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https://www.pediatrics.pitt.edu/research/cores-and-research-support/bioinformatics-core

Bioinformatics Core Facility at the John G. Rangos Sr. Research Center provides bioinformatics as well as biostatistics services across a wide range of disease domains. The next-generation sequencing data analysis includes, but is not limited to, whole genome-, whole exome-, bulk and single cell epigenome-, bulk and single cell transcriptome, spatial transcriptome, microbiome, metabolome, proteome and lipidome data analysis. The facility specializes in T-, and B- cell repertoire data analysis, multi-omics initiatives, and multimodal analysis. Shiny dashboard and other web application development is also supported.

Proper citation: University of Pittsburgh School of Medicine Bioinformatics Core Facility (RRID:SCR_025228) Copy   

•   Source: SciCrunch Registry

https://my.creighton.edu/researchservices/corefacilities/histologycore/

Facility provides equipment and services for studies utilizing animal and human tissues. Services include Sample, Processing, Embedding, Sectioning, Histochemistry, Immunohistochemistry, Imaging, Microscopy. Equipment includes microtomes for paraffin sections, cryostat for frozen sections, vibratome for plastic sections, and Nikon Eclipse Ci-L microscope for brightfield and fluorescence applications.

Proper citation: Creighton University Histology Core Facility (RRID:SCR_025163) Copy   

•   Source: SciCrunch Registry

https://mageewomens.org/for-researchers/core-facilities/confocal-microscope-core

Core for imaging from single plane acquisition, to Z-stacks and 3D reconstruction, and to live imaging on slides or in tissue culture dishes. Microscopes are user operated after intensive training and demonstration of proficiency.

Proper citation: Magee-Womens Research Institute Confocal Microscope Core Facility (RRID:SCR_025213) Copy   

•   Source: SciCrunch Registry

https://ctsi.pitt.edu/research-services/core-services/biostatistics-epidemiology-research-design/

Core provides consultation regarding study design, statistical analyses, power and sample size calculations and data collection for clinical and translational studies and grant applications. BERD offers consultation for collecting and managing data using the REDCap system. BERD also offers a series of workshops to provide essential elements involved in data collection, data management and creating reports for research studies.

Proper citation: University of Pittsburgh Clinical and Translational Science Institute Biostatistics, Epidemiology and Research Design Core Facility (RRID:SCR_025214) Copy   

•   Source: SciCrunch Registry

https://www.rad.pitt.edu/mrrc-home.html

Core is dedicated to development and application of magnetic resonance imaging and magnetic resonance spectroscopy for medical and biological research. MRRC is whole-body imaging capable with specialty in anatomical MRI imaging of brain, spine, extremities, liver, bladder as well as functional MRI to study cognitive, sensory, and motor function in the brain.

Proper citation: University of Pittsburgh Magnetic Resonance Research Center Core Facility (RRID:SCR_025215) Copy   

•   Source: SciCrunch Registry

https://bic.beckman.illinois.edu

Core supports molecular and magnetic resonance imaging. Provides facilities, equipment, and training for researchers across range of disciplines. Each BIC tool is supported by research scientists available to assist with study design, data collection, and data post-processing.

Proper citation: University of Illinois at Urbana-Champaign Beckman Institute for Advanced Science and Technology Biomedical Imaging Core Facility (RRID:SCR_025264) Copy   

•   Source: SciCrunch Registry

https://www.uni.lu/lcsb-en/facilities/rodent-facility/

Assist researchers in development and analysis of various in vivo neurodegenerative and cancer models including humanized and germ-free animals. Facility has capacity to house different transgenic and germ-free mouse strains in more than 2500 IVC cages within SOPF breeding barrier.

Proper citation: University of Luxembourg LCSB Rodent Platform Core Facility (RRID:SCR_025267) Copy   

•   Source: SciCrunch Registry

https://biotech.illinois.edu/proteomics

Core provides expertise in characterizing proteins from diverse systems. Provides proteomics services including customized sample preparation, protein identification, detection of post-translational modifications, isotopic label based and label-free quantitation, and intact protein characterization. Equipped with high resolution mass spectrometers with nanoflow liquid chromatography systems or chip-based robots. Core uses software systems such as Mascot, Proteome Discoverer, Byonic, and MaxQuant for analysis of raw mass spectrometry data. Provides assistance in protein quantitation and deeper downstream bioinformatics analysis including gene ontology, visualization of protein networks, and pathway analysis. Consultations are always welcome.

Proper citation: University of Illinois at Urbana-Champaign Roy J. Carver Biotechnology Center Proteomics Core Facility (RRID:SCR_025276) Copy   

•   Source: SciCrunch Registry

https://biotech.illinois.edu/cmto

Facility, couples cytometry with microscopy, genomics and proteomics using instrumentation, expertise and services. Utilizes advanced super resolution microscopy techniques to gain understanding of cell sorting, analysis and enable cutting-edge spatial and single cell and multi-omics services.

Proper citation: University of Illinois at Urbana-Champaign Roy J. Carver Biotechnology Center Cytometry and Microscopy to Omics Core Facility (RRID:SCR_025272) Copy   

•   Source: SciCrunch Registry

https://biotech.illinois.edu/metabolomics

Core identifies and quantifies small molecules from variety of origins such as biological tissue, blood, serum, plasma, cell, cell medium, urine, feces, among others. Provides support for untargeted and targeted metabolite profiling, detecting such compounds as sugars and sugar phosphates, alcohols, amine and polyamines, amino acids, fatty acids, complex lipids, nucleotides, organic acids, phenolics, bile acids, steroids/hormones, neurotransmitters and neuromodulators, phthalates, and many more emerging metabolites. Helps execute projects, including protocol development, sample preparation, instrument method development, instrument data acquisition, and data processing.Multiple complementary analytical methods are utilized with mass spectrometry. Our laboratory has mass spectrometers, including liquid chromatograph-mass spectrometers such as Agilent 6560 ion mobility Q-TOF and Agilent 6546 Q-TOF systems, in addition to our Thermo Fisher Q Exactive hybrid quadrupole-orbitrap, Thermo Fisher Altis triple quadrupole, Sciex 6500+ triple quadrupole, and Sciex 5500 hybrid triple quadrupole-ion trap (QTRAP), as well as gas chromatograph-mass spectrometers including Agilent 5977A, Agilent 5975C, and Agilent 5973.

Proper citation: University of Illinois at Urbana-Champaign Roy J. Carver Biotechnology Center Metabolomics Core Facility (RRID:SCR_025273) Copy   

•   Source: SciCrunch Registry

https://www.cnsi.ucsb.edu/facilities/biological-nanostructures

Multi-purpose core research facility with sub-cores. Genetics, Analytical, Autoclave and Cell Culture Cores. Genetics Core provides Next Generation Sequencing, DNA/RNA and protein quantitation, nucleic acid QC, Real-Time PCR, and Droplet Digital PCR. Analytical Core houses analytical instruments such as UV-Vis, nanoparticle analyzers and plate readers. Some basic molecular biology equipment are also available. Cell Culture Core for researchers who need access to BSL1/BSL2 cell culture facility. Also includes autoclaves or labware sterilization and biohazardous waste disposal.

Proper citation: University of California at Santa Barbara Biological Nanostructures Laboratory Core Facility (RRID:SCR_025308) Copy   

•   Source: SciCrunch Registry

https://knightadrc.wustl.edu/professionals-clinicians/request-center-resources/

Provides on request resources including Data: clinical and cognitive measures as well as MRI and amyloid imaging scans; Tissue: frozen brain tissue, paraffin brain sections, antemortem CSF, DNA, fibroblast, dermal fibroblasts, plasma (fasting and non-fasting) and iPSC; Participants: eligible participants may be invited to enroll in research of other investigators after appropriate review. Researchers can use the request portal to review Center guidelines and policies; view available data and tissue; access data tables and codebooks; and submit request for resources.

Proper citation: Washington University School of Medicine Knight ADRC Request Center Resources Core Facility (RRID:SCR_025254) Copy   

•   Source: SciCrunch Registry

https://nbcc.lunenfeld.ca/facilities/flow-cytometry

Core provides flow cytometry analyzers and cell sorters, with specialty in image-based flow cytometry and cell sorting.Services include unassisted and full-service cell sorting, training on theory and on instruments, consultation on experiment design, protocol development, data analysis, manuscript preparation and grant submission. Applications include image-based analysis powered by machine learning on the Amnis ImageStream; image-based cell sorting using the BD BACS Discover S8; cell sorting for a variety of applications including multi-color sort for bulk culture, indexed cell sort into 96-well plates, cell cycle phase sort and primary tissue sorting for RNA or DNA analysis.

Proper citation: Lunenfeld-Tanenbaum Research Institute Network Biology Collaborative Centre Flow Cytometry Core Facility (RRID:SCR_025384) Copy   

•   Source: SciCrunch Registry

https://nbcc.lunenfeld.ca/facilities/next-gen-sequencing

Core provides both short and long read sequencing capabilities for analysis of gene function and expression.Facility specializes in functional genomics and single cell biology. Services include consultation, sample preparation (especially for spatial and single cell applications), quality control, sequencing analysis, bioinformatics support, and assistance with grant and publication writing related to the services. Applications include:gene function analysis - pooled CRISPR screening, multiplexed barcode screens; whole genome sequencing - both short- and long-read sequencing; bulk gene expression profiling; single cell biology (single cells and single nuclei); spatial profiling; pathogen detection and profiling.

Proper citation: Lunenfeld-Tanenbaum Research Institute Network Biology Collaborative Centre Next-Generation Sequencing Core Facility (RRID:SCR_025385) Copy   

•   Source: SciCrunch Registry

https://sites.dartmouth.edu/cqb/projects-and-cores/data-analytics-core/

Core offers statistical analysis of genomics data. Provides suite of standardized analysis pipelines for common data types like RNA-seq, ATAC-seq, and genome assembly. For more complex datasets, such as single-cell genomics, provides tailored analysis solutions. Core team assists with all project stages, from experimental design to publication support and data management. GDSC hosts several multi-day bioinformatics workshops designed to introduce fundamental concepts for analysis of genomics data.

Proper citation: Dartmouth Genomic Data Sciences Core Facility (RRID:SCR_025383) Copy   

•   Source: SciCrunch Registry

https://nbcc.lunenfeld.ca/facilities/high-throughput-screening

Provides instrumentation and expertise for the automation of laboratory processes. Facility has automated screening platforms and accessory equipment to enable flexible and scalable in vitro and in vivo assays including organoids. Services include access to chemical and genome-wide siRNA libraries, assay development and implementation, and data analysis. Applications include drug discovery and lead validation; ELISA-based assays for immune surveillance; protein biomarker discovery using OLINK proteomics technology; multiplexed barcode screening assays.

Proper citation: Lunenfeld-Tanenbaum Research Institute Network Biology Collaborative Centre High-Throughput Screening Core Facility (RRID:SCR_025390) Copy   

•   Source: SciCrunch Registry

https://hillmanresearch.upmc.edu/research/shared-resources/cellular-therapies

Hillman/University of Pittsburgh co-managed ACCT Labs are cell therapy labs located in more than 15,000 sq ft of lab space, boasting 12 clean rooms. ACCT labs offer services and expertise including the manufacturing cell therapy products for cancer cell therapy trials. The labs are also responsible for monitoring immune function through cell therapy treatments and processing blood products for a number of clinical trials.

Proper citation: University of Pittsburgh Hillman Cancer Center Advanced Cancer Cellular Therapy (ACCT) Laboratory Core Facility (RRID:SCR_025362) Copy   

•   Source: SciCrunch Registry

https://hillmanresearch.upmc.edu/research/facilities/in-vivo-imaging/

Provides novel quantitative imaging techniques that trace biomarkers of molecular events associated with effective cancer therapy.

Proper citation: University of Pittsburgh Hillman Cancer Center In Vivo Imaging Core Facility (RRID:SCR_025360) Copy   

•   Source: SciCrunch Registry

https://bioinformatics.sph.harvard.edu/

Provides single point of contact for Harvard researchers interested in bioinformatics support, applying genomic approaches together with established and developing methodologies from epidemiology, environmental health, biostatistics and bioinformatics to improve human health.Services include analysis all types of next-generation sequencing data from RNA-seq and single cell RNA-seq to variant sequencing (exome or whole genome), to ChIP-seq or bisulfite sequencing. Offers bioinformatics training program for Harvard researchers interested in learning basic data skills and analysis of high-throughput sequencing data.

Proper citation: Harvard University Chan School of Public Health Bioinformatics Core Facility (RRID:SCR_025373) Copy   

•   Source: SciCrunch Registry

https://mriresearch.med.ubc.ca/

Facility consist of Philips 3.0 Tesla MRI scanner for studies on humans, Bruker small bore 9.4 Tesla MRI scanner, and computing facility for image archival and analysis. Scanners are entirely dedicated to research, and MR scanning is carried out on cost recovery basis. The scanners were selected to cater to a very broad range of in vivo applications and the Imaging Centre staff is trained to support any research projects that the scanners can accommodate.

Proper citation: University of British Columbia MRI Research Core Facility (RRID:SCR_025374) Copy   

•   Source: SciCrunch Registry