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http://www.broad.mit.edu/mammals/dog

The genome of the domesticated dog, a close evolutionary relation to human, is a powerful new tool for understanding the human genome. Comparison of the dog with human and other mammals reveals key information about the structure and evolution of genes and genomes. The unique breeding history of dogs, with their extraordinary behavioral and physical diversity, offers the opportunity to find important genes underlying diseases shared between dogs and humans, such as cancer, diabetes, and epilepsy. The Canine Genome Sequencing Project produced a high-quality draft sequence of a female boxer named Tasha. By comparing Tasha with many other breeds, the project also compiled a comprehensive set of SNPs (single nucleotide polymorphisms) useful in all dog breeds. These closely spaced genomic landmarks are critical for disease mapping. By comparing the dog, rodent, and human lineages, researchers at the Broad Institute uncovered exciting new information about human genes, their evolution, and the regulatory mechanisms governing their expression. Using SNPs, researchers describe the strikingly different haplotype structure in dog breeds compared with the entire dog population. In addition, they show that by understanding the patterns of variation in dog breeds, scientists can design powerful gene mapping experiments for complex diseases that are difficult to map in human populations. Contribute Although the astounding generosity of Eli and Edythe L. Broad and several other venture philanthropists empowers our scientists to tackle many of the most important problems at the cutting edge of genomic medicine, there are many other critical challenges that they cannot yet pursue because of limited resources. We need additional visionary partners to join the Broads and the Broad Institute in transforming medicine with the power of genomics.

Proper citation: Dog Genome Project (RRID:SCR_008486) Copy   

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http://www.biobankcentral.org/resource/wwibb.php

THIS RESOURCE IS NO LONGER IN SERVICE, documented on March 27, 2013. Web-based portal to connect all the constituencies in the global biobank community. The project seeks to increase the transparency and accessibility of the scientific research process by connecting researchers with an additional source of funding - microinvestments received from the broader online community. In exchange for these public investments, researchers will maintain research logs detailing the play-by-play progress made in their project, as well as publishing all of their data in a public database under a science commons license. These research projects, in turn, will serve to continually update a research-based neuroscience-based human brain & body curriculum. Biobanks are the meeting point of two major information trends in biomedical research: the generation of huge amounts of genomic and other laboratory data, and the electronic capture and integration of patient clinical records. They are comprised of large numbers of human biospecimens supplemented with clinical data. Biobanks when implemented effectively can harness the power of both genomic and clinical data and serve as a critical bridge between basic and applied research, linking laboratory to patient and getting to cures faster. As science and technology leaders work to address the many challenges facing U.S. biobanks logistical, technical, ethical, financial, intellectual property, and IT BioBank Central will serve as an accurate and timely source of knowledge and news about biorepositories and their role in research and drug development. The Web site also provides a working group venue, patient and public education programs, and a forum for international collaboration and harmonization of best practices.

Proper citation: BioBank Central (RRID:SCR_008645) Copy   

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http://www.alzfdn.org/index.htm

Non profit organization and informational portal directed towards patients and families. AFA is an umbrella orgnization uniting over 1600 member organizations to collaborate on education, resources, best practices and advocacy. AFA provides several grant opportunities for AFA's nonprofit member organizations and to individuals in need.

Proper citation: Alzheimer's Foundation of America (RRID:SCR_008724) Copy   

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http://www.alzresearch.org/index.cfm

A Alzheimer's Disease Research Center (ADRC) whose goal is to conduct basic and clinical research aimed at understanding Alzheimer's disease. The Center enrolls a variety of individuals for clinical trials, evaluation and follow-up, including: normal control subjects, individuals with mild memory problems, and patients diagnosed with Alzheimer's Disease or related dementias. Researchers can request data and specimens obtained from ADRC subjects. These include blood or DNA, brain specimens, and cross-sectional or longitudinal clinical and cognitive data, all from ADRC subjects.

Proper citation: Johns Hopkins Alzheimer's Disease Research Center (RRID:SCR_008757) Copy   

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https://www.humanconnectome.org/software/connectome-workbench

Software brain visualization, analysis and discovery tool for fMRI and dMRI brain imaging data, including functional and structural connectivity data generated by the Human Connectome Project. Used to map brain imaging data. Allows for visualization of outputs from HCP pipelines from single subject, or average data from group of subjects and register that data onto standard brain atlas.

Proper citation: Connectome Workbench (RRID:SCR_008750) Copy   

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http://depts.washington.edu/adrcweb/

Research center investigating the basic mechanisms underlying the development of Alzheimer's disease and related disorders, directing particular attention to biomarkers and experimental new treatments. They also continue to search for genetic risk factors underlying Alzheimer's disease (AD). Their main priorities are to find causes, effective treatments, and prevention strategies. Their investigators also are partnering with other Alzheimer's Centers across the country to evaluate promising new medications and other treatments for AD. The ultimate goal of their basic and clinical studies is to improve patient care and function, and improve the quality of life for both the patient and the caregiver. ADRC Cores: * Administration * Clinical Core * Satellite Core * Data Management & Biostatistics * Neuropathology Core * Education & Information Transfer * Genetics

Proper citation: University of Washington Alzheimers Disease Research Center (RRID:SCR_008814) Copy   

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http://www.nimh.nih.gov/educational-resources/neuroscience-and-psychiatry/neuroscience-and-psychiatry-module-2-fear-safety-anxiety-and-anxiety-disorders.shtml

This is the second in a series of modules on neuroscience and psychiatry. This module describes neuroscience research on animal models of fear that informed human studies of fear/safety, anxiety and anxiety disorders. This model helps shed light on the symptoms of PTSD and lead to the development of a novel treatment that has been successful in research studies for several anxiety disorders.

Proper citation: Neuroscience and Psychiatry Module 2: Fear/Safety Anxiety and Anxiety Disorders (RRID:SCR_008843) Copy   

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http://fcon_1000.projects.nitrc.org/fcpClassic/FcpTable.html

1200+ ''resting state'' functional MRI (R-fMRI) datasets independently collected at 33 sites and donated by the principal investigators for the purpose of providing the broader imaging community complete access to a large-scale functional imaging dataset. Age, sex and imaging center information are provided for each of the datasets. In accordance with HIPAA guidelines, all datasets are anonymous, with no protected health information included. We anticipate this data-sharing effort will equip researchers with a means of exploring and refining R-fMRI approaches, and facilitate the growing ethos of sharing and collaboration. Disclaimer: The ''1000 Functional Connectomes Project'' datasets are provided freely without assurance of quality or appropriateness for usage.

Proper citation: FCP Classic Data Sharing Samples (RRID:SCR_005362) Copy   

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http://www.icn.ucl.ac.uk/motorcontrol/

Using robotic devices to investigate human motor behavior, this group develops computational models to understand the underlying control and learning processes. By simulating novel objects or dynamic environments they study how the brain recalibrates well-learned motor skills or acquires new ones. These insights are used to design fMRI studies to investigate how these processes map onto the brain. They have developed a number of novel techniques of how to study motor control in the MRI environment, and how to analyze MRI data of the human cerebellum. They also study patients with stroke or neurological disease to further determine how the brain manages to control the body.

Proper citation: UCL Motor Control Group (RRID:SCR_005271) Copy   

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http://phenotype.mc.vanderbilt.edu/

Collaborative environment of building and validating electronic phenotype algorithms using electronic medical records (EMRs) and natural language processing (NLP) for use in genome-wide association studies (GWAS). On this site you can: View existing algorithms, Enter or create new algorithms, Collaborate with others to create or review algorithms, View implementation details for existing algorithms. The Electronic Medical Records and Genomics Network (eMERGE) has investigated whether data captured through routine clinical care using electronic medical records (EMRs) can identify disease phenotypes with sufficient positive and negative predictive values for use in genome-wide association studies (GWAS). Most EMRs captured key information (diagnoses, medications, laboratory tests) used to define phenotypes in a structured format; in addition, natural language processing has also been shown to improve case identification rates. PheKB is an outgrowth of that validation effort. Phenotype algorithms can be viewed by data modalities or methods used: CPT codes, ICD 10 codes, ICD 9 codes, Laboratories, Medications, Vital Signs, Natural Language Processing Algorithms can also be viewed by: * Implementation results (positive predictive value, sensitivity, publications) * Institution * Work Group

Proper citation: PheKB (RRID:SCR_005292) Copy   

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http://cmrm.med.jhmi.edu/

The goal of our laboratory is to develop new MR technologies to improve the resolution and contrast of MRI and apply them to observe brain anatomy to answer various types of biological questions. Currently we have three major research targets: Characterization of mouse brain development; Human white matter anatomy and development; and Development of diffusion tensor imaging technique and technology dissemination. The DTI database (Under the DTI Download Tab) contains raw and processed DTI data of normal population. Currently we have 2.5 mm isotropic resolution images and 2.2 mm isotropic resolution images. Only 2.5 mm data are available from this site. If you are interested in the high-resolution images, please contact susumu @ mri.jhu.edu. This database is open to public once the user is registered. Basic imaging parameters can be also downloaded.

Proper citation: Johns Hopkins Laboratory of Brain Anatomical MRI (RRID:SCR_005280) Copy   

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http://en.wikipedia.org/wiki/Gene_Wiki

The Gene Wiki is a project that facilitates transferring information on human genes to Wikipedia article stubs with the goal of promoting collaboration and expansion of the articles. Number of gene articles The human genome contains an estimated 20,00025,000 protein-coding genes. The goal of the Gene Wiki project is to create seed articles for every notable human gene, that is, every gene whose function has been assigned in the peer-reviewed scientific literature. Approximately half of human genes have assigned function, therefore the total number of articles seeded by the Gene Wiki project would be expected to be in the range of 10,000 - 15,000. To date, approximately 10,271 articles have been created or augmented to include Gene Wiki project content. Expansion Once seed articles have been established, the hope and expectation is that these will be annotated and expanded by editors ranging in experience from the lay audience to students to professionals and academics. Proteins encoded by genes The majority of genes encode proteins hence understanding the function of a gene generally requires understanding of the function of the corresponding protein. In addition to including basic information about the gene, the project therefore also includes information about the protein encoded by the gene. Stubs for the Gene Wiki project are created by a bot and contain links to the following primary gene/protein databases * HUGO Gene Nomenclature Committee official gene name * Entrez Gene database * OMIM (Mendelian Inheritance in Man) database that catalogues all the known diseases with a genetic component * Amigo Gene Ontology * HomoloGene gene homologs in other species * SymAtlasRNA gene expression pattern in tissues * Protein Data Bank 3D structure of protein encoded by the gene * Uniprot (universal protein resource) a central repository of protein data

Proper citation: Gene Wiki (RRID:SCR_005317) Copy   

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http://www.nari-icmr.res.in

In the early nineties it became evident that HIV infection was spreading widely in India and the national efforts for control of HIV infection needed to be backed by quality research. It was also realized that AIDS, being a multifaceted disease, needed multi-disciplinary research involving virology, immunology, microbiology, clinical research, epidemiology, field based trials and social and behavioral research. An Institute devoted exclusively to HIV/ AIDS that could undertake research of such a diversity and magnitude was established to meet this requirement. National AIDS Research Institute (NARI) was established in October 1992 in Bhosari, Pune on a seven acre plot. The Institute has progressively expanded its activities in various aspects of research on HIV and AIDS through infra-structural development, capacity building & research programmes. The activities of NARI are supported by the ICMR & numerous extramural agencies. For the fiscal year 2005-2006 the ICMR allocated 5.66 crores for NARI. Additionally, over 13 crores have been generated through extramural sources. The Institute''s research activities are guided by a Scientific Advisory Committee which includes eminent scientists from varied disciplines. All research projects are reviewed & approved by the Ethics Committee which also ensures that research is conducted with highest ethical standards. Establishment of a Community Advisory Board which acts as an interface between the community and the researchers is a pioneering effort by NARI.

Proper citation: National AIDS Research Institute (RRID:SCR_005355) Copy   

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http://www.aids.gov/

AIDS.gov works to increase HIV testing and care among people most at-risk for, or living with, HIV, by using emerging communication strategies to provide access to Federal HIV information, policies (e.g. the National HIV/AIDS Strategy), programs, and resources. Objectives # Expand visibility of timely and relevant Federal HIV policies, programs, and resources to the American public. # Increase use of new media tools by government, minority, and other community partners to extend the reach of HIV programs to communities at greatest risk. # Increase knowledge about HIV and access to HIV services for people most at-risk for, or living with, HIV. Unless otherwise noted, material presented on the AIDS.gov Web site is considered Federal government information and is in the public domain. That means this information may be freely copied and distributed. We request that you use appropriate attribution to AIDS.gov. AIDS.gov receives planning guidance from a cross agency planning group and uses a logic model (70 KB) and Communications Plan (702 KB) to guide AIDS.gov activities.

Proper citation: AIDS.gov (RRID:SCR_005356) Copy   

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https://alleninstitute.org/

Non profit bioscience research organization in Seattle, Washington dedicated to accelerating research globally and sharing that data within the science community. Allen Institute for Brain Science, Allen Institute for Cell Science, Allen Institute for Immunology, and The Paul G. Allen Frontiers Group are four divisions of this Institute with commitment to open science model within its research institutes.

Proper citation: Allen Institute (RRID:SCR_005435) Copy   

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http://www.massgeneral.org/children/services/treatmentprograms.aspx?id=1614

The Lurie Center for Autism is a highly successful program designed to evaluate and treat children and adults with a wide variety of developmental and handicapping conditions. Our mission is to provide the highest quality clinical, social and support services to those diagnosed with autism, pervasive developmental disorders and other developmental disabilities. The Lurie Center for Autism is unique because of the population it serves and because it uses a multidisciplinary approach that begins with comprehensive medical evaluations and extends to supporting the well-being of patients and families. Nurses, social workers, speech pathologists, occupational therapists, physical therapists, neuro-psychologists, special education professionals and family members are involved in the treatment processes in addition to physicians. Each has a depth of expertise in his/her respective field. The team, as a unit, plays an integral role in the continuum of care for individuals diagnosed with developmental disabilities. Our services and therapies include: * Extensive diagnostic evaluations * Medical, cognitive and behavioral interventions including speech and language * Speech therapy, occupational therapy, occupational with sensory integration therapy and physical therapy; psychological evaluation and counseling; * Parent skills training and family empowerment * Referral support for additional medical and educational resources at locations near each patient''s home and throughout the New England region The Lurie Center for Autism is committed to improving the medical, social and psychological well-being of children, adolescents, adults and families. To this end, our goals and objectives are to: * Provide a stable, consistent and structured environment within a medical context * Provide opportunities for each individual to achieve * Develop self control, social skills and self esteem in each individual * Support and educate families in order to transfer the learned skills to home, school, work and community environments * Provide teaching to physicians and professionals in training and to pursue research related to the treatment and causes of autism, pervasive developmental disorders and other devlopmental disorders of the central nervous system

Proper citation: Lurie Center for Autism (RRID:SCR_005456) Copy   

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http://nlmfoundation.org/

The primary mission of the Nancy Lurie Marks (NLM) Family Foundation is to help people with autism lead fulfilling and rewarding lives. The Foundation is committed to understanding autism from a scientific perspective, increasing opportunities and services available to the autism community and educating the public about autism. In pursuit of its mission, the Foundation develops and provides grants to programs in research, clinical care, policy, advocacy and education. Founded by Nancy Lurie Marks over 25 years ago, the NLM Family Foundation is one of the largest supporters of initiatives in these areas. The principal goal of the scientific program is to achieve a deeper understanding of the biological basis of autism, focusing on genetics, synaptic chemistry, the neurobiology of communication, systems biology and the physiology of movement. The Foundation funds peer-reviewed research, the development of collaborative investigator projects, and research fellowship programs. Through sponsorship of scientific conferences, symposia and workshops, the Foundation seeks to encourage innovation and provide a springboard to generate new avenues of shared inquiry. The NLM Family Foundation supports programs which focus on novel ways to improve the communication and social abilities of those with autism. Other programs are designed to increase advocacy for legal rights and access to support services for persons with autism, and to increase community understanding and openness to inclusion through education and documentary films.

Proper citation: Nancy Lurie Marks Family Foundation (RRID:SCR_005455) Copy   

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http://www.musicianbrain.com/#index

The human brain has the remarkable ability to adapt in response to changes in the environment over the course of a lifetime. This is the mechanism for learning, growth, and normal development. Similar changes or adaptations can also occur in response to focal brain injuries, e.g., partially-adapted neighboring brain regions or functionally-related brain systems can either substitute for some of the lost function or develop alternative strategies to overcome a disability. Through ongoing research, the Music and Neuroimaging Laboratory''s mission is to: * Reveal the perceptual and cognitive aspects of music processing including the perception and memory for pitch, rhythmic, harmonic, and melodic stimuli. * Investigate the use of music and musical stimuli as an interventional tool for educational and therapeutic purposes. * Reveal the behavioral and neural correlates of learning, skill acquisition, and brain adaptation in response to changes in the environment or brain injury in the developing and adult brain. * Reveal the determinants and facilitators for recovery from brain injury. Project topics include: Aphasia Therapy, Singing and Speaking, Tone Deafness / Congenital Amusia, Motor Recovery Studies, Music and Emotions, Music and Autism, Children and Music Making, Brain Stimulation, Adult Musician Studies, Absolute Pitch Studies, Acute Stroke Studies

Proper citation: Music and Neuroimaging Laboratory (RRID:SCR_005447) Copy   

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http://thebeautifulbrain.com/

The Beautiful Brain explores the latest findings from the ever-growing field of neuroscience through monthly long-form essays, reviews, galleries, short-form blog posts and more, with particular attention to the dialogue between the arts and sciences. The site illuminates important new questions about creativity, the mind of the artist, and the mind of the observer that modern neuroscience is helping us to answer, or at least to provide part of an answer. Instances where art seeks to answer questions of a traditionally scientific nature are also of great interest, and for that reason you will hear from artists as well as scientists on The Beautiful Brain. The Beautiful Brain Podcast also explores the latest findings from the ever-growing field of neuroscience, with particular attention to the dialogue between the arts and sciences. In this monthly program, host Noah Hutton reports on news from the world of brain science, interviews important thinkers about their work, and reviews new literature in the field. The show illuminates important new questions about creativity, the mind of the artist, and the mind of the observer that modern neuroscience is helping us to answer, or at least to provide part of an answer. Instances where art seeks to answer questions of a traditionally scientific nature are also of great interest, and for that reason you will hear from artists as well as scientists on The Beautiful Brain. Subscribe today to receive a brand new episode each month.

Proper citation: Beautiful Brain (RRID:SCR_005472) Copy   

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http://gnif.org/

The GNIF is a non-profit charity organization for the advancement of neurological and mental health patient welfare, education, and research. We aim to further brain related studies, end mental health stigmatization and discrimination, improve the well-being of afflicted individuals, promote the free and open-access distribution of brain related information, and institute universal and multidisciplinary distance educational programs. The paramount GNIF mission is the betterment of neurological and mental health patient welfare, education, and research. With the development of novel free and open-access Therapeutic Recreational Centers, health promotion campaigns, and other charitable activities throughout the world, this organization can aid diagnosed individuals and their advocates. By presenting free and open-access information and educational courses via a distance, the GNIF aims to educate clinicians, teachers, scientists, patients, and the general public on neuroscience, medicine, psychology, biotechnology, and computer science. Moreover, the GNIF supports a variety of sound research programs ranging from biomedical to spiritual studies on the nature of the mind-body connection, biopsychosocial model of health and disease, and health psychology/behavioral medicine practices. The Global Neuroscience Initiative Foundation (GNIF) offers several projects and partnerships adherent to its missions. The following is an alphabetical listing of the GNIF Project Directory: * Brain Blogger * Brain Sciences & Neuropsychiatry * Distance Education Division * Ethics in Mental Health * Knowledge Center * Living with a Brain Disorder * Neuropsychiatry for Kids * Surgical Webcasts * Therapeutic Recreational Centers * Visual Brain Application

Proper citation: Global Neuroscience Initiative Foundation (RRID:SCR_005468) Copy   

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