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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
rDiff
 
Resource Report
Resource Website
1+ mentions
rDiff (RRID:SCR_003162) data analysis software, data processing software, sequence analysis software, software application, software resource Software tool for detecting differential RNA processing from RNA-Seq data. It implements two statistical tests, rDiff.parametric and rDiff.nonparametric, to detect changes of the RNA processing between two samples. differential rna processing, rna processing, rna seq is listed by: OMICtools PMID:23585274 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01338 SCR_003162 2026-09-03 04:46:13 7
PIRSF
 
Resource Report
Resource Website
10+ mentions
PIRSF (RRID:SCR_003352) PIRSF data or information resource, database, narrative resource, standard specification A SuperFamily classification system, with rules for functional site and protein name, to facilitate the sensible propagation and standardization of protein annotation and the systematic detection of annotation errors. The PIRSF concept is being used as a guiding principle to provide comprehensive and non-overlapping clustering of UniProtKB sequences into a hierarchical order to reflect their evolutionary relationships. The PIRSF classification system is based on whole proteins rather than on the component domains; therefore, it allows annotation of generic biochemical and specific biological functions, as well as classification of proteins without well-defined domains. There are different PIRSF classification levels. The primary level is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture). At a lower level are the subfamilies which are clusters representing functional specialization and/or domain architecture variation within the family. Above the homeomorphic level there may be parent superfamilies that connect distantly related families and orphan proteins based on common domains. Because proteins can belong to more than one domain superfamily, the PIRSF structure is formally a network. The FTP site provides free download for PIRSF. protein annotation, classification, protein, superfamily, functional site, protein name, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: UniProtKB
has parent organization: Protein Information Resource
NHGRI U01-HG02712;
NSF DBI-0138188;
NSF ITR-0205470
PMID:19455212
PMID:14681371
Free, Freely available biotools:pirsf, OMICS_01697, nif-0000-03294 https://bio.tools/pirsf http://pir.georgetown.edu/pirsf/ SCR_003352 PIR SuperFamily, Protein Information Resource SuperFamily 2026-09-03 04:46:17 32
MouseNET
 
Resource Report
Resource Website
1+ mentions
MouseNET (RRID:SCR_003357) mouseNet analysis service resource, data analysis service, data or information resource, database, production service resource, service resource A functional network for laboratory mouse based on integration of diverse genetic and genomic data. It allows the users to accurately predict novel functional assignments and network components. MouseNET uses a probabilistic Bayesian algorithm to identify genes that are most likely to be in the same pathway/functional neighborhood as your genes of interest. It then displays biological network for the resulting genes as a graph. The nodes in the graph are genes (clicking on each node will bring up SGD page for that gene) and edges are interactions (clicking on each edge will show evidence used to predict this interaction). Most likely, the first results to load on the results page will be a list of significant Gene Ontology terms. This list is calculated for the genes in the biological network created by the mouseNET algorithm. If a gene ontology term appears on this list with a low p-value, it is statistically significantly overrepresented in this biological network. The graph may be explored further. As you move the mouse over genes in the network, interactions involving these genes are highlighted.If you click on any of the highlighted interactions graph, evidence pop-up window will appear. The Evidence pop-up lists all evidence for this interaction, with links to the papers that produced this evidence - clicking these links will bring up the relevant source citation(s) in PubMed. gene, network, mouse, protein function, visualization, open reading frame, graph is listed by: OMICtools
is related to: Gene Ontology
is related to: mouseMAP
has parent organization: Princeton University; New Jersey; USA
NSF DBI-0546275;
NIGMS R01 GM071966;
NSF IIS-0513552;
NIGMS P50 GM071508
PMID:18818725 Free, Freely available OMICS_01550, nif-0000-32003 SCR_003357 MouseNET 2026-09-03 04:46:10 3
ALDEx2
 
Resource Report
Resource Website
500+ mentions
ALDEx2 (RRID:SCR_003364) software resource Software tool to examine compositional high-throughput sequence data with Welch's t-test. A differential relative count abundance analysis for the comparison of two conditions. For example, single-organism and meta-rna-seq high-throughput sequencing assays, or of selected and unselected values from in-vitro sequence selections. Uses a Dirichlet-multinomial model to infer abundance from counts, that has been optimized for three or more experimental replicates. Infers sampling variation and calculates the expected Benjamini-Hochberg false discovery rate given the biological and sampling variation using several parametric and non-parametric tests. Can to glm and Kruskal-Wallace tests on one-way ANOVA style designs. standalone software, r, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: aldex
has parent organization: Western University; Ontario; Canada
PMID:24910773 Free, Available for download, Freely available biotools:aldex2, OMICS_04634 https://bio.tools/aldex2 SCR_003364 2026-09-03 04:46:19 609
RCircos
 
Resource Report
Resource Website
100+ mentions
RCircos (RRID:SCR_003310) software resource Software package that provides a simple and flexible way to generate Circos 2D track plot images for genomic data visualization. The types of plots include: heatmap, histogram, lines, scatterplot, tiles and plot items for further decorations include connector, link (lines and ribbons), and text (gene) label. All functions require only R graphics package that comes with R base installation. standalone software, unix/linux, mac os x, windows, r is listed by: OMICtools
is related to: shinyCircoss
has parent organization: CRAN
has parent organization: Bitbucket
PMID:23937229 Free, Available for download, Freely available OMICS_04661 https://bitbucket.org/henryhzhang/rcircos/ SCR_003310 RCircos: Circos 2D Track Plot 2026-09-03 04:46:11 285
JCVI Primer Designer
 
Resource Report
Resource Website
1+ mentions
JCVI Primer Designer (RRID:SCR_003275) JCVI Primer Designer software resource High throughput PCR primer design software. Target regions defined through a rich set of descriptors, such as Ensembl accessions and arbitrary genomic coordinates, may be specified. Primer pairs are then selected computationally to produce a minimal amplicon set capable of tiling across the specified target regions. As part of the tiling process, primer pairs are computationally screened to meet the criteria for success with one of two PCR amplification protocols. perl, command-line, pcr primer design, pcr, primer, high throughput sequencing is listed by: OMICtools
has parent organization: SourceForge
PMID:18405373 Free, Available for download, Freely available OMICS_02330 SCR_003275 2026-09-03 04:46:20 1
ddCt
 
Resource Report
Resource Website
100+ mentions
ddCt (RRID:SCR_003396) ddCt software resource Software package providing an approximation method to determine relative gene expression with quantitative real-time PCR (qRT-PCR) experiments. It requires no standard curve for each primer-target pair, therefore reducing the working load and yet returning accurate enough results as long as the assumptions of the amplification efficiency hold. The package implements a pipeline to collect, analyze and visualize qRT-PCR results, for example those from TaqMan SDM software, mainly using the ddCt method. The pipeline can be either invoked by a script in command-line or through the API consisting of S4-Classes, methods and functions. differential expression, gene expression, microtitre plate assay, q-pcr is listed by: OMICtools
has parent organization: Bioconductor
Free, Available for download, Freely available OMICS_02312 SCR_003396 Delta-Delta-Ct 2026-09-03 04:46:26 328
ggbio
 
Resource Report
Resource Website
10+ mentions
ggbio (RRID:SCR_003313) software resource An R package for extending the grammar of graphics for genomic data. The graphics are designed to answer common scientific questions, in particular those often asked of high throughput genomics data. All core Bioconductor data structures are supported, where appropriate. The package supports detailed views of particular genomic regions, as well as genome-wide overviews. Supported overviews include ideograms and grand linear views. High-level plots include sequence fragment length, edge-linked interval to data view, mismatch pileup, and several splicing summaries. standalone software, unix/linux, mac os x, windows, r, infrastructure, visualization, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
PMID:22937822 Free, Available for download, Freely available biotools:ggbio, OMICS_04660 http://www.tengfei.name/ggbio/, https://bio.tools/ggbio SCR_003313 ggbio - Visualization tools for genomic data 2026-09-03 04:46:07 16
deFuse
 
Resource Report
Resource Website
50+ mentions
deFuse (RRID:SCR_003279) data analysis software, data processing software, sequence analysis software, software application, software resource, software toolkit Software package for gene fusion discovery using RNA-Seq data. It uses clusters of discordant paired end alignments to inform a split read alignment analysis for finding fusion boundaries. rna sequencing, gene fusion, paired end alignment, split read, fusion boundary, bio.tools uses: SAMTOOLS
uses: Bowtie
uses: BLAT
uses: GMAP
uses: R Project for Statistical Computing
is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
British Columbia Cancer Foundation ;
Vancouver General Hospital Foundation ;
Genome Canada ;
Michael Smith Foundation for Health Research ;
Canadian Breast Cancer Foundation ;
Canadian Institutes of Health Research's Bioinformatics Training Program
PMID:21625565 Free, Available for download, Freely available biotools:defuse, OMICS_01345 https://sourceforge.net/projects/defuse/, http://compbio.bccrc.ca/software/defuse/, https://bio.tools/defuse http://sourceforge.net/apps/mediawiki/defuse/index.php?title=Main_Page SCR_003279 2026-09-03 04:46:12 95
NormFinder
 
Resource Report
Resource Website
1000+ mentions
NormFinder (RRID:SCR_003387) NormFinder software resource Software for identifying the optimal normalization gene among a set of candidates. It ranks the set of candidate normalization genes according to their expression stability in a given sample set and given experimental design. It can analyze expression data obtained through any quantitative method e.g. real time RT-PCR and microarray based expression analysis. NormFinder.xla adds the NormFinder functionality directly to Excel. A version for R is also available. normalization, gene is used by: RefFinder
is listed by: OMICtools
PMID:15289330 Free, Available for download, Freely available OMICS_02317 https://www.moma.dk/software/normfinder SCR_003387 NormFinder software - Determine the optimal normalization gene 2026-09-03 04:46:26 2536
Genedata Expressionist
 
Resource Report
Resource Website
10+ mentions
Genedata Expressionist (RRID:SCR_003298) data analysis software, data management software, data processing software, software application, software resource Software that provides data processing, analysis, management, and reporting of metabolomics, proteomics and biotherapeutics characterization studies based on mass spectrometry. It can process raw data from various MS instruments, serve MS processing, analysis and reporting needs, and ensure reproducibility and traceability of results. mass spectrometry data processing, mass spectrometry data analysis, mass spectrometry data management, omics software is listed by: OMICtools THIS RESOURCE IS NO LONGER IN SERVICE OMICS_00761 SCR_003298 Genedata Expressionist for Genomic Profiling 2026-09-03 04:46:06 10
PrimerSeq
 
Resource Report
Resource Website
1+ mentions
PrimerSeq (RRID:SCR_003295) PrimerSeq software resource Software that designs RT-PCR primers that evaluate alternative splicing events by incorporating RNA-Seq data. It is particularly advantageous for designing a large number of primers for validating alternative splicing events found in RNA-Seq data. It incorporates RNA-Seq data in the design process to weight exons by their read counts. Essentially, the RNA-Seq data allows primers to be placed using actually expressed transcripts. This could be for a particular cell line or experimental condition, rather than using annotations that incorporate transcripts that are not expressed for the data. Alternatively, you can design primers that are always on constitutive exons. PrimerSeq does not limit the use of gene annotations and can be used for a wide array of species. primer, rna-seq, rt-pcr, windows, mac os x, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
PMID:24747190 Free, Available for download, Freely available biotools:primerseq, OMICS_02328 https://bio.tools/primerseq SCR_003295 Primer Seek in RNA-Seq 2026-09-03 04:46:10 7
OmicCircos
 
Resource Report
Resource Website
50+ mentions
OmicCircos (RRID:SCR_003292) software resource An R software application and package used to generate high-quality circular plots for visualizing genomic variations, including mutation patterns, copy number variations (CNVs), expression patterns, and methylation patterns. standalone software, unix/linux, mac os x, windows, r, annotation, statistical method, visualization is listed by: OMICtools
has parent organization: Bioconductor
PMID:24526832 Free, Available for download, Freely available OMICS_04659 http://www.bioconductor.org/packages/release/bioc/html/OmicCircos.html SCR_003292 OmicCircos: High-quality circular visualization of omic data 2026-09-03 04:46:12 83
MIPgen
 
Resource Report
Resource Website
50+ mentions
MIPgen (RRID:SCR_003325) software resource Software for a fast, simple way to generate designs for MIP assays targeting hundreds or thousands of genomic loci in parallel. Packaged with MIPgen are scripts that aid in visualization of MIP designs and processing of MIP sequence reads to SAM files that can then be passed through any standard variant calling pipeline. standalone software, c++, python, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: University of Washington; Seattle; USA
PMID:24867941 Free, Available for download, Freely available OMICS_04657, biotools:mipgen https://github.com/shendurelab/MIPGEN, https://bio.tools/mipgen SCR_003325 MIPgen - One stop MIP design and analysis 2026-09-03 04:46:23 52
PoPoolation2
 
Resource Report
Resource Website
100+ mentions
PoPoolation2 (RRID:SCR_003284) software resource Software to compare allele frequencies for SNPs between two or more populations and to identify significant differences. PoPoolation2 requires next generation sequencing data of pooled genomic DNA (Pool-Seq). It may be used for measuring differentiation between populations, for genome wide association studies and for experimental evolution., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. standalone software, next generation sequencing, population genetics, population genomics, statistics, toolkit, population is listed by: OMICtools
has parent organization: Google Code
PMID:22025480 Free, Available for download, Freely available OMICS_05824 SCR_003284 2026-09-03 04:46:05 242
DAFGA
 
Resource Report
Resource Website
1+ mentions
DAFGA (RRID:SCR_003319) software resource A python script package which estimates the evolutionary rate of a particular functional gene in a standardized manner by relating its sequence divergence to that of the 16S rRNA gene. It provides gene-specific parameter sets for OTU clustering and taxonomic assignment at desired rank, and it can be implemented into the diversity measurements offered by QIIME or Mothur. standalone software, python is listed by: OMICtools PMID:24939150 Free, Available for download, Freely available OMICS_04654 SCR_003319 DAFGA: Diversity Analysis of Functional Gene Amplicons, Diversity analysis of Functional Gene Amplicons 2026-09-03 04:46:08 1
Snakemake
 
Resource Report
Resource Website
100+ mentions
Snakemake (RRID:SCR_003475) Snakemake software resource A Python based language and execution environment for make-like workflows. The system supports the use of automatically inferred multiple named wildcards (or variables) in input and output filenames. python, workflow, bio.tools is used by: RiboSnake
is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Google Code
PMID:22908215
DOI:10.1093/bioinformatics/bts480
Free, Available for download, Freely available OMICS_02299, biotools:snakemake https://snakemake.github.io/ SCR_003475 snakemake - A Python based language and execution environment for make-like workflows 2026-09-03 04:46:17 465
PheWAS R Package
 
Resource Report
Resource Website
1+ mentions
PheWAS R Package (RRID:SCR_003512) software resource Software package contains methods for performing Phenome-Wide Association Study. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Vanderbilt University; Tennessee; USA
PMID:20335276 Free OMICS_00242, biotools:phewas https://bio.tools/phewas SCR_003512 Phenome-Wide Association Study 2026-09-03 04:46:23 7
NGSANE
 
Resource Report
Resource Website
10+ mentions
NGSANE (RRID:SCR_003478) NGSANE software resource Software providing a Linux-based High Performance Computing (HPC) enabled framework for high-throughput data analysis that minimizes overhead for set up and processing of new projects yet maintains full flexibility of custom scripting when processing raw sequence data. next generation sequencing is listed by: OMICtools PMID:24470576 BSD License, v3 OMICS_02298 SCR_003478 Next Generation Sequencing ANalysis for Enterprises 2026-09-03 04:46:21 10
SNAPE-pooled
 
Resource Report
Resource Website
1+ mentions
SNAPE-pooled (RRID:SCR_003476) software resource Software that computes the probability distribution for the frequency of the minor allele in a certain population, at a certain position in the genome. standalone software is listed by: OMICtools
has parent organization: Google Code
PMID:22992255 GNU General Public License, v3 OMICS_05820 SCR_003476 snape-pooled: Computes the minor allele frequency spectrum in pooled DNA (sequenced) samples 2026-09-03 04:46:23 8

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