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http://www.nimh.nih.gov/funding/clinical-trials-for-researchers/practical/stard/index.shtml
A nationwide public health clinical trial conducted to determine the effectiveness of different treatments for people with major depression, in both primary and specialty care settings, who have not responded to initial treatment with an antidepressant. This is the largest and longest study ever done to evaluate depression treatment. The study is completed and no longer recruiting participants. Each of the four levels of the study tested a different medication or medication combination. The primary goal of each level was to determine if the treatment used during that level could adequately treat participants����?? major depressive disorder (MDD). Those who did not become symptom-free could proceed to the next level of treatment. The design of the STAR*D study reflects what is done in clinical practice because it allowed study participants to choose certain treatment strategies most acceptable to them and limited the randomization of each participant only to his/her range of acceptable treatment strategies. No prior studies have evaluated the different treatment strategies in broadly defined participant groups treated in diverse care settings. Over a seven-year period, the study enrolled 4,041 outpatients, ages 18-75 years, from 41 clinical sites around the country, which included both specialty care settings and primary medical care settings. Participants represented a broad range of ethnic and socioeconomic groups. All participants were diagnosed with MDD, were already seeking care at one of these sites, and were referred to the trial by their doctors. * STAR*D Study Medications: Citalopram (Celexa), Sertraline (Zoloft), Bupropion SR (Wellbutrin SR), Venlafaxine XR (Effexor XR), Buspirone (BuSpar), Mirtazapine (Remeron), Triiodothyronine (T3) (Cytomel), Nortriptyline (Pamelor, Aventyl), Tranylcypromine (Parnate), Lithium (Eskalith, Lithobid) *STAR*D Talk Therapy:Cognitive Therapy
Proper citation: Sequenced Treatment Alternatives to Relieve Depression Study (RRID:SCR_008051) Copy
http://www.cdc.gov/nccdphp/ace/
A clinical study linking childhood maltreatment and later-life health and well-being. As a collaboration between the Centers for Disease Control and Prevention and Kaiser Permanente''s Health Appraisal Clinic in San Diego, Health Maintenance Organization (HMO) members undergoing a comprehensive physical examination provided detailed information about their childhood experience of abuse, neglect, and family dysfunction. Over 17,000 members chose to participate. To date, over 50 scientific articles have been published and over 100 conference and workshop presentations have been made. Future Directions: The ACE study is now in its 10th year and the prospective phase is currently underway. In this ongoing stage of the study, data are being gathered from various sources including outpatient medical records, pharmacy utilization records, and hospital discharge records to track the subsequent health outcomes and health care use of ACE Study participants. In addition, an examination of National Death Index records will be conducted to establish the relationship between ACE and mortality among the ACE Study population. The ACE Study findings suggest that these experiences are major risk factors for the leading causes of illness and death as well as poor quality of life in the United States. Progress in preventing and recovering from the nation''s worst health and social problems is likely to benefit from the understanding that many of these problems arise as a consequence of adverse childhood experiences. :Sponsors: This resource is supported by the Centers for Disease Control and Prevention and the Kaiser Permanente''s Health Appraisal Clinic in San Diego.
Proper citation: Adverse Childhood Experiences Study (RRID:SCR_008382) Copy
A human full-length cDNA sequence analysis database focused on mRNA varieties caused by variations of transcription start site (TSS) and splicing. Also available is ATGpr, a program for identifying the translational initiation codons in cDNA sequences. Data are derived from several full-length cDNA studies in Japan. Human gene number was estimated to be 20-25 thousand. However, the number of human mRNA varieties was predicted to be about 100 thousand. The varieties are thought to be caused by variations of TSS and splicing. In their previous human cDNA project, about 30 thousand of FLJ human full-length sequenced cDNAs were deposited to DDBJ/GenBank/EMBL, and they obtained about 1.4 million of 5''-end sequences (5''-EST) of FLJ full-length cDNAs from about 100 kinds of cDNA libraries consist of human tissues and cells constructed by oligo-capping method. The majority of the insert cDNA sizes were over 2 kb and the full-length rate of 5''-end was 90. And our FLJ cDNAs were covered about 80 of human genes. About 22 thousand of finished grades of full-length sequenced cDNAs were obtained in this project. The sequence analysis databases is focused on mRNA variations using human genome and cDNA sequences, FLJ full-length sequenced cDNAs, 5-ESTs of FLJ full-length cDNAs and other cDNA sequences described below. After those sequences were mapped onto the human genome sequences, clustering of the cDNA sequences were done based on the mapping results.
Proper citation: FLJ Human cDNA Database (RRID:SCR_008253) Copy
http://www.loni.usc.edu/Software/jViewbox
A portable software framework for medical imaging research. jViewbox consists of a set of Java classes organized under a simple but extensive API that provides the core functionality of 2D image presentation needed by most imaging applications. It follows Java's Swing model closely to make it easy for application developers to build GUIs where end users can use various tools in a tool bar to manipulate the image displays. No optional add-ons or native code is used, which makes jViewBox compatible with any standard Java 2 Runtime Environment (version 1.3 or later).
Proper citation: jViewbox (RRID:SCR_008274) Copy
Cambridge, Massachusetts-based biotechnology company focused on cancer. Focus areas are blood cancers and solid tumors. Compounds: ponatinib, AP26113, ridaforolimus and AP1903., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.
Proper citation: ARIAD (RRID:SCR_008559) Copy
http://psychiatry.stanford.edu/alzheimer/
Portal for gerontology research with a variety of clinical, research and educational programs, with the aim of improving the lives of those affected by Alzheimer's Disease and memory losses associated with normal aging. The Center investigates the nature of Alzheimer's Disease, its progression over time, its response to treatments, and problems patients and caregivers experience in dealing with the changes that occur. It also conducts studies that look at changes that occur over the course of normal aging and have a Normal Aging Brain Donor Program. The Aging Clinical Research Center puts out a newsletter that showcases various projects and includes informative articles on dementia.
Proper citation: Stanford/VA Aging Clinical Research Center (RRID:SCR_008678) Copy
https://sites.google.com/ucsd.edu/drc/home
Research center across five institutions for clinical research in diabetes. Collaborators include UC San Diego's School of Medicine, Salk Institute, Cedars-Sinai Medical Center, UC Los Angeles' School of Medicine, and LA Biomedical Research Center.
Proper citation: University of California San Diego - University of California Los Angeles Diabetes Research Center (RRID:SCR_015100) Copy
Research center which operates in collaboration with the University of Alabama Birmingham Comprehensive Diabetes Center to promote excellence in diabetes research and patient care. The DRC supports the areas of animal physiology, human biology and intervention and translational research. It focuses on developing new methods to treat, prevent, and ultimately cure diabetes and its complications.
Proper citation: University of Alabama at Birmingham Diabetes Research Center (RRID:SCR_015107) Copy
https://diabetes.med.umich.edu/partners/michigan-diabetes-research-center-mdrc
Multidisciplinary unit of the University of Michigan funded by the National Institute of Diabetes and Digestive and Kidney Diseases/National Institute of Health. Promotes new discoveries and enhance scientific progress through the support of basic and clinical research related to diabetes, its complications, and related disorders. Creates environment that supports innovative research; attracts and retains early stage investigators and investigators new to diabetes research; provides core services that leverage funding and unique expertise; fosters interdisciplinary collaborations; raises awareness and interest in fundamental and clinical diabetes research at their institutions, as well as locally, regionally, and nationally.
Proper citation: Michigan Diabetes Research Center (RRID:SCR_015112) Copy
Consortium of laboratory-based and clinical investigators who research etiology, pathogenesis, treatment and cure of type 1 and type 2 diabetes, and their associated microvascular and atherosclerotic complications.
Proper citation: Boston Area Diabetes Endocrinology Research Center (RRID:SCR_015072) Copy
http://www.einstein.yu.edu/centers/diabetes-research/
Research center that facilitates the research of diabetes and related studies in obesity, metabolism and endocrinology
Proper citation: Einstein-Mount Sinai Diabetes Research Center (RRID:SCR_015070) Copy
University-affiliated center that promotes research in diabetes and related metabolic and endocrine disorders at Yale University.
Proper citation: Yale Diabetes Research Center (RRID:SCR_015142) Copy
Group whose goal is to improve health outcomes for individuals with X-linked adrenoleukodystrophy by raising disease awareness, improving education, providing support for and information to patients, and performing clinical ALD research.
Proper citation: ALD Connect (RRID:SCR_015035) Copy
Foundation for improving the quality of life for people affected by OI through treatment and cure research, education, awareness, and mutual support. OIF lists personal resources for individuals affected by osteogenesis imperfecta as well as professional and clinical resources for researchers.
Proper citation: Osteogenesis Imperfecta Foundation (RRID:SCR_015034) Copy
International non-profit organization for patients, relatives, and physicians with pituitary tumors and disorders.
Proper citation: Pituitary Network Association (RRID:SCR_015006) Copy
http://depts.washington.edu/diabetes/
University-affiliated center to support both basic and clinical research in diabetes and related metabolic disorders with the ultimate purpose of translating findings into opportunities to prevent these diseases and to improve clinical care and outcomes.
Proper citation: University of Washington Diabetes Research Center (RRID:SCR_015126) Copy
http://www.mayo.edu/research/centers-programs/center-cell-signaling-gastroenterology-c-sig
Center whose mission is to improve understanding of the signaling pathways that control the function of gastrointestinal cells in health and disease. It serves as a hub that provides access to research resources and expertise to multidisciplinary groups of basic scientists and clinical researchers.
Proper citation: Mayo Clinic Center for Cell Signaling in Gastroenterology (RRID:SCR_015224) Copy
Research center for translational research on type 2 diabetes with a strong emphasis on translation into real world health care settings and communities.
Proper citation: Georgia Center for Diabetes Translation Research (RRID:SCR_015185) Copy
http://keck.usc.edu/liver-diseases-research-center/
Center whose goal is the facilitation and fostering of interdisciplinary collaborative research in the field of pathobiology of diseases of the liver and digestive tract and the development of new treatments for these diseases.
Proper citation: USC Liver Transplant Program and Center for Liver Disease (RRID:SCR_015237) Copy
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