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https://www.ohsu.edu/xd/research/research-cores/advanced-computing-center/index.cfm

Provides technology solutions to meet non enterprise IT needs across OHSU for healthcare including limited clinical research project support, academic, and research missions. ACC is also home to Exacloud HPC cluster.

Proper citation: OHSU Advanced Computing Center Core Facility (RRID:SCR_009959) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-edfa-7bc7-b2b9-4d8780000000

Core facility that provides the following services: 96-well plasmid preparation service.

The Center for Computational and Integrative Biology (CCIB) Automation Core provides the greater Partners research community with high-throughput automation services as well as special automation project design and implementation., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: MGH CCIB Automation Core (RRID:SCR_009914) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012e-5e3a-7084-4106-535b80000000

In cooperation with the Data and Clinical Cores at the Layton Center, the Biomarkers and Genetics Core generates and maintains biomarker data for select biomarkers which have established roles in the characterization of subjects with or at risk of dementia. Biological markers of brain aging, dementia risk, and neurodegeneration have the potential to accelerate the identification of disease mechanisms and treatment strategies. Biomarkers may include genes, proteins, or other metabolites, and may be identified in DNA, cerebrospinal fluid (CSF), or plasma. Apolipoprotein E (APOE) genotype is generated for all research subjects. Sub-groups of subjects have other types of biomarker data. Many subjects have had genome-wide SNP data generated. In order to foster collaborative research as well as expand resources and expertise, samples (DNA, CSF, and plasma) and data are distributed to qualified investigators worldwide. Most of these researchers are pursuing the causes and modifiers of dementia. Data and samples are collected from well characterized research subjects including the healthy elderly and dementia patients.

Proper citation: Layton Alzheimers Disease Center Biomarkers and Genetics Core Lab (RRID:SCR_009911) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012e-5e56-c3be-4106-535b80000000

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on December 6th,2022. The Oregon Alzheimer?s Disease Center?s (OADC) Clinical Core program, directed by Dr. Jeffrey Kaye, performs longitudinal studies of the natural history of brain aging and Alzheimer''s disease in patients and healthy control volunteers. These studies which are performed through standardized neurological, neuro-psychological, and brain-imaging assessments are carried out in the Alzheimer''s Disease and Memory Assessment Clinics as well as through community-based assessments conducted in the homes of study volunteers. The Layton Center Neuroimaging Lab conducts brain-imaging MRI brain scans to assist in diagnosis of brain disease. Typically, MRI images are taken from three different planes. These planes are known as the coronal plane, sagittal plane and the axial plane. Each series of MRI images is named after the plane from which they were obtained. The Clinical Core?s research is focused on preclinical and early Alzheimer?s disease (AD) yet is also poised to participate in other relevant new research as it arises. The OADC Clinical Core recruits, assesses and follows individuals from population groups at high risk for dementia such as: the healthy ?oldest old?, subjects with family history of AD, and subjects with Mild Cognitive Impairment (MCI). Research with underserved populations The Oregon Alzheimer?s Disease Center also maintains two Satellite programs to enhance understanding of underserved populations: The Klamath Exceptional Aging Project (KEAP) is a community-based study of brain aging being conducted in Klamath Falls. The African American Dementia and Aging Project (AADAPt) s a Portland-based cohort of 100 African American seniors.

Proper citation: Layton Alzheimers Disease Center Clinical Core (RRID:SCR_009912) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013a-64b2-be79-01af-beb880000000

Core facility that provides the following services: Metabolomics profiling service. This core provides sophisticated analytical services based on liquid chromatography-mass spectrometry.

Proper citation: Penn Mass Spectrometry Molecular Profiling Core (RRID:SCR_009990) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000135-67c4-1e5a-77e4-a45080000000

Core facility that provides the following services: Microscopy, Imaging, and Analysis, Routine Histopathology, Specialized Histopathology. The purpose of this core laboratory is to assist investigators requiring detection, imaging, and morphometric analysis of gene and protein expression in any type of cell and tissue. Services, expertise and state-of -the-art biomedical imaging services will be provided with the hope of broadening and streamlining all morphological research.

Proper citation: LCRC Morphology and Imaging Core (RRID:SCR_009908) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012e-5dd8-5be1-4106-535b80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 5th,2022. The Education and Information Core of the Layton Aging & Alzheimer?s Disease Center develops and carries out a wide range of educational programs to: * Increase public awareness and understanding of Alzheimer''s Disease research, * Aid in the recruitment of subjects for research studies, and * Improve care and quality of life for persons with dementia and support their family caregivers. Our educational activities include: * Training for health care professionals which include seminars and lectures and we also provide ?hands-on? experiences for medical students, * Community education on Alzheimer''s disease and related dementia disorders, * Workshops on doctor ? patient communication for families and caregivers, * Collaboration with community organizations and groups to promote awareness of the disease and publicize research activities, a particular focus is underserved populations including rural communities and minority groups, * Collaboration with other organizations that serve patients and families, e.g., the Alzheimer?s Association and other state and local agencies that serve the elderly and the loved ones who care for them, and * Distribution of printed material that provides topical information on a variety of subjects related to Alzheimer?s disease and dementia and how best to provide quality of life to those with the disease. * A newsletter, Aging & Alzheimer''s Update, which is published twice per year. The Education Core administers the Oregon Income Tax Check-off Alzheimer''s Research Fund in collaboration with The Oregon Partnership for Alzheimer''s Research, a community advisory committee.

Proper citation: Layton Aging and Alzheimers Disease Center Education Core (RRID:SCR_009909) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000135-1b74-64ae-77e4-a45080000000

Core facility that provides the following services: FACS service, Flow cytometry analysis service, Data archival. The Cell Analysis & Immunology Core Facility is a customer oriented service dedicated to supporting the research needs of the investigators of the Louisiana Cancer Research Consortium (LCRC). It provides state-of-art instrumentation and expertise for addressing experimental issues related to single cells, nuclei and chromosomes. In addition to instrumentation, the Facility intends to collaborate with the investigators and contribute to all aspects of the research process. This includes consultation in experimental design, technical assistance in the operation of instruments, trouble shooting, data analysis and storage, interpretation of results and preparation and production of presentation graphics. The Facility is also communicating with investigators in other institutions and is devoted to introducing and developing new applications on our flow cytometers. In this way, investigators are provided with unlimited possibilities to answer questions regarding nature and function of cells by flow cytometry.

Proper citation: LCRC Cell Analysis and Immunology Core Facility (RRID:SCR_009905) Copy   

•   Source: SciCrunch Registry

https://www.ohsu.edu/research-cores/massively-parallel-sequencing-shared-resource-mpssr

As of January 1, 2024, the Integrated Genomics Laboratory is one shared resource comprising the former Massively Parallel Sequencing Shared Resource, the Gene Profiling Shared Resource, and the DNA Services Core. Please be aware that the reorganization is an ongoing process, particularly regarding our iLab integration.Provides RNA-sequencing for gene expression analysis, DNA resequencing for single nucleotide polymorphism discovery, DNA resequencing for copy number variation discovery, ChiP-sequencing for promoter analysis, DNA methylation analysis, De novo sequencing for unique genomes, Sequence capture service. Offers sequencing including genome resequencing, transcriptome analysis, miRNA analysis, and prometer analysis via ChIP-seq.

Proper citation: OHSU Massively Parallel Sequencing Shared Resource Core Facility (RRID:SCR_009984) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012f-c755-f030-a63c-45b480000000

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on December 6,2022. Core facility that provides the following services: Mouse breeding service, Behavioral testing procedures service, Mouse breeding. Three of the MARC''s research components (5, 6, and 8) include experiments with lines of mice bred to have special genetic traits. The animal core supports these components by purchasing, testing, breeding, maintaining, and distributing these animals within the center. The core will breed special mouse lines F1 and F2 that are descendents of C57BL/6J (B6) and DBA/2J (D2) inbred strains. For Components 5 and 6, the animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine drinking and for high and low methamphetamine-induced sensitization. In addition, the core is developing new behavioral-testing procedures and maintaining a database that will track individual animals and post their trait data for all MARC investigators to utilize.

Proper citation: OHSU Methamphetamine Abuse Research Center Animal Core Component (RRID:SCR_009985) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/00000131-1efe-8036-a944-114f80000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 6,2022. Core facility that provides the following services: Use of IOIC facility, In vivo optical imaging training service. The IOIC is located in Cardiac Imaging Laboratory on the first floor of the Biomedical Research Building (BRB). The laboratory was established through a Shared Instrument Grant (PI: Michael Deininger) but is maintained through user fees. The core facility includes the IVIS Spectrum optical imaging camera housed in a light-tight housing, rat and mouse imaging platforms for multi-subject simultaneous acquisition, an integrated inhaled anesthesia system, and advanced analysis software. A key component of the IOIC is the ability to operate either independently or under the guidance and supervision of core personnel. Independent use of the system requires that investigators undergo training that is offered every 2 months or on an ad hoc basis. All analysis will be charged on an hourly basis and is graduated according to the level of service (independent or supervised).

Proper citation: OHSU In Vivo Optical Imaging Center (RRID:SCR_009982) Copy   

•   Source: SciCrunch Registry

http://ohsu.eagle-i.net/i/0000012a-24ff-956f-d994-629180000000

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on December 6,2022. Core facility that provides the following services: Immunological study design and implementation, Flow cytometry assays service, High-throughput analysis service, Economies-of-scale reagent purchasing, Flow cytometry sorting service. The CIU offers all the study organization and technical expertise developed at the (Louis) Picker Lab to researchers whose questions require obtaining and processing monkey immunological samples, and/or utilizing cytometry to assay phenotype of CFC/ICS information. The CIU was originally developed as part of the Bill & Melinda Gates foundation CAVD (Collaboration for AIDS Vaccine Discovery) consortium.

Proper citation: OHSU Immunology Support Core Cellular Immunology Unit (RRID:SCR_009980) Copy   

•   Source: SciCrunch Registry

http://montana.eagle-i.net/i/0000012b-00be-16ed-df3b-3fdc80000000

Core facility that provides the following services: Lab animal technician services, Animal husbandry service.

The Mission of the Animal Resources Center is to provide healthy animals for use in IACUC-approved research, educational and testing protocols at Montana State University,ensure that University research animals are cared for in a humane and appropriate manner by the provision of modern, well maintained facilities, trained personnel, technical support, veterinary care and monitoring of animal care and use, provide resources, technical assistance, and information for University researchers and educators in meeting the requirements of animal-related protocols, and ensure observance of ethical standards and federal regulations pertaining to the care and use of animals for research, education and testing at Montana State University.

Proper citation: MSU Animal Resource Center (RRID:SCR_009936) Copy   

•   Source: SciCrunch Registry

http://msm.eagle-i.net/i/0000012b-00c2-e053-353c-df7f80000000

The Analytical Chemistry and Protein Profiling Core is comprised of three primary labs: * Analytical Chemistry * Protein Profiling/2D Gel * 2D Gel Electrophoresis Lab

Proper citation: MSM Analytical Chemistry and Protein Profiling Core (RRID:SCR_009933) Copy   

•   Source: SciCrunch Registry

http://msm.eagle-i.net/i/0000012b-00c2-b0bd-353c-df7f80000000

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 25, 2019. Core focuses on integration of MSM and affiliated health information systems into an interoperable repository. The long-term goal is to establish an integrated standards-based informatics platform to support MSM clinical and translational research investigators in their own work and in sharing research information with collaborators and other investigators in parallel fields.

Proper citation: Morehouse School of Medicine Biomedical Informatics Unit (RRID:SCR_009934) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-86f9-8ca4-8463-ad4580000000

The Visualization Core Laboratory / GIS Remote Core Laboratories were established to bond existing capabilities and talents in the areas of Geographic Information Systems (GIS), Remote Sensing (RS) and Scientific Visualization (Sci-Viz) and co-locate them in a centralized facility. This created an infrastructure of technology, data, people and institutional linkages that enables the discovery, evaluation and application of geospatial and visual data for adding value to research across various areas and disciplines. The GIS/RS laboratories support the development, enhancement and transfer of GIS/RS applications, make geospatial data available and accessible and promote research and development innovation among users. The Sci-Viz laboratory supports the need of scientists and researchers relative to modeling, program application development and production of high quality advanced visualizations for all fields or disciplines. The TLGVRC addresses human resource development to ensure a skilled workforce which is vital for sustenance of any high level technology activity.

Proper citation: JSU Remote Sensing Core Laboratory (RRID:SCR_009898) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-6bd2-db1d-75a1-b5a380000000

Core facility that provides the following services: Recombinant protein expression and purification in yeast Pichia pastoris, Large-scale production of immunotoxins for cell depletion studies, Large scale production of recombinant cytokines, Cost effective small-scale production using E.coli system.

The Recombinant Protein Expression and Purification (RPrEP) Core was established in 2009 to provide a cost-effective resource to the MGH and DF/ HCC community for expression and purification of recombinant proteins necessary for pre-clinical studies as well as for basic mechanistic studies by immunologists and cancer biologists. Recombinant Proteins can be manufactured by this Core for a variety of applications according to MGH-DF/ HCC investigator needs. In addition to large-scale production of recombinant proteins in yeast Pichia pastoris, a cost effective small-scale production service will be provided using E.coli or yeast Pichia pastoris expression system (e.g. for small animal studies, use as immunogens, ELISAs, or high throughput microarray platforms).

Proper citation: MGH Recombinant Protein Expression and Purification Core (RRID:SCR_009931) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6de9-a291-55da-381e80000000

Core facility that provides the following services: Sperm Cryoperservation - Standard Mouse Backgrounds; including quality test (QC), 129 or Hybrid ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, C57BL/6 (JM8A) ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, Microinjection of one targeted 129, JM8A, or hybrid ES Cell clone, Microinjection of one targeted C57BL/6 (JM8 & others) ES Cell clone, Transgenic / DNA pronuclear Microinjection, Transgenic/ BAC DNA pronuclear Microinjection to hybrid mouse strain, Mice colony breeding, Mice ID tag & tail biopsy, Mice tail DNA preparation, Sperm Cryoperservation - Non-Standard Mouse Backgrounds; including quality test(QC), Recovery live born pups for testing following QC, IVF recovery of one mouse line from cryopreserved sperm for most strains (~10 pups provided), Recovery of cryopreserved mice embryos (up to 80 embryos), Special DNA Prep.

The MGH Transgenic and Gene Targeting Facility generates transgenic and knockout or knock-in mice to study gene function in embryonic stem cell and somatic cell systems. Services include: microinjection of DNA into fertilized embryos for the creation of transgenic mice, transfection of DNA into ES cells for the generation of recombinant ES cell clones, injection of gene-targeted ES cell clones into host blastocysts for the generation of gene knockout or knock-in mice, and other related ES cell based services. The facility is also equipped to perform in vitro fertilization projects, cryopreservation of mouse sperm and embryos, recovery of cryopreserved mouse sperm and embryos, and derivation of ES cell lines from a variety of genetic backgrounds. The facility provides consultation within reason on experimental design and vectors for gene targeting-related projects. The facility can also provide advice for the preparation of DNA, recombinant ES clones, mouse genotyping, handling and husbandry. The facility supports innovative and experimental approaches involving transgenic and knockout or knock-in mice to better help investigators study gene regulation and function, and develop appropriate animal models to study human genetic disorders.

Proper citation: MGH Transgenic and Gene Targeting Facility (RRID:SCR_009932) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-c931-8969-0055-c4eb80000000

Core facility that provides the following services: Genomics service, Proteomics services, Functional assays service, Cell culture services, Stress enzyme analysis. The specific aims of the MCB Core Laboratory are: To provide a variety of services and technical support in molecular biology and DNA technology by offering equipment access, expert advice, demonstration of techniques, operation of equipment, participation in discussion and data interpretation, and hands-on-training in molecular biology and cell culture; to increase faculty training in recombinant DNA technology to strengthen faculty development and technology transfer; to provide a research environment and instrumentation for investigators to pursue biomedical research opportunities and enhance overall research productivity; to foster collaborative research relationships among RCMI investigators and other MCB core users at JSU and other research intensive institutions.

Proper citation: JSU Molecular and Cellular Biology Core Laboratory (RRID:SCR_009896) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000135-81af-5452-a9f8-d64580000000

Core facility that provides the following services: Mass spectrometry services. The mission of Proteomics Core Facility is to help researchers advance their biomedical research programs. The Facility is equipped with gel electrophoresis units, image analyzers and digitizers, and robotics for mass spectrometry sample preparation. Currently, a Matrix-Assisted Laser Desorption/Ionization Mass Spectrometer instrument implements protein identification. The various applications include the studies of protein expression profile, posttranslational modifications, and partial sequencing of novel proteins. The staff also consult with researchers about their particular research interests and assist with the development of specific applications and solution to problems.

Proper citation: LCRC Proteomics Core Facility (RRID:SCR_009894) Copy   

•   Source: SciCrunch Registry