, and 2) Hierarchical feature-based groupwise registration with implicit template (Groupwise-HAMMER for short). On the other hand, they also included their recently-developed groupwise longitudinal registration algorithm that aligns not only the longitudinal image sequence for each subject, but also align all longitudinal image sequences of all subjects to the common space simultaneously.
Proper citation: GLIRT (RRID:SCR_002390) Copy
https://github.com/BRAINSia/BRAINSTools/tree/master/BRAINSFit
A program for registering images with with mutual information based metric. Several registration options are given for 3,6, 9,12,16 parameter (i.e. translate, rigid, scale, scale/skew, full affine) based constraints for the registration. The program uses the Slicer3 execution model framework to define the command line arguments and can be fully integrated with Slicer3 using the module discovery capabilities of Slicer3
Proper citation: BRAINSFit (RRID:SCR_002340) Copy
http://www.bioconductor.org/packages/devel/bioc/html/MBASED.html
Software package containing functions for allele-specific gene expression (ASE) analysis using meta-analysis based allele-specific expression detection.
Proper citation: MBASED (RRID:SCR_002584) Copy
http://fmri.wfubmc.edu/software/Bpm
Software toolbox that performs SPM analysis with voxel-wise imaging covariates. The BPM toolbox incorporates information obtained from other modalities as regressors in a voxel-wise analysis, thereby permitting investigation of more sophisticated hypotheses. The BPM toolbox has been developed in Matlab with a user-friendly interface for performing analyses, including voxel-wise multimodal correlation, ANCOVA, and multiple regression. It has a high degree of integration with the SPM (statistical parametric mapping) software relying on it for visualization and statistical inference. Furthermore, statistical inference for a correlation field, rather than a widely used T-field, has been implemented in the correlation analysis for more accurate results. Requirements: * SPM2 or SPM5 * MATLAB version 6.5 or higher
Proper citation: WFU Biological Parametric Mapping Toolbox (RRID:SCR_002613) Copy
A handy, fast, and versatile 3D/4D/5D Image Visualization & Analysis System for Bioimages & Surface Objects. Vaa3D is a cross-platform (Mac, Linux, and Windows) tool for visualizing large-scale (gigabytes, and 64-bit data) 3D/4D/5D image stacks and various surface data. It is also a container of powerful modules for 3D image analysis (cell segmentation, neuron tracing, brain registration, annotation, quantitative measurement and statistics, etc) and data management. Vaa3D is very easy to be extended via a powerful plugin interface. For example, many ITK tools are being converted to Vaa3D Plugins. Vaa3D-Neuron is built upon Vaa3D to make 3D neuron reconstruction much easier. In a recent Nature Biotechnology paper (2010, 28(4), pp.348-353) about Vaa3D and Vaa3D-Neuron, an order of magnitude of performance improvement (both reconstruction accuracy and speed) was achieved compared to other tools.
Proper citation: Vaa3D (RRID:SCR_002609) Copy
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 14,2026. An interactive segmentation tool originally designed for 3D medical images. Accurate and automatic 3D medical image segmentation remains an elusive goal and manual intervention is often unavoidable. TurtleSeg implements techniques that allow the user to provide intuitive yet minimal interaction for guiding the 3D segmentation process.
Proper citation: TurtleSeg (RRID:SCR_002605) Copy
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