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http://eagle-i.itmat.upenn.edu/i/0000013f-631e-6095-a468-831a80000000

Core facility that provides the following services: Body composition measurements, Resting energy expenditure analysis. Nutrition plays a vital role in health at all ages. The Clinical and Translational Research Center offers a Bionutrition Research Unit (BRU) to facilitate and implement clinical and translational research services. Research dietitians assist investigators with research design, implementation, data collection and analysis in study protocols. The Dietary Assessment Unit of the Nutrition Core provides a broad range of nutrition-related research services to investigators at the Children''s Hospital of Philadelphia, the Hospital of the University of Pennsylvania (HUP) and Penn Presbyterian Medical Center (PMC).

Proper citation: Penn/CHOP CTRC Bionutrition Research Core Dietary Assessment (RRID:SCR_010009) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-9b9e-1bb6-9cd7-d7e280000000

Core facility that provides the following services: Biological specimen sample preparation for transmission electron microscopy, Phenotypic characterization and ultrastructural analysis of biological specimens, Consultation for transmission electron microscopy experiments, usage, and data presentation, Transmission electron microscopy image construction tomography service, Training in transmission electron microscope operation, Scanning electron microscopy service, Transmission electron microscope access. Structural organization is underlies nearly all cellular, molecular and biochemical processes in biological systems. The Electron Microscopy Resource Laboratory (EMRL) at Penn is dedicated to analysis of biological samples by electron microscopy (EM). The primary goal of the EMRL is to promote biomedical research by offering high quality EM imaging services at a low cost. With a team of experienced professional staff and state-of-the-art imaging equipment, the EMRL offers users a full spectrum of both transmission EM and scanning EM services. These services include: specimen preparation (including fixation, embedding, and sectioning of cells and tissues or preparation of non-cellular materials), operation of equipment, data acquisition, data interpretation, and free instruction on all aspects of EM analysis. We also offer free assistance on the preparation of manuscript and grant applications that incorporate various forms of EM analysis. For most users, the Core will perform a complete analysis from sample preparation through collection of data, most often with the user present during data collection. More experienced users can perform the work themselves, with the Core providing guidance and assistance as needed. The Core staff and affiliated Scientific Advisory Committee members are always available for consulting on the morphological aspects of a project, and the Core staff is willing to custom-design services to fit any investigator''s needs.

Proper citation: Penn Electron Microscopy Resource Laboratory (RRID:SCR_010010) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013b-7127-463d-83a0-df0880000000

The Penn Gene Targeting Service (PGT) is run by the Penn Gene Targeting Core and Laboratory in collaboration with two other Penn Cores (DNA Sequencing Facility and the Transgenic and Chimeric Mouse Facility) and has the capability to generate from scratch almost any type of genetically modified mouse. This includes complete knockout of any gene, tissue-specific and/or drug-inducible knockout of any gene, targeted mutagenesis of any region of any gene (knockin), tissue-specific activation of an endogenous gene using loxP flanked stop cassettes, and tissue-specific and/or drug-inducible transgene expression from defined loci. For details regarding services and prices please consult the PGT home page of the Department of Genetics and/or directly contact Dr. Tobias Raabe. The Client lab does not need to be involved in any experimental step and only needs to breed the resulting mice. However, if desired, participation of the client lab in almost any experimental step is possible. PGT has an outstanding record of germ line transmission and so far over 32 targeted mice - more than 12 in the desirable C57BL6 background - have been made, starting either with molecular design and construction of the targeting vector or with electroporation of an existing targeting vector into ES cells.

Proper citation: Penn Gene Targeting Service (RRID:SCR_010013) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012b-36bb-0138-2f73-b43980000000

Core facility that provides the following services: Aortic banding service, Echocardiogram service, Blood pressure measurement service, Osmotic pump implantation service, LAD ligation service, Mini pump insertion service, Isolated perfused heart assay service, Cryoablation service, Cardiac output measurement service, Small animal surgery service, Transverse aortic constriction service, Invasive hemodynamic measurement service, Tail vein injection service, Training and advice for general mouse surgery techniques. The Center for Cardiovascular Research provides a Mouse Phenotyping Core for the use of investigators at the University, and by special arrangement, for investigators anywhere in Hawaii. We can provide murine echocardiography, blood pressure determinations, surgical procedures and phlebotomy, as well as assistance with mouse husbandry and genotyping.(http://www2.jabsom.hawaii.edu/mousecore/)

Proper citation: UH Manoa COBRE Mouse Phenotyping Core (RRID:SCR_010092) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012a-2510-aae4-c99c-aef680000000

Core facility that provides the following services: Transgenic mouse generation, In vitro fertilization (IVF) service, Embryo culture service, Embryo freezing service. The Transgenic and Embryonic Stem Cell Gene Targeting Core is a state-of-the-art facility with the expertise in the production of genetically altered subjects. Transgenic subjects carrying new or novel genes are created by microinjection of DNA into the pronuclei of fertilized eggs. Knock-out lacking specific genes of interest are created by homologous recombination in embryonic stem cells followed by injection into blastocysts to create chimeric subjects. Highly experienced personnel produce transgenic and knock-out subjects for UH investigators at very reasonable cost and with very short lead times. (http://www.ibr.hawaii.edu/tc.html)

Proper citation: UH Manoa COBRE Transgenic Core (RRID:SCR_010093) Copy   

•   Source: SciCrunch Registry

https://med-upenn.corefacilities.org/service_center/show_external/4515

Core provides full service whole genome and targeted molecular profiling of DNA and RNA on multiple platforms. The Facility offers a range of cost and performance options suitable for a variety of experimental projects. While the Facility staff performs most of the assays, investigator-performed studies are actively encouraged through the sharing of Facility procedures, individualized training of investigators or their technical staff, and use of core equipment.

Proper citation: University of Pennsylvania Molecular Profiling Facility (RRID:SCR_010014) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-b423-f2be-9cd7-d7e280000000

The High-Performance Computing (HPC) Facility provides the hardware and staff to support bioinformatics and biocomputational research. The central component of this facility is a large cluster of 64 high-speed compute nodes, along with approximately 900 terabyte of shared disk storage and nearly 1.8 petabytes of archival storage.

Proper citation: University of Pennsylvania High-performance Computing (RRID:SCR_010016) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000142-13cf-cf71-91c7-0c6080000000

In the Interventional Radiology Catheter Lab minimally invasive procedures are performed via fluoroscopy, ultrasound and endoscopy. Percutaneous vein and arterial access is performed via ultrasound-guided technique. Surgeons are then able to guide catheters, ballon dilation, and other small instrumentation through the blood vessels. Procedures that have been performed in the lab are: * Angiography * Aneurysm creation * Balloon angioplasty * Embolization (coil, glue, embospheres) * Inferior vena Cava (IVC) filter placement & retrieval * Selective arterial catheterization * Stent placement (renal, gastric, iliac) * Peroral gastroenteric anastomosis This lab has capabilities for full surgical and anesthesia protocols and full fluoroscopy imaging. Included in the lab are a small office space, an LCD monitor and computer for the fluoroscopy unit, eye wash station and a surgeon scrub sink.

Proper citation: Penn Interventional Radiology Animal Catheter Lab (RRID:SCR_010019) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-b6a6-e595-9dbb-bb2180000000

Core facility that provides the following services: NBIC instrumentation training, Scanning probe measurement service. The NBIC serves as an incubator for new probes of nanostructure behavior and associated instrumentation development. It is equipped with a suite of scanning probes, opto-electronic/transport tools, and optical probes that are so recently developed as not to be available on commercial instruments. The environment facilitates the development and refinement of new probe-based techniques.

Proper citation: Penn NBIC Probe Facility (RRID:SCR_010023) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-baad-3af2-9cd7-d7e280000000

Core facility that provides the following services: Behavioral testing training, Behavioral testing consultation service, Neurobehavior Testing Core access, Evaluation of anxiety behavior, Evaluation of circadian activity and rest/activity patterns, Measurement of sleep/wake patterns, Video image analysis of behavioral assays, Tissue harvest and histology prep service, Customized behavior batteries. The Neurobehavior Testing Core provides core facilities and services to test mice in state of the art assays of simple and complex behaviors, including the assessment of circadian rhythms and sleep, learning and memory, motor and sensory function, as well as behavioral assays relevant to translational studies of neurological, neurodevelopmental and psychiatric disorders. The core offers comprehensive behavior phenotyping of your mice or can train your lab personnel to perform the tests in the facility. In addition, we provide consultation on study design including appropriate tests, mouse line/strain, numbers of animals, control groups and breeding strategies. The core will also provide consultation regarding ULAR, IACUC and other regulatory issues. Assistance with data analysis is also available. The behavior apparatus available in the core includes: running wheels and beam splitters to measure circadian activity and rest/activity patterns as well as EEG/EMG recording chambers to measure sleep/wake states. Motor function is assessed using open field activity monitors and Rotarod. Apparatus to measure anxiety-like behavior including zero maze, light/dark chamber, passive/active avoidance chambers and hole poke arenas are also available. Extensive assessment of cognition, learning and memory is conducted with Morris water maze, radial arm maze, 5 choice serial reaction time test and object recognition tests. Tests of behaviors associated with depression (forced swim), schizophrenia (startle/PPI), social interaction (choice and social memory), and drug addiction (conditioned place preference) are also available. Tests of general health and responsiveness are also performed, as these are critical for the evaluation of complex behavior. Support for the core is provided by the Comprehensive Neuroscience Center, the Institute for Translational Medicine and Therapeutics, the Center for Sleep and Circadian Neurobiology and the Perelman School of Medicine.

Proper citation: Penn Neurobehavior Testing Core (RRID:SCR_010024) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012b-7f26-419c-2f73-b43980000000

Core facility that provides the following services: Tissue embedding service, Tissue sectioning service, Immunohistochemistry service, In situ hybridization service, DNA extraction service, Tissue microarray slides service, Tissue microarrays service, Genotyping service. The Pathology Shared resource capitalizes on the existing infrastructure of the Center''s tissue repository. The Repository currently consists of fixed, paraffin-embedded tissue specimens from hospitals and laboratories statewide. The purpose of the repository is to provide tissue specimens to Center members and other investigators for research purposes. A priority is placed on the provision of specimens for population-based research and peer-reviewed, extramurally funded projects. The repository is a part of the Residual Tissue Repository Program of the NCI SEER program (http://seer.cancer.gov/biospecimen/).

Proper citation: UH Manoa Pathology Shared Resources (RRID:SCR_010106) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012a-2510-e7b9-c99c-aef680000000

The Biostatistics and Data Management Facility (BDMF) was established with a primary mission to provide a range of customized statistical and database management services for RCMI researchers. Realizing a need for a consolidated and integrated statistical resources for biomedical researchers and clinicians at the John A. Burns School of Medicine, the BDMF has rapidly extended services to other programs and groups, including the Asia-Pacific Institute of Tropical Medicine and Infectious Diseases (APITMID), Pacific Biosciences Research Center (PBRC), Excellence in Partnerships for Community Outreach, Research on Health Disparities, and Training (EXPORT), Specialized Neuroscience Research Program (SNRP-I/II), Center of Biomedical Research Excellence (COBRE), Centers of Clinical Research Excellence (CCRE), Clinical Research Education and Career Development (CRECD), RCMI clinical Research Infrastructure Initiative (RCRII), and IDeA Networks of Biomedical Research Excellence (INBRE). The overall mission of the BDMF is to provide quantitative resources essential for investigators to conduct methodologically rigorous medical research in a timely, cost-effective manner. (http://www5.pbrc.hawaii.edu/bdmf/index.html)

Proper citation: UH Manoa RCMI Biostatistics and Data Management Facility (RRID:SCR_010107) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012b-1c5f-99ef-06c2-9c7f80000000

Core facility that provides the following services: Training and advice for general imaging techniques, Histology processing service, Hematoxylin and eosin staining service, Training and advice for general histology techniques. This lab provides routine histology processing, specialized histochemical and immunohistological techniques, and access to several microscopic platforms. The core also provides technical assistance, training, and consultation in histological and imaging techniques to investigators throughout the University on a cost-recovery basis.

Proper citation: UH Manoa RCMI Histology and Imaging Core Facility (RRID:SCR_010109) Copy   

•   Source: SciCrunch Registry

http://uccaribe.eagle-i.net/i/00000136-c5d0-1c3d-a53f-a15a80000000

Core facility that provides the following services: Protein separation service, 2D gel production, Analysis of protein distribution of 2D gel, Standardized imaging of 2D gel, Mass spectrometry analysis service, Desalting, Trypsin Digestion. The mission of the UCC Biomedical Proteomic Facility is to accelerate discovery by giving UCC investigators access to cutting edge mass spectrometry are rapidly advancing and requires considerable technical expertise and expensive equipments. To keep UCC scientists competitive, new technologies will be incorporated into the facility as soon as possible to meet the needs. The facility is open to all investigators on collaboration or a fee-for-service basis. User fees will be adjusted depending on demand and to keep costs competitive.

Proper citation: UCC Biomedical Proteomic Facility (RRID:SCR_010073) Copy   

•   Source: SciCrunch Registry

http://uccaribe.eagle-i.net/i/00000135-aaee-9c0e-a272-8ee780000000

Core facility that provides the following services: HIV and HCV viral load extraction, Amplification and detection of HCV and HIV viral load, HIV-1 and HCV drug resistance genotyping, Neurotoxicity and neuroprotection assays, PBMC antiviral assay, MAGI antiviral assay, HIV-1 Tat inhibition assay, HIV p24 measurement service, Cytokine/Chemokine measurement, Hormone measurement, NF-kB expression induction assay, Detection of TH1, TH2, Treg, and TH17 cytokine profiles in T lymphocytes subsets, Immunophenotyping, intracellular cytokines/chemokines and apoptosis assay service, B and T cell immune activation, function, proliferation and differentiation assays, Macrophage function assay, Cell viability, cell proliferation and cytotoxicity, Cell cycle analysis, Inflammation and oxidative stress Calcium mobilization, kinase activation, and signal transduction, Gene expression service, Apoptosis test, In vivo/in vitro cytotoxicity measurement, Plaque and colony formation counting, Inflammation antibody array service, Apoptosis antibody array service, Angiogenesis antibody array, Protein and gene expression study, Standardized imaging of 2D gel. The laboratory supports research in the areas of HIV/AIDS and substances of abuse. Specialized facilities are made available to researchers for scientific studies in fields of immunology, drugs of abuse, HIV/AIDS and related infectious diseases. The core lab provides researchers with assays for nucleic acids detection, virus genotyping, flow cytometric phenotyping, lymphocyte proliferation, cytotoxic and non-cytotoxic activity, cytokine and chemokine determinations, and drugs of abuse quantification.

Proper citation: UCC HIV and Substance of Abuse Laboratory Core (RRID:SCR_010076) Copy   

•   Source: SciCrunch Registry

http://uccaribe.eagle-i.net/i/00000136-cb34-a797-a53f-a15a80000000

Core facility that provides the following services: Immunocytochemistry service. The immunocytochemistry laboratory specializes in the qualitative identification and localization of cells bearing selective markers by employing specific antibodies to these molecules.

Proper citation: UCC Immunocytochemistry Laboratory (RRID:SCR_010077) Copy   

•   Source: SciCrunch Registry

http://uccaribe.eagle-i.net/i/00000136-ca9b-b63c-a53f-a15a80000000

Core facility that provides the following services: Qualitative measure of neuronal death, Computerized image analysis. The goal of the facility is to assist UCC investigators in the use of cultured neurons, glias and organotypic cultures. The cultures are used for patch clamping after in vitro treatments with drugs of addiction or inhibitors and for in vitro models of neurodegenerative diseases. The core facility consists of a coordinator and a technician. Neuronal cultures are prepared from fetal cortex, hippocampus or astrocytes from cerebral cortex.

Proper citation: UCC Neuronal Glia Culture Facility (RRID:SCR_010078) Copy   

•   Source: SciCrunch Registry

http://upr.eagle-i.net/i/0000012c-2c98-3564-5b95-f21080000000

Core facility that provides the following services: Necropsy and tissue collection, Blood chemistries service, Bronchoalveolar lavage service, Cerebro-spinal tap service. The Animal Resources Center (ARC) is a part of the Unit of Comparative Medicine at the Medical Sciences Campus (MSC) of the University of Puerto Rico (UPR), committed to offer quality services to the university community and private entities, which through an accredited and properly regulated facility, and highly qualified personnel, provides care and maintenance of animals to be used in research.

Proper citation: UPR Animal Resources Center (RRID:SCR_010111) Copy   

•   Source: SciCrunch Registry

http://uccaribe.eagle-i.net/i/00000136-d046-71cb-a53f-a15a80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 26,2026. The facility offers microscope-based systems that allow the assessment of cellular responses, such as calcium signaling with fast temporal resolution. The facility offers 1) Confocal imaging services; 2) Brightfield, darkfield, phase contrast, Nomarski and epi-fluorescence imaging; 3) High spatial and temporal resolution imaging, 4) Collection of serial sections (Deconvolution capabilities) and 5) Morphometric analysis.

Proper citation: UCC Optical Imaging Facility (RRID:SCR_010079) Copy   

•   Source: SciCrunch Registry

http://hawaii.eagle-i.net/i/0000012b-1c5f-469c-06c2-9c7f80000000

Core facility that provides the following services: Scanning electron microscopy service, Conventional and energy-filtering transmission electron microscopy service, Laser scanning confocal microscopy service, Fluorescence microscopy service, Laser microdissection and laser tweezing service. The Biological Electron Microscope Facility (BEMF) at the University of Hawai''i is a multi-user/service facility, administered by the Pacific Biosciences Research Center (PBRC). The mission of the BEMF is to provide biological-biomedical researchers with state-of-the-art instrumentation, training and services for high-resolution scanning electron microscopy, conventional and energy-filtering transmission electron microscopy, optical, fluorescence, and laser scanning confocal microscopy, and image analysis on a recharge basis. The facility receives partial support from the Pacific Biosciences Research Center and the UH Manoa Chancellor''s Office. Includes the Richard Allen Image Collection, a unique set of images taken with electron microscopes (http://www5.pbrc.hawaii.edu/allen/).

Proper citation: UH Manoa Biological Electron Microscope Facility (RRID:SCR_010087) Copy   

•   Source: SciCrunch Registry