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An open-source Java viewer for chemical structures in 3D with features for chemicals, crystals, materials and biomolecules. It is cross-platform, running on Windows, Mac OS X, and Linux/Unix systems and features an applet, application, and systems integration component.
Proper citation: Jmol (RRID:SCR_003796) Copy
https://www.biogen.com/en_us/home.html
Global biotechnology company based in Cambridge, Massachusetts, specializing in discovering, developing, and delivering important therapies for the treatment of neurodegenerative, hematologic and autoimmune diseases to patients worldwide.
Proper citation: Biogen Idec (RRID:SCR_003790) Copy
http://purl.bioontology.org/ontology/MDDB
Ontology of master drug data base, 2009_08_05
Proper citation: Master Drug Data Base Clinical Drugs (RRID:SCR_003668) Copy
Foldit is a revolutionary new multiplayer online computer game that engages non-scientists in solving hard prediction problems, enabling you to contribute to important scientific research. Foldit players interact with protein structures using direct manipulation tools and user-friendly versions of algorithms from the Rosetta structure prediction methodology, while they compete and collaborate to optimize the computed energy. Here are the basic principles to keep in mind when folding proteins. Your score on each protein is based on how well you do with these three things: # Pack the protein: The smaller the protein, the better. More precisely, you want to avoid empty spaces (voids) in the structure of the protein where water molecules can get inside. So you want the atoms in the protein to be as close together as possible. Certain structures, such as sheets, will even connect together with hydrogen bonds if you line them up right and get them close together. This is also good. Key word: Compact. # Hide the hydrophobics: Hydrophobics are the sidechains that don't want to be touching water, just like oil or wax. Since most proteins float around in water, you want to keep the hydrophobics (orange sidechains) surrounded by as many atoms as possible so the water won't get to them. The other side of this rule is that hydrophilics (blue sidechains) do want to be touching water, so they should be exposed as much as possible. Key word: Buried. # Clear the clashes: Two atoms can't occupy the same space at the same time. If you've folded a protein so two sidechains are too close together, your score will go down a lot. This is represented by a red spiky ball (clash) where the two sidechains are intersecting. If there are clashes, you know something is wrong with your protein. So make sure everything is far enough apart. Key word: Apart. The current series of Science Puzzles, the Grand Challenges, are meant to generate the evidence needed to prove that human protein folders can be more effective than computers at certain aspects of protein structure prediction. That's what all the puzzles in Foldit are about right now: predicting the structure of a protein based on its amino acid sequence. The three rules mentioned above describe the characteristics of correct protein structures.
Proper citation: Foldit (RRID:SCR_003788) Copy
Product development company focused on therapeutic products and diagnostic devices targeting misfolded protein diseases. On July, 2015 the company name was changed to ProMIS Neurosciences, Inc.
Proper citation: Amorfix (RRID:SCR_003783) Copy
http://www.patientslikeme.com/
A for-profit health data-sharing platform that can transform the way patients manage their conditions, change the way industry conducts research and improve patient care. PatientsLikeMe aligns patient and industry interests through data-sharing partnerships. They work with trusted nonprofit, research and industry Partners who use this health data to improve products, services and care for patients. They take the information patients share about their experience with the disease and sell it to their partners (i.e., companies that are developing or selling products to patients). These products may include drugs, devices, equipment, insurance, and medical services. Except for the restricted personal information entered when registering for the site, participants should expect that every piece of information submitted (even if it is not currently displayed) may be shared with their partners and any member of PatientsLikeMe, including other patients. They do not rent, sell or share personally identifiable information for marketing purposes or without explicit consent. Because they believe in transparency, they tell members exactly what they do and do not do with their data. Patients have the opportunity to share both personal stories and health data about their conditions to help uncover great ideas and new knowledge. By sharing information on the site, they can put their disease experiences in context and find answers to the questions they have. Every partnership we develop must bring them closer to aligning patient and industry interests. Their end goal is improved patient care and quality of life.
Proper citation: PatientsLikeMe (RRID:SCR_003781) Copy
http://www.basf.com/group/corporate/us/en/
German multinational chemical company and largest chemical producer in the world. BASF Group comprises subsidiaries and joint ventures in more than 80 countries and operates six integrated production sites and 390 other production sites in Europe, Asia, Australia, the Americas and Africa.
Proper citation: BASF Corporation (RRID:SCR_003787) Copy
http://purl.bioontology.org/ontology/MSTDE
Metathesaurus Version of Minimal Standard Terminology Digestive Endoscopy. Bethesda, MD: National Library of Medicine, 2001.
Proper citation: Minimal Standard Terminology of Digestive Endoscopy (RRID:SCR_003785) Copy
Organization that develops methods, works with leaders and teams, and provides education and training to help organizations improve their products and services and to build their capability for on-going improvement.
Proper citation: Associates in Process Improvement (RRID:SCR_003784) Copy
http://sciple.org/neuroflocks/NFLKSsfn10.html
Neuroflocks is an unique tool to navigate tweets from the past SfN meeting and find out the hot topics tweeted during the conference (SfN-2010). We have collected all tweets using the hashtag #sfn10 and made them browsable via a simple visual search interface. Type in the word you want to search for and only tweets containing that word will light up! You can click on single tweets, browse the tweet content, click on the Twitter user and find new Neuroscience-enthusiast twitterers! You can also find out what was really HOT during the conference (Re-Tweeted tweets, RT have been color coded). Moreover, the tweets follow a time gradient from the inside out: the spiral's center contains tweets from the beginning of the meeting while tweets on the outside of the spiral were tweeted at the end of the meeting. Enhanced versions of neuroflocks are currently under development !!!
Proper citation: Neuroflocks - tweets from SfN2010 (RRID:SCR_003779) Copy
A service-provider company specialized in developing and managing scientific research projects. Its mission is to support research activities from the idea to the realization of project. ALTA assists in finding the proper strategy, building European Consortia and putting science in the most appropriate administrative and management framework.
Proper citation: ALTA (RRID:SCR_003898) Copy
http://synapses.clm.utexas.edu
A portal into the 3D ultrastructure of the brain providing: Anatomy of astrocytes, axons, dendrites, hippocampus, organelles, synapses; procedures of 3D reconstruction and tissue preparation; as well as an atlas of ultrastructural neurocytology (by Josef Spacek), online aligned images, and reconstructed dendrites. Synapse Web hosts an ultrastructural atlas containing more than 500 electron micrographs (added to regularly) that identify unique ultrastructural and cellular components throughout the brain. Additionally, Synapse Web has raw images, reconstructions, and quantitative data along with tutorial instructions and numerous tools for investigating the functional structure of objects that have been serial thin sectioned for electron microscopy.
Proper citation: Synapse Web (RRID:SCR_003577) Copy
A collaboration of international pharmaceutical companies, public health experts, civil society organizations, and U.S., European, and other regulatory authorities to speed the development of new and improved drug regimens for tuberculosis (TB). Its goals include creating innovative tools, including TB data standards and databases. The Initiative is built around four operating arms: Regulatory Science Consortium, Drug Development Coalition, Research Resources Group, and Drug Susceptibility Testing Group. The focus of the consortium is to: * Develop and integrate data standards * Qualify biomarkers through the Food and Drug Administration (FDA) / European Medicines Authority (EMA) * Develop quantitative disease progression (natural history) models * Create disease response metrics, develop target product profiles and supporting assays, and * Develop new pharmacokinetic/dynamic measures of drug interactions Accomplishments include: * Engaged the FDA, which has released updated regulatory guide-lines for developing new TB drug regimens with efforts to create a more favorable environment for combination regimen development * TB Alliance launched the first-ever clinical trial of a novel combination drug regimen for TB, validating the approach to regimen development set forth by CPTR, and is moving to a phase III clinical trial named STAND. * Developed and published TB data standards in collaboration with the Clinical Data Interchange Standards Consortium (CDISC). * Expanded scope to include the CPTR Rapid Drug Susceptibility Testing (RDST) Consortium and an expanded Modeling and Simulation development program. * Pursued several regulatory pathways with the FDA for the Hollow Fiber System Model for TB (HFS-TB). * Submitted a dossier to the EMA on the HFS-TB for qualification opinion consideration. * Submitted a "briefing book" to the FDA via the pre-IND process to review CPTR's data analysis plan and data inventory for liquid culture, with emphasis on time-to-positivity, as a quantitative measure of long-term outcome. * Initiated planning to develop a database supporting the RDST Consortium's goal to develop a rapid TB drug susceptibility test.
Proper citation: Critical Path to TB Drug Regimens (RRID:SCR_003698) Copy
http://www.sinobiological.com/
An Antibody supplier
Proper citation: Sino Biological (RRID:SCR_003697) Copy
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 27th, 2023. Cubist Pharmaceuticals was American biopharmaceutical company that targeted pathogens like MRSA. Company employed 638 people, mostly in Lexington, MA. On 8 December 2014, Merck acquired Cubist.
Proper citation: Cubist Pharmaceuticals (RRID:SCR_003691) Copy
http://www.pearsonclinical.com/education/products/100000105/beck-hopelessness-scale-bhs.html
20-item clinical assessment to measure key aspects of hopelessness: feelings about the future, loss of motivation, and expectations. It takes 5 to 10 minutes is self-administered or verbally administered by a trained administrator.
Proper citation: Beck Hopelessness Scale (RRID:SCR_003683) Copy
https://www.gov.uk/government/organisations/public-health-england
An executive agency of the Department of Health in the United Kingdom to protect and improve the nation''s health and well-being, and reduce health inequalities. It employs 5,500 staff, who are mostly scientists, researchers and public health professionals. They have 15 local centers and 4 regions (north of England, south of England, Midlands and east of England, and London). They work closely with public health professionals in Wales, Scotland and Northern Ireland, and internationally. Its formation came as a result of reorganization of the National Health Service (NHS) in England. It took on the role of the Health Protection Agency, the National Treatment Agency for Substance Misuse and a number of other health bodies. They are responsible for: * making the public healthier by encouraging discussions, advising government and supporting action by local government, the NHS and other people and organisations * supporting the public so they can protect and improve their own health * protecting the nation''s health through the national health protection service, and preparing for public health emergencies * sharing information and expertise with local authorities, industry and the NHS, to help them make improvements in the public''s health * researching, collecting and analyzing data to improve our understanding of health and come up with answers to public health problems * reporting on improvements in the public''s health so everyone can understand the challenge and the next steps * helping local authorities and the NHS to develop the public health system and its specialist workforce
Proper citation: Public Health England; London; United Kingdom (RRID:SCR_003905) Copy
A development-stage diagnostics company whose mission is to curb the spread of hospital-acquired infections and anti-microbial resistance by developing a small-footprint, inexpensive, and automated diagnostic instrument that will quickly deliver patient-specific information on 50+ genetic markers. With their on-chip, high-multiplex approach, they expect to offer a higher-performing, lower-cost, and more versatile solution versus bacterial culture and competing approaches in development.
Proper citation: Genewave (RRID:SCR_003903) Copy
A private limited company that specializes in data protection solutions for eHealth. They are a trusted and reliable Trusted Service Provider (TSP) in the Healthcare sector providing both consultancy and technical privacy protection solutions. Its data protection services are supported by a combination of high-level technical and legal expertise in privacy protection and e-security and a sound experience with a number of advanced e-security solutions such as PKI, VPN, Web Services security frameworks, time-stamping and more. Custodix helps businesses deal with all security and privacy related aspects of modern data management (cf. European Data Protection Directive 95/46/EC, 2001/20/EC, 2005/28/EC, the US HIPAA Privacy Rule, the WHO GCP, GPMP/ICH/135/95, ...) by offering end-to-end solutions for data protection in e-Clinical Trials, disease management and other longitudinal studies. Custodix has an international customer-base, deploying services in Europe, Asia and Australia. Customers are both commercial companies and governmental research organizations. Specialties: CATS - Custodix Anonymization Tool services, TriTob - clinical TRIal TOolBox, PIMS - Patient Identity Management System, PESF - Privacy Enhanced Storage Framework, TTPS - Trusted Third Party Services, FP7 EU Research
Proper citation: Custodix (RRID:SCR_004101) Copy
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Welcome to the Neuroscience Information Framework Project, designed to serve the biomedical research community. NIF maintains the largest searchable collection of neuroscience data, the largest catalog of biomedical resources, and the largest ontology for neuroscience on the web. We welcome all feedback and suggestions and are actively looking for resource providers to make their resources accessible through NIF. Learn about the tools available to help you share your data and discover a dynamic inventory of Web-based neuroscience resources.
