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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://bios.unc.edu/~weisun/software/asSeq.htm
Software that establishes a statistical framework for future developments of eQTL (expression quantitative trait locus) mapping methods using RNA-seq data (e.g., linkage-based eQTL mapping), and the joint study of multiple genetic markers and/or multiple genes. This R package has been submitted to R/bioconductor. It will be available on bioconductor soon. It is recommended to install this R package from bioconductor. You can also install this R package from the source code by yourself. Since the R package contains C code, a C complier is required for installation. With both R and appropriate c complier installed, this R package can be installed using the following command (in Mac Terminal window or Windows command window) R CMD INSTALL asSeq
Proper citation: asSeq (RRID:SCR_001625) Copy
http://neuronalarchitects.com/neural-cipher.html
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 17, 2016. C#.NET 4.0 application that interfaces with the Neural Maestro class library to perform Classical and Bayesian logistic polynomial regression analysis for multiple trial and experimental neuroscience / electrophysiological datasets. The idea is to build a neural feature extractor to plug into a neural recognition network based on recordings from patch clamps and/or brain computer interfaces. Frequency based feature sets are collected from the simulation of neuronal cell assemblies and examined for inclusion in combinatorial regressions using the Neural Maestro API. Regressions are evaluated based on different metrics. The application interfaces with a R and MATLAB API and produces a compendium to be published on CRAN.
Proper citation: Neural Cipher (RRID:SCR_001577) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowFP.html
A Bioconductor software package for fingerprint generation of flow cytometry data, used to facilitate the application of machine learning and datamining tools for flow cytometry.
Proper citation: flowFP (RRID:SCR_001537) Copy
http://patchwork.r-forge.r-project.org/
Software tool for analyzing and visualizing allele-specific copy numbers and loss-of-heterozygosity in cancer genomes. The data input is in the format of whole-genome sequencing data which enables characterization of genomic alterations ranging in size from point mutations to entire chromosomes. High quality results are obtained even if samples have low coverage, ~4x, low tumor cell content or are aneuploid. Patchwork takes BAM files as input whereas PatchworkCG takes input from CompleteGenomics files. TAPS performs the same analysis as Patchwork but for microarray data.
Proper citation: Patchwork (RRID:SCR_000072) Copy
http://cran.r-project.org/manuals.html
Manuals for R created on Debian Linux that can be downloaded as PDF files, EPUB files (for R-devel and R-patched), or directly browsed as HTML. They may differ from the manuals for Mac or Windows on platform-specific pages, but most parts will be identical for all platforms.
Proper citation: R Manuals (RRID:SCR_000036) Copy
http://bioconductor.org/packages/release/bioc/html/CorMut.html
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 16,2023. Software package for computing correlated mutations based on selection pressure. Three methods are provided for detecting correlated mutations, including conditional selection pressure, mutual information and Jaccard index. The computation consists of two steps: First, the positive selection sites are detected; second, the mutation correlations are computed among the positive selection sites. Note that the first step is optional. Meanwhile, CorMut facilitates the comparison of the correlated mutations between two conditions by the means of correlated mutation network.
Proper citation: CorMut (RRID:SCR_000053) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowBin.html
A software package to combine flow cytometry data that has been multiplexed into multiple tubes with common markers between them. It establishes common bins across tubes in terms of the common markers, then determines expression within each tube for each bin in terms of the tube-specific markers.
Proper citation: flowBin (RRID:SCR_000051) Copy
https://cran.r-project.org/src/contrib/Archive/MetaDE/
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 30, 2022. Software package that implements 12 major meta-analysis methods for differential expression analysis.Package was removed from the CRAN repository.Formerly available versions can be obtained from the archive.Archived on 2018-01-23 as check problems were not corrected in time.
Proper citation: MetaDE (RRID:SCR_000199) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowFlowJo.html
A Bioconductor package that can import gates defined by the commercial package FlowJo and work with them in a manner consistent with the other flow packages in Bioconductor. FlowJo is a commercial GUI based software package from TreeStar Inc. for the visualization and analysis of flow cytometry data. One of the FlowJo standard export file types is the FlowJo Workspace. This is an XML document that describes files and manipulations that have been performed in the FlowJo GUI environment. This package can take apart the FlowJo workspace and deliver the data into R in the flowCore paradigm.
Proper citation: flowFlowJo (RRID:SCR_000410) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowStats.html
Software using statistical methods and functionality to analyze flow data that is beyond the basic infrastructure provided by the flowCore package.
Proper citation: flowStats (RRID:SCR_000399) Copy
http://code.google.com/p/d2-tools/
Software toolbox for counting the frequency of K-tuple from sequencing datasets and calculate the dissimilarity.
Proper citation: d2-tools (RRID:SCR_000425) Copy
http://www.bioconductor.org/packages/release/bioc/html/iBMQ.html
Software for integrated Bayesian Modeling of eQTL data. It implements a joint hierarchical Bayesian model where all genes and SNPs are modeled concurrently.
Proper citation: iBMQ (RRID:SCR_000481) Copy
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 8, 2025. R function for computing predictions and simulating data from both Mlxtran and PharmML models that is based on MlxCompute, the model simulation engine developed by Lixoft. MlxCompute combines the Mlxtran language interpreter with the equation solvers to compute efficiently complex systems of ordinary differential equations (ODEs) and delayed differential equations (DDEs). Simulx takes advantage of the modularity of hierarchical models for simulating different components of a model: models for population parameters, individual covariates, individual parameters and longitudinal data, including continuous, count, categorical, and time-to-event data. It is also extremely flexible for defining complex dose regimens. Simulx will be the core of the next version of the DDMoRe Clinical Trial Simulator.
Proper citation: Simulx (RRID:SCR_000486) Copy
http://sourceforge.net/projects/foursig/
A suite of software programs for analyzing and visualizing 4C-seq data.
Proper citation: fourSig (RRID:SCR_000516) Copy
http://www.bioconductor.org/packages/release/bioc/html/GeneExpressionSignature.html
An R package developed for the large-scale analysis of gene expression signatures. It gives the implementations of the gene expression signature and its distance to each. Gene expression signature is represented as a list of genes whose expression is correlated with a biological state of interest. And its distance is defined using a nonparametric, rank-based pattern-matching strategy based on the Kolmogorov-Smirnov statistic. Gene expression signature and its distance can be used to detect similarities among the signatures of drugs, diseases, and biological states of interest.
Proper citation: GeneExpressionSignature (RRID:SCR_000455) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowQ.html
THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 8,2025. Software that provides quality control and quality assessment tools for flow cytometry data.
Proper citation: flowQ (RRID:SCR_000575) Copy
http://www.bioconductor.org/packages/release/bioc/html/SigFuge.html
Algorithm for testing significance of clustering in RNA-seq data.
Proper citation: SigFuge (RRID:SCR_000444) Copy
https://cran.r-project.org/web/packages/clValid/index.html
An R package which contains functions for validating the results of a clustering analysis.
Proper citation: clValid (RRID:SCR_014626) Copy
http://compbio.mit.edu/cummeRbund/index.html
Software R package used for simplifying and analyzing Cufflink RNA-Seq output. This program takes various output files from a cuffdiff run and creates a SQLite database of the results that will describe the appropriate relationships between the genes, transcripts, transcription start sites and CDS regions.
Proper citation: CummeRbund (RRID:SCR_014568) Copy
https://cran.r-project.org/web/packages/ggplot2/index.html
Open source software package for statistical programming language R to create plots based on grammar of graphics. Used for data visualization to break up graphs into semantic components such as scales and layers.
Proper citation: ggplot2 (RRID:SCR_014601) Copy
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