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http://harvard.eagle-i.net/i/0000012e-357f-dcfa-550e-f59280000000

Equipment access: All new users must be trained by the facility manager over two orientation sessions and be approved to use the equipment in the facility. All users must obtain the financial approval from their PI and financial manager. Please submit a PO number or the Harvard billing code prior to the first use of the facility.

Proper citation: HSPH Molecular Analysis Facility (RRID:SCR_008273) Copy   

•   Source: SciCrunch Registry

http://alaska.eagle-i.net/i/00000130-4c48-c245-67ac-ce7680000000

Core facility that provides the following services: Stable isotope analysis service. The Alaska Stable Isotope Facility is a state-of-the-art laboratory conducting stable isotope analyses of wide range of sample types for researchers from all over Alaska, the USA and the globe. Sample types include organic samples (C, N, O and H isotopes), inorganic samples (e.g. carbonate for C and O) and water (O and H).

Proper citation: UAF Alaska Stable Isotope Facility (RRID:SCR_009556) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2519-e7a3-5617-794280000000

Core facility that provides the following services: Mouse breeding service, Mouse genotyping service, Tail vein injections service, Tissue service, Cancer mouse model service, Human tumor xenografts service.

Proper citation: BIDMC Preclinical Murine Pharmacogenetics Core (RRID:SCR_009675) Copy   

•   Source: SciCrunch Registry

http://bidmc.org/Research/CoreFacilities/MassSpectrometryCore.aspx

Core facility that provides the following services: Mapping of post-translational modifications by LC/MS/MS, Protein (complex) identification by LC/MS/MS, Relative quantification of peptides by LC/MS/MS, SILAC, iTRAQ, and Isotope-free ratio quantification service, Metabolomics profiling service.

The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Our trained staff offers the highest quality and reliable service with meticulous attention to detail for each sample. We routinely provide services including protein identification, post-translational modification mapping, and relative peptide/protein quantification by stable isotope labeling and label free methods using highly sensitive microcapillary LC/MS/MS techniques at nanoliter flow rates. Several different types of mass spectrometry are utilized depending upon the needs of the researcher including a fast scanning and highly sensitive 2D linear ion trap and a high resolution/high mass accuracy LTQ-Oribitrap mass spectrometer acquired in 2007. In 2005, in agreement with Harvard Medical School''s Pathology Dept., the BIDMC Mass Spectrometry Core became part of the NRB Mass Spectrometry and Proteomics Core, expanding its services and became part of the Cancer Proteomics Core for the Dana Farber Harvard Cancer Center. We serve all institutions regardless of affiliation and have an interest in samples related to many diseases such as cancer and diabetes.

Proper citation: BIDMC Mass Spectrometry Core (RRID:SCR_009672) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-09f6-d7d6-6a45-990480000000

Core facility that provides the following services: Multi-Gene transcriptional profiling (MGTP) service.

Multi-Gene Transcriptional Profiling (MGTP) is a real-time PCR based technique, developed in our lab, for quantifying mRNA copy numbers per cell with high reproducibility and accuracy. Primary Goals of the MGTP Core: * To make MGTP services available to investigators, and assist them in advancing their research and obtaining grants; * To assist studies of molecular signaling mechanisms and pathways, discovery of biomarkers, and development of clinical assays; and * To share the resources of our primer library, which currently includes about 2400 pre-validated human, and mouse genes. The MGTP Core makes these unique and powerful capabilities available to biomedical researchers. Thousands of pre-validated primers are available for use, and others can be designed on demand.

Proper citation: BIDMC Multi-Gene Transcriptional Profiling Core (RRID:SCR_009673) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-1465-5617-794280000000

Core facility that provides the following services: User-based microscopy service, Microscopy training service. The Imaging Core provides access to standard digital and laser scanning confocal microscopy, multiphoton microscopy, unbiased stereology, and automated confocal microscopy for large scale genome-wide screens. In addition, the Core has substantial capabilities in quantitative and three-dimensional volumetric image reconstruction.

Proper citation: CHB Cellular Imaging Core (RRID:SCR_009671) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2519-627b-5617-794280000000

Core facility that provides the following services: DNA sequencing service.

The BIDMC DNA Sequencing Facility is equipped with an ABI 3130xl Automated DNA Sequencer. Turn around time is 24 hours: drop off samples by 10am (at CLS-426E or SL-232) and obtain results by 11am of the following day. Some results can be posted the same day of sample submission. Sample pick up is available in Longwood Medical Area - please send requests by email. Also available through the BIDMC DNA sequencing core to the Harvard Research community is the newest model of the Arcturus Laser Capture Microdissection System!

Proper citation: BIDMC DNA Sequencing Core (RRID:SCR_009664) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2519-7352-5617-794280000000

Core facility that provides the following services: Adult cardiac myocyte isolation service, Adult rat cardiac myocyte cultures service, Animal maintenance service, Aortic banding surgery service, Echocardiography service, Hind limb ischemia surgery service, I/R surgery service, Invasive cardiac output measurement service, Laser Doppler service, MI surgery service, Special animal care maintenance service, Tail vein blood collection service, Telemetric BP monitoring service.

The goal of Cardiac Physiology Core is to provide expertise in evaluation of cardiac pathology for non-cardiovascular and cardiovascular researchers who are not equipped for such analysis. The core provides non-invasive and invasive evaluation of cardiac physiology that may be difficult or time-consuming for those investigators without proper expertise, experience and equipments.

Proper citation: BIDMC Cardiac Physiology Core Laboratory (RRID:SCR_009662) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-5977-000a-55da-381e80000000

The Community Practice Research Core (CPRC) provides DF/HCC investigators access to a racially diverse population of over 11,000,000 patients within the community-based clinical practices of Harvard Vanguard Medical Associates (HVMA)/ Atrius Health, a Boston-based medical specialty group comprised of over 20 office locations across eastern Massachusetts providing care to more than 510,000 adult and pediatric patients; Harvard Pilgrim Health Care (HPHC), one of the largest health maintenance organizations in New England with close to 1,000,000 members and an extensive provider network that includes physicians who practice in a variety of settings; the Cancer Research Network is comprised of 9 health care systems and 6 affiliate sites across the nation with a total membership of 11,000,000 patients. The populations of HVMA/Atrius, HPHC, and the CRN are particularly ideal for studies: (1) involving basic, clinical, and population sciences; (2) addressing diverse communities; (3) investigating dissemination of proven technologies and interventions; (4) requiring large samples of patients and/or providers; (5) involving rare cancers; and (6) of cancer prevention.

Proper citation: DF/HCC Community Practice Research Core (RRID:SCR_009735) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-5d8c-a118-55da-381e80000000

Core provides all of the tools of modern functional proteomics. Equipped with technologies for proteomics; protein profiling, protein identification, protein and peptide fractionation, and quantization. Personalized experimental design consultation, comprehensive individualized bioinformatics support. The mission of the DF/HCC Cancer Proteomics Core is to develop a comprehensive and interdisciplinary proteomics core for High Sensitivity, High Resolution and High Throughput Proteomics with particular emphasis on in depth proteomic consultation, referral to the optimal proteomics facility and a strong focus on clinical sample analysis. The core combines consultation, service and education into a comprehensive, translationally and clinically oriented proteomics core.

Proper citation: Dana Farber and Harvard Cancer Center Cancer Proteomics Center (RRID:SCR_009733) Copy   

•   Source: SciCrunch Registry

http://ccny-cuny.eagle-i.net/i/00000137-4cd7-8ff5-bb24-040880000000

Basic research equipment for RCMI Faculty

Proper citation: CCNY RCMI Core Facility (RRID:SCR_009698) Copy   

•   Source: SciCrunch Registry

http://ccny-cuny.eagle-i.net/i/00000137-4cd8-9a02-bb24-040880000000

The microscopy center is a shared central facility whose primary goal is to promote scientific research by providing training in basic operation of the scanning electron microscope (SEM), the transmission electron microscope (TEM) and the Confocal.RRRRR RRRRR New users of the facility are asked to submit an application then schedule an appointment with the manager to discuss the project or to begin training.

Proper citation: CCNY Microscopy Facility (RRID:SCR_009697) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-9d60-89cb-b977-103480000000

Core facility that provides the following services: Scientific computing for data analysis and scientific graphics, Advice and consultation regarding grant applications and management of clinical trials data, Training in study design, data collection, computerization, and statistical methods.

The Biostatistics Core facility is a shared resource supporting consultation on biostatistics and epidemiology throughout the Dana-Farber/Harvard Cancer Center (DF/HCC). The mission of the core is to ensure that experimental designs, study monitoring and data analyses take advantage of robust, efficient methods that reflect ''best practices'' in biostatistics and epidemiology; to support NIH-funded peer reviewed grants that do not contain salary support for statisticians; and to enable pilot and small scale studies to become part of successful applications for peer-reviewed funding. These services are available to Dana-Farber / Harvard Cancer Center members only. The Biostatistics Core is located across several of the member institutions of the DF/HCC. To contact the Core, please email or call the statistician associated with your disease site.

Proper citation: DF/HCC Biostatistics Core Facility (RRID:SCR_009730) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-ab9d-72b3-ecf8-187780000000

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core provides next generation sequencing service. Collaborative effort between the CCRTD and the Ovarian Cancer Institute at Georgia Tech University (OCIGT). CCRTD provides laboratory to prepare libraries and to operate the instrument, while OCIGT contributes bioinformatics support for processing the data and additional services to complement genomics data including hardware, software, and personnel. OCIGT contributes patients sample procurement and complementary technologies including Affymetrix microarray technology and mass spectroscopy analysis.

Proper citation: Clark Atlanta University Collaborative Center for Cancer Genomics and Bioinformatics Core Facility (RRID:SCR_009695) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6e00-af62-55da-381e80000000

Core facility that provides the following services: DNA analysis - Affymetrix GeneChip arrays service, DNA analysis - Illumina infinium whole genome genotyping service, DNA analysis - custom content genotyping service, RNA Analysis - Affymetrix gene expression service, RNA Analysis - Illumina Gene Expression service, RNA Analysis - Illumina whole-genome DASL service. The Genetic Analysis Platform collaborates with scientists at the Broad and across the world to identify and characterize patterns of genetic variation and gene expression. These patterns can yield a deeper understanding of how genetic factors influence disease risk and treatment outcomes in a wide range of human diseases, including type 2 diabetes, Crohn''s disease, schizophrenia, and cancer, among many others. Over the past several years, the platform has been a leading contributor to major projects such as the International Haplotype Map Project, The Cancer Genome Atlas, the 1,000 Genomes Project, the Genes and Environment Initiative, and served as a national genotyping center under a NIH/NCRR program. Genetic Analysis Platform (GAP) scientists are experts in a wide range of genomic technologies and technology platforms, including genotyping, gene expression and directed resequencing, and routinely apply these technologies to studies of both human and non-human samples. In addition, teams of platform researchers work to test out emerging genetic technologies, develop informatics tools and infrastructure to enhance scientific research, and coordinate large-scale projects involving collaborators both within and beyond the Broad.

Proper citation: Broad Genetic Analysis Platform (RRID:SCR_009690) Copy   

•   Source: SciCrunch Registry

http://cau.eagle-i.net/i/00000135-abea-80e6-ecf8-187780000000

In CCRTD, we provide excellent support for Cell Biology research and advanced cell visualization applications. We have complete facilities for cell growth, handling, and storage. Cell Culture Facility maintains Cell Storage Cryo Tanks with uninterruptable liquid nitrogen supply and two separate Cell Culture rooms fully equipped with eight temperature and CO2-controlled Cell Growth Incubators, two Biological Safety Cabinets, Fluorescence-Activated Cell Sorter (FACS), two late model Inverted Digitized Microscope (Zeiss), one of which is fluorescence-enabled and possesses Z-stacking and live cell imaging capabilities, automated Cell Counter (Nexcelom Bioscience), and refrigerated storage for media and cell culture reagents.

Proper citation: CAU CCRTD-Cell Biology (RRID:SCR_009691) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-4506-110d-eb5b-b63c80000000

Core facility that provides the following services: Stem cell differentiation, Stem cell line propagation. The human embryonic stem cell/induced pluripotent Stem Cell (hESC/iPSC) Core generates control and patient-specific iPSC lines by cellular reprogramming using current technologies. The core has a training course in cell maintenance and growth, specialized differentiation protocols for disease modeling and drug screening, and quality-control reagents for the Children?s Hospital and University of Pennsylvania academic communities. The facility maintains five NIH-approved human ESC lines and has generated more than 60 disease-specific iPSC lines.

Proper citation: CHOP Human Embryonic stem cell/induced pluripotent stem cell Core (RRID:SCR_009727) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-60a7-d769-c437-ff0b80000000

The BWH-BRI Antibody Core Facility provides high quality, purified monoclonal antibodies to the BWH research community. Because the antibodies are made in-house and require no shipping, they are available at a cost substantially lower than that of commercial vendors. Antibodies are of standardized quality and are available in two convenient aliquots: 500ugs and 10mgs. The Core maintains an inventory of commonly used antibodies, which allows orders to be filled quickly.

Proper citation: BWH-BRI Antibody Core Facility (RRID:SCR_009689) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-7cbe-8ce9-fbab-3b8480000000

Core facility that provides the following services: Vascular laboratory services, Vascular laboratory service, Carotid intima medial thickness measurment (IMT), Vascular laboratory service, Brachial Artery Reactivity (BART), Echocardiographic laboratory services, Exercise physiology laboratory services, Vascular laboratory service, Continuous arterial spin-labeling perfusion magnetic resonance imaging. The Cardiovascular Core provides cardiac testing services for children. The Core provides the technical services and expertise to conduct the highest quality research, provides research tests in a cost-effective manner, and provides unparalleled training opportunities in clinical research for investigators, fellows, students and technicians.

Proper citation: CHOP CTRC Cardiovascular Imaging Core (RRID:SCR_009722) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2511-e97c-5617-794280000000

Core facility that provides the following services: ES cell transfection (electroporation), Thawing/expansion of targeted ES cells, Microinjection of ES cells into blastocysts, Microinjection of DNA constructs into egg pronuclei for generating transgenic mice, Microinjection of BAC DNAs, DNA injection and microdissection, Lentiviral transgenics service, Injection of induced pluripotent stem cells for testing totipotency, Tail biopsy service, Breeding services, Mouse manipulation consultation. The Brigham & Women''s Hospital Transgenic Core Facility provides services for generating transgenic and knockout mice. Established in 1992, the BWH Core Facility has been providing gene targeting and microinjection services using state-of-the-art facilities and equipment. Dr. Lina Du, formerly a plastic surgeon in Beijing and an expert in microvascular surgery, performs both blastocyst and pronuclear injections. She has over 15 years of experience in embryo manipulation and the generation transgenic mice. The Core Facility has all of the equipment necessary for generation of transgenic mice including a Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation ad transfer, a sutter needle puller and a de Fonbrune microforge. The facility maintains mice necessary for egg donors, egg recipients, and vasectomized males. This is a non-profit facility and charges are based upon anticipated mouse costs, maintenance of mice and equipment, and purchase of necessary surgical supplies and chemicals. The ES cell culture service has been offered for 6 years. Our staff carries out electroporation of targeting vectors into ES cells and provides investigators with DNA to identify ES cells carrying the desired recombination events. Then they expand the appropriate ES Cells for microinjection into blastocysts by the BWH Transgenic Core.

Proper citation: BWH Transgenic Core Facility (RRID:SCR_009688) Copy   

•   Source: SciCrunch Registry